7 research outputs found
Sicurezza: si vince in gruppo. La ricerca condotta in tre aziende bergamasche ha messo in luce l'importanza di assumere comportamenti di squadra corretti
No full textCorrection: Radioembolization for Hepatocellular Carcinoma: a Comparison on Dual-phase Cone-beam CT, Contrast-enhanced CT (CECT) and 99mTc-macroaggregated albumin-SPECT/CT in predicting final distribution volumes and dosimetry of the post-embolization 90Y PET/CT
No full textCorrection to: La radiologia medica (2024) 130:474–485 https://doi.org/10.1007/s11547-024-01946-0 In the published version, author has found errors in the Abstract section: Published version: Purpose Personalized treatment schemes are being systematically applied to ensure best treatment outcome in oncologic. patients. This is true also for personalized dosimetry in transarterial radioembolization (TARE) in hepatocellular carcinoma. (HCC) patients. Precise and detailed volumetric and functional data derived from radiological and nuclear imaging methods. are essential for personalized dosimetry. We sought to evaluate accuracy of dual-phase cone-beam CT (CBCT) in comparison. to pre-treatment contrast-enhanced CT (CECT), and 99mTc-macroaggregated albumin-SPECT/CT ([ 99mTc]MAA SPECT/ CT) to predict and assess the efficacy of TARE based on post-treatment 90Y PET/CT. Material and methods Thirty consecutive patients with HCC treated with TARE were included. Intraprocedural dual-phase. CBCT acquisition protocol was developed to distinguish tumor volume in the early arterial phase and perfused volume of nonaffected. liver in the late arterial phase. Volumetric data obtained from pre-treatment CECT, dual-phase CBCT and [99mTc]. MAA SPECT/CT were compared to post-treatment 90Y PET/CT considered the standard reference. Treatment simulations. for final calculated dose from the different imaging derived volumes were then compared to post-treatment 90Y PET/CT. Results CBCT resulted as the most accurate method in predicting tumor- ( R2 0.88) and perfused volumes ( R2 0.82). Dosimetry. prediction planning performed on derived volumes from the different methods did not show significant difference. (p < 0.05), yet highest concordance with 90Y PET/CT data was observed with dual-phase CBCT. Conclusion Our study shows that dual-phase CBCT acquisition is a novel alternative method for correctly and safely administering. more accurate and defined doses during TARE. clinicaltrials.gov ID: NCT03981497. Correct version: Purpose Personalized treatment schemes are being systematically applied to ensure best treatment outcome in oncologic. patients. This is true also for personalized dosimetry in transarterial radioembolization (TARE) in hepatocellular carcinoma. (HCC) patients. Precise and detailed volumetric and functional data derived from radiological and nuclear imaging methods. are essential for personalized dosimetry. We sought to evaluate accuracy of dual-phase cone-beam CT (CBCT) in comparison. to pre-treatment contrast-enhanced CT (CECT), and 99mTc-macroaggregated albumin-SPECT/CT ([ 99mTc]MAA SPECT/ CT) to predict and assess the efficacy of TARE based on post-treatment 90Y PET/CT. Material and methods Thirty consecutive patients with HCC treated with TARE were included. Intraprocedural dual-phase. CBCT acquisition protocol was developed to distinguish tumor volume in the early arterial phase and perfused volume of nonaffected. liver in the late arterial phase. Volumetric data obtained from pre-treatment CECT, dual-phase CBCT and [99mTc]. MAA SPECT/CT were compared to post-treatment 90Y PET/CT considered the standard reference. Treatment simulations. for final calculated dose from the different imaging derived volumes were then compared to post-treatment 90Y PET/CT. Results CBCT resulted as the most accurate method in predicting tumor- ( R2 0.89) and perfused volumes ( R2 0.84). Dosimetry. prediction planning performed on derived volumes from the different methods did not show significant difference. yet highest concordance with 90Y PET/CT data was observed with dual-phase CBCT. Conclusion Our study shows that dual-phase CBCT acquisition is a novel alternative method for correctly and safely administering. more accurate and defined doses during TARE. clinicaltrials.gov ID: NCT03981497
AVSI, AutoValutazione della Scuola dell'Infanzia. Uno strumento di formazione e il suo collaudo
