148 research outputs found
Sehnsucht, Verlangen und Schmerz : Begegnungen mit dem Wunderbaren in ”Der Goldne Topf” und ”Die Bergwerke zu Falun“ von E.T.A. Hoffmann.
No full text En grundläggande idé inom romantiken är den om att det finns en annan, sannare värld, som människorna kan ana sig till och indirekt komma i kontakt med. För den romantiska människan gäller det att kunna leva i två världar, att leva i den vanliga, vardagliga, samtidigt som man söker efter den andra, sannare. I E.T.A. Hoffmanns verk bryter den andra, ”övernaturliga” världen ofta in i den alldagliga. Så är fallet i berätteleserna ”Der Goldne Topf” och ”Die Bergwerke zu Falun”. Men trots att huvudpersonerna i berättelserna båda konfronteras med denna andra värld, slutar det mycket olika för dem. Medan Anselmus i ”Der Goldne Topf” kommer till ett underbart, poetiskt rike, Atlantis, går Elis Fröbom i ”Die Bergwerke zu Falun” under. I detta arbete analyseras och jämförs de båda huvudpersonernas möten med den ”andra världen” mot bakgrund av romantiska föreställningar och tankarna kring E.T.A. Hoffmanns så kallade ”serapiontiska princip”.
College Belonging: How First-Year and First-Generation Students Navigate Campus Life [Review]
No full textFostering a sense of belonging for students has long been considered a crucial component of retention and success for colleges and universities. However, there is no universal definition of what "belonging" actually is. In College Belonging: How First-Year and First-Generation Students Navitage Campus Life, Lisa M. Nunn (2021) delves into what it means for college students "to belong." Through student interviews during their first two years of college, Nunn explores how students define and experience belonging; in doing so, creating a new perspective on what belonging is and how students achieve (or are gifted) belonging.Johnson, C., & Gansemer-Topf, A. (2022). College Belonging: How First-Year and First-Generation Students Navigate Campus Life: [Review]. Journal of College Orientation, Transition, and Retention, 29(2). https://doi.org/10.24926/jcotr.v29i2.4869Copyright (c) 2022 Clayton Johnson, Dr. Ann Gansemer-Topf. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. Copyright of all articles published in JCOTR belong to the author(s) and are published under a CC BY-NC license. <br
The Power in Groups: Using Cluster Analysis to Critically Quantify Women’s STEM Enrollment
No full textDespite efforts to close the gender gap in science, technology, engineering, and math (STEM), disparities still exist, especially in math intensive STEM (MISTEM) majors. Females and males receive similar academic preparation and overall, perform similarly, yet females continue to enroll in STEM majors less frequently than men. In examining academic preparation, most research considers performance measures individually, ignoring the possible interrelationships between these measures. We address this problem by using hierarchical agglomerative clustering – a statistical technique which allows for identifying groups (i.e., clusters) of students who are similar in multiple factors. We first apply this technique to readily available institutional data to determine if we could identify distinct groups. Results illustrated that it was possible to identify nine unique groups. We then examined differences in STEM enrollment by group and by gender. We found that the proportion of females differed by group, and the gap between males and females also varied by group. Overall, males enrolled in STEM at a higher proportion than females and did so regardless of the strength of their academic preparation. Our results provide a novel yet feasible approach to examining gender differences in STEM enrollment in postsecondary education.This article is published as Gansemer-Topf, Ann et al. "The Power in Groups: Using Cluster Analysis to Critically Quantify Women’s STEM Enrollment" In Advances in Research in STEM Education, edited by Associate Kalogiannakis, Maria Ampartzaki. London: IntechOpen, 2022. 10.5772/intechopen.102881. © 2022 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Gefangen im eigenen Ich: Ein psychoanalytischer Vergleich von E.T.A. Hoffmanns \u3cem\u3eDer Sandmann\u3c/em\u3e und \u3cem\u3eDer goldne Topf\u3c/em\u3e
No full textThis thesis is a comparative study of two major works by the German author E.T.A. Hoffmann, Der Sandmann (1818) and Der goldne Topf (1819). Der Sandmann has been analyzed under the filter of psychoanalysis by Freud himself. The goal of this thesis was to analyze whether a psychoanalytical approach can be extended to other works by Hoffmann, showing the same underlying structures even though the content seems to differ widely between the two works at first glance. Der goldne Topf is the text that I chose to compare to Der Sandmann, as both texts tell the story of a student who is caught in a life between reality and fantasy.
