197,562 research outputs found
In vivo and in vitro evaluation of phytic acid as topical antioxidant
No full textThe use of locally applied antioxidants has been shown as an effective approach for the skin photo-protection. In a previous investigation we have demonstrated that phytic acid (PA), a component of most cereal grains and seeds, is able to reduce the erythemal response to UV-exposure when applied 30 minutes before UV-radiation. PA was used at 0.5 % concentration in a O/W emulsion containing also inositol at 2.0 % concentration. Before the test and 24 and 48 h after irradiation the extent of the reaction was evaluated with visual scoring as well as with instrumental measurement of skin redness,TEWL and hydration. In this study we have evaluated the ability of PA to protect human keratinocytes cultures against UV exposure. PA extracted from the rice bran was used at 100 μM. The experiments were performed also on ascorbic acid
at the same concentration. Human HaCaT keratinocytes were grown in 3,5 cm2 plates containing complete medium (DMEM with 10% fetal calf serum). Thirty minutes before UV radiation, medium was removed and replaced by PBS with or without the antioxidants. The light source was a 150-Watt xenon arc solar simulator. Series of cultures were irradiated with scalar UV-doses ranging from 11,56 to 92,48 mJ/cm2. After irradiation PBS solution with or without antioxidants was removed and replaced with fresh medium. The antioxidant activity was evaluated by MTT
assay after 24 hrs. The solutions containing the active ingredients demonstrated a protective ability stronger than that of the controls. Particularly PA showed an ability to protect the keratinocytes against UV damage more pronounced than vitamin C. Our investigation has proved
that phytic acid is able to protect human keratinocytes against UV radiation. This means that epidermal cells are involved in the PA-mediated photoprotection in vivo and represents a fur-ther support for the use of PA as topical photoprotective agent
Evaluation the anti-ageing and repair activity of plant stem cell extract in a topical formulation
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Topical pimecrolimus in the treatment of genital lichen Sclerosu
No full textPimecrolimus is a drug belonging to the class of macrolactamic immunosuppressants, similar to tacrolimus, and has been employed mainly in the treatment of atopic dermatitis, but is also active in other skin diseases, including genital lichen sclerosus (LS). The safety profile of pimecrolimus was the subject of special attention by the US FDA, which in 2005 issued a Public Health Advisory on the potential risk of cancer associated with the use of topical calcineurin inhibitors. However, many scientific societies have criticized the FDA note, referring to the vast literature on the subject in which there is no evidence available that topical use of the drug is dangerous. Patients with LS, of both sexes, may develop genital squamous cell carcinoma. This event, however, is not a contraindication to the use of pimecrolimus
Hot topics on UV filter ingredients
No full textThe production of sunscreens is regulated by laws and lists, constantly updated on the basis of scientific information. Most advanced countries have regulatory bodies that publish and update the list of authorized substances. Inorganic filters, zinc oxide and titanium dioxide are often used as nanostructured forms. Nanoparticles have been the subject of technological studies aimed at improving efficacy and safety. The organic ingredients are able to absorb UV radiation on a selective or broad spectrum. The latter is preferable given the role of UVA radiation in skin carcinogenesis. The organic filters may interact with epidermal proteins and induce sensitization. They can also be absorbed, causing systemic effects. In addition, some organic ingredients, such as avobenzone, may undergo photodegradation, needing special formulation requirements. © 2011 Expert Reviews Ltd
The dangerous life and ideas of Diogenes the Cynic. Jean-Manuel Roubineau, Malcolm DeBevoise, Philip Mitsis, The dangerous life and ideas of Diogenes the Cynic. New York: Oxford University Press, 2023. Pp. 208. ISBN 9780197666357.
No full textLa recensione esamina e valuta il saggio di J.-M. Roubineau intitolato «The dangerous life and ideas of Diogenes the Cynic» e pubblicato presso la Oxford University Press nel 2023
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