1,721,059 research outputs found
Wechselwirkungen zwischen Herz und Hirn : Pathophysiologie und Behandlung kardio-psycho-neurologischer Gesundheitsstörungen
No full textEconomic burden of patients with various etiologies of chronic systolic heart failure analyzed by resource use and costs
No full textRelation of circulating markers of fibrosis and progression of left and right ventricular dysfunction in hypertensive patients with heart failure
No full textObjective To study the association of circulating markers of fibrosis: procollagen type III amino-terminal propeptide (PIIINP), procollagen type I carboxy-terminal propeptide (PIP) and collagen type I carboxy-terminal telopeptide (CITP): with left (LV) and right ventricular (RV) longitudinal and LV radial systolic function in patients with heart failure in the course of essential hypertension. Methods The study population consisted of 81 patients with hypertension divided into four groups according to NYHA classification and 20 healthy controls. Cardiac function was estimated by myocardial deformation indices assessed by tissue Doppler imaging. Serum PIIINP, PIP and CITP levels were quantified by radioimmunoassay. Results Progressive LV longitudinal function impairment was demonstrated in all hypertension groups as indicated by reduced peak systolic strain and strain rate and increased postsystolic strain index. The respective indicators of LV radial function were deteriorated only in NYHA classes III-IV. Concurrently, RV longitudinal function was found abnormal in NYHA classes II-IV. PIIINP concentration was higher in NYHA class III and IV, whereas CITP level was increased and PIP/CITP ratio was decreased in the NYHA IV individuals. PIIINP was an independent correlate of LV and RV longitudinal strain (R(2)=0.52, beta=-0.34, P<0.001; R(2)=0.25, beta=-0.27, P<0.01, respectively). PIP/CITP ratio independently determined LV radial strain in patients with LV ejection fraction less than 50% (R(2)=0.44, beta=0.52, P<0.008). Conclusion In hypertensive patients, the progressive decline in cardiac longitudinal function is related to increased collagen III synthesis, whereas the changes in collagen I turnover favoring its increased degradation might contribute to LV radial and global systolic dysfunction seen in the advanced hypertensive heart disease. J Hypertens 27:2483-2491 (c) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.ICRE
Prevalence and clinical impact of iron deficiency and anaemia among outpatients with chronic heart failure: The PrEP Registry
No full textIron deficiency (ID) and anaemia are common in heart failure (HF). The prospective, observational PReP registry (Pravalenz des Eisenmangels bei Patienten mit Herzinsuffizienz) studied prevalence and clinical impact of ID and anaemia in HF outpatients attending cardiology practices in Germany. A total of 42 practices enrolled consecutive patients with chronic HF [left ventricular ejection fraction (LVEF) = 100 A mu g/l/< 300 A mu g/l plus transferrin saturation < 20%, and anaemia as haemoglobin < 13 g/dl (12 g/dl) in men (women). Exercise capacity was assessed using spiroergometry (69.4%) or 6-min walk test (30.4%). Amongst 1198 PReP-participants [69.0 +/- 10.6 years, 25.3% female, New York Heart Association (NYHA) class 2.4 +/- 0.5, LVEF 35.3 +/- 7.2%], ID was found in 42.5% (previously unknown in all), and anaemia in 18.9% (previously known in 4.8%). ID was associated with female gender, lower body weight and haemoglobin, higher NYHA class and natriuretic peptide (NP) levels (all p < 0.05). ID was also more common in anaemic than non-anaemic patients (p < 0.0001), and 9.8% of PrEP-participants had both, ID and anaemia. On spiroergometry, ID independently predicted maximum exercise capacity even after multivariable adjustment, including anaemia (p = 0.0004). In all PrEP-participants, ID predicted reduced physical performance (adjusted for age, gender, anaemia, serum creatinine, C-reactive protein, LVEF, and NP level). Despite high prevalence, ID was previously unknown in all PrEP-participants, and anaemia was often unappreciated. Given the clinical relevance, treatability, and independent association with reduced physical performance, ID should be considered more in real-world ambulatory healthcare settings and ID-screening be advocated to cardiologists in such populations.Vifor Pharm
The burden of symptoms in heart failure with reduced vs. preserved ejection fraction: differential impact of comorbidities
No full textPrognostic impact of diastolic dysfunction in patients with heart failure with reduced ejection fraction: a cross-sectional analysis from the German Competence Network Heart Failure
No full textEconomic burden of patients with various etiologies of chronic systolic heart failure analyzed by resource use and costs
No full textInteraction of stroke and CHF in the competence network heart failure patient cohort - reverse epidemiology of risk factors
No full textDeterminants of quality of life and mood in patients with heart failure and chronic obstructive disease: an analysis across five projects of the German competence network heart failure
No full text
- …
