116,079 research outputs found
Dialecticae Praestantia et Divisio. Achille Bocchi ad Antonio Bernardi, Illustrissimo filosofo
No full textIl volume raccoglie saggi dedicati all'umanista Antonio Bernardi della Mirandola, personalità di spicco della cultura filosofica italiana ed europea del primo Cinquecento. Il contributo di A. Angelini affronta la logica di Bernardi e il tentativo di emancipare l'analitica aristotelica dall'ontologia
Handheld-Impedance-Measurement System with seven-decade capability and potentiostatic function
Full text linkThis paper describes design and test of a new impedance-measurement system for nonlinear devices that exhibits a seven-decade range and works down to a frequency of 0.01 Hz. The system is specifically designed for electrochemical measurements, but the proposed architecture can be employed in many other fields where flexible signal generation and analysis are required. The system employs an unconventional signal generator based on two pulsewidth modulation (PWM) oscillators and an autocalibration system that allows uncertainties of less than 3% to be obtained over a range of 1 kΩ to 100 GΩ. A synchronous demodulation processing allows the noise superimposed to the low-amplitude input signals to be made negligibl
Ancient Mythology in the Trilogy Starcrossed of Josephina Angelini
No full textThis Bachelor thesis focuses on analysis of Ancient Mythology in the Starcrossed Trilogy of Josephina Angelini. The inspiration by ancient Greek mythology is evident throughout the series, as it's practically a transposition of the Trojan War into 21st century context. The characters are reincarnated mythical heroes of the Trojan War. The thesis contains a section dedicated to ancient Greek myths in general. The main goal of the thesis is to encapsulate all similarities, differences and elements received from the ancient Greek originals. The author accentuates the need for glossaries added into works with ancient Greek themes, since a reader who is not familiar with these might be rather confused by their adaptation in a completely different storyline. To achieve the abovementioned goal, the thesis provides literary-scientific context, definitions of key concepts, analysis of the narrator, composition, time space etc. Chapters containing transcribed interviews with book influencers provide readers' reception of the Starcrossed series on Czech literary scene and abroad. The author has performed analysis of the Starcrossed series by Josephine Angelini via comparing the series to, above all, Homer's Iliad. These works are further supplemented by literature on ancient Greek mythology and literary...Bakalářská práce nesoucí název téma Antická mytologie v trilogii Proroctví od Josephine Angelini se zaměřuje na analýzu "young adult" a mytologických prvků v trilogii obsažených. V knižní sérii je očividná inspirace antickou mytologií, jedná se de facto o vyobrazení trójské války v kontextu 21. století, která se opět odehrává v rámci reinkarnace mýtických hrdinů. V bakalářské práci ovšem nechybí ani kapitola týkající se mýtů obecně. Hlavní cíl této bakalářské práce je postihnout veškeré podobnosti, odlišnosti a převzaté prvky z mytologické předlohy čili z pramenů. Současně s cílem práce je zde snaha apelovat na důležitost doplnění slovníčků v knihách s mytologickou tematikou. Vychází se z poznatku, že neznalý čtenář mytologie může být poněkud zmaten, vzhledem ke zapracování mýtů do vlastního příběhu s odlišnou dějovou linií. Je tedy kladen důraz na zachycení všech těchto odlišností. I z těchto důvodů je práce doplněna o literárně-vědný kontext, vysvětlení klíčových termínů, zpracování analýzy vypravěče, kompozice, časoprostoru etc. Bakalářská práce dále obsahuje kapitoly zaměřené na čtenářský ohlas na sérii Proroctví z českého i zahraničního prostředí spolu s přepisy rozhovorů s knižními influencery. Analýza byla provedena na základě již zmiňované série Josephine Angelini, která byla komparována s...Katedra dějin a didaktiky dějepisuFaculty of EducationPedagogická fakult
Assessing diagnosis and managing respiratory and cardiac complications of sarcoglycanopathy
No full textIntroduction: Sarcoglycanopathies (SG) are caused by a mutation in SGCA, SGCB, SGCG, or SGCD genes and present a wide spectrum of muscle involvement and wasting. The clinical phenotypes due to a mutation in the sarcoglycan genes include severe childhood-onset forms, proximal myopathies, pseudometabolic myopathies, myopathies with respiratory complication, and hyperCKemia syndromes. Dilated cardiomyopathy is more frequent and severe in LGMD2E/R4 and LGMD2F/R6. Areas covered: In this paper, the authors review clinical, epidemiological evidence-based studies for better understanding the clinical signs, natural history and provide an update on current diagnostic and therapeutic options linked to the management of respiratory insufficiency present in 26% of the cases and cardiac complications present in 22% of the cases, as well as physiotherapy/rehabilitation and drug treatment. We also briefly over-view new treatments specific to genetic mutations and clinical trials on gene therapy. The papers covering the diagnosis and clinical respiratory care and cardiac complications of sarcoglycanopathies were reviewed in PubMed since the year 1997 and we chose to analyze those that covered series of patients, animal studies were only annotated when relevant to pathophysiology or advances in treatment. Expert opinion: Accurate molecular diagnosis of sarcoglycanopathy patients is crucial in order to offer precise genetic counseling and clinical care, both to offer effective management and to prevent cardiac insufficiency. It is important both for an early treatment of dilated cardiomyopathy and to prevent severe respiratory complications in specific subgroups of patients
The importance of avoiding double taxation of legal entities with an analysis of agreements with selected countries
