9,401 research outputs found
Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene
No full textG protein-coupled receptor regulation of gene transcription primarily occurs through the phosphorylation of transcription factors by MAPKs. This requires transduction of an activating signal via scaffold proteins that can ultimately determine the outcome by binding signaling kinases and adapter proteins with effects on the target transcription factor and locus of activation. By investigating these mechanisms, we have elucidated how pituitary gonadotrope cells decode an input GnRH signal into coherent transcriptional output from the LH beta-subunit gene promoter. We show that GnRH activates c-Src and multiple members of the MAPK family, c-Jun NH2-terminal kinase 1/2, p38MAPK, and ERK1/2. Using dominant-negative point mutations and chemical inhibitors, we identified that calcium-dependent proline-rich tyrosine kinase 2 specifically acts as a scaffold for a focal adhesion/cytoskeleton-dependent complex comprised of c-Src, Grb2, and mSos that translocates an ERK-activating signal to the nucleus. The locus of action of ERK was specifically mapped to early growth response-1 (Egr-1) DNA binding sites within the LH beta-subunit gene proximal promoter, which was also activated by p38MAPK, but not c-Jun NH2-terminal kinase 1/2. Egr-1 was confirmed as the transcription factor target of ERK and p38MAPK by blockade of protein expression, transcriptional activity, and DNA binding. We have identified a novel GnRH-activated proline-rich tyrosine kinase 2-dependent ERK-mediated signal transduction pathway that specifically regulates Egr-1 activation of the LH beta-subunit proximal gene promoter, and thus provide insight into the molecular mechanisms required for differential regulation of gonadotropin gene expression
Norm Inequalities due to Ando-Bhatia-Kittaneh
No full textFor any unitarily invariant norm ǀǀǀ・ǀǀǀ for matrices, Ando showed ǀǀǀ f(A)-f(B) ǀǀǀ ≦ ǀǀǀ f(|A-B|) ǀǀǀ for a nonnegative operator monotone function f and positive-definite matrices A and B, which was generalized by Bhatia and Kittaneh recently. Considering f(0), we give more sharp estimations for them where nonnegativity of f is not needed. For these reformed inequalities, we also give equality conditions.行列のユニタリ不変なノルムについて、安藤は正定値行列A, Bと非負作用素単調関数fに対し、ǀǀǀ f(A)-f(B) ǀǀǀ ≦ ǀǀǀ f(|A-B|) ǀǀǀ が成立することを示した。これは、Bhatiaの予想を一般の作用素単調関数で示したものであるが、彼自身とKittanehは、最近この不等式一般化した。そこで我々は、初期値f(0)を吟味することでさらに精密な不等式が得られ、fの非負性は不要になることを指摘する。これによって、等号が成立するための必要十分条件が得られる
author
No full textauthorIn other places [Old Joe, the trapper] pointed out otter (or, as he pronounced it, "author") slidesPRINTED ITEM G.M.Story April 1959Not UsedNot UsedWithdrawn[see 'otter']Checked by Jordyn Hughes on Thu 09 Jun 201
Why can dl-Sotalol prolong the QT interval in vivo despite its weak inhibitory effect on hERG K+ channels in vitro? Electrophysiological and pharmacokinetic analysis with the halothane-anesthetized guinea pig model
No full text主査 : 池田隆徳 / タイトル : Why can dl-Sotalol prolong the QT interval in vivo despite its weak inhibitory effect on hERG K+ channels in vitro? Electrophysiological and pharmacokinetic analysis with the halothane-anesthetized guinea pig model /著者 : Jun Katagi, Yuji Nakamura, Xin Cao, Hiroshi Ohara, Atsushi Honda,Hiroko Izumi-Nakaseko, Kentaro Ando, Atsushi Sugiyama /掲載誌 : Cardiovascular Toxicology /巻号・発行年等 : 16(2):138-146, 2016
Calculation of Three-dimensional Unsteady Sheet Cavitation by a Simple Surface Panel Method "SQCM"
No full textThis paper presents a calculation method for the 3-D unsteady cavitating hydrofoil problem. The method is based on a simple surface panel method "SQCM" which satisfies easily the Kutta condition even in the unsteady problem. This method is applied to the Wagner problem, heaving hydrofoil and the hydrofoil in sinusoidal gust. We show some calculated results for partially cavitating and supercavitating hydrofoil and compare them with other calculated results
