192 research outputs found
'The Next Attorney General' newspaper clipping, February 11, 1921
No full textPublished in the New York Times in 1921, written by an unidentified author, this news story discusses newly elected President Warren G. Harding's choice for Attorney General, Harry M. Daugherty. Lawyer and political insider Harry M. Daugherty served as Harding's campaign manager, despite his reputation marked by scandal and greed from his previous political dealings in Ohio. Throughout his campaign, Harding remained devoted to Daugherty and defended him to skeptics. Harding did select Daugherty as Attorney General, and he served until 1924.
This document is part of the Warren G. Harding Papers (MSS 345). This collection includes correspondence, business records, and other materials documenting Harding’s business career as owner and editor-in-chief of The Daily Marion Star, as well as the various stages of his political career. A significant portion of the collection, and what’s available on Ohio Memory, highlights his 1920 presidential campaign, spanning just before publicly announcing his candidacy to handily defeating Ohio Governor James M. Cox in the election. Correspondents include both Ohio and national businessmen, political figures, and ordinary citizens writing with questions, support, congratulatory notes, and campaign advice. Some of the most interesting insights into the tumultuous political climate in the U.S., the extreme factionalism within the Republican Party in Ohio, and Harding’s campaign strategies are described in letters between Harding and his campaign manager, Harry M. Daugherty. Some of the topics a
PERCEPTIONS OF INDIANA’S ENGINEERING/TECHNOLOGY EDUCATION CLASSROOM TEACHERS AS MEASURED BY THE CHARACTERISTICS OF TECHNOLOGY EDUCATION SURVEY
No full textThe purpose of this study was to determine Engineering/Technology Education (ETE) teachers’ perceptions of Project Lead The Way’s (PLTW) pre-engineering program in the state of Indiana utilizing the Characteristics of Technology Education Survey (CTES) (Daugherty, Hill, & Wicklein, 1996). The study focused on the perceptions of teachers who were and were not teaching PLTW’s pre-engineering curriculum as they related to curriculum content, teaching methodology, curriculum integration, and fit of curriculum in school environment. Two hundred and eighty two or 51.3% of Indiana high school ETE teachers responded to the 46 question CTES. Analysis of variance (ANOVA) and multivariate analysis of variance (MANOVA) were conducted to test for significance. The study found no significant differences in the perceptions of ETE teachers who were and who were not teaching PLTW’s pre-engineering program
3D multi-agent models for protein release from PLGA spherical particles with complex inner morphologies
No full textIn order to better understand and predict the release of proteins from bioerodible micro- or nanospheres, it is important to know the influences of different initial factors on the release mechanisms. Often though it is difficult to assess what exactly is at the origin of a certain dissolution profile. We propose here a new class of fine-grained multi-agent models built to incorporate
increasing complexity, permitting the exploration of the role of different parameters, especially that of the internal morphology of the spheres, in the exhibited release profile. This approach, based on Monte-Carlo (MC) and Cellular Automata (CA) techniques, has permitted the testing of various assumptions and hypotheses about several experimental systems of nanospheres encapsulating proteins. Results have confirmed that this modelling approach
has increased the resolution over the complexity involved, opening promising perspectives for future developments, especially complementing in vitro experimentation
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Night dreamer walks
No full textIn Night Dreamer Walks, the first eight chapters of a novel of the same name, John M. Groves imagines the predicament of a young Native American man living 8,000 years ago in Oregon's Klamath Basin. Beginning as a story to avenge his father's death during an unusual outbreak of tribal violence, the novel explores the protagonist's growing involvement in healing and witchcraft practices. The author crafts a prehistoric world by drawing on ethnographic accounts, indigenous mythology, archaeology, and contemporary Native American life. The journey of the protagonist, Night, to the ocean and back becomes a movement across the topography of greed, tradition, transformation, and morality
Pathways to Brain Aging and Their Modifiers: Free-Radical-Induced Energetic and Neural Decline in Senescence (FRIENDS) Model - A Mini-Review
No full textIn this mini-review, we survey the extant literature on brain aging, with the emphasis on longitudinal studies of neuroanatomy, including regional brain volumes and white matter microstructure. We assess the impact of vascular, metabolic, and inflammatory risk factors on the trajectories of change in regional brain volumes and white matter properties, as well as the relationships between neuroanatomical and physiological changes and their influence on cognitive performance. We examine these findings in the context of current biological theories of aging and propose the means of integrating noninvasive measures - spectroscopic indices of brain energy metabolism and regional iron deposits - as valuable proxies for elucidating the basic neurobiology of human brain aging. In a brief summary of the recent findings pertaining to age-related changes in the brain structure and their impact on cognition, we discuss the role of vascular, metabolic, and inflammatory risk factors in shaping the trajectories of change. Drawing on the extant biological theories of aging and mindful of the brain's role as a disproportionately voracious energy consumer in mammals, we emphasize the importance of the fundamental bioenergetic mechanisms as drivers of age-related changes in brain structure and function. We sketch out a model that builds on the conceptualization of aging as an expression of cumulative cellular damage inflicted by reactive oxygen species and ensuing declines in energy metabolism. We outline the ways and means of adapting this model, Free-Radical-Induced Energetic and Neural Decline in Senescence (FRIENDS), to human aging and testing it within the constraints of noninvasive neuroimaging.</jats:p
