5,527 research outputs found
Letter from Simeon Leo to his father
No full textLetter from Simeon Leo, Esq. to his father on paper torn from a notebook. Written in broken English.Digital imag
The study of cell motility and plasticity in cancer: the role of the crosstalk between BM-MSCs and tumor in osteosarcoma progression and Claisened Hexafluoro as potential inhibitor of amoeboid motility in metastatic melanoma
No full textPart 1
Growing evidence suggest that bone marrow-derived mesenchymal stem cells (BM-MSCs) are key players in tumor stroma. Here, we investigated the cross-talk between BM-MSCs and osteosarcoma (OS) cells in tumor progression.
We revealed a strong tropism of BM-MSCs towards these tumor cells and identified monocyte chemoattractant protein (MCP)-1, growth-regulated oncogene (GRO)-α and transforming growth factor (TGF)-β1 as pivotal factors for BM-MSC chemotaxis. Once in contact with OS cells, BM-MSCs trans-differentiate into cancer-associated fibroblasts, further increasing MCP-1, GRO-α, interleukin (IL)-6 and IL-8 levels in the tumor microenvironment. These cytokines promote mesenchymal to amoeboid transition (MAT), driven by activation of the small GTPase RhoA, in OS cells, as illustrated by the in vitro assay and live imaging.
The outcome is a significant increase of aggressiveness in OS cells in terms of motility, invasiveness and trans-endothelial migration. In keeping with their enhanced trans-endothelial migration abilities, OS cells stimulated by BM-MSCs also sustain migration and invasion. Thus, BM-MSC recruitment to the OS site and the consequent cytokine-induced MAT are crucial events in OS malignancy.
Part 2
Metastatic melanoma is one of the most aggressive and lethal malignancies with a poor prognosis. Melanoma cells are able to migrate using different types of cell motility such as the rounded/amoeboid-type motility and the elongated/mesenchymal-type motility thanks to their high plasticity. Really several data underline the crucial role of amoeboid motility in the dissemination process of highly metastatic melanoma cells. Thus, targeting this process could be a promising strategy to prevent the metastatic spreading of melanoma cells.
Claisened Hexafluoro is a chemical analog of Honokiol (HKL), a biphenolic compound derived from Magnolia officinalis which has antitumoral and antimetastatic effect in numerous cancers, including melanoma.
Starting from these evidence, here we tested Claisened Hexafluoro on human metastatic melanoma cells, as an inhibitor of amoeboid motility. Data here reported demonstrate that Claisened Hexafluoro, impairing mitochondrial activity and affecting AMP-activated protein kinase (AMPK) signaling, strongly inhibits amoeboid motility and many steps of the disseminating process in vitro as well as in vivo, confirming its possible future application to fight metastatic spreading of melanoma cells
Una gara per il compleanno del re Carlo: il Demofoonte di Leo, Mancini, Sarro e Sellitto (Napoli, 1735) e i suoi rapporti con la partitura di Leonaro Leo del 1741
No full textIl saggio analizza il Demofoonte di Mancini, Sarro, Leo e Sellitto prodotto in occasione del compleanno di Carlo III a Napoli nel 1735, correggendo alcune attribuzioni di paternità delle singole arie e proponendo una valutazione del tipo di prodotto rispetto alle abitudini dell'epoca. La partitura viene poi confrontata con quella del solo Leo composta pochi anni dopo, ma che presenta un'indirizzo stilistico decisamente differente
Portrait of Hans Sahl
No full textThree quarter profile portrait of the German writer Hans Sahl.Digital imageEstate of the artist.The German Jewish author and poet Hans Sahl was born in 1902 in Dresden. He fled Nazi Germany for France and then immigrated to the United States, where he gained success as a translator of American authors. Sahl returned to Tübingen in 1990, where he died in 1993.Leo Glueckselig was born in Vienna in 1914. He studied architecture and worked as an interior designer. He left Austria with his family in 1938 and immigrated to New York, where he worked as a graphic designer and illustrator. He was part of the Oskar-Maria-Graf Stammitsch. Since 1999 his artwork has been exhibited in Vienna, Salzburg, New York, Washington, and Graz. Leo Glueckselig died in New York in 2003. His brother was the poet Friedrich Bergammer (Fritz Glueckselig)
