2 research outputs found
A study on therapeutic management of allergic conjunctivitis and assessment of quality of life in patients
No full textBackground: Allergic conjunctivitis (AC) is a common ocular condition triggered by exposure to allergens. The primary objective of this study was to evaluate the therapeutic management of patients suffering from allergic conjunctivitis and to determine the prevalence of AC among patients attending an allergy center.
Methods: A retro-prospective, interventional study was conducted, for a six-month period from March to August 2024. Total of 260 patients diagnosed with AC were included from total of 1,523 individuals attending the center. Inclusion criteria focused on patients of all ages undergoing treatment for AC, excluding those with infectious conjunctivitis or other ocular pathologies. Patient data were collected using structured forms that included demographic information, presenting symptoms, other allergic conditions etc. Treatments were categorized into pharmacological, personalized and supportive therapy.
Results: Among all the 1,523 patients, 263 were diagnosed with AC, indicating a prevalence of 17.26%. Allergen testing revealed that dust mites were the leading triggers, followed by pollens. Coexisting allergic conditions were highly prevalent, particularly allergic rhinitis and dermatitis. Pharmacological therapy, like antihistamines and topical corticosteroids, was administered to 86 patients, while 105 patients received personalized treatments. A statistically significant improvement in post-treatment symptom scores was observed, with an effect size of 1.62, indicating high treatment efficacy.
Conclusions: This study highlights the need for early diagnosis, comprehensive allergen evaluation and targeted management in allergic conjunctivitis. The study contributes to the scientific understanding of AC by providing real-world data on allergen prevalence and treatment outcomes
Prionailurus rubiginosus
No full textPrionailurus rubiginosus (Geoffroy Saint-Hilaire, 1831) Rusty-Spotted Cat Felis rubiginosa I. Geoffroy Saint-Hilaire, 1831:140. Type locality “bois de lataniers qui couvrent une hauteur voisine de Pondichery,” [= India, wooded hills in the vicinity of Pondicherry]. Viverriceps rubiginosa: Gray, 1867:269. Name combination. [Prionailurus] rubiginosa: Pocock, 1917:332. Name combination. [Prionailurus] rubiginosus: Pocock, 1917:339. First use of current name combination. CONTEXT AND CONTENT. Order Carnivora, suborder Feliformia, family Felidae, subfamily Felinae. Taxonomy of the leopard cat lineage of Asian small cats has been controversial for many decades, as evidenced by its long history of reclassification at the generic (e.g., Felis, Prionailurus, Viverriceps, Ictailurus Zibethailurus, Ailurogale, Ailurinus, and Mayailurus) and species levels (Nowell and Jackson 1996; Kitchener et al. 2017). The placement of rubiginosus in Prionailurus was considered problematic by several investigators (Sunquist and Sunquist 2002; Wozencraft 2005). However, relatively recent phylogenetic work based on both morphological and molecular evidence suggests this classification is correct (Johnsen et al. 2006; O’Brien and Johnson 2007; Kitchener et al. 2017). Here, I have followed Kitchener et al. (2017), who recognized three subspecies of rubiginosus: © The Author(s) 2019. Published by Oxford University Press on behalf of American Society of Mammalogists. P. r. koladivius Deraniyagala, 1956:113. Type locality “Kathiraveli (E.P.),” Sri Lanka. P. r. phillipsi Pocock, 1939:278. Type locality “Mousakanda, Gammaduwa, C. P., 3,000 ft,” Sri Lanka. P. r. rubiginosus (Geoffroy Saint-Hilaire, 1831). See above. NOMENCLATURAL NOTES. Common names for Prionailurus rubiginosus are rusty-spotted cat and rustie or rusty. Local names from the Indian subcontinent are spoken in Kannada or Kanarese, Waddari, and Tamil, and in these vernacular are Kiraba-bekku, Ark-philli, and Namali Pilli, listed respectively (Srinivasulu 2019). In Sri Lankan Tamil, common names include Kadu-poona, Verewa puni, and Kardup-poonai (Srinivasulu 2019). There are a number of additional common names in the Sri Lankan vernacular Sinhala, which include Kola Diviya, Balal Diviya (Miththapala 2012; Weerakoon 2012), Wal-balala, Handun Diviya, and Kula Diya (Srinivasulu 2019). The common names Ceylon rusty-spotted cat and small jungle cat specifically refer to P. r. phillipsi (Srinivasulu 2019). Other vernacular names include the French names chat rougeâtre, chat rubigineux, and chat-léopard de l’Inde and the Spanish or Castilian names gato rojizo and gato rubiginosa (Mukherjee et al. 2016). DIAGNOSIS Prionailurus rubiginosus is distinguished from Prionailurus bengalensis, the