71 research outputs found
The investigation of resveratrol and analogs as potential inducers of fetal hemoglobin
No full textBeta-thalassemia, is a hemoglobinopathy characterized by reduced beta-globin chain synthesis, leading to imbalanced globin chain production, ineffective erythropoiesis and anemia. Increasing gamma-globin gene expression is a promising therapeutic approach as it reduces this imbalance by combining with the excess alpha globin chains and producing fetal hemoglobin (HbF). Furthermore, increased iron absorption and repeated blood transfusions lead to iron overload and tissue damage secondary to reactive oxygen species. Compounds exhibiting both antioxidant and HbF inducing activities are, therefore, highly desirable therapeutic agents. Resveratrol, a natural phytoalexin, combines these two activities but is also cytotoxic. Nine hydroxystilbenic resveratrol derivatives were synthesized in an attempt to identify compounds that retain the HbF-inducing and antioxidant activities of resveratrol but exhibit reduced cytotoxicity. Three derivatives (P1, P4 and P11) exhibited similar hemoglobin-inducing properties to resveratrol in K562 cells, however, only P11 showed reduced cytotoxicity. All three derivatives demonstrated variable HbF-inducing activity in primary erythroid progenitor cells from healthy donors. Resveratrol and P11 increased HbF induction significantly, with P11 having the highest activity. Additionally, P4 significantly increased progenitor numbers. A combinatorial treatment in K562 cells using resveratrol and decitabine resulted in a statistically significant increase in hemoglobin-inducing activity only above the level shown by resveratrol alone
Group music sessions in a special school: A case study of a non-verbal child with autism
No full textAutism Spectrum Disorder (ASD) is a lifelong developmental disorder which appears early in life. Its core symptoms are the deficits in social, communication and emotional skills. This study constitutes an action research which is modelled by a single case study of a non-verbal boy with autism. The aim is to examine the interactions of the boy during five group music sessions at a special educational setting, and to identify potential benefits of using music to treat his autistic behaviours. Mixed methods design was adopted, by combining a small-scale survey with the members of staff as participants and observations of the music sessions. The findings indicate potential increase and improvement of the child’s social, communication and emotional skills. The limitations of the study are among others, the time constraints, the researcher’s bias and the issue of transferability. Finally, further research needs to be conducted, in order to confirm these findings. In the future, authors should consider to examine whether different types of music therapy can be adopted in music education at schools
Group music sessions in a special school: A case study of a non-verbal child with autism
No full textAutism Spectrum Disorder (ASD) is a lifelong developmental disorder which appears early in life. Its core symptoms are the deficits in social, communication and emotional skills. This study constitutes an action research which is modelled by a single case study of a non-verbal boy with autism. The aim is to examine the interactions of the boy during five group music sessions at a special educational setting, and to identify potential benefits of using music to treat his autistic behaviours. Mixed methods design was adopted, by combining a small-scale survey with the members of staff as participants and observations of the music sessions. The findings indicate potential increase and improvement of the child’s social, communication and emotional skills. The limitations of the study are among others, the time constraints, the researcher’s bias and the issue of transferability. Finally, further research needs to be conducted, in order to confirm these findings. In the future, authors should consider to examine whether different types of music therapy can be adopted in music education at schools
Screening and delineation of molecular mechanisms of action of HbF inducing agents for the treatment of β-thalassaemia
No full textMotivation of companies to join climate action: An agent-based modelling approach
No full text: There has been a growing number of companies that join, commit and set targets to the Science-Based Targets initiative in recent years. This thesis explores how factors which were found in previous studies to influence the companies’ decision to join SBTi or climate action in general, interact dynamically. Using an agent-based model, the companies’ interactions, the SBTi strategies and external factors will be examined in the temporal dimension in order to shed light on what is the projected uptake of SBTi.Industrial Ecolog
Beyond the success and failure of the Athens D.O.E.S. 2002 cultural olympiad competition
No full textOn the occasion of the Athens 2004 Olympics the Hellenic Ministry of Culture supported the launching of an open international architecture competition on Ephemeral Structures in the City of Athens (Athens D.O.E.S.) under the auspices of the International Union of Architects (UIA). The competition was organized in the context of the Cultural Olympiad\u92s programme for architecture and approached the contemporary Athenian cityscape as a site for experimentation by considering it to be both the site of practice and the site of thought. The competition brief provided architects an opportunity to invent \u91fields of forces\u92 whose impact would offer the inhabitants an opportunity to re-orient their perception of Athens. Structured into two parts, an ideas category for the students and a professional category for architects, the competition attracted 1279 registrations, 466 submissions from 54 countries and 34 prizes were awarded. 60 professionals were involved in the various stages, as members of the jury, authors of the brief, exhibitions designers etc., and backed the aspirations of their client, i.e., the 21st Greek State\u92s wish to challenge the prevailing 19th century perception of Athens. Nevertheless, the commissioning of the competition projects stumbled on the local construction industry that resisted any idea of research and innovation in architecture. The paper reframes the Athens 2004 competition in the context of the current financial crisis to discuss the potential of introducing Bruno Latour\u92s actor-network theory to think competition briefs that can be designed and implemented by an assemblage of clients, architects, emerging technologies and common usage
Manipulating a graph-like data-model on top of a key-value datastore
No full textDe begeleider en/of auteur heeft geen toestemming gegeven tot het openbaar maken van de scriptie.
The supervisor and/or the author did not authorize public publication of the thesis.
Diurnal behavior of the agrimi, Capra aegagrus
No full textCapra aegagrus cretensis on Theodorou Island Wildlife Preserve, Greece, have seasonal and daily activity patterns that minimize their exposure to high ambient temperatures. There were significant differences in time spent lying, standing, feeding, and moving among subsets of the population classified by sex, season, and time of day. Agrimi usually were solitary, but they often formed small groups that varied in both age and sex composition. There was an age-and sex-specific dominance hierarchy with older, consequently larger, males being dominant. -from Author
Author Correction: Synthesize high-dimensional longitudinal electronic health records via hierarchical autoregressive language model
No full textErratum: Corrigendum to “Esophageal remnant cancer 35 years after acidic caustic injury: A case report” (International Journal of Surgery Case Reports (2016) 25 (215–217) (S2210261216302358) (10.1016/j.ijscr.2016.06.051))
No full textThe authors regret to change the first name of the second author; more specifically we would like to change the first name “Stamatina” to “Tania”—the family name (“Triantafyllou”) remains as it is. On behalf of all the authors, I assure that we are in agreement with this change. The authors would like to apologise for any inconvenience caused. © 2016 The Author(s
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