Freud\u27s analysis of Der Sandmann is almost completely based on the role of the father in the text. The strongest difficulty in showing the same underlying motivation for the two protagonists, Anselmus and Nathanael, to choose fantasy over reality, death over life, is that there is no apparent father figure in Der goldne Topf. However, by interpreting the two texts on the basis of Freud\u27s psychoanalysis, it can be shown that a father figure is indeed present in both texts, even though it might not seem like it at first.
In chapter 1 of this thesis, I will give an overview over those parts of Freud\u27s theory, which will be of importance in the analyses of the two selected works by Hoffmann, namely narcissism, the oedipus complex and the analysis of dreams. In chapter 2, I interpret Der Sandmann and in chapter 3, Der goldne Topf is analyzed, applying the same theories as far as possible. Finally, in chapter 4, I compare the two works, and I show that many features of the texts can be matched up on the basis of this theory, including the role of the father. So far, Der goldne Topf has never been analyzed exclusively on the basis of Freud\u27s psychoanalysis before and, therefore, the findings of this thesis provide new insights for research on the two texts and on E.T.A. Hoffmann in general
Mitochondrial DNA diversity and origin of human communities from 4th- 11th century Britain.
No full textNeither the archaeological nor the historical data have yet allowed a full understanding of the nature of the Germanic settlement in England. Analysis of the genetic structure of past history has mostly been carried out by inference from extant populations. However, genetic flow through migration over time is likely to have altered the genetic composition of modem samples. Analysis of the genetic composition of ancient populations (provided the authenticity of their DNA is obtained) gives a direct sight into the past. Thus, mitochondrial DNA from pre-Saxon (4th century), early Saxon (5th -7th century) and late Saxon (9th – 11th century) settlements has been analysed to obtain a better understanding of the population history of Britain. A methodology has been optimised, by which, ancient DNA from 1,000-1,800 year old archaeological material was extracted and ~200-bp fragments of the HVS-1, amplified and sequenced. Rigorous controls for work in human ancient DNA were undertaken to prevent and recognise contamination. Established authenticity criteria were followed, including expected ancient DNA behaviour, internal replication of sequences and confirmation by independent labs. The sample size obtained has enabled a population-level study of communities of ancient Britain. In addition, an extensive database of >6500 mitochondrial DNA sequences was compiled for comparisons. Several estimates of haplotype and nucleotide genetic diversity were computed for modem and ancient populations. Counter-intuitively, the modem population of England, encompassing all successive waves of migration to the island, has a lower diversity than the ancient population, suggesting that diversity has been lost over the last millennium. In addition, mtDNA genetic continuity between ancient and modem England seems to have been intermpted. Founder analyses of early (5th -7th century) and late (9th -11th century) periods indicate that, whereas the late period seems to have had Viking genetic influences, the early period has no close relationship with Germanic populations. Instead, the females of the early Anglo-Saxon period seem to represent the native British population. The female contribution of the Anglo-Saxon invasion would have therefore been minor, at least at that time and at these sites. The close genetic affinity between the ancient British population and the northern most populations of Europe suggests they might have shared a common past during pre-history. It is proposed that, after post-glacial times, inhabitants of areas now submerged expanded to northern territories. The early settlements analysed reflect that very early expansion. Some time since then, reduction in diversity seem to have occurred (possibly due to variation in family size after repeated epidemics) leading to the present day mtDNA composition of England
The Ovenbuilders of the Holocaust. A case-study of corporate complicity to international crimes
