422 research outputs found
Derrick Anson Interview
No full textThe interview begins with the description of Anson’s early life. He describes his family life, his dad being in the Navy, and growing up in San Diego. He states he graduated from Silver Bluff High School in South Carolina in 2003 and that he was on the football team during high school. Derrick then discusses the reasons he joined the military right out of high school and his family and friends’ reactions to his decision. Next, Derrick discusses his military life, including basic training in Parris Island, SC, being stationed in Cherry Point MCAS, NC, the units he was in, and his two deployments to Iraq. He reflects on how being in the military changed him and his outlook and discusses when and why he decided to leave the military. Derrick also describes the jobs he had after leaving the military and what he liked and disliked about them and his struggle to integrate back into the civilian working world after being in the military. He talks about his time at USCA, what he likes and dislikes about USCA, how it is different being a student veteran rather than a traditional student, his choice of major, and his career goals. Lastly, Derrick discusses his current family and what he hopes to do within the next ten years.
**Note: the video interview file is incomplete, due to a technical glitch. The full interview transcript is available belo
Author and Activist Derrick Jensen
No full textplenary talk at the Michigan Social Justice Conference 2009Derrick talks about his book Endgame, in which he outlines the reasons for the collapse of industrial capitalism and the destruction of the environment.Progressive Alliance of Students at UMhttp://deepblue.lib.umich.edu/bitstream/2027.42/62080/2/DerrickJensen-2009apr04-QandA.mp4http://deepblue.lib.umich.edu/bitstream/2027.42/62080/1/DerrickJensen-2009apr04-talk.mp
Correction of murine mucopolysaccharidosis type IIIA central nervous system pathology by intracerebroventricular lentiviral-mediated gene delivery
No full textAbstract not availableChantelle McIntyre, Ainslie L. K. Derrick-Roberts, Sharon Byers, Donald S. Anso
Skeletal response to lentiviral mediated gene therapy in a mouse model of MPS VII
No full textData source: Supplementary Data, https://doi.org/10.1016/j.ymgme.2012.03.022Mucopolysaccharidosis VII (MPS VII) is an autosomal recessive, lysosomal storage disorder caused by β-glucuronidase (GUSB) deficiency, resulting in the accumulation of glycosaminoglycans (GAGs), in a variety of cell types. Severe, progressive skeletal pathology, termed dysostosis multiplex, is a prominent clinical feature of MPS VII. We have evaluated a gene therapy protocol for its efficacy in preventing the development and progression of bone pathology in MPS VII mice treated with a lentiviral vector at birth or at 7 weeks. Two weeks after injections, high levels of vector expression were observed in liver, spleen and bone marrow and to a lesser extent in kidney, lung and heart.Carmen E. Macsai, Ainslie L.K. Derrick-Roberts, Xiaodan Ding, Krystyna H. Zarrinkalam, Chantelle McIntyre, Paul H. Anderson, Don S. Anson and Sharon Byer
Gene silencing of EXTL2 and EXTL3 as a substrate deprivation therapy for heparan sulphate storing mucopolysaccharidoses
No full textNeurological pathology is characteristic of the mucopolysaccharidoses (MPSs) that store heparan sulphate (HS) glycosaminoglycan (gag) and has been proven to be refractory to systemic therapies. Substrate deprivation therapy (SDT) using general inhibitors of gag synthesis improves neurological function in mouse models of MPS, but is not specific to an MPS type. We have investigated RNA interference (RNAi) as a method of targeting SDT to the HS synthesising enzymes, EXTL2 and EXTL3. Multiple shRNA molecules specific to EXTL2 or EXTL3 were designed and validated in a reporter gene assay, with four out of six shRNA constructs reducing expression by over 90%. The three EXTL2-specific shRNA constructs reduced endogenous target gene expression by 68, 32 and 65%, and decreased gag synthesis by 46, 50 and 27%. One EXTL3-specific shRNA construct reduced endogenous target gene expression by 14% and gag synthesis by 39%. Lysosomal gag levels in MPS IIIA and MPS I fibroblasts were also reduced by EXTL2 and EXTL3-specific shRNA. Incorporation of shRNAs into a lentiviral expression system reduced gene expression, and one EXTL2-specific shRNA reduced gag synthesis. These results indicate that deprivation therapy through shRNA-mediated RNAi has potential as a therapy for HS-storing MPSs.Xenia Kaidonis, Wan Chin Liaw, Ainslie Derrick Roberts, Marleesa Ly, Donald Anson and Sharon Byer
