438 research outputs found
The Andrew Olle Lecture: Lisa Wilkinson
No full textIn an amusing and poignant talk Lisa Wilkinson considers the impact of social media on journalism and expresses her despair at the unfair treatment experienced by so many women working in the Australian media.The annual Andrew Olle lecture, established in 1996 to remember and honour an iconic ABC broadcaster, focuses on the role and future of the media.Highlights of the 2013 Andrew Olle lecture, Australian Technology Park, in Redfern, Sydney on Friday 25 Octobe
Supplemental material for Measuring height and weight as part of routine mammographic screening for breast cancer
No full textSupplemental Material for Measuring height and weight as part of routine mammographic screening for breast cancer by Ellie Darcey, Ravi Ambati, Helen Lund, Andrew Redfern, Christobel Saunders, Sandra Thompson, Elizabeth Wylie and Jennifer Stone in Journal of Medical Screening</p
The Folly
No full textCatalogue of an exhibition held at Gallery 1, Grantpirrie, Redfern, N.S.W., 5-28 February 2009."The Folly is a three-screen digital work in which Arlo Mountford has animated three paintings by the sixteenth century Flemish artist, Pieter Bruegel the Elder. Using the computer, Mountford redrew the genre paintings The Corn Harvest (1565), The Hunters in the Snow (1565) and Landscape with the Fall of Icarus (c1558)"--Website.Catalogue essay by Zara Stanhope
Radiograph evaluation in children with acute hip pain
No full textAcute hip pain is relatively common in children. The etiology varies according to age and sex. Conventional radiography is commonly used to evaluate the painful hip. The views obtained depend on local departmental protocol, and there is no scientific basis for the choice of preferred projection. The authors' aim was to evaluate the role of anteroposterior (AP) and frog lateral (FL) radiographs in children younger than 14 years of age with hip pain to develop rational, evidence-based investigation guidelines. Four investigators retrospectively reviewed AP and FL radiographs of 96 children. The results were analyzed using the chi-square statistic. Overall results showed a reduction in sensitivity to about 70% and specificity to 90% when using a single view instead of combined views. These results indicate that despite the potential risks of increased radiation exposure with more than one view, combined AP and FL radiographs improve the diagnostic accuracy compared with single views alone. The authors believe that the additional radiation burden is therefore justified
Redfern kids connect : technology and empowerment
No full textRedfern Kids Connect is a community technology project that has run in inner-city Sydney since 2002. Redfern is known to many as the heart of urban Aboriginal Australia and as a diverse community facing challenges around poverty, crime and race relations. For three years, children (8-12 years old), and volunteers (university students and young professionals) have met each Saturday to play on computers and socialise. The project’s experiences with relationships, technology, and empowerment have been as confusing as they have been exciting. In the spirit of action research, this thesis explores the impacts the project has had. Uniquely embedded in the process of reflection occurring away from its on-the-ground activities, it tells the project’s story through the eyes of its volunteers. The research concludes that the project's main contributions to empowerment have been through building social capital (Cox, Putnam) and improving new forms of literacy (Warschauer). Vital to supporting and extending these outcomes have been taking a social approach to supporting technology use, shaping a safe and open environment (Marvin et. al), supporting critical thinking and expression (Freire) and examining the project 'behind the scenes'. The author takes the dual role of researcher and participant in the research
Additional file 8 of Loss of tumor-derived SMAD4 enhances primary tumor growth but not metastasis following BMP4 signalling
No full text<b>External Organisations</b><br/>Olivia Newton-John Cancer Research Institute; St. Vincent's University Hospital; University of New South Wales (UNSW); La Trobe University; University of Melbourne<b>Associated Persons</b><br/>Lap Hing Chi (Creator); Suraya Roslan (Creator); Ian P. Street (Creator); Allan D. Burrows (Creator); Robin L. Anderson (Creator)Additional file 8: Supplementary table 2. Western blotting / IHC antibodies used in this study
Additional file 7 of Loss of tumor-derived SMAD4 enhances primary tumor growth but not metastasis following BMP4 signalling
No full text<b>External Organisations</b><br/>La Trobe University; St. Vincent's University Hospital; University of New South Wales (UNSW); Olivia Newton-John Cancer Research Institute; University of Melbourne<b>Associated Persons</b><br/>Lap Hing Chi (Creator); Suraya Roslan (Creator); Ian P. Street (Creator); Allan D. Burrows (Creator); Robin L. Anderson (Creator)Additional file 7: Supplementary table 1. Cloning primers and relevant shRNA sequences used in this study
Additional file 9 of Loss of tumor-derived SMAD4 enhances primary tumor growth but not metastasis following BMP4 signalling