Ktētōr and Synthesis: Epigrams, Miniatures, and Authorship in the Leo Bible
No full textThesis (Master's)--University of Washington, 2014The Leo Bible (Rome, Vat. Reg. Gr. 1) is an illuminated Old Testament produced in Byzantium during the mid-tenth century. Presented as a gift to a monastery of St. Nicholas by Leo Sakellarios, a court eunuch and palace treasurer, the Bible is the only surviving manuscript of its kind from Byzantium. Known for its luxurious epigrams and miniatures, the Leo Bible's classicizing miniatures are frequently cited as exemplars of tenth-century Byzantine art, although the manuscript is rarely considered as whole. This study takes a new approach to the Leo Bible, focusing on the manuscript as a work of visual and poetic exegesis, in which word and image work together to frame the Old Testament in a Christian context. Beyond its exegetical nature, the Leo Bible also demonstrates a marked interest in the theme of authorship. By considering Byzantine notions of authorship in conjunction with the Bible's visual and epigrammatic program, this study offers new insights into the concept of patronage in Byzantium and the means by which patrons constructed their image and legacy through their commissions. In the case of the Leo Bible, this study will address how Leo Sakellarios is understood to be the author of the manuscript and its exegetical commentary, and how this act of authorship is reflected in the Bible's visual and poetic programs
“Valutazione del circolo cerebrale, mediante Eco-Color-Doppler transcranico in pazienti con ipertensione essenziale ed in soggetti con familiarità ipertensiva, a riposo e dopo Hand-Grip Test”
No full textAprire spazi di possibilità nel governo del territorio: note da un’esperienza sul campo
No full textLeo Katz as an author of children’s books. A failed attempt?
No full textDas Ziel dieses Beitrags ist es, Leo Katz als Kinderbuchautor zu betrachten und darüber
nachzudenken, welche Rolle seine Jugendbücher in seinem gesamten Werk und in der
Geschichte der deutschsprachigen Kinder- und Jugendliteratur spielen. Es werden nicht
nur seine veröffentlichten Kinderbücher betrachtet, sondern auch andere
unveröffentlichte Jugendromane, die unbekannt bzw. unpubliziert geblieben sind.
Um den Autor aus der Vergessenheit zu holen, werden unter anderem die nicht
bekannten Werke des Autors für Jugendliche vorgestellt und es wird überlegt, weshalb
sie damals nicht veröffentlicht wurden.Stadt Wien KulturDepto. de Filología Alemana y Filología EslavaFac. de Comercio y TurismoTRUEpu
JLS 315-001: White Collar and Commercial Crime - course syllabus
No full text12 pages.Submitted by Angela Kim ([email protected]) on 2010-02-03T16:59:23Z
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JLS 315.001 White Collar and Commercial Crime Leo Wise.pdf: 95391 bytes, checksum: 0d4cec96e554a9a7e97cd287bf3b30a7 (MD5)Made available in DSpace on 2010-02-03T16:59:23Z (GMT). No. of bitstreams: 1
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Previous issue date: 2009-0
Fondo Angela Zucconi | Cepas
No full textAngela Zucconi (Terni, 1914 - Anguillara Sabazia, 2000), storica, traduttrice, scrittrice, insegnante, ambientalista, nelle sue varie esperienze, ha incontrato figure importanti della cultura del ’900 come Leo Longanesi, Lodovico Quaroni, Cesare Pavese, Bobi Bazlen, Natalia Ginzburg, Rocco Scotellaro e Adriano Olivetti. Con quest’ultimo instaurò un sodalizio, lungo più di un decennio, che segnò in manierà indelebile il suo ruolo nella storia del servizio sociale italiano.
Direttrice del Cepas, la storica scuola per gli assistenti sociali, partecipò alla costruzione del villaggio «La Martella» in Lucania e coordinò il Progetto Pilota per l’Abruzzo e per il Molise che si caratterizzò, più di ogni altro progetto di sviluppo comunitario, per le caratteristiche innovative di condivisione, partecipazione e interdisciplinarità.
In questo volume è pubblicato l’inventario del Fondo Angela Zucconi conservato nella sede di Roma della Fondazione Adriano Olivetti, e l’inventario di un nucleo documentale aggregato relativo al Cepas, nel periodo tra il 1963 e il 1967
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