117,626 research outputs found
Renal dysplasia in grey Alpine breed cattle unrelated to CLDN16 mutations
Get PDFRENAL dysplasia (RD) is a developmental disorder of the renal parenchyma characterised by anomalous differentiation of the nephrons and collecting ducts (Woolf and others 2004). In human medicine, RD is one of the principal causes of childhood end-stage renal failure. In veterinary medicine, it has been described in several species, including cattle (Dunham and others 1989, Simon and others 1999, Ohba and others 2001, Castro and others 2007, Maxie and Newman 2007, Aresu and others 2009, Philbey and others 2009). In Japanese Black cattle, RD shows autosomal recessive inheritance, caused by CLDN16 mutations (Hirano and others 2000, Ohba and others 2000, Hirano and others 2002). These mutations affect one of the members of the claudin family of genes which plays an important role in the formation of tight junctions in the kidney (Simon and others 1999). In Japanese Black cattle, RD is classified into two types, according to two independent CLDN16 mutations (Hirano and others 2002), but no morphological or histopathological differences between the two types have been reported. This short communication deals with a case of RD in twin grey Alpine heifers which are not related to mutations of the CLDN16 gene
Presentazione
No full textViene presentata l'importanza del volume, che si configura come la prima opera dedicata alla storia dei rom in Italia che sia scritta in prevalenza da storici di professione che presentano studi di prima mano
Transformation of canine lymphoma/leukemia to more aggressive diseases : anecdotes or reality?
Get PDFTransformation is the evolution of an indolent lymphoma/leukemia to an aggressive
lymphoma, typically harboring a very poor prognosis. This phenomenon is well described
in humans, but underestimated in dogs although recognized as a possible evolution
of indolent lymphomas/leukemias. In canine chronic leukemias, blast crisis (mainly in
myeloid) and Richter syndrome (transformation into a high grade lymphoma) (mainly in
B-cell lymphocytic leukemia) have been reported. Transformation is a possible event
also in canine low grade lymphomas, although rare. The increased knowledge has also
generated new questions and posed challenges that need to be addressed to improve
outcome, including the recognition of the clinical characteristics at diagnosis associated
with a higher risk of transformation in an attempt of anticipating the typical evolution
Perspectives on the design of clinical trials for targeted therapies and immunotherapy in veterinary oncology
No full textThe field of oncology research has undergone major changes in recent years. Progress in molecular and cellular biology has led to a greater understanding of the cellular pathways and mechanisms of cell proliferation and tissue invasion associated with cancer. New classes of cancer therapies are becoming available or are in development but these new agents require a paradigm shift in the design of oncology clinical trials. This review provides an overview of clinical trial designs for the development of tumour vaccines and targeted therapeutic agents. In addition, some of the successes, limitations and challenges of these trials are discussed, with a special emphasis on the difficulties and particularities that are encountered in veterinary medicine compared to similar work in human patients. (C) 2015 Elsevier Ltd. All rights reserved
Transformation of canine lymphoma/leukemia to more aggressive diseases: Anecdotes or reality?