No full text<b>External Organisations</b><br/>Olivia Newton-John Cancer Research Institute; St. Vincent's University Hospital; University of New South Wales (UNSW); La Trobe University; University of Melbourne<b>Associated Persons</b><br/>Lap Hing Chi (Creator); Suraya Roslan (Creator); Ian P. Street (Creator); Allan D. Burrows (Creator); Robin L. Anderson (Creator)Additional file 9: Supplementary table 3. Primers and probes for (RT-)qPCR analysis in this study
Eyes for Ears: Usage and Efficacy of a Podcast for Ophthalmic Education
No full textAndrew E Pouw,1 Fei Cai,2 Amanda J Redfern,3 Jessica Chow,4 Benjamin K Young3 1Department of Ophthalmology & Visual Sciences, University of Iowa Carver College of Medicine, Iowa City, IA, USA; 2Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Hospital of University of Pennsylvania, Philadelphia, PA, USA; 3Department of Ophthalmology, Oregon Health and Science University, Portland, OR, USA; 4Department of Ophthalmology and Visual Sciences, Yale University School of Medicine, New Haven, CT, USACorrespondence: Andrew E Pouw, Department of Ophthalmology & Visual Sciences, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA, 52242, USA, Tel +1 319-356-3938, Email [email protected]: To characterize listenership and perceived educational impact of the ophthalmic podcast “Eyes for Ears”.Methods: A cross-sectional, internet-distributed, 9-question Qualtrics survey was made available to podcast listeners. Listenership metrics were analyzed from the podcast host platform.Results: From January 10, 2019 to September 2, 2021, the podcast was downloaded over 422,000 times, averaging about 4442 downloads per episode. 209 Qualtrics survey responses were analyzed from podcast listeners with backgrounds in eye care including medical students, residents, fellows, clinicians and technicians. The majority were residents (60.3%), representative of the target audience of the podcast. Listeners reported using the podcast while commuting (81.3%), felt it increased the time they could spend on self-care (63.2%), and thought it improved their fund of knowledge (99.0%). Respondents recalled feeling better prepared for the OKAP or written boards after using this podcast (before median = 50/100 on Likert Scale, IQR 30– 65 vs median = 70/100, IQR 56– 81, p < 0.001). Respondents identified question banks as the most helpful for OKAP studying, followed by podcasts. Podcasts were preferred over articles and lectures in terms of helpfulness (p < 0.001).Conclusion: The Eyes for Ears podcast has achieved a robust international audience. The surveyed audience felt the podcast was useful for their education and well-being.Keywords: medical education, technological innovation, ophthalmology, resident education, graduate medical educatio
Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines
No full textINTRODUCTION: The normal process of epithelial mesenchymal transition (EMT) is subverted by carcinoma cells to facilitate metastatic spread. Cancer cells rarely undergo a full conversion to the mesenchymal phenotype, and instead adopt positions along the epithelial-mesenchymal axis, a propensity we refer to as epithelial mesenchymal plasticity (EMP). EMP is associated with increased risk of metastasis in breast cancer and consequent poor prognosis. Drivers towards the mesenchymal state in malignant cells include growth factor stimulation or exposure to hypoxic conditions. METHODS: We have examined EMP in two cell line models of breast cancer: the PMC42 system (PMC42-ET and PMC42-LA sublines) and MDA-MB-468 cells. Transition to a mesenchymal phenotype was induced across all three cell lines using epidermal growth factor (EGF) stimulation, and in MDA-MB-468 cells by hypoxia. We used RNA sequencing to identify gene expression changes that occur as cells transition to a more-mesenchymal phenotype, and identified the cell signalling pathways regulated across these experimental systems. We then used inhibitors to modulate signalling through these pathways, verifying the conclusions of our transcriptomic analysis. RESULTS: We found that EGF and hypoxia both drive MDA-MB-468 cells to phenotypically similar mesenchymal states. Comparing the transcriptional response to EGF and hypoxia, we have identified differences in the cellular signalling pathways that mediate, and are influenced by, EMT. Significant differences were observed for a number of important cellular signalling components previously implicated in EMT, such as HBEGF and VEGFA. We have shown that EGF- and hypoxia-induced transitions respond differently to treatment with chemical inhibitors (presented individually and in combinations) in these breast cancer cells. Unexpectedly, MDA-MB-468 cells grown under hypoxic growth conditions became even more mesenchymal following exposure to certain kinase inhibitors that prevent growth-factor induced EMT, including the mTOR inhibitor everolimus and the AKT1/2/3 inhibitor AZD5363. CONCLUSIONS: While resulting in a common phenotype, EGF and hypoxia induced subtly different signalling systems in breast cancer cells. Our findings have important implications for the use of kinase inhibitor-based therapeutic interventions in breast cancers, where these heterogeneous signalling landscapes will influence the therapeutic response.Joseph Cursons, Karl-Johan Leuchowius, Mark Waltham, Eva Tomaskovic-Crook, Momeneh Foroutan, Cameron P Bracken, Andrew Redfern, Edmund J Crampin, Ian Street, Melissa J Davis and Erik W Thompso
- …