No full textI saperi del tirocinio. Formare gli insegnanti nelle SSIS
No full textNel volume ci si propone di riflettere sulla formazione degli insegnanti a partire dalla peculiare esperienza del tirocinio nelle SSI
Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial) : a randomised, double-blind, placebo-controlled trial
No full textBackground: Large observational studies, small prospective studies and post-hoc analyses of randomised clinical trials have suggested that statins could be beneficial in patients with chronic heart failure. However, previous studies have been methodologically weak. We investigated the efficacy and safety of the statin rosuvastatin in patients with heart failure. Methods: We undertook a randomised, double-blind, placebo-controlled trial in 326 cardiology and 31 internal medicine centres in Italy. We enrolled patients aged 18 years or older with chronic heart failure of New York Heart Association class II-IV, irrespective of cause and left ventricular ejection fraction, and randomly assigned them to rosuvastatin 10 mg daily (n=2285) or placebo (n=2289) by a concealed, computerised telephone randomisation system. Patients were followed up for a median of 3·9 years (IQR 3·0-4·4). Primary endpoints were time to death, and time to death or admission to hospital for cardiovascular reasons. Analysis was by intention to treat. This study is registered with ClinicalTrials.gov, number NCT00336336. Findings: We analysed all randomised patients. 657 (29%) patients died from any cause in the rosuvastatin group and 644 (28%) in the placebo group (adjusted hazard ratio [HR] 1·00 [95·5% CI 0·898-1·122], p=0·943). 1305 (57%) patients in the rosuvastatin group and 1283 (56%) in the placebo group died or were admitted to hospital for cardiovascular reasons (adjusted HR 1·01 [99% CI 0·908-1·112], p=0·903). In both groups, gastrointestinal disorders were the most frequent adverse reaction (34 [1%] rosuvastatin group vs 44 [2%] placebo group). Interpretation: Rosuvastatin 10 mg daily did not affect clinical outcomes in patients with chronic heart failure of any cause, in whom the drug was safe. Funding: Società Prodotti Antibiotici (SPA; Italy), Pfizer, Sigma Tau, and AstraZeneca
Prognostic impact of diabetes and prediabetes on survival outcomes in patients with chronic heart failure: A post-hoc analysis of the GISSI-HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca-Heart Failure) trial
No full textBackground-The independent prognostic impact of diabetes mellitus (DM) and prediabetes mellitus (pre-DM) on survival outcomes in patients with chronic heart failure has been investigated in observational registries and randomized, clinical trials, but the results have been often inconclusive or conflicting. We examined the independent prognostic impact of DM and pre-DM on survival outcomes in the GISSI-HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca-Heart Failure) trial. Methods and Results-We assessed the risk of all-cause death and the composite of all-cause death or cardiovascular hospitalization over a median follow-up period of 3.9 years among the 6935 chronic heart failure participants of the GISSI-HF trial, who were stratified by presence of DM (n=2852), pre-DM (n=2013), and non-DM (n=2070) at baseline. Compared with non-DM patients, those with DM had remarkably higher incidence rates of all-cause death (34.5% versus 24.6%) and the composite end point (63.6% versus 54.7%). Conversely, both event rates were similar between non-DM patients and those with pre-DM. Cox regression analysis showed that DM, but not pre-DM, was associated with an increased risk of all-cause death (adjusted hazard ratio, 1.43; 95% CI, 1.28-1.60) and of the composite end point (adjusted hazard ratio, 1.23; 95% CI, 1.13-1.32), independently of established risk factors. In the DM subgroup, higher hemoglobin A1c was also independently associated with increased risk of both study outcomes (all-cause death: adjusted hazard ratio, 1.21; 95% CI, 1.02-1.43; and composite end point: adjusted hazard ratio, 1.14; 95% CI, 1.01-1.29, respectively). Conclusions-Presence of DM was independently associated with poor long-term survival outcomes in patients with chronic heart failure
Evaluation of the reaction of commercial potato materials Solanum tuberosum Andigena Group to late blight (Phytophthora infestans (Mont.) de Bary).
