1,721,050 research outputs found
La correlazione tra i linfociti infiltranti il tumore e le cellule staminali tumorali nel carcinoma polmonare non a piccole cellule (NSCLC).
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Le cellule CD44+/EPCAM+ individuano una sottopopolazione di cellule ALDHhigh nel carcinoma polmonare non a piccole cellule (NSCLC): una chance per targettare le cellule staminali tumorali?
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La elevata presenza di cellule staminali neuroendocrine cancerose (CSC-NET) in un caso di carcinoide atipico del polmone.
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La trasposizione del muscolo pettorale in associazione alla tecnica di ravitch modificata per la correzione chirurgica del Pectus Excavatum di grado severo.
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Isolamento e identificazione delle cellule staminali tumorali nell’adenocarcinoma e nel carcinoma squamocellulare del polmone: uno studio pilota.
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Procedura di Claggett modificata per empiema necessitatis postlobectomia: report di un caso clinico trattato con successo.
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Mircrining the injured heart with stem cellderived exosomes: an emerging strategy of cell-free therapy.
Full text linkBone marrow-derived mesenchymal stem cells (MSCs) have successfully progressed to phase III clinical trials successive to an intensive in vitro and pre-clinical assessment in experimental animal models of ischemic myocardial injury. With scanty evidence regarding their cardiogenic differentiation in the recipient patients’ hearts post-engraftment, paracrine secretion of bioactive molecules is being accepted as the most probable underlying mechanism to interpret the beneficial effects of cell therapy. Secretion of small non-coding microRNA (miR) constitutes an integral part of the paracrine activity of stem cells, and there is emerging interest in miRs’ delivery to the heart as part of cell-free therapy to exploit their integral role in various cellular processes. MSCs also release membrane vesicles of diverse sizes loaded with a wide array of miRs as part of their paracrine secretions primarily for intercellular communication and to shuttle genetic material. Exosomes can also be loaded with miRs of interest for delivery to the organs of interest including the heart, and hence, exosome-based cell-free therapy is being assessed for cell-free therapy as an alternative to cell-based therapy. This review of literature provides an update on cell-free therapy with primary focus on exosomes derived from BM-derived MSCs for myocardial repair
Thoracic surgery
No full textVengono descritti brevemente gli aspetti di diagnosi e stadiazione delle neoplasie polmonari. Gli autori descrivono poi dettagliatamente gli aspetti dello studio funzionale cardiorespiratorio preoperatorio e la valutazione del rischio perioperatorio. Più brevemente si soffermano sulle principali procedure chirurgiche e infine si descrivono gli aspetti relativi al trattamenti riabilitativo e generale postoperatorio. Il tutto focalizzato ai pazienti anziani,
Intraoperative aortic endograft placement for an unexpected plaque rupture during lung surgery
No full textBackground: Surgical resection of tumors invading the aorta is a challenging procedure. More recently, the use of thoracic aortic endografts has been reported to facilitate en bloc resection of tumors invading the aortic wall. The best treatment option is to keep the procedure separated before lung resection to reduce the risks of bleeding, therefore avoiding adverse consequences for the patient. However, an aortic stent placement before surgery is not mandatory with no clear signs of tumor or atherosclerotic plaque infiltrating the entire aortic wall. Case presentation: A 72-year-old man came to our Department for a persistent cough. Computed tomography (CT) scan with enhancement showed a mass located in the left upper lobe of the lung with no clear sign of infiltration or calcified plaques along the entire vascular wall. A positron emission tomography with 2-deoxy-2-[fluorine-18] fluoro-D-glucose integrated with computed tomography (PET/CT with 18F-FDG) was positive for hypermetabolic mass with negative lymph node stations bilaterally. Patient was undergone surgery for major lung resection by left thoracotomy. For an unexpected intraoperative bleeding due to the rupture of a calcified plaque, a stent was placed before proceeding with lung surgery. Patient was persistently stable, discharged after six days from surgery with no morbidities. Conclusions: In our case, no signs of the atherosclerotic plaque infiltration as well as no tumor infiltration were shown. In these situations, the aortic stent placement is possible in emergency, even during another operation. Nevertheless, surgeon experience and the good coordination among specialists is mandatory to yield a satisfying solution
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