5 research outputs found
Field Data for "Structure and properties of the Cascadia plate interface: evidence from a newly-described exhumed paleomegathrust in the Olympic Subduction Complex"
No full textStraboField project associated with GSA Bulletin manuscript "Structure and properties of the Cascadia plate interface: evidence from a newly-described exhumed paleomegathrust in the Olympic Subduction Complex" by Anna M. Ledeczi, Harold J. Tobin, Tsai-Wei Chen, Sean R. Mulcahy, and Cailey B. Condit. DOI: 10.1130/B38335.
Photomicrographs for "Structure and properties of the Cascadia plate interface: evidence from a newly-described exhumed paleomegathrust in the Olympic Subduction Complex"
No full textStraboMicro project associated with GSA Bulletin manuscript "Structure and properties of the Cascadia plate interface: evidence from a newly-described exhumed paleomegathrust in the Olympic Subduction Complex" by Anna M. Ledeczi, Harold J. Tobin, Tsai-Wei Chen, Sean R. Mulcahy, and Cailey B. Condit. DOI: 10.1130/B38335.
Late Quaternary Surface Displacements on Accretionary Wedge Splay Faults in the Cascadia Subduction Zone: Implications for Megathrust Rupture
No full textBecause splay faults branch at a steep dip angle from the plate-boundary décollement in an accretionary wedge, their coseismic displacement can potentially result in larger tsunamis with distinct characteristics compared to megathrust-only fault ruptures, posing an enhanced hazard to coastal communities. Elsewhere, there is evidence of coseismic slip on splay faults during many of the largest subduction zone earthquakes, but our understanding of potentially active splay faults and their hazards at the Cascadia subduction zone remains limited. To identify the most recently active splay faults at Cascadia, we conduct stratigraphic and structural interpretations of near-surface deformation in the outer accretionary wedge for the ~400 km along-strike length of the landward vergence zone. We analyze recently acquired high-frequency sparker seismic data and crustal-scale multi-channel seismic data to examine the record of deformation in shallow slope basins and the upper ~1 km of the surrounding accreted sediments and to investigate linkages to deeper décollement structure. We present a new fault map for widest, most completely locked portion of Cascadia from 45 to 48°N latitude, which documents the distribution of faults that show clear evidence of recent late Quaternary activity. We find widespread evidence for active splay faulting up to 30 km landward of the deformation front, in what we define as the active domain, and diminished fault activity landward outside of this zone. The abundance of surface-deforming splay faults in the active outer wedge domain suggests Cascadia megathrust events may commonly host distributed shallow rupture on multiple splay faults located within 30 km of the deformation front
Caerin 1 Antimicrobial Peptides that Inhibit HIV and Neisseria May Spare Protective Lactobacilli
No full textAlthough acquired immunodeficiency syndrome (AIDS) caused by the human immunodeficiency virus (HIV) is a manageable disease for many, it is still a source of significant morbidity and economic hardship for many others. The predominant mode of transmission of HIV/AIDS is sexual intercourse, and measures to reduce transmission are needed. Previously, we showed that caerin 1 antimicrobial peptides (AMPs) originally derived from Australian amphibians inhibited in vitro transmission of HIV at relatively low concentrations and had low toxicity for T cells and an endocervical cell line. The use of AMPs as part of microbicidal formulations would expose the vaginal microbiome to these agents and cause potential harm to protective lactobacilli. Here, we tested the effects of caerin 1 peptides and their analogs on the viability of two species of common vaginal lactobacilli (Lactobacillus rhamnosus and Lactobacillus crispatus). Several candidate peptides had limited toxicity for the lactobacilli at a range of concentrations that would inhibit HIV. Three AMPs were also tested for their ability to inhibit growth of Neisseria lactamica, a close relative of the sexually transmissible Neisseria gonorrhoeae. Neisseria lactamica was significantly more sensitive to the AMPs than the lactobacilli. Thus, several candidate AMPs have the capacity to inhibit HIV and possible N. gonorrhoeae transmission at concentrations that are significantly less harmful to the resident lactobacilli
