12,242 research outputs found
THU0143 Cholesterol efflux capacity of hdl is otherwise improved by different biologic-dmards in rheumatoid arthritis
No full textEULAR Congress 2017 Madri
A novel translocation t(2;9)(q14;p12) in AML-M2 with an uncommon phenotype: myeloperoxidase-positive and myeloid antigen-negative
No full textGiant Cell Tumor of Synovial Sheath: Of Two Cases Treated with Intra-Articular Infiltration of Infliximab
No full textIntentional etanercept use during pregnancy for maintenance of remission in rheumatoid arthritis
No full textANTI-TNFA THERAPY IN PSORIATIC ARTHRITIS: DIFFERENT RATE OF REMISSION IN POLYARTICULAR AND OLIGOARTICULAR SUBSETS
No full textA chronic myelocytic leukemia case bearing deletions on the three chromosomes involved in a variant t(9;22;11).
No full textAbsorption-based detection of urea concentration in hydroalcoholic solutions and white wine with a compact optical setup
No full textContactless detection of urea concentration in solution is very important in industrial, chemical, biological and agri-food applications. Urea, naturally contained in wine, when reacting with ethanol especially at high temperature may become the precursor of ethyl carbamate (urethane) which is carcinogen. Close monitoring of urea concentration in wine is necessary to prevent risks and diseases related to high urethane intake. In this work, we propose an optoelectronic measuring system for absorption-based detection of urea in water, in hydroalcoholic solutions with ethanol concentration of 12%, and in white wine with a 12% nominal concentration of ethanol. The urea concentration of the tested samples, contained in a 1-mm-deep rectangular glass capillary, was in the range from 0 up to 40 mg/mL. Two low-cost, low-power LEDs with emission spectra in the near infrared were employed as readout sources. The emission peaks of the selected LEDs were at λ = 1450 nm, where water absorbs more than urea, and at λ = 2350 nm, where urea absorption is higher than that of water. An amplified photodiode allowed to measure the transmitted optical power through the sample. To highlight the specificity of the measures, we also compared results of the optical measurements performed on urea-water solutions and on NaCl-water solutions. We demonstrate that measuring light intensity transmitted through each fluid mixture at the selected wavelengths allows not only to identify different urea concentrations, but also to distinguish samples of water-ethanol solutions from samples of white wine with the same urea concentration. This work represents the Proof of Principle of an optical method for specific urea detection in wine. Future work will be devoted to improving the system operation to enhance the limit of detection and to achieve recognition of urea concentration of the order of 0.001-0.003 mg/mL, typical values found in winery products
Study on the Mg-Li-Zn ternary alloy system with improved mechanical properties, good degradation performance and different responses to cells
No full textNovel Mg-(3.5, 6.5wt%)Li-(0.5, 2, 4wt%)Zn ternary alloys were developed as new kinds of biodegradable metallic materials with potential for stent application. Their mechanical properties, degradation behavior, cytocompatibility and hemocompatibility were studied. These potential biomaterials showed higher ultimate tensile strength than previously reported binary Mg-Li alloys and ternary Mg-Li-X (X=Al, Y, Ce, Sc, Mn and Ag) alloys. Among the alloys studied, the Mg-3.5Li-2Zn and Mg-6.5Li-2Zn alloys exhibited comparable corrosion resistance in Hank's solution to pure magnesium and better corrosion resistance in a cell culture medium than pure magnesium. Corrosion products observed on the corroded surface were composed of Mg(OH)2, MgCO3 and Ca-free Mg/P inorganics and Ca/P inorganics. In vitro cytotoxicity assay revealed different behaviors of Human Umbilical Vein Endothelial Cells (HUVECs) and Human Aorta Vascular Smooth Muscle Cells (VSMCs) to material extracts. HUVECs showed increasing nitric oxide (NO) release and tolerable toxicity, whereas VSMCs exhibited limited decreasing viability with time. Platelet adhesion, hemolysis and coagulation tests of these Mg-Li-Zn alloys showed different degrees of activation behavior, in which the hemolysis of the Mg-3.5Li-2Zn alloy was lower than 5%. These results indicated the potential of the Mg-Li-Zn alloys as good candidate materials for cardiovascular stent applications. Statement of significance: Mg-Li alloys are promising as absorbable metallic biomaterials, which however have not received significant attention since the low strength, controversial corrosion performance and the doubts in Li toxicity. The Mg-Li-Zn alloy in the present study revealed much improved mechanical properties higher than most reported binary Mg-Li and ternary Mg-Li-X alloys, with superior corrosion resistance in cell culture media. Surprisingly, the addition of Li and Zn showed increased nitric oxide release. The present study indicates good potential of Mg-Li-Zn alloy as absorbable cardiovascular stent material.Accepted Author ManuscriptBiomaterials & Tissue Biomechanic
Genomic deletions on other chromosomes involved in variant t(9;22) chronic myeloid leukemia cases
No full textThe Philadelphia (Ph) chromosome is the cytogenetic hallmark of chronic myeloid leukemia (CML) and is observed in more than 90% of CML cases. At diagnosis, in 5-10% of CML patients the Ph chromosome is derived from variant translocations other than the standard t(9;22). Deletions adjacent to the translocation junction on the derivative chromosome 9 were recently described by different groups. The deletions may identify a subgroup with a worse prognosis. The presence of similar deletions on the third derivative other than the 9 and 22 chromosomes in CML with variant translocation has never been investigated. We studied three cases of CML variants showing relatively large deletions on the third chromosome involved in the translocation. Known tumor-suppressor genes (TSGs) or genes involved in signal transduction and in the modulation of cell proliferation were found to be located inside these deleted regions. As an alternative to Knudson's two-hit model, the "haplo-insufficiency" hypothesis suggests that the deletion of a single allele of a TSG can play an important role in tumor progression. Our findings suggest that great attention should be paid to the molecular cytogenetic characterization of variant t(9;22) CML patients to unveil fully the biological heterogeneity of CML
Genomic deletions on the third chromosome involved in variant t(9;22) chronic myeloid leukaemia cases
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