leopard cat, by its typically smaller size, with a total length of 500–780 mm (Sunquist and Sunquist 2002), whereas the total length of P. bengalensis is generally 750– 925 mm. In specimens where total lengths overlap, it is advisable to compare coat patterns; overall, P. rubiginosus has a characteristically subdued pelage pattern in comparison to that of P. bengalensis, as well as a notable uniform coloring and indistinct patterning of the tail. Additionally, in P. rubiginosus, the solid spots are small, widely separated, often lanceolate, and arranged linearly on the dorsum, whereas the pattern of spots on the shoulders and head form clear stripes (Pocock 1939; Fig. 1). P. rubiginosus is distinguishable from Prionailurus viverrinus, the fishing cat, by comparisons of tail length in relation to head and body length and the length of the hind foot. In P. rubiginosus, the tail is greater than one-half the length of the head and body and more than twice as long as the hind foot, whereas in P. viverrinus, the tail is less than one-half the head-body length and less than two times the length of the hind foot. Additionally, P. viverrinus is considered the largest member of the genus Prionailurus (Pocock 1939). The flatheaded cat, Prionailurus planiceps, is easily distinguished from P. rubiginosus by its short tail, at 140 mm as opposed to 150– 300 mm for P. rubiginosus; its flat or lengthened head; and its delicate and elongated extremities (Vigors and Horsfield 1827; Sunquist and Sunquist 2002). With a range that does not extend much beyond the islands of the Sunda Shelf, the Sunda leopard cat, Prionailurus javanensis, does not occur sympatrically with P. rubiginosus (Kitchener et al. 2017). The skulls of the five species in the genus Prionailurus are noticeably different. Strongly compressed nasals and greatly expanded maxillae are characteristic of P. rubiginosus (Fig. 2); both are useful traits to distinguish its skull from that of P. bengalensis, the type of Prionailurus (Pocock 1939). P. bengalensis has the most generalized skull with a mean total length of about 93 mm, and is most similar to that of Felis. In comparison, P. rubiginosus has a much smaller skull, roughly 75 mm long, with weakly developed musculature tending to superficially resemble the skull of a young P. bengalensis (Pocock 1939). P. javanensis, which was recently recognized as a separate species rather than a subspecies of P. bengalensis (Kitchener et al. 2017), is similarly distinguished by its larger skull, with a mean total length of 85 mm (Sicuro and Oliveira 2015). In contrast to P. viverrinus, P. rubiginosus lacks a sagittal crest, always has a narrower rostrum than the postorbital area, and only two upper premolars are present (Pocock 1939). The skull of P. planiceps is immediately distinguishable from that of P. rubiginosus by the extreme depression of the skull that extends from the anterior portion of the frontal bones along the length of the nasal bones (Vigors and Horsfield 1827). GENERAL CHARACTERS Prionailurus rubiginosus has short, predominately brownish gray fur with a hint of rust color (Sunquist and Sunquist 2002). This color extends from the head to the tip of the tail, and also trails down the outside of the limbs (Fig. 1). The Sri Lankan subspecies, P. r. phillipsi, which occurs in more tropical regions, is generally darker, richer, and warmer in hue than its dry zone counterpart, P. r. koladivius, and the Indian subspecies, P. r. rubiginosus, both of which on average have more of a grayish wash to their coats (Pocock 1939; Deraniyagala 1956; Kitchener et al. 2017). P. r. koladivius differs from P. r. rubiginosus by its generally darker, less gray head, and its dorsal spots and bands that are nearly black rather than rusty in color (Deraniyagala 1956; Kitchener et al. 2017). In all subspecies, the back and flanks have faintly colored elliptical rust spots and a white underbelly and throat with large dark spots and bars. The soles of its feet are black and the tail is substantial and thick. The tail is also markedly darker and more uniformly colored than the rest of the body, rendering the spots less distinct and more difficult to discern (Pocock 1939; Sunquist and Sunquist 2002). There are two streaks of darker fur on the cheeks of the face and four streaks of darker fur extending from above the eyes, over the forehead toward the back of the head, and down onto the shoulders (Sunquist and Sunquist 2002). The skulls of the subspecies of P. rubiginosus are not distinguishable from one another (Pocock 1939; Kitchener et al. 2017). Prionailurus rubiginosus is considered to be the smallest felid species in the world with adults approximately one-half the mass of Felis