922 research outputs found
Author, Geraldine Brooks at the National Library of Australia for the 2009 Ray Mathew Lecture, Canberra, 23 October 2009 [picture] /
No full textTitle from acquisitions documentation.; Part of the collection: Portraits of author, Geraldine Brooks during her visit to the National Library of Australia for the 2009 Ray Mathew Lecture, Canberra, 23 October 2009.; Acquired in digital format; access copy available online.; Mode of access: Internet via World Wide Web.; Photographed by a staff member of the National Library of Australia
Ventriloquism Days: In Conversation with David Mathew
No full textDavid Mathew is the author of three novels – O My Days, Creature Feature, and most recently Ventriloquists – and a volume of short stories entitled Paranoid Landscapes. His wide areas of interest include psychoanalysis, linguistics, distance learning, prisons and online anxiety. With approximately 600 published pieces to his name, including a novel based on his time working in the education department of a maximum security prison (O My Days), he has published widely in academic, journalistic and fiction outlets. In addition to his writing, he co-edits The Journal of Pedagogic Development (at the University of Bedfordshire, UK), teaches academic writing, and he particularly enjoys lecturing in foreign countries and learning about wine. He is a member of the Tavistock Society of Psychotherapists and Allied Professionals, Evidence Informed Policy and Practice in Education in Europe (EIPPEE), and the European Association for the Teaching of Academic Writing. He was also a member of The Health Technology Assessment programme (www.hta.ac.uk), as part of the NIHR Evaluation, Trials and Studies Coordinating Centre at the University of Southampton (2009-2013). We met at his home in the south-east of England in November 2014 to discuss his approaches to writing and his new novel, Ventriloquists
Fifty Forensic Fables
No full textThis book does for the legal profession in England what George Ade's fables do more broadly. These are enjoyable tales with pleasing caricatures. All the actors are humans. A funny appendix follows The Story of an Ancient Line through twelve generations. The book shows what fable meant earlier in this century.This is a hardbound book (hard cover)This book has a dust jacket (book cover)O (Theo Mathew
CD8+ T Cell and NK Responses to a Novel Dengue Epitope: A Possible Role for KIR3DL1 in Dengue Pathogenesis: A Dissertation
No full textVariation in the sequence of T cell epitopes between dengue virus (DENV) serotypes is believed to alter memory T cell responses during second heterologous infections contributing to pathology following DENV infection. We identified a highly conserved, novel, HLA-B57-restricted epitope on the DENV NS1 protein, NS126-34. We predicted higher frequencies of NS126-34-specific CD8+ T cells in PBMC from individuals undergoing secondary, rather than primary, DENV infection due to the expansion of memory CD8+T cells. We generated a tetramer against this epitope (B57-NS126-34TET) and used it to assess the frequencies and phenotype of antigen-specific T cells in samples from a clinical cohort of children with acute DENV infection established in Bangkok, Thailand. High tetramer-positive T cell frequencies during acute infection were seen in only 1 of 9 subjects with secondary infection. B57-NS126-34-specific, other DENV epitope-specific CD8+ T cells, as well as total CD8+ T cells, expressed an activated phenotype (CD69+ and/or CD38+) during acute infection. In contrast, expression of CD71 was largely limited to DENV-specific CD8+ T cells. In vitro stimulation of CD8+ T cell lines, generated against three different DENV epitopes, indicated that CD71 expression was differentially sensitive to stimulation by homologous and heterologous variant peptides with substantial upregulation of CD71 detected to peptides which also elicited strong functional responses. CD71 may therefore represent a useful marker of antigenspecific T cell activation. During the course of our analysis we found substantial binding of B57-NS126-34 TET to CD8- cells. We demonstrated that the B57-NS126-34 TET bound KIR3DL1, an inhibitory receptor on natural killer (NK) cells. NK sensitive target cells presenting the NS126-34 peptide in the context of HLA-B57 were able to dampen functional responses of only KIR3DL1+ NK cells. Analysis of the activation of an NK enriched population in our Thai cohort revealed peak activation during the critical time phase in patients with severe dengue illness, dengue hemorrhagic fever, compared to people with mild illness. Our data identified CD71 as biologically useful marker to study DENV-specific CD8+ T cell responses and highlighted the role of viral peptides in modulating NK cell activation through KIR-MHC class I interactions during DENV infection.MD/Ph
The Psalter in the Description of Jesus’ Passion from the Gospel of St. Mathew
No full textThe author focuses on the quotations from the psalms that we find in the description of Jesus’ Passion in the Gospel of St. Mathew. It turns out that almost all the quotations from the psalms (with the exception of 26, 64: Ps 109, 1 LXX) stress the human nature of Jesus, i.e. they are anthropologically oriented. The author discusses each of the seven quotations in the context of the psalm, and then in the context of Jesus’ Passion. Following partly the Gos¬pel of St. Mark, St. Mathew enhances in the reader a belief that Jesus in His Passion is the Suffering Just and the suffering poor Jehovah
Further Forensic Fables
No full textI had earlier found Fifty Forensic Fables, though in a republication by the original publisher in 1949. See my comments there. Again, these stories had all appeared in the Law Journal. Before the thirty fables, this volume, like the first, offers a table of cases cited and a table of statutes. Again, each story has an enjoyable newspaper-like caricature. One can get a good sense of these stories, I believe, by trying the second and third of them. In The Industrious Youth and the Stout Stranger (5), a con man looking like W.C. Fields hires the industrious youth and then borrows a sum of money from him. Of course the industrious youth never sees him again. In Mr. Whitewig and the Rash Question (9), the young Mr. Whitewig has established a very strong case when he asks one question too many of the Police Inspector, i.e., why he arrested the defendant. That question produces the records of nine previous convictions. There are twenty-six pages given to an index starting on 107. The covers are heavy boards with titles pasted on.This is a hardbound book (hard cover)By O (Theo Mathew
A short account of the malignant fever, lately prevalent in Philadelphia [electronic resource] : with a statement of the proceedings that took place on the subject in different parts of the United States. By Mathew Carey.
