239 research outputs found
Eumycetoma of the hand caused by Leptosphaeria tompkinsii and refractory to medical therapy with voriconazole
No full textWe report on the first case of eumycetoma caused by the organism Leptosphaeria tompkinsii to be diagnosed and possibly acquired within the United Kingdom. Conventional culture of fungal grains and surgical tissue specimens was negative and the diagnosis was achieved using panfungal polymerase chain reaction and sequencing technology. Despite limited surgical resection and prolonged antifungal therapy with voriconazole, the patient developed progressive disease with mycetoma bone involvement. This case highlights the usefulness of molecular diagnostic techniques in eumycetoma where organisms may fail to grow with conventional culture or be difficult to identify morphologically. It also reminds us that eumycetoma is a difficult infection to treat and despite optimism regarding the efficacy of the newer triazole antifungals in this condition, treatment failures may still occur
Right to farm laws
No full textIn the lead up to the 2015 State election it was reported in The Land that the Coalition Government and NSW Farmers had entered into “an unprecedented” memorandum of understanding. Among the “key commitments” entered into were the reform of biodiversity laws and consideration of “proposals for a Right to Farm policy during 2015”.
In July 2014, at its annual conference, NSW Farmers passed a motion calling for “right to farm” legislation. Based on an article by Graham Brown, a NSW Farmers’ executive councillor, that argument seems to have two main aspects:
primarily, granting immunity to farmers from litigation involving nuisance complaints, in particular those arising from the interface between the “smelly, sometimes noisy” realities of farming and “expanding urban centres”; and
secondarily, providing protection from regulatory imposition by governments, State and local, referred to as “hindrances” to land use, including the placing by local councils of e-zones over agricultural property.
The article by Graham Brown concluded:
"In the face of extractive issues, expanding urban centres and red and green tape on-farm, protecting and promoting our farmers’ ability to conduct business, manage the landscape, provide environmental stewardship and grow food, must be supported in legislation."
The case was expressly adopted on 23 June 2015 by Robert Brown MLC of the Shooters and Fishers Party. He spoke in favour of “right to farm” policy and, calling for a parliamentary inquiry into the issue, Mr Brown argued that:
"The increasing trend of urban sprawl has presented some grim implications when the interests of agriculture clash with the lifestyle expectations of semi-rural property owners on the fringes of urban areas, or indeed in whole regions of New South Wales."
This e-brief discusses the history and purpose of “right to farm” laws and their application in the US and Canada. The position in Australia is also discussed, as is the question of the place of such laws in the broader context of the system of planning legislation. 
Współpraca, do której nie doszło. O zamiarze wydawania „Wiadomości” przez Jerzego Giedroycia
No full textCooperation which has not been. The intention to publish Wiadomości by Jerzy GiedroycKultura and Wiadomości wrote down in history as two opposite magazines, even fighting each other. A little known fact is that at the turn of 1945 and 1946 Jerzy Giedroyc later editor of Kultura and Antoni Borman close associate of Wiadomości began efforts to resume publishing of Wiadomości in Instytut Literacki — a publishing house founded by Giedroyc. The article describes actions undertaken by Borman and Giedroyc, which aimed to convince Mieczysław Grydzewski, editor-in-chief of Wiadomości, to leave London and move the editorial office of his weekly to Italy. Moreover, the author present the specific functioning of the Polish community in exile in the early post-war years.Cooperation which has not been. The intention to publish Wiadomości by Jerzy GiedroycKultura and Wiadomości wrote down in history as two opposite magazines, even fighting each other. A little known fact is that at the turn of 1945 and 1946 Jerzy Giedroyc later editor of Kultura and Antoni Borman close associate of Wiadomości began efforts to resume publishing of Wiadomości in Instytut Literacki — a publishing house founded by Giedroyc. The article describes actions undertaken by Borman and Giedroyc, which aimed to convince Mieczysław Grydzewski, editor-in-chief of Wiadomości, to leave London and move the editorial office of his weekly to Italy. Moreover, the author present the specific functioning of the Polish community in exile in the early post-war years
Towards standardization for mycological examination of sputum samples from Cystic Fibrosis patients: From the French multicenter experience to an international study
No full textIntroduction:
Prognosis of cystic fibrosis (CF) essentially depends on impairment of the lung function. While considerable attention therefore has been paid over recent decades to the prevention and treatment of bacterial respiratory infections, leading to a marked increase in life expectancy of the patients, prevalence of colonization of the airways by filamentous fungi or yeasts, sometimes leading to true respiratory infections, has been regularly increasing. However, recently, Borman et al. (2010) reported wide variations in the range of the causative fungal pathogens and in their prevalence, related at least to a lack of standardization in the methods used to detect these microorganisms.
Here, our aims are:
to analyze the impact of the culture conditions used on the detection of specific fungal pathogens throughout the French multicenter experience, and
to discuss the methods used in various European or Australian laboratories, in order to carry out an international prospective study that will make possible a standardized protocol for efficient detection of the whole fungal biota that can be encountered in respiratory secretions of CF patients.
Results:
First, from January 2007 to the end of 2009, a multicenter study was conducted in France encompassing 7 university or general hospitals which agreed to use the same
procedure for mycological analysis of sputum saples from CF patients, including prior
digestion of the sample with dithiolbutane and inoculation of the digested sample on 6 semi- selective agar-based media ("MucoFong" study – PHRC1902). Data obtained during one year were analyzed using the CHAID (Chi-squared Automatic Interaction Detector) method, which is a statistical approach able to give best association of media to detect a specific pathogen. CHAID is a type of decision tree technique, based upon adjusted significance testing that we apply to our data in order to define the best set of semi-selective media able to isolate 99.99% of the fungal pathogens that were detected in our CF population. Second, the major data of the international survey will be presented, and discussed with the purpose of developing a standardized approach for mycological examination of respiratory secretions from CF patients.
Conclusion:
Defining the optimal method for mycological analysis of the fungal components of CF lungs microbiome through a large international study is becoming a major requirement. This will make possible not only to analyze the role of some "rare" filamentous species in CF exacerbation or the existence of geographic variations in the fungal species that colonize the airways, but also to study the complexity of the CF lung microbiome as well as its dynamics
Fungal taxonomy and nomenclature
No full textThis chapter summarizes historical and modern approaches to fungal taxonomy, the current taxonomic standing of medically important fungi, and the implications for fungal nomenclature following the recent Amsterdam Declaration on Fungal Nomenclature, which prohibits dual nomenclature. Fungi comprise an entire kingdom, containing an estimated 1–10 million species. Traditionally, fungal identification was based on examination of morphological and phenotypic features, including the type of sexual spores they form, and method of formation, and structural features of their asexual spores. Thus, many fungi have been described and named independently several times based on either their sexual or asexual stages, resulting in a single genetic entity having multiple names. Recent molecular approaches to fungal identification have led to profound changes in fungal nomenclature and taxonomy. Certain phyla have now been disbanded, cryptic species have been identified via molecular approaches, and long-recognized species have been transferred to new genera based on genotypic comparisons.</p
A study of fund administrators' job performance in a financial institution
No full textBibliography: leaves 119-140
Of mice and men and larvae: Galleria mellonella to model the early host-pathogen interactions after fungal infection
No full text
A Tribute to Professor Jerold Israel--My Teacher, My Co-author, My Good Friend
No full textA Tribute to Jerry Israe
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