4,666 research outputs found
Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy
Get PDFMaternal endothelial dysfunction in preeclampsia is associated with increased soluble fms-like tyrosine kinase-1 (sFlt-1), a circulating antagonist of vascular endothelial growth factor and placental growth factor. Angiotensin II (Ang II) is a potent vasoconstrictor that increases concomitant with sFlt-1 during pregnancy. Therefore, we speculated that Ang II may promote the expression of sFlt-1 in pregnancy. Here we report that infusion of Ang II significantly increases circulating levels of sFlt-1 in pregnant mice, thereby demonstrating that Ang II is a regulator of sFlt-1 secretion in vivo. Furthermore, Ang II stimulated sFlt-1 production in a dose- and time-dependent manner from human villous explants and cultured trophoblasts but not from endothelial cells, suggesting that trophoblasts are the primary source of sFlt-1 during pregnancy. As expected, Ang II-induced sFlt-1 secretion resulted in the inhibition of endothelial cell migration and in vitro tube formation. In vitro and in vivo studies with losartan, small interfering RNA specific for calcineurin and FK506 demonstrated that Ang II-mediated sFlt-1 release was via Ang II type 1 receptor activation and calcineurin signaling, respectively. These findings reveal a previously unrecognized regulatory role for Ang II on sFlt-1 expression in murine and human pregnancy and suggest that elevated sFlt-1 levels in preeclampsia may be caused by a dysregulation of the local renin/angiotensin system
Deletion of Smad7 enhances ANG II-induced renal inflammation.
No full text<p><b>A:</b> TNFα. <b>B:</b> IL-1β. <b>C:</b> F4/80<sup>+</sup> macrophages. Immunohistochemistry (IHC, i, ii) and real-time PCR (iii) analyses show that deletion of Smad7 enhances ANG II-induced renal inflammation with up-regulation of TNFα and IL-1β, and an increased macrophage infiltrate when compared with Smad7 WT mice. Each bar represents means ± SE for groups of 6 mice. Scale bar, 50 µM. *<i>P</i><0.05, **<i>P</i><0.01, ***<i>P</i><0.001 compared with saline (SL) control mice. <sup>#</sup><i>P</i><0.05, <sup>##</sup><i>P</i><0.01 when compared with ANG II-infused Smad7 WT mice.</p
Deletion of Smad7 enhances ANG II-induced renal fibrosis.
No full text<p><b>A:</b> Collagen I. <b>B:</b> α-SMA. Immunohistochemistry (IHC, i, ii), real-time PCR (iii), and Western blot (WB, iv, vi) analyses show that deletion of Smad7 enhances ANG II-induced renal fibrosis when compared with Smad7 WT mice. Each bar represents means ± SE for groups of 6 mice. Scale bar, 50 µM. *<i>P</i><0.05, **<i>P</i><0.01, ***<i>P</i><0.001 compared with saline (SL) control mice. <sup>#</sup><i>P</i><0.05, <sup>##</sup><i>P</i><0.01, <sup>###</sup><i>P</i><0.001 compared with ANG II-infused Smad7 WT mice.</p
Ang mga Ilo ni Magdalena G. Jalandoni sa Filipino
No full textLayunin ng Pag-aaral. Ang pagsasalin ng mga nobelang naisulat sa katutubong wika ay isang mahalagang gawain na maaaring tahakin nang sinumang may kakayahang pangwika at pangkultura. Ito ay dahil na rin sa ang pagsasalin ay makakatulong sa pagpapayaman sa literaturang Filipino at makakatulong sa pagbibigay rekognisyon sa mga manunulat, di lamang sa wikang Filipino kundi maging sa katutubong wika.Kaugnay ng pag-aaral, layon na isalin ang nobelang Ang Mga Ilo ni Magdalena Gonzaga Jalandoni sa Filipino. Sa pagsalin ng nobela, layon ng tagasalin na maging tapat di lamang sa kahulugan ng nobela kundi maging sa kultura at anyo ng orihinal. Ang pagsasalin ay isinagawa upang maipalaganap ang mga akdang nasa wikang katutubo bilang pagpapahalaga sa literaturang Filipino.TeoryaKaugnay ng mga nabanggit na layunin, ang teoryang batayan sa pagsasagawa ng salin ay ang tesis ni Andre Lefevere (1992) na ang pagsasalin ay akulturasyon. Kaugnay ng tesis na ito, apat na antas ng pagsasalin ang siyang pamamaraan sa pagsasakatuparan: