9,188 research outputs found
Providence College Faculty Author Series 2012-2013: Dr. Adrian Weimer
No full textDr. Adrian Weimer (History, Providence College) discusses her new book Martyrs\u27 Mirror: Persecution and Holiness in Early New England and the cultural importance of martyrdom within Colonial America
Providence College Faculty Author Series 2012-2013: Dr. Adrian Weimer
No full textDr. Adrian Weimer (History, Providence College) discusses her new book Martyrs\u27 Mirror: Persecution and Holiness in Early New England and the cultural importance of martyrdom within Colonial America
Adrian Matejka, 34th Annual ODU Literary Festival
No full textAdrian Matejka is the author of The Devil’s Garden and Mixology, which was a winner of the 2008 National Poetry Series. He is the recipient of two Illinois Arts Council Literary Awards and fellowships from Cave Canem and the Lannan Foundation. His work has been featured in American Poetry Review, The Best American Poetry 2010, and Ploughshares, among other journals and anthologies. He teaches at Southern Illinois University Edwardsville
Identifying the existence of barriers to students’ learning from assessment results
No full textJustin Read, Adrian George and Anthony Masters, Michael Kin
Extractive Reserves: Building Natural Assets in the Brazilian Amazon
No full textIn the Amazon rainforest, Brazil's rubber tappers were the first social group to challenge the predatory development model that is threatening ecological disaster there. Their strategy to set up “extractive reserves”—conservation areas where the local population can harvest non-timber forest products—is examined in “Extractive Reserves: Building Natural Assets in the Brazilian Amazon,” by Anthony Hall.
Students’ perceptions of their understanding in chemistry 1 for veterinary science
No full textJustin Read, Adrian George, Anthony Masters, and Mike Kin
The development of a novel native prothrombin assay for the more efficient management of oral anticoagulation therapy
No full textDisturbances of the natural balance between pro-coagulant and anticoagulant systems, due to hereditary or acquired factors may result in haemorrhagic or thrombotic diseases.
Currently the INR/ISI coagulation monitoring system, introduced in 1983 by the World Health Organisation (WHO), is that of choice for most anticoagulation management clinics. Patients undergoing anticoagulation therapy must regularly attend specialised outpatient clinics for the close monitoring and maintenance of their INR. The automated laboratory caters for rapid online simultaneous analysis of multiple blood samples, resulting in the calculation of a patient’s INR from the recorded prothrombin time. The insensitivity of the prothrombin time test has been well documented, requiring a reduction in the prothrombin concentration of 45 % prior to the materialisation of clinically significant prothrombin times.
The project aims to employ three avenues of biotechnology to aid in the development of an immuno or molecular imprinted polymer (MIP) based anticoagulation assay. The project will utilise computational molecular modelling in an attempt to visualise the tertiary structure of human prothrombin, which will allow the rational selection of antigenic sites for molecular imprinting or antibody production.
An aqueous, prothrombin-imprinted homo-polymer was grafted to the gold surface of a surface plasmon resonance biosensor (Biacore). The Biacore allowed the real time monitoring of imprinted polymer binding characteristics to i
homogeneous protein solutions. As a direct comparison of two technologies, molecular imprinting and immuno technology, polyclonal antibodies showing specificity towards the same prothrombin antigen were immobilised onto Biacore chips. The imprinted polymer graft and polyclonal antibody based assays recognised homogeneous solutions of prothrombin at a concentration range of 0.01 nM to 14.2 nM and 0.01 nM to 0.5 nM respectively. A randomised preliminary clinical trial was initiated to compare the two assays’ ability to differentiate plasma samples with a variety of INR values.
The results thus far show promise for the development of a new anticoagulation assay using molecularly imprinted polymer technology. The ultimate aim for this project is to develop a consistently more accurate point-of-care anticoagulation therapy monitoring kit, incorporating this new technology, which can replace or be used concomitantly with the INR/ISI system currently in use. This thesis raises more questions regarding the efficacy of oral anticoagulation therapy (OACT) and argues for and against the necessity of a novel OACT management assay
Bridging the gap - student understanding and the chemistry bridging course
No full textDavid Youl, Justin Read, Adrian George, Anthony Masters, Siegbert Schmid and Michael Kin
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