183,056 research outputs found
Artists and Gamblers on the Way to Quantum Physics
No full textThe representation space of Renaissance painting is compared to the representation space of quantum physics in [this chapter]. The action of a “semi-transparent” mirror splitting the trajectory of a photon, or any quantum particle, resembles the action of “Alberti’s window” in painting. According to Alberti, painting must recreate a view through a window. To accomplish this task, the light coming from the scene (to be painted) must be caught by the painter’s eye and projected on the plane surface of an ideal veil. The pictorial image results from a “double projection,” for that window acts both as a glass intersecting the visual pyramid and as a mirror reflecting the painter’s eye. When Narcissus realizes how a mirror acts, the shadow which he observes allows him to see another side of himself. When physicists realize how quantum interference acts, “photon-shadows” become “observables.” The awareness shared by Narcissus, Renaissance perspectivists, and quantum observers involves a revision of the function of shadow with respect to the Platonic condemnation and to the “fantastic” conception of the classic world. In the girl’s attempt to fix her lover’s image (told by Pliny), one can already see a “measuring her self against the other” that Plato’s myth had not envisaged. Despite the separation from the young man, the image she drew, the “artificial” representation, would maintain the link (of her self) with the “other.” This view of painting giving shape to “relational” forms marks itself off from a view of science describing “objective” properties of physical reality, hence losing or denying any link between the scientist-observer and the observed object
Profili dell'ombra. Presentazione
No full textIl breve saggio funge da introduzione all'insero monogradico del n. 21 (2014) di "Dianoia" dedicato ai Profili dell'ombra, e che raccoglie i contributi di B. Saint-Girons, A. Angelini, G. Longo, R. Danna, F. Malhomme, M. Matteoli. Attraverso alcuni exempla giudicati significativi, la rassegna documenta il ruolo dell'"ombra" nella cultura estetica, matematica,tecnico-artistica, musicale, letteraria e filosofica nell'età modern
Il senso della materia di n! studio
No full textrecensione e testo critico di Rosetta Angelini di alcuni progetti e realizzazioni dell'autore con testi citati (A.Stella e S.Ferrini
Rhynchorthoceras angelini
No full textRhynchorthoceras angelini (Boll, 1857) Figs 9–12, Tables 2–3 Lituites Angelini Boll, 1857: 89. Rhynchorthoceras Oelandicum Remelé, 1882: 134–135, pl. 5 fig. 5. Rhynchorthoceras tenuistriatum Remelé, 1882: 137–138. Rhynchorthoceras Angelini var. lineata Remelé, 1882: 136. Rhynchorthoceras Angelini var. virgata Remelé, 1882: 136. Orthoceras Angelini – Boll 1857: pl. 4 fig. 11. Ancistroceras Angelini – Remelé 1881: 195. Rhynchorthoceras Angelini – Remelé 1882: 135; 1890: 19. — Rüdiger 1889: 37. Rhynchorthoceras Oelandicum – Rüdiger 1889: 40. Rhynchorthoceras tenuistriatum – Remelé 1890: 74, pl. 5 fig. 7. Rhynchorthoceras Angelini var. lineata – Remelé 1890: pl. 5 fig. 6, pl. 6 fig. 6. Rhynchorthoceras Angelini var. virgata – Remelé 1890: pl. 3 fig. 5, pl. 5 figs 3–5. Rhynchorthoceras angelini var. lineata – Neben & Krueger 1971: pl. 21 figs 10–12. ? Rhynchorthoceras angelini – Sweet 1958: 140. Diagnosis Species of the genus Rhynchorthoceras with expansion angles between 8° and 13°; whorl profile circular, in the apical part of the conch sometimes slightly compressed and flattened on the dorsum. Shell surface consists of lirae with oblique and straight course across the flank, not oblique and straight ventrally, a low dorsal projection. Transverse profile of lirae either crested or flat, commonly asymmetric. Shell wall sometimes faintly undulated. Distance of lirae regular or slightly fluctuating, gradually decreases during ontogeny. Siphuncle 0.12–0.19 of whorl height, central or almost central in position. Type material Not available for study; Boll (1857) did not specify a type but he had at least three specimens available, of which one was figured (Boll 1857: pl. 4 fig. 11). Material examined GERMANY • 1 spec.; Berlin-Schmargendorf; Ordovician, Upper Red Orthoceratite Limestone; Schmidt Coll.; MB.C.11727 • 12 specs; Brandenburg, Heegermühle; Ordovician, Upper Red Orthoceratite Limestone; Kgl. Forstakademie Eberswalde Coll.; MB.C.11724, MB.C.11726.1 to MB.C.11726.7, MB.C.11729.2 to MB.C.11729.4, MB.C.11732.2 • 8 specs; Brandenburg, Heegermühle; Ordovician, Upper