2,723 research outputs found
Heritability and Linkage Analysis of Appendicitis Utilizing Age at Onset
No full textAppendicitis usually afflicts the young, but there is a large tail in the distribution of onset age. The genetics of this disease are still not well understood. A heritability analysis and genome wide linkage analysis of a large twin dataset was undertaken. Treating age of onset of appendicitis as a censored survival trait revealed a heritability of 0.21, and found evidence of linkage to Chromosome 1p37.3. Author(s): Christopher Oldmeadow 1 * | Kerrie Mengersen 2 | Nicholas Martin 3 | David L. Duffy
Forbidden Colors in the Regulation of Clerical Dress from the Fourth Lateran Council (1215) to the Time of Nicholas of Cusa (d. 1464)
No full textMedieval canon law attempted to distinguish clergy from the laity by restricting their dress choices. The article focuses on prohibition of wearing red or green on the street. Both colors were identified with the nobility.The published version was published as Chapter 7 in Medieval Clothing and Textiles 1Izbicki, Thomas M. (2005), "Forbidden Colors in the Regulation of Clerical Dress from the Fourth Lateran Council (1215) to the Time of Nicholas of Cusa (d. 1464)" in Netherton, Robin and Owen-Crocker, Gale R., eds., Medieval Clothing and Textiles 1 (Boydell Press),105-114ISBN: 9781843831235 (published book
The maternal immune system during pregnancy and its influence on fetal development
No full textThe maternal immune system plays a critical role in the establishment, maintenance, and completion of a healthy pregnancy. However, the specific mechanisms utilized to achieve these goals are not well understood. Various cells and molecules of the immune system are key players in the development and function of the placenta and the fetus. Effector cells of the immune system act to promote and yet limit placental development. The T helper 1 (Th1)/T helper 2 (Th2) immune shift during pregnancy is well established. A fine balance between proinflammatory and anti-inflammatory influences is required. We herein review the evidence regarding maternal tolerance of fetal tissues and the underlying cell-mediated immune and humoral (hormones and cytokines) mechanisms. We also note the many unanswered questions in our understanding of these mechanisms. In addition, we summarize the clinical manifestations of an altered maternal immune system during pregnancy related to susceptibility to common viral, bacterial, and parasitic infections, as well as to autoimmune diseases.Peer reviewe
External interventions and the duration of civil wars
No full textThe authors combine an empirical model of external intervention, with a theoretical model of civil war duration. Their empirical model of intervention allows them to analyze civil war duration, using"expected"rather than"actual"external intervention as an explanatory variable in the duration model. Unlike previous studies, they find that external intervention is positively associated with the duration of civil war. They distinguish partial third-party interventions that extend the length of war, from multilateral"peace"operations, which have a mandate to restore peace without taking sides - and which typically take place at war's end, or at least when both sides have agreed to a cease-fire. In a future paper, the authors will examine whether partial third-party interventions - whatever their effect on a war's duration - increase the risk of war's recurrence. If that proves true, then even if interventions reduce the length of civil war, they may do so at the cost of further destabilizing the political system, and sowing the seeds of future rebellion.Children and Youth,Peace&Peacekeeping,Post Conflict Reconstruction,Post Conflict Reconstruction,International Affairs,Post Conflict Reconstruction,Social Conflict and Violence,Peace&Peacekeeping,Post Conflict Reconstruction,International Affairs
The Memoirs of a Retooled Geoscientist or How I Came to Know and Love Remote Sensing
No full textDr. Nicholas M. Short is a former employee at NASA Goddard Space Flight Center and is the author of numerous books touching on the subject of remote sensing. He gained his B.S. from St. Louis University, an M.A. from Washington University, and received his PhD in 1958 from MIT
Christiformitas in Nicholas of Cusa’s Roman Sermons (1459)
No full textNicholas of Cusa (1401-1464) served as vicar of Rome in the absence of Pope Pius II at the Congress of Mantua (1459). Cusanus held a synod and did visitations of major churches. His sermons for these events emphasized conformity with Christ as the means of knowing God.This is the Version of Record (VoR) of the article that was originally published in Perspectives in the Arts and Humanities Asia, Volume 1, Number 1 (2011
Reintroducing Bunky at 125: E.M. Jellinek’s life and contributions to Alcohol Studies
No full textObjective:
Elvin Morton Jellinek (1890–1963) was one of the founders of modern addiction science. This overview is a brief survey of his life and achievements, intended to re-introduce alcohol scholars to his contributions (and possible failings) as well as stimulate interest and historical research in the field.
