20 research outputs found
Einfühlung/ Empathie in psychosozialer Beratung : eine Untersuchung zu Einflussfaktoren auf die Bereitschaft für Einfühlung/ Empathie und die einfühlsame/ empathische Wahrnehmung seitens SozialarbeiterInnen in psychosozialer Beratung
No full textIn dieser Arbeit werden Einfühlung und Empathie synchron als Synonyme verwendet. Nach dem Modell von Einfühlung/ Empathie, welches dieser Arbeit zu Grunde liegt, stellen Bereitschaft für Einfühlung/ Empathie und einfühlsame/ empathische Wahrnehmung zwei grundlegende Schritte des Einfühlungs-/ Empathieprozesses dar.
Die Bachelorarbeit befasst sich mit den Einflussfaktoren auf diese grundlegenden Schritte im Rahmen psychosozialer Beratung. Die Faktoren werden der Mikro-, Meso- und Makroebene zugeordnet. Die Makroebene bezieht sich auf Deutschland. Die Bearbeitung erfolgte anhand einer Literaturrecherche
Der (un‑)sichtbare Einfluss von Sprachkontakt auf Wortbildungsverfahren im französisch‑ italienischen Vergleich
No full textLe français et l’italien se sont enrichis mutuellement au plan lexical. Malgré leur proximité généalogique, ces langues divergent quantitativement et qualitativement face à l’introduction de signifiés venus de la langue sœur respective. L’étude montrera dans quelle mesure les mots composés impliqués au contact des deux langues se rendent visibles ou disparaissent au sein de la langue receveuse. Les gallicismes italiens se présentent en majorité sous forme de calques, imperceptibles pour le locuteur moyen. Par contre, en français langue d’arrivée, les unités lexicales complexes empruntées à l’italien sont souvent inaltérées ou subissent des assimilations phonétiques et morphologiques après le transfert. Les deux approches pour intégrer des concepts étrangers témoignent de préférences différentes quant aux types de formation des mots.XXXI. Forum Junge Romanistik in Rostock (5.–7. März 2015
Measurement of 3-Nitro-Tyrosine in Human Plasma and Urine by Gas Chromatography-Tandem Mass Spectrometry
No full textDeletion of the Synechocystis sp. PCC 6803 kaiAB1C1 gene cluster causes impaired cell growth under light-dark conditions
No full textNitro‐fatty Acids Occur in Human Plasma in the Picomolar Range: a Targeted Nitro‐lipidomics GC–MS/MS Study
No full text
GC-MS and GC-MS/MS measurement of ibuprofen in 10-μL aliquots of human plasma and mice serum using [α-methylo-(2)H3]ibuprofen after ethyl acetate extraction and pentafluorobenzyl bromide derivatization: Discovery of a collision energy-dependent H/D isotope effect and pharmacokinetic application to inhaled ibuprofen-arginine in mice.
No full textGC-MS and GC-MS/MS methods were developed and validated for the quantitative determination of ibuprofen (d0-ibuprofen), a non-steroidal anti-inflammatory drug (NSAID), in human plasma using α-methyl-(2)H3-4-(isobutyl)phenylacetic acid (d3-ibuprofen) as internal standard. Plasma (10μL) was diluted with acetate buffer (80μL, 1M, pH 4.9) and d0- and d3-ibuprofen were extracted with ethyl acetate (2×500μL). After solvent evaporation d0- and d3-ibuprofen were derivatized in anhydrous acetonitrile by using pentafluorobenzyl (PFB) bromide and N,N-diisopropylethylamine as the base catalyst. Under electron-capture negative-ion chemical ionization (ECNICI), the PFB esters of d0- and d3-ibuprofen readily ionize to form their carboxylate anions [M-PFB](-) at m/z 205 and m/z 208, respectively. Collision-induced dissociation (CID) of m/z 205 and m/z 208 resulted in the formation of the anions at m/z 161 and m/z 164, respectively, due to neutral loss of CO2 (44 Da). A collision energy-dependent H/D isotope effect was observed, which involves abstraction/elimination of H(-) from d0-ibuprofen and D(-) from d3-ibuprofen and is minimum at a CE value of 5eV. Quantitative GC-MS determination was performed by selected-ion monitoring of m/z 205 and m/z 208. Quantitative GC-MS/MS determination was performed by selected-reaction monitoring of the mass transitions m/z 205 to m/z 161 for d0-ibuprofen and m/z 208 to m/z 164 for d3-ibuprofen. In a therapeutically relevant concentration range (0-1000μM) d0-ibuprofen added to human plasma was determined with accuracy (recovery, %) and imprecision (relative standard deviation, %) ranging between 93.7 and 110%, and between 0.8 and 4.9%, respectively. GC-MS (y) and GC-MS/MS (x) yielded almost identical results (y=4.00+0.988x, r(2)=0.9991). In incubation mixtures of arachidonic acid (10μM), d3-ibuprofen (10μM) or d0-ibuprofen (10μM) with ovine cyclooxygenase (COX) isoforms 1 and 2, the concentration of d3-ibuprofen and d0-ibuprofen did not change upon incubation at 37°C up to 60min. The trough pharmacokinetics of an inhaled arginine-containing ibuprofen preparation in mice was studied after once-daily treatment (0.0, 0.07, 0.4 and 2.5mg/kg body weight) for three days. A linear relationship between ibuprofen concentration in serum (10μL) and administered dose 24h after the last drug administration was observed
18O-Labeled nitrous acid and nitrite: Synthesis, characterization, and oxyhemoglobin-catalyzed oxidation to 18O-labeled nitrate
No full text
