907 research outputs found
New developments in the genetics, pathogenesis, and therapy of IgA nephropathy
No full textRecent years have brought notable progress in the field of IgA nephropathy. Here, we highlight important new directions and latest developments, including successful discovery of several genetic susceptibility loci, formulation of the multihit pathogenesis model, introduction of the Oxford pathology scoring system, and formalization of the Kidney Disease Improving Global Outcomes (KDIGO) consensus treatment guidelines. We focus on the latest genetic findings that confirm a strong contribution of inherited factors and explain some of the geoethnic disparities in disease susceptibility. Most IgA nephropathy susceptibility loci discovered to date encode genes involved in the maintenance of the intestinal epithelial barrier and response to mucosal pathogens. The concerted pattern of interpopulation allelic differentiation across all genetic loci parallels the disease prevalence and correlates with variation in local pathogens, suggesting that multilocus adaptation might have shaped the present-day landscape of IgA nephropathy. Importantly, the 'Intestinal Immune Network for IgA Production' emerged as one of the new targets for potential therapeutic intervention. We place these findings in the context of the multihit pathogenesis model and existing knowledge of IgA immunobiology. Lastly, we provide our perspective on the existing treatment options, discuss areas of clinical uncertainty, and outline ongoing clinical trials and translational studies.Kidney International advance online publication, 16 September 2015; doi:10.1038/ki.2015.252
Gerald Gorman
No full textPhorograph - Gerald Gorman in traditional Scottish clothing, (Edinburgh, Scotland). A note with the picture reads: "Hoot Mon", The Canadian Kid. Sincerely Yours, Gerald Gorma
Re tsuwet.s re Secwepemc: the things we do
No full text"An exhibit of Secwepemc photography, then and now, in commemoration of the tenth anniversary of the partnership between Secwepemc Cultural Education Society and the Simon Fraser University." -- cover. The booklet contains photographs along with an essay written by Marianne B. Ignace, Ron Ignace and Gerald Etienne.Not peer reviewedArtist catalogueHistoric bookle
Re tsuwet.s re Secwepemc: the things we do
No full text"An exhibit of Secwepemc photography, then and now, in commemoration of the tenth anniversary of the partnership between Secwepemc Cultural Education Society and the Simon Fraser University." -- cover. The booklet contains photographs along with an essay written by Marianne B. Ignace, Ron Ignace and Gerald Etienne.Not peer reviewedArtist catalogueHistoric bookle
745829_supp_mat – Supplemental material for Use of online recruitment strategies in a randomized trial of cancer survivors
No full textSupplemental material, 745829_supp_mat for Use of online recruitment strategies in a randomized trial of cancer survivors by Stephen P Juraschek, Timothy B Plante, Jeanne Charleston, Edgar R Miller, Hsin-Chieh Yeh, Lawrence J Appel, Gerald J Jerome, Debra Gayles, Nowella Durkin, Karen White, Arlene Dalcin and Manuel Hermosilla in Clinical Trials</p
Athabasca School District No. 839 (1955-1956)
No full textPhotograph - Teacher Alice B. Donahue and her class at Athabasca Public School, Athabasca, Alberta. Back row, left to right: Gerald Shank, Janet McLevin, John Smith, Victor Oakes, Shirley Shank, Scott MacLeod, James Sale, Brenda Marsten, Johnny Rypien. Centre row, left to right: Corinne Saley, Marilyn Nelson, Diane Stelter, Chrissy Preece, Donald Stuart, Eddie Sundby, Robin Wood, Barry Rypien, Alice B. Donahue. Front row, left to right: Judy Sundby, Edward Patry, Sylvia Tymchuk, David Richards, Deb Preece, Joyce Senz, Johnny Sorokowski, Ferris Zelman, unknown, Louella Roger
Groundwater resources of the Harney Basin, southeastern Oregon
No full textReport -- Plate 1. Location of Selected Geographic Features, Wells, Springs, Streamgaging Stations, Section Traces, and Sampling Locations, Harney Basin, Southeastern Oregon -- Plate 2. Water-Table Contour Map, 2018, Harney Basin, Southeastern Oregon -- Plate 3. Water-Level Contour Map for Wells Greater than 100 Feet Deep, 2018, Harney Basin, Southeastern Oregon.by Stephen B. Gingerich, Henry M. Johnson, Darrick E. Boschmann, Gerald H. Grondin, and C. Amanda Garcia ; prepared in cooperation with the Oregon Water Resources Department.Title from PDF title page (viewed on May 2, 2022).This archived document is maintained by the State Library of Oregon. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references.Mode of access: Internet from the State Library of Oregon U.S. Government Publications Collection.Text in English
The Indiana Student Free Press Act : an honors thesis [(HONRS 499)]
No full textIn 2001, three students from Governors State University in Illinois sued the university after administrators demanded prior review of the Innovator, the student newspaper. Patricia Carter, the school of communication's dean, had told the newspaper's printer to hold future issues of the paper pending approval of its content.In 2005, the 7th U.S. Circuit Court of Appeals decided in Hosty v. Carter said that the Supreme Court's 1988 Hazelwood decision limiting high school student free expression rights could extend to student media on college and university campuses. The Supreme Court refused to rule on the case in 2006.During the 2007-08 school year, the Indiana Collegiate Press Association attempted to pass a Student Free Press Act in Indiana, similar to those already enacted in Illinois, Oregon and California. The act would have given First Amendment free press rights back to the students of public universities in Indiana, making the Hosty v. Carter decision inapplicable.This thesis documents the steps taken by the ICPA committee in their efforts — and the opposition that eventually led to the demise of "Dave's Law." It also includes a booklet that could be sent to other states in order to encourage them to join our fight; the booklet provides the basic information they would need to start the process.Thesis (B.?.)Honors Colleg
Novel B cell therapeutic targets in transplantation and immune-mediated glomerular diseases
No full textB cells and antibodies play an important role in the alloresponse to renal grafts as well as in immune-mediated glomerular diseases. In transplantation, greater recognition and improved diagnosis of antibody-mediated rejection have been a catalyst to the introduction of newer drugs and regimens that target B cells, plasma cells, and donor-specific antibodies to improve the outcome associated with antibody-mediated rejection. In immune-mediated renal disease, novel and more selective B cell therapies are gradually modifying the traditional therapeutic approach that consists of steroids and other immunosuppressants. A new era of selective and more effective immunosuppression agents that target the humoral response is finally emerging in transplantation and renal diseases. Copyright © 2010 by the American Society of Nephrology
Analyzing the effects of U.S. agricultural policy on Mexican agricultural markets using the MEXAGMKTS model
No full textThis paper uses results from simulations of the FAIRMODEL, USAGMKTS, and MEXAGMKTS models to analyze the effects of changes in U.S. agricultural policy on Mexican agricultural markets. The author concludes that under a scenario of trade liberalization for Mexico, Mexican agricultural production, prices, and trade are quite sensitive to agricultural policy changes in the U.S. The genesis of the research project was the perception that agricultural policies in Mexico (and many other countries) are often second best responses to the negative side effects of broad economic policies aimed primarily at macroeconomic and international trade objectives. The paper also discusses the role of agriculture in Mexican economic policy, and MEXAGMKTS, FAIR and USAGMKTS models. The paper includes an analysis of the sensitivity of Mexican agricultural markets to U.S. agricultural policy and a brief summary of the implications of the results.Environmental Economics&Policies,Economic Theory&Research,Agricultural Research,Access to Markets,Markets and Market Access
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