Method:
The article draws largely from the archival collection of the Rutgers Center of Alcohol Studies (CAS) Library and the Jellinek memorial issue of the CAS Information Services Newsletter. Scholarly works and personal and institutional records by or about E. M. Jellinek were assembled and, when necessary, translated into English.
Results:
Born in 1890 in New York and raised in Hungary, Jellinek studied at several European universities and worked for various institutions and organizations in Budapest (1914–1920), Sierra Leone, Honduras, and at the Worcester State Hospital, in Massachusetts. In 1941 he became an associate professor of applied physiology at Yale University, where he directed the Yale Summer School of Alcohol Studies from 1941 to 1950. After more than a decade of work with the World Health Organization and several Canadian institutions, he taught and conducted research at the Institute for the Study of Human Problems at Stanford University until his death in 1963. Jellinek was a pioneer in research on the nature and causes of alcoholism and was an early proponent of the disease theory of alcoholism.
Conclusions:
With the help of E. M. Jellinek, the modern era of addiction science was launched with an international outlook that included critical attention to the physical infrastructure and intellectual capital needed to form an interdisciplinary field of basic research, applied science, and clinical practice.Peer reviewe
Induction and kinetics of complement-fixing antibodies against Plasmodium vivax merozoite surface protein 3alpha and relationship with immunoglobulin G subclasses and immunoglobulin M
No full textBackground: Complement-fixing antibodies are important mediators of protection against Plasmodium falciparum malaria. However, complement-fixing antibodies remain uncharacterized for Plasmodium vivax malaria. P. vivax merozoite surface protein 3α (PvMSP3α) is a target of acquired immunity and a potential vaccine candidate. Methods: Plasma from children and adults with P. vivax malaria in Sabah, Malaysia, were collected during acute infection, 7 and 28 days after drug treatment. Complement-fixing antibodies and immunoglobulin M and G (IgM and IgG), targeting 3 distinctive regions of PvMSP3α, were measured by means of enzyme-linked immunosorbent assay. Results: The seroprevalence of complement-fixing antibodies was highest against the PvMSP3α central region (77.6%). IgG1, IgG3, and IgM were significantly correlated with C1q fixation, and both purified IgG and IgM were capable of mediating C1q fixation to PvMSP3α. Complement-fixing antibody levels were similar between age groups, but IgM was predominant in children and IgG3 more prevalent in adults. Levels of functional antibodies increased after acute infection through 7 days after treatment but rapidly waned by day 28. Conclusion: Our study demonstrates that PvMSP3α antibodies acquired during P. vivax infection can mediate complement fixation and shows the important influence of age in shaping these specific antibody responses. Further studies are warranted to understand the role of these functional antibodies in protective immunity against P. vivax malaria.Damian A. Oyong, Danny W. Wilson, Bridget E. Barber, Timothy William, Jianlin Jiang, Mary R. Galinski, Freya J.I. Fowkes, Matthew J. Grigg, James G. Beeson, Nicholas M. Anstey, and Michelle J. Boyl
M. M. Speransky’s Administrative Reform Projects in a Comparative Retrospective of the Reigns of Alexander I and Nicholas I
No full textThe article was submitted on 20.02.2023.Предмет данного исследования – реформы и реформаторские поиски в сфере государственного управления в царствование Александра I и в начале правления Николая I, преемственные и отличительные черты правительственной преобразовательной политики в контексте проективной деятельности М. М. Сперанского. Особое внимание уделено определению причин актуализации преобразований в системе высшего и центрального аппарата в 1802 – начале 1830‑х гг., анализу специфики модернизационного процесса в разные периоды институционального развития России, выявлению сходств и различий «административных конструкций» Александра I и Николая I. Установлено, что в целом официальное реформаторство в сфере государственного управления первой трети XIX в., базирующееся на теоретико-концептуальной основе, разработанной М. М. Сперанским, носило последовательный, системный и