catus, domestic cat (Pocock 1939; Dmoch 1997; Sunquist and Sunquist 2002). Adults have a mean weight of 1.1 kg for females (n = 3) and 1.6 kg for males (n = 5), as measured from specimens of P. r. phillipsi (Phillips 1935), whereas adult domestic cats average 2.7 kg for females (n = 34) and 3.8 kg for males (n = 63–– Eberhard 1954). Head-body length of P. rubiginosus is 350–480 mm, and tail length is 150–300 mm, for a total length of 500–780 mm (Sunquist and Sunquist 2002). According to Pocock (1939), the average adult hind foot measurement is 88.5 mm (n = 14). The small rounded ears of P. rubiginosus average 40 mm, as measured from three specimens in the British Museum. DISTRIBUTION Prionailurus rubiginosus is restricted to the Indian subcontinent and Sri Lanka (Pocock 1939; Sunquist and Sunquist 2002; Fig. 3). It inhabits both humid and wet or dry deciduous forests as well as scrub and grassland, but it is likely absent from evergreen forests because it prefers dense vegetation and rocky areas (Nowell and Jackson 1996; Kittle and Watson 2004; Patel 2006). P. rubiginosus was originally believed to be confined to Sri Lanka and a small portion of southwestern India (Weigel 1972; Guggisberg 1975; Sterndale 1884), but more recent research and sightings have established its presence throughout most of India (Nowell and Jackson 1996; Sunquist and Sunquist 2002) and in Nepal’s Shuklaphanta Wildlife Reserve and Bardiya National Park (Lamichhane et al. 2016). Accordingly, the distribution of the subspecies P. r. phillipsi and P. r. koladivius are restricted to Sri Lanka, whereas P. r. rubiginosus is distributed throughout most of India (Pocock 1939; Deraniyagala 1956; Nowell and Jackson 1996; Dmoch 1997; Khan and Mukherjee 2008; Fig. 3) and in the western region of Nepal’s Terai (Lamichhane et al. 2016). Kittle and Watson (2004) observed P. r. phillipsi outside of Yala National Park in Sri Lanka in addition to a possible hybrid with a domestic cat. In the state of Tamil Nadu, India, P. r. rubiginosus is found in the Varushanad Valley in the southern region of the Western Ghats, a noted biodiversity hotspot (Pillay 2008). Its presence has also been well documented in the Nagarjunasagar Srisailam Tiger Reserve, as well as in the Nellore district, and throughout the state of Andhra Pradesh (Behera 2008). Furthermore, its presence is known from the Nugu Wildlife Sanctuary among other areas in the state of Karnataka (Kumara and Singh 2005) and from areas in the state of Orissa (Prater 1998; Sunquist and Sunquist 2002). Camera traps first documented P. rubiginosus in Central India at the Nagzira Wildlife Sanctuary (Anwar et al. 2010; Patel 2010) and later in the Tadoba-Andhari Tiger Reserve (Dubey 1999); both areas are in the state of Maharastra. Since then, sightings in the state of Maharastra have increased notably. Moreover, researchers have identified a breeding population in western Maharastra, an area with human and agriculturally dominated landscapes, where high rodent densities have been recorded (Athreya 2010). Prionailurus rubiginosus is present in the Gir Wildlife Sanctuary and National Park (Pathak 1990) in the state of Gujarat, its southern part (Singh 1987), as well as in eastern Gujarat (Patel 2006). The species also occurs in the states of Madhya Pradesh and Rajasthan (Mukherjee 1998; Bhatnager et al. 2000), and additional observations indicate its presence on the east coast (Manakadan and Sivakumar 2006). Sightings of P. rubiginosus in the Pilibhit Tiger Reserve in the Indian Terai region of the state of Uttar Pradesh were once thought to represent the northernmost extent of its range (Anwar et al. 2010), but more recently camera traps have detected its presence in the Corbett Tiger Reserve in Uttarakhand. Additionally, reports of sightings in the states of Jammu and Kashmir have been recorded (Prater 1998; Sunquist and Sunquist 2002), indicating that its distribution extends even farther north than formerly suspected. However, the contiguity of its distribution remains unknown due to a lack of information on habitat preferences (Nowell and Jackson 1996). No fossils are known. FORM AND FUNCTION The low-set rounded ears of Prionailurus rubiginosus are small in relation to the head (Pocock 1939). As with other felid species, P. rubiginosus has sharp, strongly curved, and retractile claws. Its short rostrum has wide postorbital and zygomatic areas to accommodate the substantial craniomandibular muscles. These muscles are responsible for the powerful bite that is typical of members of the Felidae. Furthermore, P. rubiginosus has the archetypal cat carnassial pair of molars, which provides the shearing and cutting action of its mostly animal diet (Sicuro 2011). The