4,037 research outputs found
English folk songs from the southern Appalachians : comprising two hundred and seventy-four songs and ballads with nine hundred and sixty-eight tunes, including thirty-nine tunes contributed by Olive Dame Campbell. Volume II
No full textA collection of folk songs gathered by Cecil Sharp and Olive Campbell, and edited by Maud Karples, from the Southern Appalachian Mountains. Volume two contains 135 songs, 5 hymns, 27 nursery songs, 15 jigs, and 20 play-party games.Herbert Halpert Collection. -- Includes index. -- First edition, "by Olive Dame Campbell and Cecil J. Sharp," published in 1917.Includes bibliographical references (p. 402-405)
Maternal sex chromosome non-disjunction: evidence for X chromosome-specific risk factors
No full textHuman trisomy is attributable to many different mechanisms and the relative importance of each mechanism is highly chromosome specific. The association between altered recombination and maternal non-disjunction is well documented: reductions in recombination have been reported for maternal meiosis I (MI) errors involving chromosomes 15, 16, 18 and 21 and increased recombination has been reported for meiosis II (MII) errors involving chromosome 21. We therefore investigated maternal X chromosome non-disjunction, to determine whether the effects of recombination are unique to the X chromosome or similar to any of the autosomes thus far studied. We genotyped 45 47,XXX females and 95 47,XXY males of maternal origin. Our results demonstrate that 49% arose during MI, 29% during MII and 16% were postzygotic events; a further 7% were meiotic but could not be assigned as either MI or MII because of recombination at the centromere. Among the MI cases, a majority (56%) had no detectable transitions and so absent recombination is an important factor for X chromosome non-disjunction. However, similar to trisomy 15 and unlike trisomy 21, we observed a significant increase in the mean maternal age of transitional MI errors compared with nullitransitional cases. In our studies of MII errors, recombination appeared normal and there was no obvious effect of maternal age, distinguishing our results from MII non-disjunction of chromosomes 18 or 21. Thus, surprisingly, the risk factors associated with both MI and MII non-disjunction appear to be different for virtually every chromosome that has been adequately studied
Copy number variation of the <i>REXO1L1</i> gene cluster; euchromatic deletion variant or susceptibility factor?
No full textRelatively little is known about the function of the RNA exonuclease 1 homologue (Saccharomyces cerevisiae)-like 1 gene (REXO1L1) in humans and only two titles in PubMed contain the REXO1L1 acronym. Evidence published in this journal indicated that copy number variation (CNV) of the REXO1L1 gene and pseudogene cluster was common and likely to be benign.1 In contrast, it has been proposed that de novo heterozygous deletion of the REXO1L1 cluster in a single patient is responsible for a new microdeletion syndrome including dysmorphic features, cleft palate, incomplete spina bifida, dyspraxia, global developmental delay, growth retardation and gastrointestinal malabsorption.2 Here we argue that determining the possible clinical significance of large-scale CNV requires the application of accurate quantitative techniques to both individual families and large cohorts of affected and unaffected individuals
Sharp, Andrew J.
No full textSee entry in Madison County, volume 1, page 106: https://digital.archives.alabama.gov/digital/collection/voter1867/id/343
Sharp, Andrew J.