No full textCorporate complicity in international crimes is a largely neglected phenomenon that exists on the border of the criminological study of international crimes and the study of corporate crime. In this article, the German corporation Topf & Söhne is analysed as a case study of corporate involvement in international crimes. Topf built the cremation ovens for various concentration and extermination camps in Nazi Germany. It is clear that existing explanations of corporate crime such as the urge to survive, competition between sub-units, corporate culture, normalization and neutralization are applicable. However, the extraordinary circumstances of the Nazi regime had a crucial influence on the motivations, opportunity and lack of control that caused Topf's involvement in the Holocaust. © 2012 The Author 2012. Published by Oxford University Press on behalf of the Centre for Crime and Justice Studies (ISTD). All rights reserved
STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39
No full textGain-of-function mutations on STIM1 and ORAI1 genes are responsible for an increased store-operated calcium entry, and underlie the characteristic symptoms of three overlapping ultra-rare genetic disorders (i.e tubular aggregate myopathy, Stormorken syndrome, York platelet syndrome) that can be grouped as tubular aggregate myopathies. These mutations lead to a wide spectrum of defects, which usually include muscle weakness and cramps. Negative modulators of store-operated Ca2+-entry targeting wild-type STIM1 and ORAI1 have entered clinical trials for a different array of disorders, including pancreatitis, COVID-19, cancer, and autoimmune disorders and, while efficacy data is awaited, safety data indicates tolerability of this STIM1/ORAI1 mutations are amenable to pharmacological intervention. If this were so, given that there are no approved treatments or clinical trials ongoing for these rare disorders, it could be envisaged that these agents could also rehabilitate tubular aggregate myopathy patients. In the present contribution we characterized the Ca2+-entry patterns induced by eleven STIM1 and three ORAI1 mutations in heterologous systems or in patient-derived cells, i.e. fibroblasts and myotubes, and evaluated the effect of CIC-37 and CIC-39, two novel store-operated calcium entry modulators. Our data show that all STIM1 and ORAI1 gain-of-function mutations tested, with the possible exception of the R304Q STIM1 mutation, are amenable to inhibition, albeit with slightly different sensitivities, paving the way to the development of SOCE modulators in tubular aggregate myopathies
Incremento del diagnóstico mas allá del análisis estándar del exoma en una cohorte de pacientes con LGMD
No full text[ES] La distrofia muscular es un grupo heterogéneo de trastornos neuromusculares. Muchos
pacientes presentan debilidad progresiva y desgaste muscular, y pueden tener una esperanza de
vida reducida debido a comorbilidades como la insuficiencia respiratoria y cardíaca. Dentro de
los diferentes tipos de distrofias se encuentra la distrofia de cinturas (LGMD, Limb-girdle
muscular dystrophy) cuya prevalencia se estima en alrededor de 20-40/1.000.000, frecuencia
probablemente subestimada por la falta de diagnóstico debido a la heterogeneidad genética y
clínica. En el año 2014 se propuso realizar un proyecto colaborativo europeo, basado en utilizar
la secuenciación del exoma completo en una cohorte de 1466 pacientes con distrofia de cinturas
sin diagnóstico, para ayudar a comprender mejor la etiología de la enfermedad y como iniciativa
de emplear esta técnica en el diagnóstico rutinario, proyecto denominado MYO-SEQ.
La tasa de casos diagnosticados después de cuatro años ha sido del 54%, estando dentro de los
valores esperados y observados en otros estudios. El objetivo de nuestro proyecto se ha centrado
en profundizar en el análisis de datos y comprender mejor la falta de diagnóstico en el resto de
pacientes, enunciando diferentes hipótesis explicativas: herencia digénica, presencia de
variantes intrónicas, papel modificador de variantes patogénicas y estudio funcional de nuevos
genes candidatos utilizando el sistema modelo Danio rerio. Para ello hemos analizado los datos
de la secuenciación del exoma desde la plataforma Seqr, integrando al mismo tiempo la
información clínica de los médicos de cada paciente obtenida del software PhenoTips,
permitiendo reevaluar los hallazgos clínicos, histopatológicos y de resonancia magnética.