skull has a notably short rostrum, plus the ends of the nasals curve downward and the anterior nares are in a plane nearly vertical with the maxilla-premaxillary suture. The nasals are strongly constricted posteriorly and the maxillae are laterally expanded. In adults, the orbits are completely surrounded by bone. P. rubiginosus lacks a sagittal crest and the temporal ridges form a U- or lyriform shape (Pocock 1939). The skulls of four males, one female, and one of unknown sex averaged (mm) total length 76, condylobasal length 70, zygomatic width 50, postorbital width 24, inter-orbital width 12, maxillary width 19, and mandibular length 48 (Pocock 1939). The dental formula of P. rubiginosus is i 3/3, c 1/1, p 2/2, m 1/1, total 28. As a result of the evolutionarily shortened muzzle, the area immediately behind the upper canine is reduced and the first two premolars are lost (Pocock 1939). The P4/m1 form the carnassial pair, wherein the inner lobe of the upper carnassial is reduced. The P4 averages 8 mm (n = 6), and the m1 averages 7 mm (n = 6) in length (Pocock 1939). Published data on basic physiological aspects, such as basal metabolic rate, heart and respiration rates, or cellular processes, are virtually unavailable. ECOLOGY Population characteristics. —Little is known of the ecology of Prionailurus rubiginosus in the wild, so aspects of its ecology and behavior are inferred from captive individuals and observational reports (Dmoch 1997; Sabapara 1999; Sunquist and Sunquist 2002; Behera 2008; Pillay 2008). Unlike many species of small felids, relatively few P. rubiginosus have been held in captivity (Dmoch 1997; Sabapara 1999; Sunquist and Sunquist 2002). Longevity ranges from 12 to 18 years in captivity. Males and females reach sexual maturity within their first year. Gestation is 67–71 days (mean 69 days, n = 22), and litter size is 1–3 kittens (n = 58— Dmoch 1997; see “Husbandry” for additional details). Space use. —In India, Prionailurus rubiginosus inhabits both wet and dry deciduous forests, scrub forests, tropical forests, grass and shrub lands, rocky areas, and hilly slopes. Sightings occur often in grassy areas, teak or bamboo forests, and arid vegetation areas (Pocock 1939; Guggisberg 1975; Pathak 1990; Nowell and Jackson 1996; Sunquist and Sunquist 2002), but sometimes dense vegetation and rocky areas are favored (Kittle and Watson 2004; Patel 2006). In Sri Lanka, they are found in humid forests, in low scrub lands, on mountaintops, and in arid coastal belts ranging from sea level to elevations as high as 2,100 m (Sunquist and Sunquist 2002). In recent years, P. rubiginosus frequents human-inhabited agricultural areas as well as the attics of abandoned houses in urbanized areas. Some investigators speculate that P. rubiginosus is responding more to substantial rodent populations rather than to habitat type (Nowell and Jackson 1996; Mukherjee 1998; Pillay 2008). Diet. —Information on the diet of wild Prionailurus rubiginosus is scant. Early descriptions of diet include small mammals, birds, and possibly small lizards and frogs (Phillips 1935; Pocock 1939; Sunquist and Sunquist 2002). Direct observations suggest it feeds primarily on small rodents, but one particular cat hunted frogs (Patel 2006). Hunting activity tends to increase after heavy rains, which is likely the direct result of a corresponding increase in the activity of rodents, their primary prey, and of frogs (Worah 1991; Bambaradeniya and Amarasinghe 2001). They also prey on domestic fowl (Phillips 1935; Pocock 1939; Sunquist and Sunquist 2002), which has resulted in their persecution (Pillay 2008; see “Husbandry” for further details on captive diet). Diseases and parasites. —Information on diseases and disease transmission, illness and infection, and parasitism is drawn exclusively from captive animals and from a handful of necropsied wild animals. Feral domestic cats transmit diseases to Prionailurus rubiginosus (Bambaradeniya and Amarasinghe 2001), specifically feline enteritis (Sunquist and Sunquist 2002), panleucopaenia, pneumonia, pseudo-tuberculosis, and bone-marrow disease (Dmoch 1997). Some zoos vaccinate their P. rubiginosus for calicivirus and herpes (Dmoch 1997). Over the course of several decades, Dmoch (1997) of the Frankfurt Zoo (Germany) recorded 13 cases of adult mortality and their causes, as follows: three from nephritis and one each of foreign bodies, food aspiration, gastro-intestinal inflammation, gastritis, rhinitis, uterus rupture, pneumonia, acute hepatitis, pseudo-tuberculosis, and hypernatremia amyloidosis. Furthermore, P. rubiginosus is highly susceptible to parasites. Round worms in the stomach and intestines of a necropsied wild kitten suggested that the severe