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Giovanna Zaniolo: An inspiring scientist, teacher, mentor, and colleague. Active: 1967–2012
Full text linkHot topics on UV filter ingredients
No full textThe production of sunscreens is regulated by laws and lists, constantly updated on the basis of scientific information. Most advanced countries have regulatory bodies that publish and update the list of authorized substances. Inorganic filters, zinc oxide and titanium dioxide are often used as nanostructured forms. Nanoparticles have been the subject of technological studies aimed at improving efficacy and safety. The organic ingredients are able to absorb UV radiation on a selective or broad spectrum. The latter is preferable given the role of UVA radiation in skin carcinogenesis. The organic filters may interact with epidermal proteins and induce sensitization. They can also be absorbed, causing systemic effects. In addition, some organic ingredients, such as avobenzone, may undergo photodegradation, needing special formulation requirements. © 2011 Expert Reviews Ltd
The analysis of desensitizing CNGA1 channels reveals molecular interactions essential for normal gating
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The protonation thermodynamics of ferulic acid/gamma-cyclodextrin inclusion compounds
No full textThe physico-chemical properties of ferulic acid (FA) and its inclusion compounds with the -cyclodextrin (-CD) have been studied at
25 ◦C in aqueous solution (0.15M NaCl) by potentiometry and solution calorimetry. The two basicity constants of the ionized FA, log K1
8.94 and logK2 4.48, in agreement with those of compounds of similar structure, were attributed to the protonation of hydroxyl and carboxyl
ionized groups, respectively. Unlike log K2, the first basicity constant showed a slight decreasing pattern on increasing the amount of -CD.
On the other hand, calorimetric data showed greater exothermicity during the protonation of the COO− group in FA when in the presence of
the -CD. Any increase of the latter led to greater enthalpy (–H◦) and lower entropy (S◦) changes. The increase of –H◦ and the decrease
of S◦ values reached a constancy only beyond -CD/FA molar ratios of 1. Thermodynamic data were consistent with the hypothesis of the
inclusion complexation obtained by the penetration of the neutralized guest FA into the -CD host cavity
THE SYNTHESIS OF DIASTEREOISOMERIC 2-TERT-BUTYL-6-METHYLTETRAHYDROPYRAN-3-OLS - AN INTERPRETATION OF THE STERIC COURSE OF THE HYDROBORATION OF 2,3-DIHYDRO-4H-PYRANS
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