Red Orthoceratite Limestone; Remelé Coll.; MB.C.11725.1, MB.C.11725.2, MB.C.11731.1 to MB.C.11731.6 • 6 specs; Brandenburg, Heegermühle; Ordovician, Upper Red Orthoceratite Limestone; MB.C.22577, MB.C.30494, MB.C.30495.1, MB.C.30495.2, MB.C.30496, MB.C.30497 • 1 spec.; Brandenburg, Hohensaaten; Ordovician, Upper Red Orthoceratite Limestone; Neben and Krueger Coll.; MB.C.30498 • 1 spec.; Brandenburg, Joachimsthal (Uckermark); Ordovician, Upper Grey Orthoceratite Limestone; Hentig 1880 Coll.; MB.C.11716 • 1 spec.; Mecklenburg-Vorpommern, Neu-Ruthenbeck (Parchim); Ordovician, Upper Grey Orthoceratite Limestone; Helms 1974 Coll.; MB.C.11717. SWEDEN • 1 spec.; Dalarna, Skattungbyn; Ordovician, Upper Red Orthoceratite Limestone; Dames 1890 Coll.; MB.C.11720.1 • 1 spec.; Island of Öland; Ordovician; MB.C.11723 • 2 specs; Island of Öland, Skärlöv; Ordovician, Segerstad Limestone (upper part of the Upper Red Orthoceratite Limestone); Bottke Coll.; MB.C.29656, MB.C.29653. COUNTRY UNKNOWN • 1 spec.; Ordovician; Otto Coll.; MB.C.11729.1. Description All available specimens are fragments of faintly curved or orthoconic phragmocones (Figs 9–10) and represent various growth stages; the smallest preserved whorl height is 3 mm and the largest is 40 mm. Initial parts of the phragmocones and also mature body chambers are not preserved in any of the specimens. The expansion angles vary between 8° and 13° (median = 11°, n = 13; Fig. 13A). The relative chamber length is variable with a CLR between 0.25 and 0.50 (Fig. 11). The siphuncle has a central or almost central position, with diameters between 0.12 and 0.19 (median = 0.14, n = 13; Fig. 13B) of the whorl height. The shell ornament consists of lirae, which are up to 1.3 mm apart in the largest specimens. The distance of lirae is more or less regular, fluctuates only slightly and gradually decreases during ontogeny (e.g., MB.C.11724, relative distance from ca 0.04 at wh 19 mm to ca 0.02 at wh 39 mm, Fig. 12B–C). The lirae extend straight across the venter; they are oblique and straight on the flanks and form a low projection on the dorsum (Fig. 12A, MB.C.11725.1). Their profile is crested and symmetric (MB.C.30495.1, MB.C.11724, MB.C.29656), crested and asymmetric (MB.C.11725.1) or flat and weakly asymmetric or symmetric (MB.C.11727, MB.C.22577). Remarks Rhynchorthoceras angelini differs from R. tenuistriatum (from Middle Ordovician erratics of northern Germany) in the slightly lower expansion angle (8–12° vs 13°) and from R. oelandicum (from Middle Ordovician strata of Öland and erratics of northern Germany) in the central (vs slightly eccentric) position of the siphuncle in large growth stages. In all other characters, including the shell ornament, R. angelini is indistinguishable from R. tenuistriatum and R. oelandicum. Consequently, both R. tenuistriatum and R. oelandicum are synonymised with R. angelini herein. The intraspecific variation of R. angelini also concerns the shell ornament. Remelé (1882, 1890) recognised two varieties within the species: R. angelini var. virgata with more prominent lirae with acute, symmetric or asymmetric crests, while the lirae in R. angelini var. lineata are flat and only very slightly asymmetric. Remelé considered them as varieties of a single species because of common transitions between the two types of ornament. Furthermore, the specimens do not differ in any other morphological characters. Based on the study of original specimens of Remelé (1882, 1890) and subsequently collected material, the varieties are not distinguished here and only the name R. angelini is used. Rhynchorthoceras angelini is, together with R. conicum, by far the most abundant representative of Rhynchorthoceras in the Aserian and Lasnamägian (Middle Ordovician) strata of Baltoscandia and erratics in Germany and Poland. Most of the reported occurrences come from the Upper Red Orthoceratite Limestone, where R. angelini co-occurs with Trilacinoceras discors (Holm, 1891) and possibly other lituitids (e.g., Jaanusson 1960). The species is palaeogeographically widespread and stratigraphically long-ranging compared to other species of the genus; it probably occurs already in the latest Dapingian (early Middle Ordovician) rocks of central Bohemia (Marek 1999; Manda 2008; Aubrechtová & Turek 2018). Geographic and stratigraphic occurrence Norway (?), Sweden (in situ) and northern Germany (in erratics within Pleistocene gravels), central Bohemia (?); middle Volkhov (?), Kunda to Lasnamägi regional stages (latest Dapingian (?) to late Darriwilian, Middle Ordovician).Published as part of Aubrechtová, Martina & Korn, Dieter, 2022, Taxonomy and ontogeny of the Lituitida (Cephalopoda) from Orthoceratite Limestone erratics (Middle Ordovician), pp. 1-108 in European Journal of Taxonomy 799 (1) on pages 13-19, DOI: 10.5852/ejt.2022.799.1681, http://zenodo.org/record/634127