взаимосвязанный характер и являлось составной частью модернизации российской государственности. Показано, что преобразовательные поиски начала царствования Николая I, нашедшие отражение в деятельности Комитета 6 декабря 1826 г., являя собой логическое продолжение реформ Александра I, были направлены на создание усовершенствованной управленческой системы абсолютизма Нового времени. Административные преобразования двух эпох подчинялись законодательной реформе и являлись составной частью двух моделей взаимоотношений власти и общества – александровской и николаевской.This article studies the reforms and reformist searches in the sphere of public administration during the reign of Alexander I and the beginning of the reign of Nicholas I, the successive and distinctive features of the government reform policy in the context of the project activity of M. M. Speransky. The author focuses on determining the reasons for the actualization of transformations in the system of the higher and central apparatus between 1802 and the early 1830s, analysing the specifics of the modernization process in different periods of the institutional development of Russia, identifying similarities and differences in the “administrative structure” of Alexander I and Nicholas I. It has been established that, in general, the official reformation in the field of public administration in the first third of the nineteenth century, based on the theoretical and conceptual framework developed by M. M. Speransky, was consistent, systemic, and interconnected and was an integral part of the modernization of Russian statehood. The author demonstrates that the transformational searches of the beginning of the reign of Nicholas I reflected in the activities of the Committee on December 6, 1826, and being a logical continuation of the reforms of Alexander I, were aimed at creating an effective, unified, and rationalized management system of absolutism of the New Age. The administrative transformations of the two epochs were subject to legislative reform and were an integral part of two models of relations between the government and society, Alexander and Nicholas, respectively.Работа выполнена при поддержке РНФ, проект № 23–28–00769 «Документальная память российской государственности: кейс Сперанского. Новые подходы к изучению рукописного наследия»
Characterization and structure in the development of Tudor comedy
No full textThe role of characterization in dramatic structure is assessed by theoretical criteria.
Characters who perform actions necessary for the completion of the narrative sequence are
said to be "bound" to the narrative; those without such obligations are "free". Characters
who maintain a single, constant meaning during the course of a play are said to be "static";
characters who change or develop into new roles are "dynamic". Horatian decorum
demanded that comic characters be static, and the characters of Plautine and Terentian
tradition were almost always bound to narrative intrigue. However, evaluations of six
Tudor comedies show an increasing use of non-classical characterization within the comic
form.
In the early comedies lohan lohan and Roister Doister all characters are bound and
static, yet the impetus to enlarge the role of characterization is evident. The characters of
lohan lohan are expanded from their French source, and Roister Doister includes
extraneous episodes in which Udall displays his braggart hero. Free characters abound in
Misogonus; as well the play brings dynamic characterization into the scope of comedy with
the conversion of its prodigal son.
Free characters offer new possibilities of non-narrative plotting. In comedies of the
1580s favourite traditional characters appear as diversions outside the action, and thematic
arrangements of characters inform the increasingly complex plots. Lyly stresses the
symbolic potential of characters in Endimion, whereas Greene uses dynamic
characterization to heighten the illusion of independent figures in Friar Bacon and Friar
Bungay. Love's Labour's Lost exposes the limitations of comic artifice by pulling the
characters between convention and individualization.
By the end of the sixteenth century free and dynamic characters had become
common, and characterization had established a sizable claim on the design of English
comedy. These developments set the English form apart from its neoclassical counterparts
- …