No full textIlustraciones, tablasLa papa (Solanum tuberosum L.) constituye una de las principales actividades agrícolas
de la zona andina. El tizón tardío es considerada la enfermedad más devastadora de este
cultivo y es vista como una amenaza para la seguridad alimentaria, su agente causal es el
Oomycete Phytophthora infestans (Mont.) de Bary, las pérdidas en la región Andina se
estiman entre el 30 y el 100% del rendimiento a causa de la enfermedad. En esta
investigación se evaluó la respuesta a la enfermedad de 4 materiales comerciales
ampliamente sembrados en condiciones de campo, donde fue posible observar la alta
susceptibilidad del material Diacol Capiro (100% de área afectada) con una disminución
severa del 89% del rendimiento total. Además fue posible observar la pérdida de
resistencia de la variedad ICA Única, reportada como altamente resistente en 2001 y que
durante este estudio presentó niveles de daño cercanos al 75%, con una disminución del
rendimiento del 49,88%, por otro lado, los materiales comerciales Pastusa Suprema y
Superior presentaron el mejor comportamiento hacia la enfermedad tizón tardío, donde, el
nivel de daño de los 2 materiales fue de alrededor 30% de área afectada, reducciones del
rendimiento del 30.5% y 40.92% respectivamente. Es importante resaltar que la variedad
Pastusa Suprema exhibió características de tolerancia a la enfermedad. Resultados que
resaltan el papel fundamental de materiales como Pastusa Suprema y Superior, y su rol
como pilares en el manejo integrado y sostenible de la enfermedad, a través de la siembra
de variedades con características de resistencia a la enfermedad. (Texto tomado de la fuente)Potato (Solanum tuberosum L.) are one of the main agricultural activities in the Andean
region. Late blight is considered the most devastating disease of this crop and is seen as
a threat to food security. Its causal agent is the Oomycete Phytophthora infestans (Mont.)
de Bary; losses in the Andean region are estimated at between 30 and 100% of the yield
due to the disease. In this research the response to the disease of 4 commercial materials
widely planted in field conditions was evaluated, where it was possible to observe the high
susceptibility of the Diacol Capiro material (100% of affected area) with a severe decrease
of 89% of the total yield. It was also possible to observe the loss of resistance of the ICA
Única variety, reported as highly resistant in 2001, which during this study showed damage
levels close to 75%, with a yield reduction of 49.88%, where the damage level of the 2
materials was around 30% of the affected area, with yield reductions of 30.5% and 40.92%,
respectively. It is important to highlight that the Pastusa Suprema variety exhibited
characteristics of tolerance to the disease. These results highlight the fundamental role of
materials such as Pastusa Suprema and Superior, and their role as pillars in the integrated
and sustainable management of the disease, through the planting of varieties with disease
resistance characteristics.MaestríaMagíster en Ciencias AgrariasLos ensayos se realizaron en campo abierto, con manejo agronómico convencional hasta los 52 días después de siembra (DDS) y con inóculo
natural, durante dos ciclos de evaluación; segundo semestre de 2018, donde se presentaron lluvias escazas y mal distribuidas, temperaturas superiores con relación al
segundo ciclo de evaluación, condiciones típicas de efecto niño y primer semestre de 2019 donde se presentaron lluvias bien distribuidas y temperaturas más bajas con relación al primer ciclo de evaluación (efecto niña). Cada parcela experimental estuvo conformada por 4 surcos de 5 metros cada uno, se evaluaron 4 tratamientos, correspondientes a los
materiales comerciales, y se establecieron 4 repeticiones para un total de 16 parcelas experimentales. Se evaluaron en condiciones de campo, cuatro materiales comerciales de papa Solanum tuberosum Grupo andigena identificadas como las más sembradas en el departamento de Nariño, las variedades evaluadas correspondieron a Diacol Capiro, ICA Única, Pastusa Suprema y Superior. La semilla con la cual se establecieron los lotes experimentales correspondió a semilla básica, producida bajo acompañamiento del ICA, organismo encargado de la certificación de semilla en el país.
Se establecieron parcelas experimentales, de los materiales Diacol Capiro (DC), Ica Única (IU), Pastusa Suprema (PS) y Superior (S), la distancia de siembra usada fue; 1,20 metros entre surcos por 0,30 metros entre plantas, la parcela experimental estuvo constituida por 4 surcos de 5 metros de largo.
El manejo agronómico aplicado fue estándar en los cuatro tratamientos, donde, prácticas como fertilización, manejo de plagas y enfermedades y labores culturales como aporque, se realizaron de manera similar en los 4 tratamientos hasta el día 52 después de siembra, a partir de este momento se suspendió la aplicación química, para el control de la enfermedad tizón tardío, la evaluación de incidencia y severidad se realizó en los 2 surcos centrales de cada parcela a través de las 4 repeticiones establecidas, la evaluación se realizó cada 7 o 14 días, situación que dependió de las condiciones ambientales presentes en la zonaProtección de cultivo
