8,554 research outputs found
Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene
No full textG protein-coupled receptor regulation of gene transcription primarily occurs through the phosphorylation of transcription factors by MAPKs. This requires transduction of an activating signal via scaffold proteins that can ultimately determine the outcome by binding signaling kinases and adapter proteins with effects on the target transcription factor and locus of activation. By investigating these mechanisms, we have elucidated how pituitary gonadotrope cells decode an input GnRH signal into coherent transcriptional output from the LH beta-subunit gene promoter. We show that GnRH activates c-Src and multiple members of the MAPK family, c-Jun NH2-terminal kinase 1/2, p38MAPK, and ERK1/2. Using dominant-negative point mutations and chemical inhibitors, we identified that calcium-dependent proline-rich tyrosine kinase 2 specifically acts as a scaffold for a focal adhesion/cytoskeleton-dependent complex comprised of c-Src, Grb2, and mSos that translocates an ERK-activating signal to the nucleus. The locus of action of ERK was specifically mapped to early growth response-1 (Egr-1) DNA binding sites within the LH beta-subunit gene proximal promoter, which was also activated by p38MAPK, but not c-Jun NH2-terminal kinase 1/2. Egr-1 was confirmed as the transcription factor target of ERK and p38MAPK by blockade of protein expression, transcriptional activity, and DNA binding. We have identified a novel GnRH-activated proline-rich tyrosine kinase 2-dependent ERK-mediated signal transduction pathway that specifically regulates Egr-1 activation of the LH beta-subunit proximal gene promoter, and thus provide insight into the molecular mechanisms required for differential regulation of gonadotropin gene expression
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PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis
No full text© 2015, Saburo Ito, Jun Araya, Yusuke Kurita, Kenji Kobayashi, Naoki Takasaka, Masahiro Yoshida, Hiromichi Hara, Shunsuke Minagawa, Hiroshi Wakui, Satoko Fujii, Jun Kojima, Kenichiro Shimizu, Takanori Numata, Makoto Kawaishi, Makoto Odaka, Toshiaki Morika
Evidencia sobre la movilidad intergeneracional de ingresos laborales para un país en desarrollo: el caso de Uruguay
No full textAntecedentes: Responder en qué medida el desempeño de los hijos depende de los resultados obtenidos por sus padres ha sido un importante objeto de estudio de la ciencia económica en los últimos años (Fields y Ok, 1999; Jäntti y Jenkins, 2013). Este documento busca aportar evidencia original sobre la movilidad social intergeneracional (MSI) para Uruguay, medida a través de los ingresos laborales.Metodología: La elasticidad intergeneracional del ingreso (EII), así como la asociación intergeneracional en el ranking (IRA) son estimadas por medio de mínimos cuadrados en dos etapas en dos muestras (2S2SLS), estimador usualmente utilizado en la literatura empírica en aquellos países que no disponen de información de corte longitudinal. Asimismo, mediante la aplicación de matrices de transición y la estimación por medio de regresiones cuantílicas, se estudia la presencia de no linealidades en la MSI.Resultados: Los hallazgos ubicarían a Uruguay dentro del grupo de países latinoamericanos con alta MSI de ingresos, junto con Argentina y Chile. No obstante, este nivel parece ser bajo si se compara con los países desarrollados de Europa, en particular, los escandinavos. Asimismo, la menor MSI se halla en las colas de la distribución del ingreso.Conclusiones: Los resultados sugieren que aquellas personas que nacen en hogares de bajos recursos presentan mayores dificultades para lograr MSI ascendente, mientras que parece poco probable que las personas que nacen en hogares de altos recursos sufran MSI descendente
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No full textauthorIn other places [Old Joe, the trapper] pointed out otter (or, as he pronounced it, "author") slidesPRINTED ITEM G.M.Story April 1959Not UsedNot UsedWithdrawn[see 'otter']Checked by Jordyn Hughes on Thu 09 Jun 201
Jia ru ju he wu dui jun yun tuan liu ji jun yun tuan liu dui liu de ying xiang
No full textWong, Chai Kwok = 加入聚合物對均勻湍流及均勻湍流對流的影響 / 黃濟國.Thesis M.Phil. Chinese University of Hong Kong 2013.Includes bibliographical references (leaves 89-91).Abstracts also in Chinese.Title from PDF title page (viewed on 01, November, 2016).Wong, Chai Kwok = Jia ru ju he wu dui jun yun tuan liu ji jun yun tuan liu dui liu de ying xiang / Huang Jiguo
Author Correction: Manipulating anion intercalation enables a high-voltage aqueous dual ion battery
No full textThe original version of this Article did not acknowledge Prof. Jun Fan as a corresponding author. This has now been corrected in both the PDF and HTML versions of the Article.link_to_subscribed_fulltex
Author Correction: A proteomic landscape of diffuse-type gastric cancer
No full textThe original version of this Article contained an error in the email address of the corresponding author Jun Qin. The correct email is [email protected]. The error has been corrected in the HTML and PDF versions of the Article.</jats:p
Corrigendum: The taeniaticornis-group of genus Apanteles Foerster (Hymenoptera, Braconidae, Microgastrinae) from China with one new species. Journal of Hymenoptera Research 96: 21–31. doi: 10.3897/jhr.96.99649
No full textIn a paper about a new species of Apanteles (Microgastrinae)(Liu & Chen, 2023), we regret the omission of one author Jun-hua Chen in the second place of the author list who did great job in construction of the ZJUH collection for this study and the mistake in institution order and corresponding author. We provide the correct information below.Zhen Liu1, 2, Jun-hua He1, Xue-xin Chen11 Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China. 2 Zoology Key Laboratory of Hunan Higher Education, College of Life and Environmental Sciences, Hunan University of Arts and Science, Changde 415000, China
Yong yu you hua zhi bei chao leng yuan zi hun he wu de guang xue ou ji jing
No full textChen, Jun = 用於優化製備超冷原子混合物的光學偶極阱 / 陳軍.Thesis M.Phil. Chinese University of Hong Kong 2014.Includes bibliographical references (leaves 109-117).Abstracts also in Chinese.Title from PDF title page (viewed on 29, November, 2016).Chen, Jun = Yong yu you hua zhi bei chao leng yuan zi hun he wu de guang xue ou ji jing / Chen Jun
A PORTRAITURE OF DOMESTIC SLAVERY IN THE UNITED STATES
No full textA Portraiture of Domestic Slavery, in the Unite~ States: with
reflections on the practicability of restoring the moral rights of the
Slave, without impairing the legal privileges of the possessor; and a
Project of a Colonial ARJlum for Free Pcrsons of Colour: inclUding
Memoirs of Facts on the interior Tmffie iB Slaves, and on IidBapping.
Illustrated with Engravings. By Jesse Torrey, jun. Physician.
Author of a Series of Essays on Morals aDd the Diffusion of Knowledge.
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