No full textSee entry in Morgan County volume 1, page 36: https://digital.archives.alabama.gov/digital/collection/voter/id/239
Modification of the Failure Assessment Diagram for Non-Sharp Defects
No full textCurrent defect assessment procedures assume all flaws to be sharp. While this assumption may be appropriate for fatigue cracks, in other cases such as voids, mechanical dents or welding defects it can be an over-conservative assumption that can lead to pessimistic assessment of structures and significant under-estimation of their safety margin against fracture. This study has developed an assessment procedure for predicting the cleavage fracture resistance of structures containing non-sharp defects. The new assessment method was developed using the Weibull stress based toughness scaling model and an approach based on a modification of the Failure Assessment Diagram (FAD). In the new assessment procedure, the notch driving force is described by the notch J-integral, the notch tip loading severity by the elastic notch tip opening stress σN, the notch geometry by a load-independent parameter βN, and the sensitivity of the material toughness to the notch effect by the material parameters γ and l. Finite element analysis of SE(B) specimens containing U-notches was used to demonstrate that the notch J-integral can be estimated using existing expressions in fracture toughness testing standards intended for pre-cracked specimens. A test programme of SE(B) specimens containing U-notches was used to validate the new assessment procedure. Failure predictions of the SE(B) specimens using the notch-modified FAD approach result in significantly reduced conservatism compared to the standard FAD assessment approach for sharp cracks.</jats:p
Expansion of a 12-kb VNTR containing the REXO1L1 gene cluster underlies the microscopically visible euchromatic variant of 8q21.2
No full textCopy number variants visible with the light microscope have been described as euchromatic variants (EVs) and EVs with extra G-light material at 8q21.2 have been reported only once before. We report four further patients with EVs of 8q21.2 ascertained for clinical (3) or reproductive reasons (1). Enhanced signal strength from two overlapping bacterial artificial chromosomes (BACs) and microarray analysis mapped the EV to a 284-kb interval in the reference genome. This interval consists of a sequence gap flanked by segmental duplications that contain the 12-kb components of one of the largest Variable Number Tandem Repeat arrays in the human genome. Using digital NanoString technology with a custom probe for the RNA exonuclease 1 homologue (S. cerevisiae)-like 1 (REXO1L1) gene within each 12-kb repeat, significantly enhanced diploid copy numbers of 270 and 265 were found in an EV family and a median diploid copy number of 166 copies in 216 controls. These 8q21.2 EVs are not thought to have clinical consequences as the phenotypes of the probands were inconsistent, those referred for reproductive reasons were otherwise phenotypically normal and the REXO1L1 gene has no known disease association. This EV was found in 4/3078 (1 in 770) consecutive referrals for chromosome analysis and needs to be distinguished from pathogenic imbalances of medial 8q. The REXO1L1 gene product is a marker of hepatitis C virus (HCV) infection and a possible association between REXO1L1 copy number and susceptibility to HCV infection, progression or response to treatment has not yet been excluded
Dns Of Compressible Turbulent Boundary Layer Around A Sharp Cone
No full textDirect numerical simulation of the turbulent boundary layer over a sharp cone with 20 degrees cone angle (or 10 degrees half-cone angle) is performed by using the mixed seventh-order up-wind biased finite difference scheme and sixth-order central difference scheme. The free stream Mach number is 0.7 and free stream unit Reynolds number is 250000/inch. The characteristics of transition and turbulence of the sharp cone boundary layer are compared with those of the flat plate boundary layer. Statistics of fully developed turbulent flow agree well with the experimental and theoretical data for the turbulent flat-plate boundary layer flow. The near wall streak-like structure is shown and the average space between streaks (normalized by the local wall unit) keeps approximately invariable at different streamwise locations. The turbulent energy equation in the cylindrical coordinate is given and turbulent energy budget is studied. The computed results show that the effect of circumferential curvature on turbulence characteristics is not obvious
Sharp characters of finite groups
No full textAbstractIf χ is a virtual (generalized) character of a finite group G, with n=χ and L={χ(g)|g∈G, g≠1 {χ(g)¦gϵG, g ≠ 1}, then ¦G¦ dividesfL(n), where fL(x) is the monic polynomial of least degree having L as its set of roots. (This generalises a result of the second author for permutation characters.) We say that the pair ((G,χ)) is L-sharp if ¦G¦=fL(n). We characterise the L-sharp pairs for various sets L, sometimes under additional hypotheses, and give a number of examples
Highly-conformal sputtered through-silicon vias with sharp superconducting transition
No full textThis paper describes the microfabrication and electrical characterization of aluminum-coated superconducting through-silicon vias (TSVs) with sharp superconducting transition above 1 K. The sharp superconducting transition was achieved by means of fully conformal and void-free DC-sputtering of the TSVs with Al, and is here demonstrated in up to 500μ m-deep vias. Full conformality of Al sputtering was made possible by shaping the vias with a tailored hourglass profile, which allowed a metallic layer as thick as 430 nm to be deposited in the center of the vias. Single-via electric resistance as low as 160 mΩ at room temperature and superconductivity at 1.27 K were measured by a three-dimensional (3D) cross-bridge Kelvin resistor structure. This work establishes a CMOS-compatible fabrication process suitable for arrays of superconducting TSVs and 3D integration of superconducting silicon-based devices. [2020-0354].Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.EKL ProcessingElectronic Components, Technology and MaterialsTera-Hertz SensingElectronic
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