Get PDFTransformation is the evolution of an indolent lymphoma/leukemia to an aggressive lymphoma, typically harboring a very poor prognosis. This phenomenon is well described in humans, but underestimated in dogs although recognized as a possible evolution of indolent lymphomas/leukemias. In canine chronic leukemias, blast crisis (mainly in myeloid) and Richter syndrome (transformation into a high grade lymphoma) (mainly in B-cell lymphocytic leukemia) have been reported. Transformation is a possible event also in canine low grade lymphomas, although rare. The increased knowledge has also generated new questions and posed challenges that need to be addressed to improve outcome, including the recognition of the clinical characteristics at diagnosis associated with a higher risk of transformation in an attempt of anticipating the typical evolution
Rom: linguaggi istituzionali e (auto)rappresentazioni in due recenti volumi
Get PDFBook review of Martina Giuffré, ed, Uguali, diversi, normali. Stereotipi, rappresentazioni e contronarrative del mondo rom in Italia, Spagna e Romania, Roma, Castelvecchi, 2014, pp. 286; Leonardo Piasere, Nicola Solimano, Sabrina Tosi Cambini, eds, Wor(l)ds which Exclude. The Housing Issue of Roma, Gypsies and Travellers in the Language of the Acts and the Administrative Documents in Europe, Fiesole, Fondazione Michelucci Press, 2014, pp. 240.Nota critica di Martina Giuffré, a cura di, Uguali, diversi, normali. Stereotipi, rappresentazioni e contronarrative del mondo rom in Italia, Spagna e Romania, Roma, Castelvecchi, 2014, pp. 286; Leonardo Piasere, Nicola Solimano, Sabrina Tosi Cambini, eds, Wor(l)ds which Exclude. The Housing Issue of Roma, Gypsies and Travellers in the Language of the Acts and the Administrative Documents in Europe, Fiesole, Fondazione Michelucci Press, 2014, pp. 240
Use of mouth guard in basketball: observational study of a group of teenagers with and without motivational reinforcement
No full textAim This study aims at ascertaining the capacity of
2 groups of young athletes to be faithful to the initial
oral prevention project, with the difference that the
study group received motivational reminders by either
researchers and technical staff members of the team
during the observation period, while the control group
did not receive any motivational reminders.
Materials and methods This observational study
was based on two groups selected from a wide group
of 150 adolescent basketball players who accepted
to use a custom-made mouth guard during their
sport sessions. None of the selected athletes (60
adolescents aged between 12 and 15 years ) had ever
worn a mouth guard during their sports activity. A
customised mouth guard was supplied, and subjetcs
were requested to wear it for 12 months during
training sessions and competitions. The study group
was composed of 30 athletes, 15 males and 15 females,
who received a constant motivational reinforcement to
the use of the mouth guard by their coach and during
checkups. Similarly, the control group was composed
of 30 athletes (15 males and 15 females) who did not
receive any motivational reinforcement.
Results Twelve months after the beginning of the
study, 24 subjects belonging to the control group werenot using the mouth guard, while only 7 subjects of
the study group were not using it. It was also noticed,
six months after the beginning of the observation
period, a rapid decline in the participants’ interest in
the use of the mouth guard.
Conclusion No traumatic event was registered
among those adolescents who had used the mouth
guard for the whole period of the study. Female
athletes showed greater compliance to this prevention
project. It is important that all technical staff members,
and particularly the leading coach, encourage the
regular use of oral protection device
Use of mouth guard in basketball: observational study of a group of teenagers with and without motivational reinforcement
No full textAIM: This study aims at ascertaining the capacity of 2 groups of young athletes to be faithful to the initial oral prevention project, with the difference that the study group received motivational reminders by either researchers and technical staff members of the team during the observation period, while the control group did not receive any motivational reminders.MATERIALS AND METHODS: This observational study was based on two groups selected from a wide group of 150 adolescent basketball players who accepted to use a custom-made mouth guard during their sport sessions. None of the selected athletes (60 adolescents aged between 12 and 15 years) had ever worn a mouth guard during their sports activity. A customised mouth guard was supplied, and subjetcs were requested to wear it for 12 months during training sessions and competitions. The study group was composed of 30 athletes, 15 males and 15 females, who received a constant motivational reinforcement to the use of the mouth guard by their coach and during checkups. Similarly, the control group was composed of 30 athletes (15 males and 15 females) who did not receive any motivational reinforcement.RESULTS: Twelve months after the beginning of the study, 24 subjects belonging to the control group were not using the mouth guard, while only 7 subjects of the study group were not using it. It was also noticed, six months after the beginning of the observation period, a rapid decline in the participants' interest in the use of the mouth guard.CONCLUSION: No traumatic event was registered among those adolescents who had used the mouth guard for the whole period of the study. Female athletes showed greater compliance to this prevention project. It is important that all technical staff members, and particularly the leading coach, encourage the regular use of oral protection devices for prevention among teenagers practicing sports
Parachini-Winter et al “A case of canine high-grade T-cell lymphoma immunophenotypically consistent with T-zone lymphoma”
No full text
- …