congestion and hemorrhages in the intestines were linked to the heavy worm infestation (Sabapara 1999). On examination, the feces contained large numbers of eggs of Toxoscaris leonini, Trichuris, and Anchylostoma. Additionally, liver, spleen, and lung tissue samples revealed the presence of Pseudomonas, a bacterium. Infestations of Uncinaria, Toxocara, Coccidia, and Toxascaris were often treated at the Frankfurt Zoo (Dmoch 1997). For further information, see “Husbandry.” Interspecific interactions. — Prionailurus rubiginosus is sympatric with other small felids, such as P. bengalensis and Felis chaus, the jungle cat, but interspecific interactions have scarcely been investigated (Nowell and Jackson 1996). Although P. rubiginosus has no known wild predators, because of its size it is often assumed that it is prey for larger predators. Mostly ground dwelling, P. rubiginosus is quite agile and adept in trees, perhaps its primary means of escape from larger predators (Sunquist and Sunquist 2002). Miscellaneous. —Detailed research on Prionailurus rubiginosus is grossly deficient (Dmoch 1997; Sabapara 1999; Sunquist and Sunquist 2002; Behera 2008; Pillay 2008) and therefore standard methods of capture, marking, tracking, recording, censusing, or sampling are virtually lacking. Camera traps, used to document much of its known range (Dubey 1999; Anwar et al. 2010; Patel 2010), sometimes capture the variable stripe patterns along the inner sides of limbs, making it possible to identify individuals (Lamichhane et al. 2016). However, such coat variation is not always visible or captured with camera trapping. Prionailurus rubiginosus is easily domesticated yet rarely held in captivity (Sunquist and Sunquist 2002). Accounts describe them as graceful and agile, superbly vicious hunters relative to their size, and expressive, playful, and affectionate toward their human owners (Jerdon 1874; Sunquist and Sunquist 2002; see “Husbandry”). HUSBANDRY Prionailurus rubiginosus is rarely held in zoos, and currently the Frankfurt, Cincinnati (USA), Port Lympne (England), and Colombo (Sri Lanka) zoos host the majority of the small captive population (Sunquist and Sunquist 2002; Jayaratne et al. 2015) with all animals originating from the founding pair at the Frankfurt Zoo (Dmoch 1997). These felines do not fare well in captivity if not immediately vaccinated after capture or arrival because they are prone to contracting a host of diseases, such as feline enteritis (Sunquist and Sunquist 2002), panleucopaenia, pneumonia, pseudo-tuberculosis, and bone-marrow disease (Dmoch 1997). Despite its susceptibility to disease, those held in captivity can have high longevity, with the longest lifespan recorded at 18 years in the Frankfurt Zoo (Dmoch 1997). Breeding has ceased at the Frankfurt and Cincinnati zoos, probably due to the effects of inbreeding depression. To ensure the future of captive P. rubiginosus, new founder animals from the wild are required to restore genetic diversity (Dmoch 1997). In the Frankfurt Zoo, kittens are vaccinated against panleucopaenia with Felidovac P, and annual vaccination is needed to prevent this condition (Dmoch 1997). Wild kittens taken into captivity need immediate treatment for intestinal parasites, such as Uncinaria, Toxoscaris, Trichuris, and Anchylostoma (Dmoch 1997; Sabapara 1999). Because P. rubiginosus is generally believed to be strictly nocturnal based on reported sightings in the wild only occurring at night, dawn, or dusk, captive animals are kept on a similar light regime. At the Frankfurt Zoo, P. rubiginosus is housed in the nocturnal section, and the reversed lighting conditions are set to mimic seasonal variation in day length (Dmoch 1997). Observations of captive animals indicate that P. rubiginosus may not be strictly nocturnal, but this may be a captive behavior (Dmoch 1997; Sunquist and Sunquist 2002). Based on observations of six individuals in non-exhibit enclosures at the National Zoological Gardens in Dehiwala, Sri Lanka, P. rubiginosus tends to be most active between the hours of 1800 to 2000 (Javaratne et al. 2015). However, these authors discussed the difficulties of comparing the behaviors of wild and captive animals. The original enclosure at Frankfurt Zoo consisted of a forest display with a soil substrate, a range of climbing options, and a number of sleeping boxes (Scherpner 1982). Very young kittens in captivity are fed pasteurized lukewarm milk through a sterile feeding bottle, usually every 2 h during the day and every 4 h at night (Sabapara 1999). Older kittens brought to the Frankfurt Zoo were reared on a diet of minced beef muscle and heart, protein-rich mash, and mice and rats, and they mostly declined eating day-old
