380 research outputs found
DQ100613, Homo sapiens clone P1-97, Sp6 end, genomic sequence DQ100614, Homo sapiens clone P1-80, T7 end, genomic sequence
No full textAF164654, Homo sapiens tyrosine kinase (RON) gene, intron 19, 3' end. AF164653, Homo sapiens tyrosine kinase (RON) gene, intron 19, 5' end. AF164652, Homo sapiens tyrosine kinase (RON) gene, intron 18. AF164651, Homo sapiens tyrosine kinase (RON) gene, intron 17. AF164650, Homo sapiens tyrosine kinase (RON) gene, intron 16. AF164649, Homo sapiens tyrosine kinase (RON) gene, intron 15. AF164648, Homo sapiens tyrosine kinase (RON) gene, intron 14, 3' end. AF164647, Homo sapiens tyrosine kinase (RON) gene, intron 14, 5' end. AF164646, Homo sapiens tyrosine kinase (RON) gene, intron 13. AF164645, Homo sapiens tyrosine kinase (RON) gene, intron 12. AF164644, Homo sapiens tyrosine kinase (RON) gene, intron 11. AF164643, Homo sapiens tyrosine kinase (RON) gene, intron 10. AF164642, Homo sapiens tyrosine kinase (RON) gene, intron 9. AF164641, Homo sapiens tyrosine kinase (RON) gene, intron 8. AF164640, Homo sapiens tyrosine kinase (RON) gene, intron 7. AF164639, Homo sapiens...
No full textMolecular analysis of deletions in human chromosome 3p21 and the role of resident cancer genes in disease
No full textMicrogravity inhibits autophagy in human capillary endothelial cells in space flight
No full textMicrogravity and space radiation (SR) are the two environmental factors that most affect human crews in space flight (SF). The endothelium is highly sensitive to gravitational unloading and several health problems reported by astronauts derive from endothelial dysfunction and impaired homeostasis. Recently, we found that space-flown, endothelial cells show cell softening, the presence of stress granules, reduced motility, profound cytoskeletal reorganization, an increased number of primary cilia, mitochondrial senescence, activation of DNA repair mechanisms, changes of chromosome territories, telomere shortening and increased apoptosis. The transcriptomic study showed activation of oxidative stress, inflammation and DNA damage repair pathways. In general, pathways for metabolism and a pro-proliferative phenotype are activated by microgravity and downregulated by SR. SR upregulates pathways for endothelial activation (hypoxia, cytokines, inflammation), DNA repair and apoptosis, promoting macroautophagy/autophagy flux and an ageing-like phenotype, which instead are downregulated by microgravity. Microgravity and SR exert opposite effects on the MTORC1 gene pathway: SR inhibits the pathway (with consequent enhancement of autophagy), while microgravity strongly stimulates MTORC1 (with consequent inhibition of autophagy). The sum of both contributions results in the net effect of autophagy inhibition in space-flown cells. Microgravity and SR should be considered separately to tailor effective countermeasures to protect astronauts’ health. Potentiation of autophagy is worthy of further investigation as a possible physiological countermeasure to SF-induced cell stress
The MST1R (Macrophage stimulating 1 receptor) Gene
No full textURL: http://www.infobiogen.fr/services/chromcancer/Tumors/RONID287.htm
The amphibian clock system
No full textThe variety of experimental approaches possible in amphibians, in particular in the anuran species Xenopus laevis, have been crucial in discovering key regulators of circadian rhythms, such as melatonin and melanopsin. Differently from mammals, amphibians are characterized by the peculiar presence of multiple anatomical structures and cell types that feature photosensitive and self-sustained circadian activities. In particular, in amphibians, both the retina and the pineal complex are photosensitive and display circadian melatonin secretion. Furthermore, skin melanophores are light-responsive and represent an exclusive model to study a peripheral circadian clock.
In this chapter, we will review:
• the cellular and molecular mechanisms regulating circadian rhythms in amphibian retina
• the molecular bases of pineal circadian rhythms and its link to cell differentiation and cell proliferation
• the Xenopus melanophore system as an example of a well-described peripheral, light sensitive, cloc
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