7 research outputs found
Additional file 2 of Functional and structural characteristics in patients with diabetic macular oedema after switching from ranibizumab to aflibercept treatment. Three year results in real world settings
No full textAdditional file 2: Table S2. Number of eyes per CMT increase or reduction category. Number of eyes with more than 50 μm reduction in CMT, remaining stable (increase or decrease less than 50 μm), more than 50 μm increase in CMT every trimester after the switch, up to 36 months follow-up
Additional file 1 of Functional and structural characteristics in patients with diabetic macular oedema after switching from ranibizumab to aflibercept treatment. Three year results in real world settings
No full textAdditional file 1: Table S1. Number of eyes per visual gain or loss category. Number of eyes gaining more than 10 letters, gaining 5–9 letters, remaining stable (gaining or losing less than 5 letters), losing 5–9 letters and losing more than 10 letters every trimester after the switch, up to 36 months follow-up
The Role of Organizational Behavior to Sustainable Health Care: The Case of Greece
No full textThe role healthcare systems can play in surmounting global challenges like climatic change and resource scarcity is large, considering the major social and environmental impact. The research investigates the role of organizational behavior in influencing the adoption of sustainability initiatives in Greek healthcare organizations in regard to climate change. The research surveys 379 healthcare professionals from the public and private sectors with regard to organizational attitudes toward climate change, the adoption of sustainable practices, and individual environmental perspectives. Results underline that health care administration is still cut off from environmental considerations, with limited employee involvement in such initiatives of sustainability. The major barriers were poor communication, lack of education, and inadequate awareness across institutions. The study also emphasized that healthcare organizations need to align their values with environmental strategy so they can work in unison toward seeking sustainability. These would be stimulating initiatives for more leadership and active staff who become involved in making meaningful contributions toward global sustainability from the healthcare sector
Environmental costs in healthcare system: the case studies of Greece health care
No full textAbstract Climate change is considered one of the greatest threats to environmental sustainability, human health and social well-being worldwide. The healthcare sector is one of the main actors with a strong negative environmental footprint, being responsible for about 4% of global emissions, and is also considered one of the costliest sectors, with healthcare spending absorbing about 10% of global economic output. This article examines the environmental costs of the healthcare system in Greece, with a focus on public hospitals. The data analysis methodology was based on linear ordinary regression (OLS) models to calculate environmental costs related to energy consumption, waste management and water consumption. Data was collected through the Ministry of Health’s platform (BI Health) and analyzed using Stata software. The main findings suggest that environmental costs are a significant part of total operating costs, particularly in university and specialist hospitals. Factors such as the number of beds, the existence of special units (e.g. ICU) and the use of natural gas have a significant impact on environmental costs. The study offers a mathematical model for predicting environmental costs, which can help hospital administrators to make decisions about sustainable practices. This model could provide an important opportunity for practical application to make targeted decisions such as investing in sustainable technologies, improving energy efficiency and enhancing waste management, leading to cost-effective and environmentally sustainable practices
Inner Retinal Thinning Comparison between Branch Retinal Artery Occlusion and Primary Open-Angle Glaucoma
No full textPurpose: to assess the tomographic retinal layers’ thickness in eyes affected by branch retinal artery occlusion (BRAO) and to compare it to those of patients affected by primary open angle glaucoma (POAG). Methods: retrospective review of 27 patients; 16 with BRAO (16 eyes) and 11 with POAG (20 eyes) were identified among those who received SD-OCT scans, including analysis of macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), neuroretinal rim (NRR), circumpapillary RNFL at 3.5 mm and hemisphere asymmetry (HA). Results: the total IPL and INL thinning difference between the two groups was statistically significant (p = 0.0067 and p p Conclusions: unilateral inner retinal thinning may represent a sign of temporal BRAO, particularly for INL thinning and HA difference over 17µm in total retinal layer thinning. This information is particularly useful in the diagnosis of previous, undiagnosed BRAO and may help prevent further retinal arterial occlusion and possible cerebrovascular incidents
LRG1 Alters Pericyte Phenotype and Compromises Vascular Maturation
No full textUpregulation of leucine-rich alpha-2-glycoprotein-1 (LRG1) contributes to aberrant neovascularization in many different diseases. In contrast, LRG1 is not involved in developmental angiogenesis. Here, we investigated the vasculopathic properties of LRG1 by examining its effect on developing retinal blood vessels. By injecting recombinant protein or an expression vector into the mouse retina during vascular development, we showed that exogenous LRG1 reduces pericyte coverage and NG2 expression. It leads to diminished collagen IV sheathing, fewer adhesion and gap junctions, and reduced vessel calibre and vascular density. Moreover, in mouse retinae containing exogenous LRG1, the developing blood–retinal barrier remains more permeable with significantly higher numbers of transcytotic vesicles present in microvascular endothelial cells. These results reveal that exogeneous LRG1 is sufficient to interfere with the maturation of developing retinal vessels and drive vessel development towards a dysfunctional phenotype. These observations deliver further evidence that LRG1 is an angiopathic factor and highlight the therapeutic potential of blocking LRG1 in diseases characterized by pathogenic angiogenesis or vascular remodelling