The Art of Science. From Perspective Drawing to Quantum Randomness
No full textLike linear perspective, complex numbers and probability are notable discoveries of the Renaissance. History has been quick to recognize the crucial impact of linear perspective on painting, but reluctant to acknowledge the importance of complex numbers and probability. Both were treated with a great deal of suspicion by the scientific establishment and overlooked for many years. It was only in the twentieth century, when quantum theory defined the notion of "complex probability amplitude", that complex numbers merged with probability and transformed the image of the physical world. From a theoretical point of view, however, the space opened to painting by linear perspective and the space opened to science by complex numbers are equally valuable and share significant characteristics. By exploring that common ground, The Art of Science will lead the reader to complement Leonardo’s vision of painting as a science and to see science as an art. Its aim is to restore a visual dimension to mathematical sciences – an element dulled, if not obscured, by historians, philosophers, and scientists themselves
Amphicyllis globiformis C. R. Sahlberg 1833
No full textAmphicyllis globiformis (C. R. Sahlberg, 1833) Anisotoma globiformis C. R. Sahlberg, 1833: 468. Type locality: In Fennia australi: Yläne. Distribution in Iran. MaZandaran, Nowshahr (CA-MGE); Northern Khorasan, Kopet-Dagh (CA-MGE); MaZandaran, Nashtarud, 2 eXX., 10.VII.1973 (leg.Senglet, coll. MG) (Angelini 1988). General distribution. Europe, AZerbaijan, Iran, Turkey (Angelini 1995; Perreau 2015).Published as part of Perreau, Michel, Ghahari, Hassan & Angelini, Fernando, 2017, A checklist of Leiodidae (Coleoptera: Staphylinoidea) of Iran in Zootaxa 4286 (1), DOI: 10.11646/zootaxa.4286.1.3, http://zenodo.org/record/82832
Ruolo di composti fito-chimici ad azione antiossidante e antinfiammatoria in colture di fibroblasti del derma umano nella protezione dal foto-invecchiamento
No full textRuolo di composti fito-chimici ad azione antiossidante e antinfiammatoria in colture di
fibroblasti del derma umano nella protezione dal foto-invecchiamento
L’invecchiamento cutaneo è strettamente correlato allo stress ossidativo; le specie reattive
dell’ossigeno (ROS) prodotti da vari stimoli esogeni e endogeni sono in grado di reagire e
danneggiare le proteine, il DNA e i lipidi della componente cellulare (fibroblasti, cheratinociti) e
della matrice extracellulare nella pelle. Tali danni radicalici sono alla base dei segni caratteristici
dell’invecchiamento cutaneo come: rughe, cute lassa, e pelle sensibile. La radiazione UV
rappresenta il principale fattori ambientali alla base della produzione di ROS, in particolare la
radiazione UVA. Nel nostro lavoro testiamo materie prime innovative di natura fitochimica a
potenziale attività antiossidante e anti-infiammatoria, contro il fotoinvecchiamento UVA-indotto nei
fibroblasti. Lo studio ha previsto la realizzazione di un modello di fotoinvecchiamento dei
fibroblasti irradiati con UVA (36 J/cm2) per valutare l’efficacia dei composti, singoli e in miscela,
nel contrastare la formazione di ROS UVA-indotti impiegando sonde fluorescenti in associazione a
metodologie citofluorimetriche. Inoltre è stato altresì valutato l’effetto anti-infiammatorio in seguito
ad esposizione a LPS (10ng/ml per 3 h), tramite la valutazione dell’espressione di citochine proinfiammatorie
(IL6, IL8, COX2 e MCP-1) in real time PCR. Lo studio ha consentito di identificare
un sotto insieme di composti foto stabili, biocompatibili ed il loro range di concentrazione efficace
nel prevenire il danno indotto da UVA ed in particolare le combinazioni più promettenti delle stesse
per un futuro sviluppo di formulazioni di prodotti per l’industria cosmetica. Il progetto è stato
supportato da ACRAF Angelini SpA e dalla Regione Marche nell’ambito del progetto EUREKARole of phytochemicals with antioxidant and anti-inflammatory capacity in
preventing photo-aging in human dermal fibroblasts
Skin ageing is strictly connected to oxidative stress, reactive oxygen species (ROS) produced either
