102,493 research outputs found
Peripheral blood stem cell collection from G-CSF-stimulated unrelated donors for second transplant
No full textPeripheral blood stem cells (PBSCs) collected following stimulation with cytokines are commonly used for autologous haematopoietic transplants. Currently, PBSCs are being used for syngeneic or allogeneic transplants from matched or haploidentical donors. However, many issues are still unanswered regarding the early or late side-effects cytokines have on recipients and on healthy donors. The aims of this paper were to evaluate the experience acquired worldwide in this field, to define the acceptability of stem cell donation by G-CSF-stimulated apheresis from unrelated donors after the failure of a first donation, and to assess side-effects of G-CSF on unrelated donors. The use of PBSCs has increased tremendously over the last few years and in the near future PBSCs will probably become the most relevant source of stem cells. Studies conducted so far have definitely concluded that G-CSF is safe and well tolerated. Results observed in transplants utilizing marrow stem cells compared with results obtained in transplants utilizing PBSCs have shown that patients undergoing this latter procedure recover earlier, require a lower number of transfusions and spend fewer days in hospital with a consequent decrease in costs. We concluded that a second transplant by G-CSF-stimulated apheresis from an unrelated donor is definitely acceptable and we designed a prospective study to better define all controversial aspects. Donors will be given 10 microg/kg/day of G-CSF subcutaneously for 5 days. One or two PBSC collection procedures will be performed: the first on day 5 and the second, if necessary, on day 6. Donors will be surveyed and blood counts monitored in a standardized manner during the process
Tourism management and industrial ecology: a theoretical review
No full textIndustrial Ecology (IE) is based on the relation between the natural ecosystem and economic ecosystem. The concept refers to the metaphorical relation between the natural and industrial ecosystems as a model for transforming unsustainable industrial systems. Several tools and strategies are particularly significant for the IE development. In other words, the primary purpose of industrial ecology is to assess and reduce the impact economic activities on the environment. Tourism, as an economic activity, resulting in a full range of environmental impacts, should be treated like any other industry. This paper propose uses a theoretical review focused on IE for to investigate what is the best way to implement industrial ecology in the tourism activities. It seemed interesting to search within the IE concept for a model for the tourism sector, one of the fields with the greatest environmental interaction and economic implications
Are we sure we all do the same things? Results from a GITMO survey on basic practices in allogeneic bone marrow transplantation
No full textStart-up Made in Italy: un modello predittivo di exit a partire dagli indicatori di bilancio.
No full textSocial Life Cycle Assessment as a Management Tool: Methodology for Application in Tourism
No full text""As is widely known, sustainability is an important factor in competition, increasing the added value of a company in terms of image and credibility. However, it is important that sustainability assessments are effectively addressed in a global perspective. Therefore, life cycle tools are adopted to evaluate environmental and social impacts. Among these, and of particular significance, appears the Social Life Cycle Assessment (SLCA), which, although in its early stage of development, seems to have extremely promising methodological features. For this reason, it seemed interesting to propose a first application to the tourism sector, which could be better than other methods, studied in terms of social sustainability data. The particular characteristics of service delivery lend themselves more to the development of data related to social sustainability than other sectors. In this paper the results of a case study carried out using social accounting and business management tools are shown."
Environmental Analysis Based on Life Cycle Assessment: An Empirical Investigation on the Conventional and Hybrid Powertrain
No full textThe Life Cycle Sustainability Assessment (LCA) methodology is today considered as a crucial paradigm with multiple levels of analysis, including the economic, social and environmental aspects. In this scenario, the purpose of the present research is to carry out an accurate and extensive LCA based analysis to compare the environmental impact, between conventional gasoline and hybrid vehicle powertrains. Two different powertrain scenarios were considered maintaining the same vehicle chassis. The performed analysis concerned resources and energy consumption as well as pollutant emission of each process, evaluating the impact of powertrain production, the vehicle use phase, and powertrain end of life scenarios. A large set of indicators-including human toxicity, eutrophication, and acidification-was considered. The study indicates that the potential of electrified vehicles basically depends on efficient production and recycling of the battery. We found that the conventional powertrain determines a higher Global Warming Potential (GWP) than hybrid powertrain (by almost 30%). Conversely, the water-related impact is higher in hybrid powertrain, and this is associated to the extraction and processing of the metal and mischmetal within the battery pack. Furthermore, the incidence of transport in the use phase for the conventional powertrain has high impact related to freshwater and marine aquatic ecotoxicity
Dall'Innovazione alla Start-up - L'esperienza di imprenditori italiani in Italia e in California
No full text"The concept of Innovation is prevalent in so many studies, books and blogs as to. become, in some ways, a trite term. Some of these writings present a “recipe” for how. to make an innovative product, while others offer advice about how to expand a business. with an innovative idea, and still others focus their attention on some specific aspects. of this vast concept.. Nevertheless, a univocal description of the concept of innovation does not exist;. the only certainty is with regard to its importance. One of the many definitions that. could be representative is that given by Schumpeter, according to which innovation is. the introduction for the first time, into the economic or social system, of a new product,. process or system (Schumpeter J. A., 1911). This implies an entrepreneurial act. capable of passing an invention from the conceptual phase to concrete commercial. application. A business structure that supports such a transformation is therefore essential.. In this study, we will focus our attention precisely on the businesses that translate. an idea into “innovative businesses,” also known as “startups.”