265 research outputs found
Wragg's improved flute preceptor, or The whole art of playing the German flute : rendered perfectly easy to every capacity, on principles entirely new, and by which any one, who has a taste for music, may soon acquire a knowledge of that instrument, without the aid of a master : to which are added, a set of progressive lessons, sixty one original duets, progressively arranged in the most useful keys, each of which is preceded by an easy prelude, and an explanatory note, by which the pupil is enabled to proceed by progressive steps, from the easiest to the most difficult key : to which are also added, a set of ariettes, a pleasing collection of Scottish and other airs, a set of preludes in the various keys, & ample instructions for an eight key'd flute, op. 6 / by the author.
No full text[2], 62 p. of music ; 33 cm.3rd ed.Book is signed "J. Wragg" in red ink.
Engraved.Scanned to PDF from microfilm, Pres. Film 62, PM 544
Flight of the Dodo
No full textBeth Shapiro, Dean Sibthorpe, Andrew Rambaut, Jeremy Austin, Graham M. Wragg, Olaf R. P. Bininda-Emonds, Patricia L. M. Lee, Alan Coope
Invoice from Silver, Wragg, and Wheadon, Mobile, Alabama, to A. C. Hargrove, April 26, 1867
No full textPractical Filters Using Distributed RC Structures
No full textTitle: Practical Filters Using Distributed RC Structures, Author: Edmund J. Wragg, Location: ThodeTheoretical and experimental studies into practical filters using distributed RC structures are described. Various techniques to surmount the transcendental nature of the circuit parameters of such structures are considered and shown to be mostly too clumsy or restricted for practical use. The use of computer-aided analysis together with a sound physical understanding is suggested as an alternative. Application of the structures to active filters is considered and the experimental development of lowpass and bandpass amplifiers using them described. This leads to the presentation of a general design procedure for bandpass amplifiers using distributed RC null circuits. It is concluded that distributed RC filters suffer from a number of limitation but have a part to play as a circuit element and are now ready to advance to the stage of practical implementation.ThesisMaster of Engineering (ME
An Exploration of the Dynamics of Consensual Approaches in Biodiversity Planning for the Wider Countryside: Evaluating the Usefulness and Applicability of Actor-Network Theory
No full textThis research examines the usefulness of applying theoretical principles from the Sociology of
Translation and Actor Network Theory to the scenario of biodiversity planning in Oxfordshire
between the early nineteen nineties and 2001. It develops a model derived from a social
constructionist approach to considering Nature, and seeks to apply it to empirical data on the
development of Oxfordshire's Local Biodiversity Action Plan. The data is considered in relation
to the four poles of the model which are the 'scientific knowledge or technical' pole; the
'institutional' pole; the 'production of practices' pole and the 'nature protected' pole. The idea
that is applied is that scientific knowledge that is generated for a purpose becomes the accepted
wisdom and consequently is institutionalized. From this acceptance of the importance of
scientific or technical authority, practices will then be generated (for example, land or water
management strategies) and these then protect particular elements of nature; essentially what
society, and more specifically, the actors involved with problematising the issue deem as being
elements that are important to preserve.
Also, there is a time and space dimension built into the model since the author builds on the
ideas of actor-network theorists who argue that a network is not a flat shape but that actors may
act at a distance (e. g. global actor) but still be linked into a localized network. Similarly, actors
may be incorporated from different times but may be held into place within a given network
because their views or actions are part of a stable agreement (e. g. text/intermediary object) that
has encapsulated a number of different actors.The actor-networks presented in this thesis are
heterogeneous in nature in that they incorporate elements of nature and the human world as
different actors represent the views of others. The research explores stable and unstable
networks that are founded within consensual approaches through partnership working between
many different types of organisation
Bone marrow derived cells as endothelial precursors and the role of multi-potent progenitor cells in repairing ischaemic tissues.
No full textPhDIntroduction: Atherosclerosis and its complications are a major cause of death and
disability and it remains a major challenge to develop new therapies for patients with
irreversible end organ damage and ongoing ischaemia. The discovery of adult stem
and progenitor cells with the ability to regenerate adult tissues holds great promise.
Bone marrow is the source of both endothelial progenitor cells (EPCs) and multi-potent
adult progenitor cells (MAPCs). MAPCs are rare pluripotent bone marrow derived cells
with the theoretical potential to differentiate into tissues of all three germ cell layers,
including endothelium. These cells may have the potential to facilitate cardiac repair.
The aim of this thesis was to further characterise bone marrow derived endothelial
progenitor cells including multi potent adult progenitor cells and assess their angiogenic
potential and mechanisms of action in animal models of cardiovascular disease.
Findings: EPCs were isolated from humans and mice and their phenotype, markers
and function determined, including gene tracking experiments in mice utilising the
Cre/Lox system. It was not possible to isolate cells with the same phenotype as
MAPCs from rodent bone marrow. However, cells with pluri-potent properties, named
rat multi-potent progenitor cells (rMPCs), were isolated from rat bone marrow. These
cells had the ability to up regulate tissue specific antigens from all 3 germ cell lineages
and in addition secreted multiple cytokines related to angiogenesis and inflammation.
To investigate the in vivo properties of rMPCs a rat hind limb model of ischaemia was
established and syngeneic rMPCs were transplanted into the ischaemic hind limbs.
rMPCs engrafted selectively into the adventitia of arterioles of ischaemic muscles.
