191 research outputs found
Despre creierul femeii și alți demoni. Antologia textelor publicistice, Sofia Nădejde, (ediție îngrijită de Maria Cernat și Adina Mocanu) Editura Paralela 45, Pitești, 2019. : Sofia Nădejde. Of woman's brain and other demons. Anthology of Sofia Nădejde's published writings (eds Maria Cernat and Adina Mocanu). 2019 Ed Paralela 45, Pitești
No full textThis book review aims to highlight the significance of retreiving the long ignored contributions of Sofia Nădejde’s to the progress of understanding gender inequalities that are deeply rooted in our culture. Through the careful work of reshaping the original texts published between 1881-1885 in Contemporanul. Revistă Științifică și Literară, Maria Cernat and Adina Mocanu bring new insights into the genesis and the evolution of local feminist thought by critically situating it within the global feminist movement
Insights Into Clozapine’s Kinetic Interactions: Enzymatic Inhibition of CYP1A2 by Ciprofloxacin and Norfloxacin
No full textThis study aimed to evaluate the kinetic interactions between clozapine (CLZ) and the fluoroquinolone antibiotics ciprofloxacin and norfloxacin using a systematic three-step compartmental modelling approach. Clozapine, primarily metabolized by CYP1A2 and CYP3A4, is known to exhibit altered kinetics when co-administered with fluoroquinolones due to their inhibitory effect on CYP1A2. The proposed models evaluated the absorption, distribution, metabolism, and elimination (ADME) of clozapine and its active metabolite, N-desmethyl clozapine (CLZ-M), under both reference conditions and in the presence of these antibiotics. The selected kinetic models demonstrated a strong correlation between experimental data and predictions (R² > 0.96), providing robust insights into the mechanisms underlying these interactions. Ciprofloxacin and norfloxacin significantly affected CLZ\u27s presystemic and systemic metabolism, with ciprofloxacin altering relative bioavailability more prominently. These findings emphasize the necessity of dose adjustments for clozapine in clinical practice to mitigate potential adverse effects due to higher drug exposure when co-administered with fluoroquinolones. This study offers a mechanistic framework for understanding complex drug-drug interactions and optimizing dosing strategies in combined therapeutic regimens
KINETICS OF DAPAGLIFLOZIN 10 MG IMMEDIATE RELEASE TABLET IN HEALTHY CAUCASIAN VOLUNTEERS: DOES FOOD INTAKE AFFECT ITS DISPOSITION IN THE BODY?
No full textThe aim of the current study was to investigate whether food intake alters the kinetics of dapaglliflozin, a modern anti-diabetic agent, after single-dose oral administration of a new 10 mg immediate release tablet. The evaluated formulation was developed and manufactured by Sun Pharmaceutical Industries Limited, India, and the studies were performed in healthy Caucasian subjects. The data obtained during the fasting and fed bioequivalence studies were analyzed to observe the influence of food on the bioavailability and disposition of the evaluated formulation. Although differences were observed between studies concerning some of the main parameters that describe dapagliflozin’s disposition (maximum plasma concentration – Cmax, and the time to reach it -Tmax), they were proved bioequivalent. The 90% confidence intervals for the evaluated parameters were within the accepted range of 80.00-125.00% for bioequivalence conclusion, therefore the treatments are bioequivalent (dapagliflozin with/without food) and interchangeable. Hence, dapagliflozin can be administered regardless of food intake in diabetic patients
Gendered Life-Course Patterns in Post-Socialist Romania: An Illustration from Households Situated in Precarious Prosperity
No full textRomanians’ current perception of threat from immigrants in a context of co-ethnic migration: assessing the role of intergroup conflict and active/passive contact
No full textFood-effect study on the pharmacokinetics of indapamide prolonged-release tablets
No full textA comparative study was performed to evaluate the food impact on the pharmacokinetics of indapamide 1.5 mg prolonged release tablets (SR)
Numerical Study of the Bond Strength Evolution of Corroded Reinforcement in Concrete in Pull-Out Tests
