1,721,130 research outputs found
In vivo evidence that human adrenal glands possess 11ß-hydroxysteroid dehydrogenase activity.
No full textBlood samples were collected intraoperatorily from inferior vena cava (VC) and adrenal vein (AV) of 8 male and 9 female consenting adult patients undergoing unilateral nephrectomy with ipsilateral adrenalectomy for kidney cancer, and steroid-hormone concentrations were assayed by quantitative HPLC. Hormonal concentrations were significantly higher in AV than in VC (systemic) blood and did not display significant differences between males and females. Higher levels not only of the main glucocorticoids cortisol and corticosterone, but also of their inactive oxidized forms corticosterone and 11-dehydrocorticosterone (DH-B), respectively, were detected in AV than in VC blood. Highly significant inverse correlations between cortisol and cortisone, and corticosterone and DH-B concentrations were observed in AV, but not in VC blood. Moreover, in AV blood the concentration of the main cortisol precursor 11-deoxycortisol correlated inversely with those of both cortisone and DH-B. Taken together, these findings are in keeping with previous in vitro evidence that human adrenal glands possess 11beta-hydroxysteroid dehydrogenase activity, which is engaged in the inactivation of newly formed glucocorticoids and is probably negatively regulated by the local concentrations of non-11beta-hydroxylated steroid-hormone precursors
L'adenocarcinoma du Larynx: à propos d'un cas.etude histologique,immunohistochimique et en microscopie electronique.
No full textAssociation of angiomyolipoma and renal adenocarcinoma: histologic, arteriographic and microangiographic correlation.
No full text
CD10 and HHF35 actin in the differential diagnosis between Collagenous spherulosis and adenoid-cystic carcinoma of the breast.
No full textollagenous Spherulosis (CS) and Adenoid-Cystic Carcinoma (AdCC) of the breast consist of cribriform proliferations of epithelial and myoepithelial cells with an immunophenotypic overlap of some myoepithelial markers, such as p63 and smooth muscle actin (SMA). To our knowledge, CD10 and HHF35 actin have not been assessed in the differential diagnosis of these two breast lesions. We performed an immunohistochemical study on 6 cases of CS and 9 cases of AdCC. We found CD10, muscle-specific actin (HHF35), Estrogen and Progesterone receptors (ER and PR) to be strongly expressed in CS, but not in AdCC; C-kit was diffusely positive in AdCC and scanty in CS; SMA, p63 and Cytokeratine 5/6 (CK5/6) were positive in both. Our results also confirm that AdCC could be true basal-like neoplasia, probably arising from a basal stem line tending to divergent differentiation toward CK5/6/C-kit+, ER/PR-, epithelial basal-like cell type, and toward a myoepitelial-like cell type, with an incomplete SMA/p63+, CD10/HHF35- immunophenotype. By contrast, CS is a reactive, benign proliferation of two well-differentiated cell types: epithelial (ER/PR+, C-kit-) and myoepithelial cells with a complete immunophenotype including CD10/HHF35 positivity. Our study highlights the usefulness of CD10 and HHF35 in the differential diagnosis and helps to understand the histogenesis of the two lesions
Utilità dell'immunoistochimica nel differenziare un carcinoma papillare della tiroide insorto su tessuto ectopico da una metastasi laterocervicale
No full textInternal pudendal artery of the male in childhood. Submacroscopic anatomico-surgical study.
No full textDecreased expression of thymidylate synthase and low proliferation index assessed by ki67 in " signet ring cell component" of colorectal carcinomas
No full textGrowth hormone secretagogue receptor subtypes 1a and 1b are expressed in the human adrenal cortex
No full textGhrelin is an endogenous ligand of the growth hormone secretagogue receptors
(GHS-Rs), two subtypes of which have been recognized: the biologically active 1a
and the biologically inactive 1b subtype. Reverse transcription-polymerase chain
reaction demonstrated ghrelin and GHS-R1b mRNAs in eight human adrenal cortexes,
and GHS-R1a mRNA only in six of the eight adrenal specimens. The GHS-R1a
expression was absent in the two adrenal cortexes obtained from 76- and 79-year
old male patients. Since previous studies showed that ghrelin does not affect
steroid-hormone secretion, the present findings suggest that ghrelin via the
GHS-R1a could be involved in the autocrine-paracrine control of human-adrenal
growth
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