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Un adattamento alla popolazione italiana della Scala di Fletcher ed Averill (1984) per la misura dell’abilità di role play. (The Italian version of the scale for the measurement of role play ability by Fletcher and Averill (1984)
"Disponibilità di spazio conversazionale e strutturazione delle interazioni intragruppo"
Abstract, I Congresso Nazionale della Sezione di Psicologia Sociale della A.I.P., Roma. Pubbl. in: B. Mazzara & G. Petrillo (a cura di), A.I.P. Associazione Italiana di Psicologia Sezione di Psicologia Sociale I Congresso Nazionale Roma, 9-11 ottobre 1997 Riassunti delle comunicazioni, IRACE, Napoli (p. 175-177
Omeprazole and ultrastructural modifications occurring in reflux esophagitis [1]
Dilated intercellular spaces are a sign of esophageal epithelial
damage in acid-perfused rabbits. This alteration can be identified only
by transmission electron microscopy (TEM).1,2 The same changes
have also been demonstrated in reflux esophagitis in humans, occurring
in patients with either erosive or nonerosive esophagitis.3 As yet,
we do not know if successful medical therapy induces a regression of
these ultrastructural changes.
We observed a case of hematemesis and melena occurring in an
11-month-old child. Upper gastrointestinal endoscopy revealed a
hemorrhagic erosive esophagitis (stage IV of Savary-Miller modified
classification). Eight endoscopic biopsies were taken 5 cm above the
Z line. Of these, 4 were stained with H&E, to assess general pathology,
and 4 were selected for processing by TEM.4 The latter biopsies
showed mean intercellular space diameters of 2.5 mm (Figure
1B). As a consequence, the patient was treated with omeprazole 10
mg/day for 18 months (the half granular content of the capsule of 20
mg was administrated in a few milliliters of orange juice, 30 minutes
before breakfast). During this period, the patient was asymptomatic,
growth was normal, and no side effects were recorded. Upper GI
endoscopy at the end of therapy showed a normal esophageal mucosa
both endoscopically and histologically. TEM also demonstrated the
complete recovery of the ultrastructural changes (Figure 1C) with the
mean intercellular space diameters being #0.40.
This is the first demonstration that omeprazole is effective not only
in inducing the regression of symptoms and macroscopic lesions but
in the restoration of normal intercellular space dimensions, whose
dilatation must be considered the first alteration of reflux esophagitis.
Nevertheless, to date we do not know if such an outcome is achieved
in every patient considered clinically and endoscopically cured, nor do
we know details of the treatment time interval required to achieve
complete ultrastructural recovery
Diffuse oesophageal leiomyomatosis
Diffuse leiomyomatosis of the oesophagus is a rare pathological condition characterised by diffuse hypertrophy of the oesophageal muscles, without involvement of the muscularis mucosae. This disease involves children and young adults, occasionally associated with other localisation of leiomyomatosis or with Alport’s syndrome.
We report on the case of a 61-year-old male with a progressive dysphagia to solids along with moderate weight loss over the previous 2 years admitted to our department
with a food bolus impaction
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