268 research outputs found

    Data Set of PLOS Computational Paper PCOMPBIOL-D-18-02181R1

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    Figures Data of PLOS Computational paper:Modeling of the axon plasma membrane structure and its effects on protein diffusionAuthors: Yihao Zhang, Anastasios V. Tzingounis, and George LykotrafitisCorresponding Author: George Lykotrafitis, Ph.D.University of ConnecticutStorss, CT UNITED STATES</div

    The state of modern Greek language as spoken in Victoria

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    Deposited with permission of the author. © 1986 Dr. Anastasios TamisThis thesis reports a sociolinguistic study, carried out between 1981 and 1984, of the state of the Modern Greek (MG) language in Australia, as spoken by native-speaking first-generation Greek immigrants in Victoria. Particular emphasis is given to the analysis of those characteristics of the linguistic behaviour of these Greek Australians which can be attributed to the contact with English and to other environmental, social and linguistic influence. (For complete abstract open document

    New historical evidence for Anastasios Emm. Papas

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    No AbstractThe author’s attention has been drawn to the existence of this historicalevidence in the National Archives of Vienna, by his friend the writer EteoclesGregoriadis together with the numbers of the relevant files. Most of the documents were written in the old German script. Thus the author asked for the help of his friend and former colleague at the University of Thessaloniki and director of the Goethe Institute, Graf Kurt v. Posadowsky, for reading andstudying those documents. Without his help this study would have been impossible. This new evidence concerns the sojourn of Anastasios Papas·—son of Emmanuel Papas, leading figure of the Greek Revolution—in Austria andGermany between the 3rd January and 11th March 1822. There is informationabout his short imprisonment in Trieste, after his arival from Vienna. He then visits various towns in Germany and after negotiations with the Philhellene professor Fr. Thiersch in Munich, he purchases large quantities of ammunition to be despatched to Greece. He finally arrives in Greece early in 1824, and takes part—together with his three brothers who were already fighting—in the struggle for the liberation of the common great fartheland

    Η αλληλεπίδραση της φυσικής ανοσίας, των αιμοπεταλίων και του μορίου sCD40L σε ζωϊκό πρότυπο της σχετιζόμενης με κολίτιδα καρκινογένεσης του παχέος εντέρου.

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    Σκοπός: Σχεδιάσαμε την ανάπτυξη καρκίνου σχετιζόμενου με κολίτιδα και καθορίσαμε την πιθανή συμβολή του sCD40L στην καρκινογένεση, χρησιμοποιώντας το καθιερωμένο πρωτόκολλο AOM/DSS. Υλικά και μέθοδος: Δώδεκα Wild Type (WT) και δώδεκα TLR4 Knock Οut (KO) θηλυκά C57BL6 πειραματόζωα χωρίστηκαν σε τέσσερις ομάδες πειραματισμού. Έξι C57BL6 WT και έξι C57BL6 TLR4 KO πειραματόζωα έλαβαν ενδοπεριτοναική έγχυση ΑΟΜ (10 mg/kg) ακολουθούμενη από τρεις κύκλους των 7 ημερών DSS 2.5% w/v, σε κάθε κύκλο να μεσολαβεί μια περίοδος 14 ημερών ξεκούρασης με λήψη ύδατος. Οι άλλες δυο ομάδες πειραματισμού αποτέλεσαν τις ομάδες ελέγχου (control group), λαμβάνοντας μόνο πόσιμο ύδωρ. Τα πειραματόζωα θυσιάστηκαν μόλις ολοκλήρωσαν 84 ημέρες πειραματισμού. Αποτελέσματα: Το σύνολο των 6 WT πειραματοζώων ανέπτυξαν αδενοκαρκίνωμα παχέος εντέρου, ενώ από την ομάδα των TLR4 KO υπήρχε θανατηφόρος έκβαση για 4 πειραματόζωα και επέζησαν από τις διαδικασίες 2 πειραματόζωα τα οποία επέδειξαν προστασία στην καρκινογένεση. Η μέτρηση του sCD40L σε ορό και παθολογικό ιστό έγινε με την μέθοδο ELISA (quantitative sandwich enzyme-linked immunoassay) και προσπαθήσαμε να ελέγξουμε την κύρια υπόθεση της πιθανής αύξησης του sCD40L στο γκρουπ που ανέπτυξε καρκίνο. Συμπέρασμα: Υψηλότερα επίπεδα sCD40L στον ορό των πειραματοζώων συσχετίσθηκαν με ανάπτυξη καρκίνου σχετιζόμενου με κολίτιδα.Background/Aim: We aimed to develop an animal model of colitis-associated colorectal cancer and determine the possible role of sCD40L in carcinogenesis by using the well-established azoxymethane/dextran sulfate sodium (AOM/DSS) protocol. Material and methods:Twelve Wild type (WT) and twelve TLR4 Knock out (KO) female C57BL6 mice were divided into 4 experimental groups. Six female C57BL6 WT and six female C57BL6 TLR4 KO mice were treated with a single intraperitoneal dose (10 mg/kg of body weight) of AOM followed by three 7-day cycles of oral 2.5 % DSS, with each cycle interrupted by a 2-week rest period. The other two groups included 6 WT and 6 TLR4 KO mice that received only water and characterized as the control groups. The mice of each group were sacrificed at 84 days. Results: All 6 animals of the WT group developed adenocarcinomas and from the TLR4 KO group 4 animals succumbed before the end of the procedures and the other 2 animals were protected from colorectal cancer. We measured the serum and pathologic tissue levels of sCD40L with quantitative sandwich enzyme-linked immunoassay (ELISA) and we aimed to check the hypothesis of a possible increased level of sCD40L in colitis associated cancer group. Conclusion: Higher levels of sCD40L in serum were associated with colitis associated cancer.