Full text linkV magistrski nalogi je obravnavana problematika mednarodnega dvojnega obdavčevanja dohodkov pravnih oseb skozi analizo ukrepov za izogibanje dvojnega obdavčevanja tako na nacionalni kot bilateralni ravni. Podana je analiza določb slovenskega korporacijskega zakona, ki so relevantne za preprečevanje dvojnega obdavčevanja rezidentov na podlagi svetovnega dohodka kot tudi nerezidentov za dohodke z virom v Sloveniji. Poseben poudarek je namenjen povezanim osebam, od analize različnih zakonskih opredelitev pojma povezanih oseb do analize določb zakona, ki obravnava obdavčitev povezanih oseb. Opravljena je primerjalna analiza treh mednarodnih sporazumov o izogibanju dvojnega obdavčevanja, ki jih je sklenila Slovenija, in sicer z Nemčijo, Italijo in Srbijo. Sporazumi temeljijo na Vzorčni konvenciji OECD, ki skupaj s komentarjem predstavlja pomemben inštrument pri izogibanju dvojnega obdavčevanja. Primerjalno so analizirani sistemi obdavčitve pravnih oseb v izbranih državah s poudarkom na unilateralnih merilih za odpravo dvojnega obdavčevanja. Teoretične podlage in zakonske rešitve so podkrepljene s številnimi primeri, kar nalogi daje pomembno uporabno vrednost. Slovenija kot članica Evropske unije je podvržena pravnemu redu te skupnosti, zato so v nalogi analizirane nekatere sodbe Sodišča EU, ki obravnavajo problematiko dvojnega obdavčevanja.The master’s thesis discusses the issue of double taxation of legal entities’ income based on an analysis of measures aimed at avoiding double taxation at the national and bilateral levels. It presents an analysis of the Slovenian corporate law provisions relevant to preventing the double taxation of residents based on their world income as well as of non-residents whose income source is Slovenia. Special emphasis is placed on related persons, ranging from an analysis of different legal definitions of the term “related persons” to an analysis of the provisions of the law on taxation of related persons. A comparative analysis was conducted on three international agreements on the avoidance of double taxation which Slovenia had concluded with Germany, Italy and Serbia. The agreements are based on the OECD Model Convention which, together with the commentary, represents an important instrument for the avoidance of double taxation. The systems of taxation of legal entities in the selected countries are analysed comparatively, with the emphasis on unilateral criteria for eliminating double taxation. The theoretical premises and the legal solutions are underpinned by a number of examples, thus adding to the applied value of the thesis. Slovenia as a European Union member is bound by the Community acquis, therefore the thesis also analyses some judgments of the Court of Justice of the EU related to double taxation
Primi test per la rivelazione di plastiche in acqua mediante fluorescenza indotta da Laser (LIF)
Full text linkVista l’importanza dal punto di vista ambientale che riveste la rapida rivelazione delle microplastiche in acqua, sono stati svolti dei primi test di fattibilità per l’utilizzo di un lidar fluorosensore per la rivelazione ed il riconoscimento di plastiche in ambiente marino. In particolare, è stata testata la capacità del sistema LIF (basato sulla fluorescenza indotta da laser) a scansione di linea del Laboratorio FSNTECFIS-DIM di Frascati di rivelare differenti campioni di plastiche, tra quelle che più comunemente si trovano nelle analisi di acque marine, sotto diversi spessori di acqua. I risultati si sono mostrati interessanti ed aprono le porte a studi più approfonditi per lo sviluppo di sistemi LIF specifici per la rivelazione
di microplastiche in ambiente marino senza la necessità di campionamenti.From the environmental point of view the rapid detection of microplastics in water is of primary importance. Here the first feasibility tests carried out for the implementation of a lidar fluorosensor to detect and recognition of plastics in the marine environment are presented. In particular, the ability of the linear scan system LIF (laser induced fluorescence) developed at the FSN-TECFIS-DIM Laboratory of Frascati to detect different plastics samples, among those that are most commonly found in water analysis, through different thicknesses of water have been carried out. The results have provided
interesting results, opening the way to more in-depth studies for the development of specific spectroscopic systems for the detection of microplastics in the marine environment without sampling
Circulating miR-206 as a biomarker for patients affected by severe limb girdle muscle dystrophies
Full text linkLimb-girdle muscular dystrophies (LGMD) are clinically and genetically heterogeneous conditions, presenting with a wide clinical spectrum, leading to progressive proximal weakness caused by loss of muscle fibers. MiR-206 is a member of myomiRNAs, a group of miRNAs with important function in skeletal muscle. Our aim is to determine the value of miR-206 in detect-ing muscle disease evolution in patients affected by LGMD. We describe clinical features, disease history and progression of eleven patients affected by various types of LGMD: transportinopathy, sarcoglycanopathy and calpainopathy. We analyzed the patients’ mutations and we studied the circulating miR-206 in serum by qRT-PCR; muscle MRI was done with a 1.5 Tesla apparatus. The severe evolution of disease type is associated with the expression levels of miR-206, which was significantly elevated in our LGMD patient cohort in comparison with a control group. In particular, we observed an over-expression of miR-206 that was 50–80 folds elevated in two patients with a severe and early disease course in the transportinopathy and calpainopathy sub-types. The functional impairment was observed clinically and muscle loss and atrophy documented by muscle MRI. This study provides the first evidence that miR-206 is associated with phenotypic expression and it could be used as a prognostic indicator of LGMD disease progression
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