ideology, poetics, universe of discourse at illocutionary language use.Sa pagsasalin ng nobela, sa mga pagkakataong may malaking balakid sa pagsasagawa ng akulturasyon, ibabaling ng tagasalin ang pagpapahalaga sa target na mambabasa at sa kultura nito dahil sila ang siyang huhusga sa kaangkupan ng salin.MetodolohiyaSa pangkalahatan, tatlong hakbang ang isinagawa sa pagsasalin ng nobela ni MGJ: paghahanda sa pagsasalin, aktwal na pagsasalin, at ang ebalwasyon ng salin.Sa paghahanda sa pagsasalin nakapaloob ang pagpili ng manunulat na isasalin pati na rin ng akda na siyang kakatawan dito bilang isang manunulat. Kasunod ay ang pagtukoy sa target na ng mambabasa upang masiguro na ang paglilipat ay angkop sa kanila. Matapos matukoy ang target na mambabasa, mahalaga ang pagpili ng isang teorya ng pagsasalin na siyang magiging gabay nag tagasalin. Bago magsimula ang tagasalin sa aktwal na pagsasalin, mahalagang mabasa ang akdang isasalin. Kaugnay ng aktwal na pagsasalin, mahalagang matuklasan ang kahulugan na siyang magbibigay daan sa pag-unawa ng akda upang matukoy ang katumbas ng simulang lenggwahe (SL) sa target na lenggwahe (TL). Sa paglilipat, tinukoy ang yunit ng pagsasalin upang maging sistematik ang pagsasalin ng nobela. Kaugnay ng pag-aaral na isinagawa, ang yunit ng pagsasalin ay ang talata. Bago tuwirang ilipat ang nobela sa TL, mahalagang maaydentifay ang mga suliranin kaugnay ng apat na antas ng pagsasalin n Lefevere upang mabigyan ng solusyon ang mga balakid sa pagsasalin ng nobela. Matapos maisagawa ang mga nabanggit na pamamaraan ay maaari nang isalin ang nobela sa TL.Hindi natatapos ang gawain sa paglilipat ng akda sa TL dahil kailangang sumailalim din ito sa isang ebalwasyon upang masiguro na ang salin ay tama . Kaugnay ng ebalwasyon, tatlong pamamaraan ang isinagawa ng tagasalin. Una ay ang pagsuri na natural ang daloy ng salin sa TL. Ang ikalawa ay ang pagpapagawa ng isang back translation o ang pagsasalin sa mga katuwang sa ebalwasyon ng ilang bahagi ng naisaling nobela sa Filipino sa Hiligaynon. Ang ikatlo ay ang pagpapasalin sa mga katuwang sa ebalwasyon ng ilang bahagi ng orihinal sa TL
Modulation of Magnetoresistance Polarity in BLG/SL-MoSe2 Heterostacks
No full textTwo-dimensional (2D) layered materials have an atomically thin and flat nature which makes it an ultimate candidate for spintronic devices. The spin-valve junctions (SVJs), composed of 2D materials, have been recognized as unique features of spin transport polarization. However, the magnetotransport properties of SVJs are highly influenced by the type of intervening layer (spacer) inserted between the ferromagnetic materials (FMs). In this situation, the spin filtering effect at the interfaces plays a critical role in the observation of the magnetoresistance (MR) of such magnetic structures, which can be improved by using promising hybrid structure. Here, we report MR of bilayer graphene (BLG), single-layer MoSe2 (SL-MoSe2), and BLG/SL-MoSe2 heterostack SVJs. However, before annealing, BLG and SL-MoSe2 SVJs demonstrate positive MR, but after annealing, BLG reverses its polarity while the SL-MoSe2 maintains its polarity and demonstrated stable positive spin polarizations at both interfaces due to meager dopingeffect of ferromagnetic (FM) contacts. Further, Co/BLG/SL-MoSe2/NiFe determines positive MR, i.e., ~ 1.71% and ~ 1.86% at T = 4 K before and after annealing, respectively. On the contrary, NiFe/BLG/SL-MoSe2/Co SVJs showed positive MR before annealing and subsequently reversed its MR sign after annealing due to the proximity-induced effect of metals doping with graphene. The obtained results can be useful to comprehend the origin of polarity and the selection of non-magnetic material (spacer) for magnetotransport properties. Thus, this study established a new paragon for novel spintronic applications.Peer reviewe
Deletion of Smad7 enhances ANG II-induced renal injury.