Los resultados obtenidos indican la necesidad de profundizar el análisis en los pacientes todavía
no diagnosticados utilizando otras técnicas de secuenciación para dilucidar los posibles
mecanismos involucrados en la LGMD, para asegurar en un futuro un diagnóstico más preciso
y, por lo tanto, un asesoramiento genético y tratamiento que permita mejorar la calidad de vida
de estos pacientes.[EN] Muscular dystrophy is a heterogeneous group of neuromuscular disorders. Many patients
present with proximal muscle weakness and wasting, and may have a reduced life expectancy
due to respiratory and cardiac failure. Among the different types of dystrophies is the limbgirdle muscular disease (LGMD), whose prevalence is estimated at 20-40/1.000.000, a
frequency probably underestimated because of the lack of diagnosis due to genetic and clinical
heterogeneity. In 2014, it was proposed to carry out a European collaborative project, based on
applying whole exome sequencing to a cohort of 1466 patients with unexplained limb‐girdle
weakness, to help better understand disease aetiology and as an initiative to use this technique in
routine diagnosis; a project called MYO-SEQ.
The diagnostic rate has been 54%, being within the values observed in other studies. The aim of
our project has focused on deepening data analysis and better understanding the lack of
diagnosis in the rest of the patient cohort, establishing different explanatory hypotheses: digenic
inheritance, presence of intronic variants, genetic modifiers and functional work of new
candidate genes using Danio rerio as a model organism. For this, we have analyzed the exome
sequencing data from the Seqr platform, while integrating the clinical information of the
reference physicians of each patient obtained from the PhenoTips software, which allows to
reevaluate the clinical, histopathological and magnetic resonance imaging reports.
Our findings suggest the need to deepen the analysis in undiagnosed patients using other
sequencing techniques to elucidate the possible mechanisms involved in LGMD, to ensure in
the future a more accurate diagnosis and, therefore, a genetic counseling and treatment that
improves the quality of life of these patients.Casasús Tomás, AB. (2019). Incremento del diagnóstico mas allá del análisis estándar del exoma en una cohorte de pacientes con LGMD. Universitat Politècnica de València. https://riunet.upv.es/handle/10251/129808TFG
Empowering Professional Skill Training for STEM Graduate Students Through Active Learning and Inductive Teaching
No full textThe Graduates Advancing Professional Skills (GAPS) program, funded by the National Science Foundation, supports professional skills development in STEM graduate education. In traditional STEM curricula, technical knowledge is often prioritized, while key competencies such as project management, communication, and teamwork are frequently overlooked. This imbalance in STEM education can impact graduate students’ preparedness for various career paths in both academia and industry. GAPS course design combines active learning and inductive teaching methods, enabling students to apply professional skills directly to their thesis research through community-based experiential learning. In-class discussions, online forums, and peer feedback also facilitate collaborative problem-solving and reflective engagement. In this study, GAPS was used to evaluate the effectiveness of these pedagogical approaches. The study aimed to understand how these strategies lead to the development of essential professional skills among STEM graduate students by examining the incorporation of active learning and inductive teaching within the GAPS program. The findings reveal the impacts of innovative teaching practices on professional skills development in graduate education. They show that the GAPS program participants are highly satisfied with the course’s practical skill adoption and knowledge integration. Furthermore, the increased class engagement offered an inclusive learning environment. This experience helped the participants to enhance their professional skills, especially in communication, teamwork, and project management. The results help inform best practices for integrating professional skills training into graduate curricula and enhance the preparedness of students for both academic and non-academic career paths.This presentaton is published as Namodi, J., & Gansemer-Topf, A. M., & Kremer, G. E., & Li, Q., & Jiang, S., Empowering Professional Skill Training for STEM Graduate Students Through Active Learning and Inductive Teaching Paper presented at 2025 ASEE Annual Conference & Exposition , Montreal, Quebec, Canada, June 2025; https://doi.org/10.18260/1-2--56341This work is supported by the National Science Foundation under Grant No.1954946. Any opinions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. We acknowledge help from Emmanuel Owusu-Sekyere and Andrew Guhin for their assistance in the coursework and collecting data for the focus study group. We also thank Kathy Jackson for her assistance in evaluating the program and offering valuable suggestions
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