In Memory of Professor Derrick Bell
No full textDerrick Bell—law teacher, mentor, scholar, activist, author, loving husband and father—larger than the sum of his many parts. The articles in this symposium are fitting tributes to his legacy and valuable contributions to Derrick’s memory
She Gets the Girl
No full textAlex Blackwood is an undeniably courageous flirt. Molly Parker is a socially awkward compassionate soul. The duo strikes a deal that helps Molly explore her flirtatious nature and helps Alex prove to her ex that she is not self-centered. The question is: Do Molly and Alex want other people or each other? Author Alyson Derrick, a No. 1 New York Times best-selling author, depicts a beautiful dichotomy between wants and needs in romance.https://ecommons.udayton.edu/ul_popularromance/1050/thumbnail.jp
Forecasting banknotes
No full textA central bank’s liquidity forecast is important in ensuring that it supplies the banking system’s need for central bank money. Banknote (or currency in circulation) demand is the largest and for some central banks the most variable component of the liquidity forecast. Accurate forecasting of banknotes is essential in ensuring an accurate liquidity forecast and in turn effective monetary policy implementation. This Handbook discusses these issues and outlines a structural time series state space (STSSS) model which is now used by central banks including the Bank of England and ECB to forecast banknotes (currency in circulation).Forecasting banknotes
Lentiviral-mediated gene therapy results in sustained expression of beta-Glucuronidase for up to 12 Months in the Gus mps/mps and up to 18 Months in the Gus tm(L175F)Sly mouse models of mucopolysaccharidosis type VII
No full textA number of mucopolysaccharidosis type VII (MPS VII) mouse models with different levels of residual enzyme activity have been created replicating the range of clinical phenotypes observed in human MPS VII patients. In this study, a lentivirus encoding murine β-glucuronidase was administered intravenously at birth to both the severe (Gus(mps/mps) strain) and attenuated (Gus(tm(L175F)Sly) strain) mouse models of MPS VII. Circulating enzyme levels were normalized in the Gus(mps/mps) mice and were 3.5-fold higher than normal in the Gus(tm(L175F)Sly) mouse 12 and 18 months after administration. Tissue β-glucuronidase activity increased over untreated levels in all tissues evaluated in both strains at 12 months, and the elevated level was maintained in Gus(tm(L175F)Sly) tissues at 18 months. These elevated enzyme levels reduced glycosaminoglycan storage in the liver, spleen, kidney, and heart in both models. Bone mineral volume decreased toward normal in both models after 12 months of therapy and after 18 months in the Gus(tm(L175F)Sly) mouse. Open-field exploration was improved in 18-month-old treated Gus(tm(L175F)Sly) mice, while spatial learning improved in both 12- and 18-month-old treated Gus(tm(L175F)Sly) mice. Overall, neonatal administration of lentiviral gene therapy resulted in sustained enzyme expression for up to 18 months in murine models of MPS VII. Significant improvements in biochemistry and enzymology as well as functional improvement of bone and behavior deficits in the Gus(tm(L175F)Sly) model were observed. Therapy significantly increased the lifespan of Gus(mps/mps) mice, with 12 months being the longest reported lentiviral treatment for this strain. It is important to assess the long-term outcome on enzyme levels and effect on pathology for lentiviral gene therapy to be a potential therapy for MPS patients.Ainslie L.K. Derrick-Roberts, Carmen E. Pyragius, Xenia M. Kaidonis, Matilda R. Jackson, Donald S. Anson, and Sharon Byer
From Roach Powder to Radical Humanism: Professor Derrick Bell\u27s \u27Critical\u27 Constitutional Pedagogy
No full textThis essay is a tribute to the late Professor Derrick Bell, who passed away on October 5, 2011. The author was the Derrick Bell Fellow at New York University School of Law in 2009-10 and assisted Professor Bell in teaching his constitutional law courses. The essay discusses Professor Bell\u27s \u27critical\u27 constitutional and life pedagogy, by giving illustrations from Professor Bell\u27s classes and anecdotes from several of his former students. It highlights not only Professor Bell\u27s comprehensive approach to constitutional law, but also the radical humanism he brought to teaching and mentoring students
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