No full textAlso issued as the fifth title in: Select pamphlets: viz. 1. Lessons to a young prince .. Philadelphia : Published by Mathew Carey, 1796 (Evans 31172).Two states noted. In one, the last word on p. 61 is "un-". In the other, the last word is "'till".Partial list of those who died in Philadelphia between August and November, 1793, p. 100-103.Statistics gathered in Philadelphia, August to November, 1793, including meteorological observations compiled by David Rittenhouse, [9] p. at end.Signatures: [A]p4s B-Np4s Op2s Pp2sEvans,Austin, R.B. Early Amer. medical imprints,Electronic reproduction.English Short Title Catalog,Reproduction of original from British Library
Telomere Length Dynamics in Human T Cells: A Dissertation
No full textTelomere length has been shown to be a critical determinant of T cell replicative capacity and in vivo persistence in humans. We evaluated telomere lengths in virus-specific T cells to understand how they may both shape and be changed by the maintenance of memory T cells during a subsequent virus re-infection or reactivation. We used longitudinal peripheral blood samples from healthy donors and samples from a long-term HCV clinical interferon therapy trial to test our hypotheses. To assess T cell telomere lengths, I developed novel modifications to the flow cytometry fluorescence in situ hybridization (flowFISH) assay. These flowFISH modifications were necessary to enable quantification of telomere length in activated, proliferating T cells. Adoption of a fixation-permeabilization protocol with RNA nuclease treatment prior to telomere probe hybridization were required to produce telomere length estimates that were consistent with a conventional telomere restriction fragment length Southern blot assay. We hypothesized that exposure to a non-recurring, acute virus infection would produce memory T cells with longer telomeres than those specific for recurring or reactivating virus infections. We used two acute viruses, vaccinia virus (VACV) and influenza A virus (IAV) and two latent-reactivating herpesviruses, cytomegalovirus (CMV) and varicella zoster virus (VZV) for these studies. Combining a proliferation assay with flowFISH, I found telomeres in VACV-specific CD4 + T cells were longer than those specific for the recurring exposure IAV; data which support my hypothesis. Counter to my hypothesis, CMV-specific CD4 + T cells had longer telomeres than IAV-specific CD4 + T cells. We assessed virus-specific CD4 + T cell telomere length in five donors over a period of 8-10 years which allowed us to develop a linear model of average virus-specific telomere length changes. These studies also found evidence of long telomere, virus-specific CD45RA + T cell populations whose depletion may precede an increased susceptibility to latent virus reactivation. I tested the hypothesis that type I interferon therapy would accelerate T cell telomere loss using PBMC samples from a cohort of chronic hepatitis C virus patients who either did or did not receive an extended course of treatment with interferon-alpha. Accelerated telomere losses occurred in naïve T cells in the interferon therapy group and were concentrated in the first half of 48 months of interferon therapy. Steady accumulation of CD57 + memory T cells in the control group, but not the therapy group, suggested that interferon also accelerated memory turnover. Based on our data, I present proposed models of memory T cell maintenance and impacts of T cell telomere length loss as we age.Immunology and Microbiolog
[Freeman Hunt, half-length portrait, slightly to the left]
No full textJournalist, author, publisher.Manuscript label on cover glass: Mr. Hunt.Scratched on back of plate: 399.Edges trimmed.Original served by appointment only.Produced by Mathew Brady's studio.Transfer; U.S. War College; 1920; (DLC/PP-1920:46153).Forms part of: Daguerreotype collection (Library of Congress)
Author Correction: Global diversity and biogeography of bacterial communities in wastewater treatment plants (Nature Microbiology, (2019), 4, 7, (1183-1195), 10.1038/s41564-019-0426-5)
No full textIn the version of this Article originally published, the name of the author ‘Mathew Robert Brown’ was incorrectly written as ‘Mathew Brown’ in the main author list and as ‘Matthew Brown’ in the Global Water Microbiome Consortium list. In addition, in the Global Water Microbiome Consortium list, the names of the authors ‘Kevin F. Boehnke’, ‘Janeth Sanabria’ and ‘Adalberto Noyola’ were incorrectly written as ‘Kevin Boehnke’, ‘Janeth Sanabria Gómez’ and ‘Adalberto Noyola Robles’, respectively. The names have now been corrected and the author initials in the author contributions section updated accordingly
- …