No full textThe corrosion of rebars in reinforced concrete structures impacts their geometry (diameter and ribs) and mass, damages the concrete at the interface between the two materials, deteriorates the bond strength, and causes the cracking of the concrete cover. In the following study, a 2D numerical model of the pull-out test is presented in order to study the impact of corrosion on the bond strength. Several parameters are investigated: the embedment depth, the rebar’s diameter, and the width of the concrete cover. The model reproduces the slip of the rebar and the failure through the splitting of concrete. It integrates an interface between the two materials and a concrete damage model that simulate the deterioration of concrete in compression and tension. The results obtained are validated with experimental data from the literature. Moreover, a parametric study is carried out to determine the impact of the embedment depth, the diameter of the rebar, and the concrete cover on the bond strength. The present study confirms that a greater embedment depth increases the pulling load. The study also confirms that the rebar’s diameter impacts highly the loss of bond between the rebar and the concrete cover. Lastly, the final main result of this paper is that the width of the concrete cover slows the loss of bond strength between the two materials
Beyond Poverty in Romania: An Analysis of Household-Level Factors of Poverty and Precarious Prosperity
No full textBeyond Poverty in Romania: An Analysis of Household-Level Factors of Poverty and Precarious Prosperity. This paper looks at both poverty and a specific layer of population in Romania we call precarious prosperity with the goal of understanding the household-level factors that contribute to the likelihood of being in this respective category. Drawing upon the emerging literature on precarious prosperity, this approach is an attempt to look beyond measures of poverty that are limited from appropriately capturing the relevant economic circumstances of disadvantaged households. Based on the latest wave of available EU-SILC data, multinomial logistic regression shows that similar household-level factors like housing type, unemployment, household production and household type have an impact on the likelihood of being in poverty or precarious prosperity
THE PHYTOCHEMICAL ANALYSIS AND ANTIOXIDANT CAPACITY DETERMINATION OF FIVE HYPERICUM SPECIES
No full textMedicinal plants are a valuable source of lead compounds and novel drugs. The Hypericum L. species traditionally treats skin wounds, sciatica, and depression. Presently, only a small percentage of the Hypericum species have been phytochemically characterised and 60% still requires analysis. Ethanolic and methanolic extracts were obtained by ultrasound assisted extraction and maceration extraction methods. Polyphenols, sterols, methoxyflavones, hyperforin and hypericin were detected through HPLC-MS analysis. ABTS assay was used to evaluate the total antioxidant capacity. H. maculatum and H. moserianum had the highest antioxidant capacity. The most abundant polyphenol in H. humifusum, H. moserianum and H. miracle-pistache was chlorogenic acid. For H. maculatum and H. perforatum, hyperoside and rutoside were the most abundant polyphenols. Sterols and methoxyflavones were quantified for the first time in all the species. β-sitosterol was the most abundant sterol across all species and ergosterol was absent in all species. Hispidulin was the only methoxyflavone (in small concentrations) found in all species except H. miracle-pistache. Hypericin was absent in H. moserianum and H. miracle-pistache and was most abundant in H. maculatum. Interestingly, H. miracle-pistache had higher concentrations of hyperforin than H. perforatum. The phytochemical profile of analysed Hypericum species prove to be a valuable bioactive’s source
Selection of a Digitalis purpurea Cell Line with Improved Bioconversion Capacity of Hydroquinone into Arbutin
No full textThis study aimed to investigate the biotransformation capabilities of a hydroquinone-tolerant Digitalis purpurea cell line (DpHQ) for bioconverting hydroquinone (HQ) into arbutin, a compound with significant therapeutic and cosmetic applications. The research evaluated the influence of various HQ concentrations, feeding protocols, and carbon sources on arbutin bioconversion yield. By using HPLC-MS for the quantification of arbutin in biomass and medium, the study revealed that higher precursor (HQ) concentration led to a more pronounced growth inhibition under single dosing than sequential dosing. At lower sugar (3%) and precursor (4 mM HQ) levels, arbutin predominantly remained within the cells, whereas higher sugar (6%) and HQ (5–6 mM) levels promoted its release into the medium. Arbutin production ranged from 591 mg/L under single dosing to 3049 mg/L with sequential dosing, with the highest yield being achieved with 5 mM HQ in divided doses and 6% glucose. This study holds novelty for being the first to demonstrate the DpHQ’s tolerance to high concentrations of HQ and its efficient capabilities to bioconvert HQ to arbutin, indicating that D. purpurea is equipped with the enzymes required for this process. These aspects highlight its potential as a biotechnological source for arbutin synthesis
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