. The origins of this type of business can be found in the United States and, more. specifically, in California. South of San Francisco, in the area the entire world knows. as Silicon Valley, a unique and inimitable “entrepreneurial ecosystem” developed,. from which all countries today seek to draw ideas and inspiration.. This ecosystem is constituted of some distinctive elements such as: The presence of many big businesses.. The presence of universities, such as Berkeley and Stanford, that are. the principal sources of intellectual capital.. The presence of solid financial structures of venture capitalism, angel. investors and legal support.. The presence of consistent human capital coming from various countries. and the influence this has on the general cultural environment.. The culture of failure together with the presence of brilliant personalities. like Steve Jobs, Bill Hewlett and David Packard (to cite some of. the most famous), driven by a preeminent desire to create innovation.. In Italy, following the economic crisis of 2008, the boom of the ecosystem tied to. innovative startups could be explained by the desire for recovery and development.. The research project (carried out over approximately one year) from which this. work arises was born following studies performed at the University of California,. Berkeley. During that period, the research conducted in the area allowed for the indepth. analysis of the Californian situation and the understanding of the dynamics that. are at play this entrepreneurial ecosystem.. The objective was to analyze all of the key variables existing between startups. created by Italians, in Italy and in Silicon Valley, to then note any commonalities and. differences that may exist (not only cultural and in the ecosystem but also in the business. models used).. Although the two ecosystems (Italian and Californian) are not comparable, it was. still possible to research and compare the reasons for which Italians choose to build. their businesses in Italy or in California. The entire research project was developed. from this starting point, based on which the results will be presented in this work.. More specifically, the work is divided into five chapters, together with a preface. by Prof. Alberto Onetti and a presentation of the work.. The first chapter aims to explain the historic developments of the concept of innovation. in economic and managerial literature, in order to understand the determinants. that are at the core of the innovative businesses that drive startups.. The second chapter provides the definition of startups and describes the organizational. models, their life cycles and the players that participate in the same, specifically. those who are not part of the traditional ecosystems such as advisors and mentors, the. role played by business incubators and accelerators and the characteristics of backers. such as angel investors and venture capitalists.. The third chapter concentrates on the historic development of the Californian and. Italian ecosystems. The same concludes with a map that traces, based on the life cycle. of the startup, the general trends related to the profile of the innovative businesses. and the players who comprise them.. In the fourth chapter, the empirical analysis and the results obtained are presented.. The sample considered is comprised of 52 startups, 22 created by Italians with at least. one branch in the United States, and 30 created by Italians in Italy. Through the use. of a questionnaire, it was possible to better understand the various determinants, from. general information characterizing the startupper and business to past experiences. from the incubation factors to the investment and location factors that drive Italian. startups, both in Silicon Valley and in Italy.. To supplement the questionnaire, interviews were also conducted on part of the. sample to better understand the specific situations of the startups and to collect various. opinions regarding the strong and weak points of doing business in Italy and in. Silicon Valley.. Finally, the fifth chapter presents a critical analysis of the results of the research. project and the conclusions of the authors. To provide further opportunities to inspire. the reflections of the readers, the chapter also relates opinions on the theme, “Startups. and the Future of Italy” by some of the principal players of the Italian startup scene,. such as: Riccardo Luna, Augusto Coppola, Stefano Bernardi and Niccolò Sanarico.. The volume offers a representation of the economic panorama concerning the new. entrepreneurial ecosystem, which is gradually becoming stabilized through the establishment. of new businesses identifiable as startups.. The objective of the authors was to describe, in a balanced way, the important and. varied aspects of innovation, emphasizing both the particular elements of the scientific. debate and the methods with which, on the various international markets, the. theoretic concepts were transformed into competitive advantage for existing companies. and in new best practices for newly established businesses.. The text is addressed primarily to experts in the sector and to those who work in. the field of startups, such as consultants, managers and entrepreneurs, but does not. exclude those who would simply like to deepen their knowledge or acquire new skills,. with the ultimate goal of encouraging reflection about the subject.
"Lo sviluppo del marchio Ecolabel nel settore turistico"
No full textThe concept of ‘environmental consumption’ helps in developing an interest in eco-labels. This is a shift away from traditional command and control measures imposed by governments towards market governance which is a self-regulatory new environmental policy instrument, eco-labelling. Taken into consideration of this eco-labels potentiality to attain sustainability, various eco-labelling schemes have been introduced since early 90’s. Ecolabels is a voluntary labelling systems for food and consumer products. They are a form of sustainability measurement directed at consumers, intended to make it easy to take environmental concerns into account when shopping. Some labels quantify pollution or energy consumption by way of index scores or units of measurement; others simply assert compliance with a set of practices or minimum requirements for sustainability or reduction of harm to the environment. The EU Ecolabel is a voluntary product label. It was established in 1992 to encourage businesses to market products and services that meet high standards of environmental performance and quality. The labels are awarded according to environmental criteria set by the member states of the EU with involvement of industry and consumer and environmental NGOs European Commission of Environment. These criteria cover the whole life cycle of a product, from the extraction of raw materials, through manufacture, distribution, use and disposal of the product. These assessment criteria are not generic and specific products and services have their own criteria. There is a significant body of legislation that has been assembled to back up the EU Eco Label which has been periodically reviewed since 1992 to keep the text up to date and ensure that lessons learned in the implementation of ecolabel schemes are incorporated. The EU Ecolabel is part of a broader EU Action Plan on Sustainable Consumption and Production and Sustainable Industrial Policy adopted by the European Commission on 16 July 2008, which also links the Flower to other EU policies such as Green Public Procurement (GPP) and Ecodesign of Energy Using products
"From the producer to the consumer: walking toward safety and quality along goods and food chain"
No full text- …