A book of stone
No full textA significant example in the history of the stereotomy is provided by a special ‘barrel-vault’ stone device which created roofing for spiral staircases. Already known and used in the twelfth century, this surface was first mentioned in a treatise at the end of the fourth book of Le premier tome de l’Architecture by Philibert De l’Orme: among the various examples of spiral staircase there is the first reference to a spiral barrel vault as the Saint-Gilles screw or spiral staircase. The name of this surface derives from the presence of an example of vault roofing whose intrados is characterised by the above-mentioned surface at the Abbey of Saint-Gilles in France. Although the staircase was completed in 1142, long before the first rigorous formulations of stone-cutting, the excellence and accuracy of the construction ensured that the ‘vis de Saint-Gilles’ became consecrated as a vital stage of the pilgrimages made by stone masons’ corporations to visit the works of greatest importance for learning the art of stereotomy. Evidence of their visits is provided by the marks engraved in the side walls of the staircase left by members of the corporations
The Plan. Speciale Giappone
No full text9 progetti di architettura contemporanea giapponese. Progetti di Fumihiko Maki, Toyo Ito, Tadao Ando, Ken Yokogawa, Kengo Kuma, Kazuyo Sejima, Jun Aoki, Shigeru Ban, Shuhei End
Firm Characteristic Determinants of SME Participation in Production Networks
No full textThis paper provides an empirical analysis of small and medium enterprise (SME) participation in production networks. It gauges firm characteristic determinants of SME participation in production networks. The empirical investigation utilizes results obtained from an ERIA Survey on SME Participation in Production Networks, conducted over a three month period at the end 2009 in most ASEAN countries (i.e., Thailand, Indonesia, Malaysia, Philippines, Vietnam, Cambodia, and Laos PDR) and China. The results suggest that productivity, foreign ownership, financial characteristics, innovation efforts, and managerial/entrepreneurial attitudes are the important firm characteristics that determine SME participation in production networks. The paper extends the analysis to identify the determinants that allow SMEs to move from low to high quality or value adding participation in production networks. The results suggest that size, productivity, foreign ownership, and, to some extent, innovation efforts and managerial attitudes, are the important firm characteristics needed by SMEs to upgrade their positions in production networks. The finding suggests that SMEs really exploit competitiveness from economies of scale only when they are able to engage in production networks.
Jia ru ju he wu dui jun yun tuan liu ji jun yun tuan liu dui liu de ying xiang
No full textWong, Chai Kwok = 加入聚合物對均勻湍流及均勻湍流對流的影響 / 黃濟國.Thesis M.Phil. Chinese University of Hong Kong 2013.Includes bibliographical references (leaves 89-91).Abstracts also in Chinese.Title from PDF title page (viewed on 01, November, 2016).Wong, Chai Kwok = Jia ru ju he wu dui jun yun tuan liu ji jun yun tuan liu dui liu de ying xiang / Huang Jiguo
Why can dl-Sotalol prolong the QT interval in vivo despite its weak inhibitory effect on hERG K+ channels in vitro? Electrophysiological and pharmacokinetic analysis with the halothane-anesthetized guinea pig model
No full text主査 : 池田隆徳 / タイトル : Why can dl-Sotalol prolong the QT interval in vivo despite its weak inhibitory effect on hERG K+ channels in vitro? Electrophysiological and pharmacokinetic analysis with the halothane-anesthetized guinea pig model /著者 : Jun Katagi, Yuji Nakamura, Xin Cao, Hiroshi Ohara, Atsushi Honda,Hiroko Izumi-Nakaseko, Kentaro Ando, Atsushi Sugiyama /掲載誌 : Cardiovascular Toxicology /巻号・発行年等 : 16(2):138-146, 2016 /本文ファイル: 査読後原稿 /The final publication is available at Springer via http://dx.doi.org/10.1007/s12012-015-9322-2
- …
