14 research outputs found
Impaired Metabolism of Selenomethionine in Graves’ Disease: A Biokinetics Study of Soft Gel Capsule Formulation
No full textAbstractPatients with Graves’ disease are known to have low selenium (Se) status, Se supplementation resulting in clinical and biochemical improvement. Selenomethionine (SeMet) in a new soft gel capsule formulation was used in a pilot study in 6 patients with acute Graves’ disease and low selenium levels (61.3±12.9 μg/l) before and in 4/6 patients 3 months after combined treatment with methimazole and SeMet 200 μg/day (113.3±46.3 μg/l), as well as in 6 euthyroid controls (82±11.8 μg/l). The biokinetics were studied following ingestion of 200 μg SeMet (single dose) soft gel capsule, Se serum concentrations being measured at various time points within 24 h. Se levels rose variably in all patients and controls. While levels peaked in all subjects following 8 h of intake, the increase was somewhat slower in acute hyperthyroidism as compared to 3 months later when these patients had been rendered euthyroid, this possibly due to derangement of Se storage capacity by SEPP or increased requirements in the acute phase of the disease, leading to depletion of the trace element. The compound was shown to be bioavailable and safe and patients treated for 3 months exhibited higher Se levels at the different time points. These findings are of major importance for sufferers of GD since they indicate that early Se supplementation, with its beneficial antioxidant impact on inflammatory activity, could slow, or possibly even forestall, the clinical progression of the disease.</jats:p
Timely and dose assessment of serum parathormone and calcium levels by cinacalcet in patients with primary hyperparathyroidism: an individualized approach
No full textDiagnostic accuracy of 123I-FP-CIT (DaTSCAN) in dementia with Lewy bodies: A meta-analysis of published studies
No full textElbow Hemiarthroplasty for Late Reconstruction of a Traumatic Elbow Bone Defect in a Young Patient
No full textConstitutional Advancement of Growth Is Associated with Early Puberty in Girls
No full text<i>Background:</i> Constitutional advancement of growth (CAG) is the growth pattern of early growth acceleration that has been shown to be characteristic in girls with idiopathic precocious puberty (IPP). The aim of this study was to examine the growth pattern of girls with early puberty compared to girls with IPP. <i>Methods:</i> We studied the growth pattern, from birth to presentation, of 61 girls with early puberty, of 40 girls with IPP and of 100 healthy girls with normal pubertal onset that served as controls. <i>Results:</i> Height SDS (HSDS) at presentation was significantly different among the 3 groups (p < 0.001). Girls with early puberty were shorter than girls with IPP (HSDS 0.63 ± 1.09 vs. 0.98 ± 0.95, respectively, p < 0.001) and taller than control girls (HSDS 0.05 ± 0.94, p < 0.05). By comparing the linear growth pattern from birth to presentation, pairwise comparisons showed that it differed significantly between early puberty and control (p < 0.001) as well as between IPP and control girls (p < 0.001), whereas the difference between girls with IPP and early puberty was not significant (p = 0.09). <i>Conclusion:</i>Girls with early puberty present the pattern of CAG suggesting that IPP lies at the extreme of the distribution of the normal timing of puberty onset.</jats:p
Constitutional Advancement of Growth Is Associated with Early Puberty in Girls
No full textBackground: Constitutional advancement of growth (CAG) is the growth pattern of early growth acceleration that has been shown to be characteristic in girls with idiopathic precocious puberty (IPP). The aim of this study was to examine the growth pattern of girls with early puberty compared to girls with IPP. Methods: We studied the growth pattern, from birth to presentation, of 61 girls with early puberty, of 40 girls with IPP and of 100 healthy girls with normal pubertal onset that served as controls. Results: Height SDS (HSDS) at presentation was significantly different among the 3 groups (p < 0.001). Girls with early puberty were shorter than girls with IPP (HSDS 0.63 +/- 1.09 vs. 0.98 +/- 0.95, respectively, p < 0.001) and taller than control girls (HSDS 0.05 +/- 0.94, p < 0.05). By comparing the linear growth pattern from birth to presentation, pairwise comparisons showed that it differed significantly between early puberty and control (p < 0.001) as well as between IPP and control girls (p < 0.001), whereas the difference between girls with IPP and early puberty was not significant (p = 0.09). Conclusion: Girls with early puberty present the pattern of CAG suggesting that IPP lies at the extreme of the distribution of the normal timing of puberty onset. Copyright (C) 2011 S. Karger AG, Base
Functional outcome and structural integrity following mini-open repair of large and massive rotator cuff tears: A 3-5 year follow-up study
No full textLinguistic translation and validation of the Menopause-specific Quality of Life (MENQOL) questionnaire in Greek menopausal women
No full textAdditional file 2: Table S1. of Suprascapular neuropathy in the setting of rotator cuff tears: study protocol for a double-blinded randomized controlled trial
Get PDFPatient forms which will contain preoperative and postoperative clinical signs and brief outcomes of neurophysiological and imaging studies. (PDF 667 kb