from exogenous and endogenous sources are able to react and damage proteins, DNA and lipids of
the cellular (fibroblast and keratinocyte) and extracellular matrix component of the skin underlying
the typical sign of ageing in this tissue (wrinkles, sagging, hypersensitivity). UV radiation, among
environmental factors, represent a major source of ROS, in particular UVA. In our study we tested
innovative phytochemical substances with potential antioxidant and anti-inflammatory activities for
their ability to prevent UV-mediated oxidative damage to fibroblasts . In particular we developed a
model of UV photo-damaged fibroblast using a UVA source at 36 J/cm2 where isolated substances
or mixes of those were used to evaluate through flow-cytometric techniques their ability in lowering
ROS intracellular content triggered by UV irradiation. Moreover, antinflammatory effect of the
same substances was also evaluated following LPS exposure (10 ng/ml for 3h) by quantifying the
expression of pro-inflammatory cytokines (IL6, IL8, COX2 and MCP-1) in real time PCR. The
study allowed the identification of a sub set of photostable compounds, biocompatible and their
optimal range of concentrations in preventing UVA mediated damage. In particular the
identification of most promising combinations represent a first step toward the development of
novel formulation for the cosmetic industry. The project was supported by ACRAF Angelini SpA
and Regione Marche within the EUREKA project
Frammenti di Futuro. Alessandro Anselmi e la cultura dell'Architettura a Roma
No full textConferenza “Frammenti di Futuro” organizzata dal Dottorato di Ricerca in Architettura - Teorie e Progetto, coordinato dal Professor Antonino Saggio, in occasione del trigesimo della scomparsa di Alessandro Anselmi, avvenuta il 28 gennaio 2013.
Sono intervenuti gli architetti Franco Purini, Antonino Saggio, Lucio Altarelli, Maria Argenti, Valter Bordini, Francesco Cellini, Paolo Grassi, Francesco Montuori, Marcello Pazzaglini, Paolo Portoghesi, Pierluigi Serraino, Mario Spada, Valentino Anselmi, Valerio Palmieri e i dottorandi di ricerca in Architettura Teorie e Progetto Domenico Ferrara, Carla Molinari, Anna Riciputo, Eride Caramia, Gaetano De Francesco, Erika Maresca, Selena Anders, Rosetta Angelini, Leopoldo Russo Ceccotti, Stefano Bigiotti, Raphaela Papaléo Farias a cura di Rosetta Angelini, Eride Caramia, Carla Molinari.
Gli atti della conferenza sono pubblicati nel volume Alessandro Anselmi Frammenti di futuro
New treatments for myasthenia: a focus on antisense oligonucleotides
No full textCorrado Angelini,1 Sara Martignago,2 Michela Bisciglia21IRCCS S Camillo, Via Alberoni, Venice, Italy; 2Department of Neurosciences, University of Padova, Via Giustiniani 5, 35128, Padova, ItalyAbstract: Autoimmune myasthenia gravis (MG) is a neuromuscular disorder caused by autoantibodies directed against the acetylcholine receptor (AChR). Current symptomatic therapy is based on acetylcholinesterase (AChE) drugs. The available long-term current therapy includes steroids and other immunomodulatory agents. MG is associated with the production of a soluble, rare isoform of AChE, also referred as the “read-through” transcript (AChE-R). Monarsen (EN101) is a synthetic antisense compound directed against the AChE gene. Monarsen was administered in 16 patients with MG and 14 patients achieved a clinically significant response. The drug is now in a Phase II study. Further investigations are required to confirm its long-term effects.Keywords: myasthenia gravis, antisense oligonucleotides, acetyl cholinesterase, EN10
AUTONOMIC REGULATION IN MUSCULAR DYSTROPHY
No full textAutonomic Nervous System (ANS) function has been assessed in several muscular dystrophies. In the last two decades it has been recognized a signi ficant relationship between ANS and cardiac mortality (Politano et al., 2008). Cardiovascular ANS is frequently studied by using cardiovascular autonomic reflex tests and spectral analysis of heart rate in time and frequency domain (Ewing and Clarke, 1982; van Ravenswaaij-Arts et al., 1993). Heart rate variability (HRV) analysis, which involves measurement and analysis of heart rate variation, provides a quantitative marker of autonomic activity and has proved to be able to detect and measure modification in sympathetic or vagal activity. Moreover, it can be used to estimate the susceptibility for heart arrhythmias (Heart rate variability, 1996a, b). © 2013 Angelini, Di Leo and Cudia
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