No full text<p><b>A:</b> Systolic blood pressure. <b>B:</b> Proteinuria. <b>C: S</b>erum creatinine. <b>D:</b> Creatinine clearance (CCR). <b>E:</b> Histological damage [periodic acid-Schiff (PAS)-stained sections]. Note that disruption of Smad7 enhances ANG II-mediated renal injury, including higher levels of proteinuria and serum creatinine, a greater fall in CCR, and histological damage such as glomerular hypercellularity, vascular sclerosis (arrows), and ECM deposition when compared with Smad7 WT mice, despite equal levels of high blood pressure. Values are means ± SE for groups of 6 mice. Scale bar, 50 µM. *<i>P</i><0.05, **<i>P</i><0.01, ***<i>P</i><0.001 compared with saline (SL) control mice.<sup> #</sup><i>P</i><0.05,<sup> ##</sup><i>P</i><0.01, <sup>###</sup><i>P</i><0.001 compared with ANG II-infused Smad7 WT mice.</p
CR1 Knops blood group alleles are not associated with severe malaria in the Gambia
No full textThe Knops blood group antigen erythrocyte polymorphisms have been associated with reduced falciparum malaria-based in vitro rosette formation (putative malaria virulence factor). Having previously identified single-nucleotide polymorphisms (SNPs) in the human complement receptor 1 (CR1/CD35) gene underlying the Knops antithetical antigens Sl1/Sl2 and McC(a)/McC(b), we have now performed genotype comparisons to test associations between these two molecular variants and severe malaria in West African children living in the Gambia. While SNPs associated with Sl:2 and McC(b+) were equally distributed among malaria-infected children with severe malaria and control children not infected with malaria parasites, high allele frequencies for Sl 2 (0.800, 1,365/1,706) and McC(b) (0.385, 658/1706) were observed. Further, when compared to the Sl 1/McC(a) allele observed in all populations, the African Sl 2/McC(b) allele appears to have evolved as a result of positive selection (modified Nei-Gojobori test Ka-Ks/s.e.=1.77, P-valu
Quantum and its irreducible representations
Get PDFWe define for real a unital -algebra
quantizing the universal enveloping
-algebra of . The -algebra
is realized as a -subalgebra of the
Drinfeld double of and its dual Hopf -algebra
, generated by the equatorial Podle\'s sphere coideal
-subalgebra of and
its associated orthogonal coideal -subalgebra . We then classify all the irreducible
-representations of .Comment: 22 pages; author accepted manuscrip
Deletion of Smad7 enhances upregulation of Sp1 but dowregulates miR-29b expression in ANG II-induced hypertensive nephropathy.
No full text<p><b>A.</b> Western blot and real-time PCR analysis show that disruption of Smad7 enhances ANG II-induced upregulation of Sp1 at both protein and mRNA levels. <b>B.</b> Real-time PCR detects that disruption of Smad7 results in a further inhibition of miR-29b expression in the hypertensive kidney. Each bar represents means ± SE for groups of 6 mice. *<i>P</i><0.05, **<i>P</i><0.01, ***<i>P</i><0.001 compared with saline (SL) control mice. <sup>#</sup><i>P</i><0.05, <sup>##</sup><i>P</i><0.01 when compared with ANG II-infused Smad7 WT mice.</p
On the sheaf-theoretic SL(2, C) Casson–Lin invariant
No full textWe prove that the (τ-weighted, sheaf-theoretic) SL(2, C) Casson–Lin invariant introduced by Manolescu and the first author is generically independent of the parameter τ and additive under connected sums of knots in integral homology 3-spheres. This addresses two questions asked by Manolescu and the first author. Our arguments involve a mix of topology and algebraic geometry, and rely crucially on the fact that the SL(2, C) Casson–Lin invariant admits an alternative interpretation via the theory of Behrend functions.</p
- …
