1,721,236 research outputs found
Modified discrete vortex method to simulate the unsteady aerodynamics of two-dimensional insect-like flapping wing models in hover
No full textThe Effects of Wing Mass Asymmetry on Low-Speed Flight Characteristics of an Insect Model
No full textWing asymmetries can be found in real insects and flapping-wing micro air vehicles. This paper investigates some characteristics, including the trim conditions, power requirements and passive open-loop dynamics of an insect model with the asymmetry in wing mass in low-speed flight. The motion of the insect model is obtained through a simulation framework that couples an unsteady vortex-lattice method and a multibody dynamics code. The results show that a heavier wing has to be moved with a larger stroke amplitude to compensate for the wing mass asymmetry. The power required by the heavier wing is also found greater. Moreover, we can observe the asymmetries in lateral dynamics while comparing dynamic responses due to rightward and leftward gust disturbances.
sj-docx-1-npx-10.1177_1934578X221112812 - Supplemental material for Phytochemicals, Antiinflammatory, and Analgesic Effects of the Ethanol Extract From the Leaves of <i>Premna Flavescens</i> Wall. ex C. B. Clarke
No full textSupplemental material, sj-docx-1-npx-10.1177_1934578X221112812 for Phytochemicals, Antiinflammatory, and Analgesic Effects of the Ethanol Extract From the Leaves of Premna Flavescens Wall. ex C. B. Clarke by Ha Minh Le, Phuong Thi Ngo, Anh Tuan Nguyen and Huyen Thi Thanh Do in Natural Product Communications</p
Abstract A39: Modeling organelle-specific O-glycosylation in driving liver tumor growth, invasion, and metastasis
No full textAbstract
Cancer progression is driven by the ability of tumor cells to invade surrounding tissues. Invasiveness correlates with perturbation of a covalent modification of cell surface proteins: O-glycosylation. However, the underlying molecular mechanisms are still unclear. Here, we show that O-glycosylation initiating enzymes are activated during liver tumor growth by intracellular relocation from Golgi to ER. In a Nras/shp53 mouse liver cancer model, coexpressing an ER-targeted glycosyl-transferase GALNT1 (ER-G1) massively increased tissue growth, invasion, and metastases. ER-G1, but not its Golgi-localized counterpart, strongly stimulates glycosylation of the key cancer matrix metalloprotease MT1-MMP, this modification being essential for collagenase activity. Conversely, expression of an ER-targeted inhibitor of GALNTs inhibits liver tumor progression in Nras/shp53-injected mice. In summary, our model comprehensively demonstrates the generation and analyses of the GALA (GALNTs Activation) pathway driving liver tumor invasiveness; thus, further characterization of glycosylation substrates will unveil mechanisms of tumor growth and help identify potential therapeutic targets in human liver cancer.
Citation Format: Anh Tuan Nguyen, Frederic Bard. Modeling organelle-specific O-glycosylation in driving liver tumor growth, invasion, and metastasis [abstract]. In: Proceedings of the AACR Special Conference: Advances in Modeling Cancer in Mice: Technology, Biology, and Beyond; 2017 Sep 24-27; Orlando, Florida. Philadelphia (PA): AACR; Cancer Res 2018;78(10 Suppl):Abstract nr A39.</jats:p
The beam modelling of the hawkmoth wing structure
No full textHawkmoth wings consist of veins and membrane elements that undergo large deformations while moving through the air. The intention of this paper is to create an Euler-Bernoulli beam that can model the complex structure of a hawkmoth forewing. The beam undergoes bending and torsion, and its modal analysis and deformation data are validated against those of the wing structure created based on the finite-element method and a biological wing. A multibody dynamics approach is employed to model the deformation of the beam wing when it oscillates at the frequency of an actual hawkmoth
Towards an examiners training model for standardized oral assessment qualities in Vietnam
No full textSpot.Exhibition
No full textSpot.Exhibition is an international exhibition, curated by the Faculty of Industrial Fine Arts, Ton Duc Thang University, Ho Chi Minh City, Vietnam. The exhibition includes Vietnamese and international artists and designers, who have recently been cooperating with the faculty. Participating artists: Nguyen Thi Thuy Van, Ulrich Klieber, Michael Ling, Rudolf Schäfer, Isbah Afzal, Salman Afzal, Filipa De Araujo Cristina, Griet Moors, Nguyen Van Man, Phan Anh Tuan, Nguyen Hong Khiem, Pham Ngoc Quinh Giao, e.a
Spot.Exhibition
No full textSpot.Exhibition is an international exhibition, curated by the Faculty of Industrial Fine Arts, Ton Duc Thang University, Ho Chi Minh City, Vietnam. The exhibition includes Vietnamese and international artists and designers, who have recently been cooperating with the faculty. Participating artists: Nguyen Thi Thuy Van, Ulrich Klieber, Michael Ling, Rudolf Schäfer, Isbah Afzal, Salman Afzal, Filipa De Araujo Cristina, Griet Moors, Nguyen Van Man, Phan Anh Tuan, Nguyen Hong Khiem, Pham Ngoc Quinh Giao, e.a
SDC – Supplemental material for Introduction of Novel Surgical Techniques: A Survey on Knowledge, Attitude, and Practice of Surgeons
No full textSupplemental material, SDC for Introduction of Novel Surgical Techniques: A Survey on Knowledge, Attitude, and Practice of Surgeons by Ali Mahmoud Ahmed, Hoang Thi Nam Giang, Sherief Ghozy, Hosni Salem, Mohamed Osman Algazar, Ahmed Altibi, Huynh Thanh Son, Tang Ha Nam Anh, Tran Dinh Cuong, Le Quan Anh Tuan, Nguyen Lam Vuong, Mohamed Abdou, Muhammad Mohieddin Ghorab, Ngan Bich Tran, Sameh Samir Elawady, Ahmed Elmaraezy, Le Huu Nhat Minh, Kenji Hirayama and Nguyen Tien Huy in Surgical Innovation</p
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