28 research outputs found
A CD40 Bridge between Innate and Adaptive Immunity
No full textAbstractIn this issue of Immunity, Brodeur et al. show that C4b binding protein (C4BP), a regulator component of the classical complement (C) pathway, can bind to CD40 receptors on B cells and activate them. This suggests a novel way by which CD40 may function to bridge innate and adaptive immune responses
Macrophage- and dendritic cell—dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF
No full textBAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway
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Different Protein Tyrosine Kinases Are Required for B Cell Antigen Receptor–mediated Activation of Extracellular Signal–Regulated kinase, c-Jun NH2-terminal Kinase 1, and p38 Mitogen-activated Protein Kinase
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Inositol 1,4,5-Triphosphate and Inositol 1,3,4,5-Tetrakisphosphate: Functions, Metabolism and Interconversion
No full textOptimization Methodology of Polar Direct-Drive Illumination for the National Ignition Facility
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