    The interplay between innate immunity (TLR-4) and sCD40L in the context of an animal model of colitis associated cancer

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    We aimed to develop an animal model of colitis-associated colorectal cancer and determine the possible role of sCD40L in carcinogenesis by using the well-established azoxymethane/dextran sulfate sodium (AOM/DSS) protocol. Material and methods: Twelve Wild type (WT) and twelve TLR4 Knock out (KO) female C57BL6 mice were divided into 4 experimental groups. Six female C57BL6 WT and six female C57BL6 TLR4 KO mice were treated with a single intraperitoneal dose (10 mg/kg of body weight) of AOM followed by three 7-day cycles of oral 2.5 % DSS, with each cycle interrupted by a 2-week rest period. The other two groups included 6 WT and 6 TLR4 KO mice that received only water and characterized as the control groups. The mice of each group were sacrificed at 84 days. Results: All 6 animals of the WT group developed adenocarcinomas and from the TLR4 KO group 4 animals succumbed before the end of the procedures and the other 2 animals were protected from colorectal cancer. We measured the serum and pathologic tissue levels of sCD40L with quantitative sandwich enzyme-linked immunoassay (ELISA) and we aimed to check the hypothesis of a possible increased level of sCD40L in colitis associated cancer group. Conclusion: Higher levels of sCD40L in serum were associated with colitis associated cancer. Σχεδιάσαμε την ανάπτυξη καρκίνου σχετιζόμενου με κολίτιδα και καθορίσαμε την πιθανή συμβολή του sCD40L στην καρκινογένεση, χρησιμοποιώντας το καθιερωμένο πρωτόκολλο AOM/DSS. Υλικά και μέθοδος: Δώδεκα Wild Type (WT) και δώδεκα TLR4 Knock Οut (KO) θηλυκά C57BL6 πειραματόζωα χωρίστηκαν σε τέσσερις ομάδες πειραματισμού. Έξι C57BL6 WT και έξι C57BL6 TLR4 KO πειραματόζωα έλαβαν ενδοπεριτοναική έγχυση ΑΟΜ (10 mg/kg) ακολουθούμενη από τρεις κύκλους των 7 ημερών DSS 2.5% w/v, σε κάθε κύκλο να μεσολαβεί μια περίοδος 14 ημερών ξεκούρασης με λήψη ύδατος. Οι άλλες δυο ομάδες πειραματισμού αποτέλεσαν τις ομάδες ελέγχου (control group), λαμβάνοντας μόνο πόσιμο ύδωρ. Τα πειραματόζωα θυσιάστηκαν μόλις ολοκλήρωσαν 84 ημέρες πειραματισμού. Αποτελέσματα: Το σύνολο των 6 WT πειραματοζώων ανέπτυξαν αδενοκαρκίνωμα παχέος εντέρου, ενώ από την ομάδα των TLR4 KO υπήρχε θανατηφόρος έκβαση για 4 πειραματόζωα και επέζησαν από τις διαδικασίες 2 πειραματόζωα τα οποία επέδειξαν προστασία στην καρκινογένεση. Η μέτρηση του sCD40L σε ορό και παθολογικό ιστό έγινε με την μέθοδο ELISA (quantitative sandwich enzyme-linked immunoassay) και προσπαθήσαμε να ελέγξουμε την κύρια υπόθεση της πιθανής αύξησης του sCD40L στο γκρουπ που ανέπτυξε καρκίνο. Συμπέρασμα: Υψηλότερα επίπεδα sCD40L στον ορό των πειραματοζώων συσχετίσθηκαν με ανάπτυξη καρκίνου σχετιζόμενου με κολίτιδα

    Price Competition Analysis In Ict Business

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    The information and communication technology (ICT) industry is one of the most capital intensive among the high-technology industries. ICT business analysis, especially after the industry deregulation, has become a difficult task. This study integrates Real Options and Game Theory perspectives and examines multi-period price competition in order to find the optimal ICT business strategy in terms of the time entry in the market and the service price. The analysis focuses on e-learning business activities showing how it can be formulated in the specific field

    Measurement of damage growth in ultrasonic spot welded joint

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    Ultrasonic spot welding is a joining technique for thermoplastic composites with great potential regarding processing speed and cost. To investigate the damage tolerance and possible inherent damage arresting behavior of multi-spot welded joints, a technique is necessary to measure damage growth in the joints under cyclic loading. Visual inspection is not possible because the damage is not located on the outside surface and conventional techniques such as C-scan are not practical during a fatigue test because the specimen would have to be removed from the setup. This paper details a methodology for quantifying damage growth rates in singlespot welded joints using surface strain measurements made by Digital Image Correlation. This represents the first step towards developing a methodology for quantifying damage progression behavior in complex multi-spot welded joints.Structural Integrity & CompositesAerospace Structures & Computational Mechanic
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