However, engrafted cells did not differentiate into an endothelial or smooth muscle
phenotype. Cytokine analysis of muscles 5 days after rMPC injection revealed raised
levels of cytokines, including chemokines MCP1 and SDR. Limb perfusion, measured
by microspheres, increased after rMPC injection. In addition a novel MRI based
assessment of ischaemic muscles revealed a significant normalisation of MRI signal
after rMPC transplantation. However, there was no improvement in limb function
assessed by treadmill running distance 4 weeks after cell injection. These findings
suggest that transplantation of rMPCs into ischaemic muscles may modulate local
inflammatory and angiogenic responses through paracrine mechanisms.
Conclusion: Despite the potential for stem and progenitor cells to be used for the
treatment of chronic cardiac ischaemia the biology of stem cells is still relatively poorly
understood, as is the mechanism of action of cells after transplantation. As set out in
the aims, the work in this thesis adds further to our understanding of both EPCs and
BM derived pluri-potent stem cells. In addition it provides insight into the hind limb
ischaemia model and the mechanism of action of cell therapy after transplantation into
ischaemic muscle
Quaternary environments and archaeology of Jersey: a new multidisciplinary project looking at the early prehistoric occupation of the English Channel Region
No full textThis paper presents a summary of the first season of fieldwork and archive assessment undertaken in 2010 as part of the of Jersey, through targeted sampling and key-hole excavation of poorly understood find spots, as well as a major reassessment of La Cotte de St Brelade. This paper presents the successful results of two weeks of intensive fieldwork at three localities, demonstrating the rich potential for early prehistoric archaeology on the island. Furthermore, the value of the island’s record in further understanding the long term record of human occupation in the English Channel region is discussed
Co-producing public involvement training with members of the public and research organisations in the East Midlands: creating, delivering and evaluating the lay assessor training programme
No full textPlain english summaryMembers of the public share their views with researchers to improve health and social care research. Lay assessing is one way of doing this. This is where people, drawing upon personal and general life experience, comment on material, such as grant applications and patient information, to highlight strengths and weaknesses and to suggest improvements. This paper reports on setting up a training programme for lay assessors.Meetings were held between interested public and staff from research organisations. People discussed what lay assessing is, why they want to do it, skills and support needed and if training was wanted. They were invited to form a group to develop the training together. Training was delivered in the East Midlands. People who attended gave their thoughts about it by completing questionnaires and joining a feedback event.The group developed the structure of the training programme together and it oversaw the development of the training content by individual members. People who attended training reported feeling more confident about lay assessing. This was particularly so for those who had not done lay assessing before. They indicated how valuable it was to talk with others at the training. Our findings support the National Institute for Health Research recommendations for improving learning and development for public involvement in research.This project has created a solid base for local research organisations to work together in public involvement training. Lay assessor training is now part of a wider programme of shared resources called the Sharebank.AbstractBackground Involving members of the public in research can improve its quality and incorporate the needs and views of patients. One method for doing this is lay assessing, where members of the public are consulted to improve research materials. This paper documents the establishment of a pilot training programme for lay assessors. It describes a way of working that embodies a regional, cross-organisational approach to co-producing training with members of the public.Methods Open meetings, led by AH, were held for existing and aspiring lay assessors to define lay assessing, motivations for doing it, skills required, associated learning and development needs, and to gauge interest for training. Those who attended meetings, including members of the public and staff, were invited to form a working group to co-produce the training programme. Training was delivered in modules at two centres in the East Midlands and evaluated through participant feedback at the end of each module and at an evaluation event. Feedback was through a mix of Likert scale scoring, open text and verbal responses.Results Discussions from the open meetings informed the development of the training by the working group. Led by AH, the working group, as a whole, co-produced the structure and format of the training and oversaw training content development by individuals within the group. Training was well-received by participants. Feedback through Likert scoring (n = 14) indicated higher feelings of confidence in knowledge of relevant subject matter and in fulfilling the lay assessor role, particularly amongst those who had not done lay assessing before. Opportunities that the training afforded for interaction between participants – sharing of varied experiences and knowledge – and a ‘learn by doing’ approach was of particular value, as indicated by 10 responses to open-ended questions.Conclusions This project has created a solid foundation for collaboration between research organisations in the East Midlands in devising and delivering training in public involvement together. Our evaluation provides evidence in support of National Institute for Health Research (NIHR) recommendations on principles for learning and development for public involvement in research
Genome-wide analysis reveals the extent of EAV-HP integration in domestic chicken
No full textBackground: EAV-HP is an ancient retrovirus pre-dating Gallus speciation, which continues to circulate in modern
chicken populations, and led to the emergence of avian leukosis virus subgroup J causing significant economic losses to
the poultry industry. We mapped EAV-HP integration sites in Ethiopian village chickens, a Silkie, Taiwan Country chicken,
red junglefowl Gallus gallus and several inbred experimental lines using whole-genome sequence data.
Results: An average of 75.22 ± 9.52 integration sites per bird were identified, which collectively group into 279 intervals
of which 5 % are common to 90 % of the genomes analysed and are suggestive of pre-domestication integration events.
More than a third of intervals are specific to individual genomes, supporting active circulation of EAV-HP in
modern chickens. Interval density is correlated with chromosome length (P < 2.31−6), and 27 % of intervals are
located within 5 kb of a transcript. Functional annotation clustering of genes reveals enrichment for immunerelated
functions (P < 0.05).
Conclusions: Our results illustrate a non-random distribution of EAV-HP in the genome, emphasising the
importance it may have played in the adaptation of the species, and provide a platform from which to
extend investigations on the co-evolutionary significance of endogenous retroviral genera with their hosts
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