12,687 research outputs found
Genetic bases of dilated cardiomyopathy
No full textCardiomyopathies represent a wide and heterogeneous group of diseases wherein a genetic cause has been consistently identified.Dilated cardiomyopathy (DCM) is characterized by ventricular dilation and progressive systolic dysfunction, and it is the most common form of cardiomyopathy.Causative genetic mutations have been identified in more than 40 genes encoding proteins belonging to different cellular structures and pathways.A great diversity of pathways has been implied in the pathogenesis of DCM, depending on the affected genes and on the dislodged intracellular structures or mechanisms.This review describes the major genes and focus on the pathophysiologic mechanisms of DCM, with a special consideration of the most recent discoveries in the field
Re: Marzio Angelo Zullo, Francesco Plotti, Marco Calcagno, Elettra Marullo, Innocenza Palaia, Filippo Bellati, Stefano Basile, Ludovico Muzii, Roberto Angioli and Pierluigi Benedetti Panici. One-Year Follow-up of Tension-free Vaginal Tape (TVT) and Trans-obturator Suburethral Tape from Inside to Outside (TVT-O) for Surgical Treatment of Female Stress Urinary Incontinence
No full text[No abstract available
MABS validation through repeated execution and data mining analysis
No full textAgent Based Modelling is the most interesting and advanced approach for simulating a complex system: in a social context, the single parts and the whole are often very hard to describe in detail. Besides, there are agent based formalisms which allow to study the emergency of social behaviour with the creation and study of models, known as artificial societies. Thanks to the ever increasing computational power, it's been possible to use such models to create software, based on intelligent agents, which aggregate behaviour is complex and difficult to predict, and can be used in open and distributed systems. Data mining is born in the last decades in order to help users in finding useful knowledge from the otherwise overwhelming amount of data available nowadays from the web and the data collected every day by companies. Data Mining techniques can therefore be the keystone to reveal non-trivial knowledge expressed by the initial assumption used to build the micro-level of the model and the structure of the society of agents that emerged from the simulation
Facades of the Libreria di San Marco in Venice, The: An Interpretation of the Design Process
No full text"A new work in which I propose an interpretation of the design process Sansovino used to create the magnificent facades of the Libreria di San Marco in Venice, a masterpiece of Renaissance architecture." Sent to Marquand librarian by author Dec. 202
Art without an Author: Vasari’s Lives and Michelangelo’s Death
No full textMonografia sulla rappresentazione di Michelangelo nelle due edizioni delle Vite, sulla storia del libro e la questione della sua paternitàBook dedicated to the representation of Michelangelo in Vasari's Lives of the Artists, to the history of the book, and to the problem of its authorshi
Clinical outcomes of bioresorbable versus durable polymercoated everolimus-eluting stents in real-world complex patients
No full textAIMS: The aim of this study was to evaluate the safety and efficacy profile of new-generation, SYNERGY everolimus-eluting stents (S-EES) as compared to XIENCE everolimus-eluting stents (X-EES) with a durable polymer coating in "complex patients".
METHODS AND RESULTS: We included 2,001 consecutive patients treated with S-EES (n=400) or X-EES (n=1,601) at two Italian centres between May 2013 and May 2015. We used propensity score matching to obtain two cohorts of patients with similar baseline risk profiles. Patients were stratified according to baseline complexity based on the EVOLVE II trial exclusion criteria. The primary outcome was major adverse cardiac events (MACE), defined as the composite of all-cause death, myocardial infarction (MI), and target lesion revascularisation (TLR), at one year. Among 391 matched pairs of patients treated with S-EES or X-EES, we identified 253 (63%) as complex. At one-year follow-up, among "complex" patients, MACE rates did not differ between the S-EES and X-EES groups (9.9% vs. 9.5%, p=0.830, HR 1.04, CI: 0.72-1.48). Similarly, death, MI, and TLR, stratified for complexity, were comparable between S-EES and X-EES treated patients at one year. Of note, no definite ST was observed in either the S-EES or the X-EES cohort.
CONCLUSIONS: New-generation S-EES with a bioresorbable polymer coating appear to be safe and effective irrespective of patient complexity as compared to X-EES
How to prevent crimes using earthquakes
No full textIn this chapter the author describes how techniques coming from earthquakes prediction has been used to produce successful mathematical models useful in preventing crimes
The Research Agenda: Marco Bassetto on the Quantitative Evaluation of Fiscal Policy Rules
No full textMarco Bassetto is a Senior Economist in the Economic Research Department at the Federal Reserve Bank of Chicago. He is interested in political-economy models of fiscal policy and in applications of game theory to the analysis of macroeconomic policy more in general. This piece reflects the personal views of the author and not necessarily those of the Federal Reserve Bank of Chicago or the Federal Reserve System.
Princes, Towns, Palaces: A Renaissance “Architecture of Power”
No full textThis essay is the introductory chapter of a book collecting the results of a joint research project on ‘royal’ palaces in early modern Italy coordinated by Marco Folin. By summarizing the results of his studies on Italian court architecture, the author underlines the pluralistic character of Quattrocento architectural language, due to the strenght of municipal traditions often dating back to communal age
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