1,721,083 research outputs found
Ectomesenchymal chondromyxoid tumour of the tongue. A review of histological and immunohistochemical features.
No full textBackground: Ectomesenchymal chondromyxoid tumour (ECT) is a rare, benign neoplasm of uncertain histogenesis, which appears to exclusively involve the oral cavity, particularly the tongue. Case Report: We report the case of a 27-year-old woman with a 0.7 cm tumoral lesion of 3 months' duration on the dorsum of the tongue. Histologically, it comprised well-circumscribed, unencapsulated lobular proliferations of fusiform and polygonal cells, with varying degrees of cellularity, with neoplastic cells often set in a myxoid, chondroid or hyalinized background. Immunohistochemistry revealed positivity of the neoplastic cells for antibodies directed against S-100, glial fibrillary acidic protein and vimentin, plus negativity for CD-57(leu-7), epithelial membrane antigen, smooth muscle actin, desmin and cytokeratin AE1-AE3. The diagnosis was consistent with ECT. Total excision was performed and there has been no recurrence after 10 months' follow-up. Conclusion: This is the 37th case reported in the English language literature; ECT is characterized microscopically by a biphasic myxoid and chondroid pattern. Immunohistochemical expression of S100, glial fibrillary acidic protein and vimentin, very helpful in confirming diagnosis, suggest a probable mesenchymal and neural origin of this rare entity
HEAD AND NECK HEMANGIOMA IN PAEDIATRIC PATIENTS TREATED WITH ENDOLESIONAL LASER DIODO 810-980-1420 nm - OPTIC FIBER 200-800μ
No full textVALUTAZIONE DEGLI EFFETTI CITOTOSSICI E GENOTOSSICI DEGLI ADESIVI ORTODONTICI SULLE PAPILLE GENGIVALI UMANE ATTRAVERSO L'ESPRESSIONE IMMUNOISTOCHIMICA DI P53, P63 E P16
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Extraskeletal Myxoid Chondrosarcomaof the Left Buccal Mucosa
No full textExtraskeletal chondrosarcoma (ECS) is a rare malignant neoplasm of bone or soft-tissue origin, characterized by the presence of spindle cells admixed with well-differentiated cartilage or chondroid stroma. A case of ECS is reported in a 102-year-old woman who presented with a painful swelling of 2 cm in the left buccal vestibular area. Orthopantomography was insignificant. Biopsy and histopathological examination revealed a tumor composed of an undifferentiated small round cell component that surrounded a myxoid matrix of malignant cartilage. Immunohistochemical studies showed the tumor cells to be positive for nuclear S-100 protein immunostaining, focally positive for vimentin and synaptophysin, and negative for epithelial membrane antigen, desmin, chromogranin, Leu-7, glial fibrillary acid protein, actin muscle-specific, cytokeratin, carcinoembryonic antigen, and CD99 (MIC2). The proliferative index (MIB-1) was 20%. The tumor was treated by surgery with wide margins. There was no evidence of disease at one-year follow-up. This report presents a very rare case of ECS of the left buccal mucosa of the maxilla, and describes the histological characteristics and the immunoprofile
Hyalinizing clear cell carcinoma arising on the anterior palatoglossal arch.
No full textHyalinizing clear cell carcinoma (HCCC) is very rare in the oral cavity, arising more frequently in the minor salivary glands. We present the case of a 57-year-old woman with a swelling on the anterior palatoglossal arch of 2x1 cm size. An incisional biopsy was taken and histological examination revealed typical clear cells arranged in anastomosing trabeculae, cords, nests, and solid sheets with a hyalinizing stroma. These clear cells were strongly positive to periodic acid-Schiff stain (PAS) but were negative for mucicarmine. Immunohistochemically, the neoplastic cells were immunoreactive to pancytokeratin, focally positive to EMA, but negative for smooth muscle actin (SMA), vimentin and S-100 protein, HMB45, CD68, carcinoembryonic antigen (CEA) and glial fibrillary acid protein (GFAP). These findings allowed us to define this tumor as a clear cell tumor of the anterior palatoglossal arch. The tumor was subjected to radical excision and the patient is doing well at twelve months after surgery. This report focuses on the heterogeneous group of clear cell neoplasms with the intent of pointing out some aspects that may contribute to forming a diagnosis of HCCC, and which, above all enable us to distinguish this neoplasm from other very similar forms occurring in the oral cavity
Dental pulp metastasis from oral squamous cell carcinoma: a case report and a review of the literature
No full textA 61-year-old man was seen in the Oral Pathology Department with a three months history of right mandibular pain. Clinical examination revealed a 3 cm mass involving the body and the angle of the right site of the mandible and palpable masses in the neck. The dental panoramic radiography showed on the right a radiolucency area surrounding the lower second molar extending to the mandible angle. Additionally, chest radiograph and routine laboratory analysis results were unremarkable. An incisional biopsy of the area, revealed histologically a well differentiated squamous cell carcinoma and after few days, the patient was operated of right hemimandibulectomy with dissection of submandibular salivary gland and laterocervical lymphnodes on the same side. The histology of surgical material confirmed the diagnosis of a differentiated squamous cell carcinoma G1, omotateral diffusion in the mandible bone and metastasis to the dental pulp of the second lower molar tooth and to one of 18 lymphnodes dissected. In this report is described a very rare metastasis to the dental pulp and literature review, in which only fifteen other cases are reported
Metastatic embryonal carcinoma in the maxillary gingiva.
No full textGingival metastases from embryonal carcinoma are very rare and often associated with widespread disease and poor prognosis. Because of their indistinct clinical appearance, they may be difficult to discriminate from more frequent gingival hyperplastic or reactive lesions. The case of a 35-year-old man who presented with a swelling in the left maxillary gingiva, extending from the first premolar to the second molar is reported. This medical history revealed that, 2 years previously, he had been diagnosed with a testicular mixed germ cell tumor (GCTs), for which he had undergone right inguinal orchidectomy and chemotherapy, leading to complete remission. Histology revealed a metastatic embryonal carcinoma. Imaging of the chest and abdomen showed this was the only site of metastasis. He is currently undergoing chemotherapy and responding well. This case draws attention to the multiple diseases that may present as gingival masses and stresses the difficulty of making a correct diagnosis. It is emphasized that in some mixed cases of testicular GCT it may be the more aggressive component that metastasizes, without being clearly apparent
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