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No full textIFIT (interferon-induced with tetratricopeptide repeats) proteins are critical mediators of mammalian innate antiviral immunity. Mouse IFIT1 selectively inhibits viruses that lack 2'O-methylation of their mRNA 5' caps. Surprisingly, human IFIT1 does not share this antiviral specificity. Here, we resolve this discrepancy by demonstrating that human and mouse IFIT1 have evolved distinct functions using a combination of evolutionary, genetic and virological analyses. First, we show that human IFIT1 and mouse IFIT1 (renamed IFIT1B) are not orthologs, but are paralogs that diverged >100 mya. Second, using a yeast genetic assay, we show that IFIT1 and IFIT1B proteins differ in their ability to be suppressed by a cap 2'O-methyltransferase. Finally, we demonstrate that IFIT1 and IFIT1B have divergent antiviral specificities, including the discovery that only IFIT1 proteins inhibit a virus encoding a cap 2'O-methyltransferase. These functional data, combined with widespread turnover of mammalian IFIT genes, reveal dramatic species-specific differences in IFIT-mediated antiviral repertoires
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Beckett, Barthelme, and Vonnegut : finding hope in meaninglessness
No full textThis thesis is a study of the shifting philosophical trends in the works of Samuel Beckett, Donald Barthelme, and Kurt Vonnegut as representations of a greater shift from modernism to postmodernism. I have chosen to explore Beckett's plays Waiting for Godot and Krapp's Last Tape, Barthelme's short stories "Nothing: A Preliminary Account," "The New Music," and "Kierkegaard Unfair to Schlegal," and Vonnegut's book Timequake to see how each author seeks to find a new hope in the face of a collapsed causal system. This work is an examination of the form and content of each author's work as it pertains to their own philosophical standing and in relation to the other two authors' works. I argue that each author finds a different hope for humanity depending on their place among the philosophical trends during their time
Models of first responder coping: Police officers as a unique population
No full textThe term “first responders” refers to a range of professional occupations, including police officers, fire fighters, search and rescue personnel, ambulance personnel, and military personnel. Research by the present authors has developed empirical models of first responder coping, identifying 2 coping pathways with differential outcomes: approach and avoidance coping. The present investigation considers police officers as a unique group and measures the extent to which police officers differ from other first responders in coping behaviours following trauma, based upon a nationally representative survey of 917 Swedish police officers. Although the model of coping behaviours following trauma and the effects on well-being displayed several similarities between police officers and other first responders, there was compelling evidence to suggest that there are professionally bound aspects of psychological coping, resilience, and well-being that merit further exploration. Among police officers, for example, avoidant coping was related to worse well-being, and police officers reported greater consequence to well-being related to substance use than other first responders. The unique aspects of police officer coping in comparison with other first responder groups are explored
Neuroimaging measures of iron and gliosis explain memory performance in aging
No full textEvidence from animal and histological studies has indicated that accumulation of iron in the brain results in reactive gliosis that contributes to cognitive deficits. The current study extends these findings to human cognitive aging and suggests that magnetic resonance imaging (MRI) techniques like quantitative relaxometry can be used to study iron and its effects in vivo. The effects of iron on microstructure and memory performance were examined using a combination of quantitative relaxometry and multicompartment diffusion imaging in 35 young (21.06 ± 2.18 years) and 28 older (72.58 ± 6.47 years) adults, who also completed a memory task. Replicating past work, results revealed age-related increases in iron content (R2*) and diffusion, and decreases in memory performance. Independent of age group, iron content was significantly related to restricted (intracellular) diffusion in regions with low-moderate iron (hippocampus, caudate) and to all diffusion metrics in regions with moderate-high iron (putamen, globus pallidus). This pattern is consistent with different stages of iron-related gliosis, ranging from astrogliosis that may influence intracellular diffusion to microglial proliferation and increased vascular permeability that may influence all sources of diffusion. Further, hippocampal restricted diffusion was significantly related to memory performance, with a third of this effect related to iron content; consistent with the hypothesis that higher iron-related astrogliosis in the hippocampus is associated with poorer memory performance. These results demonstrate the sensitivity of MRI to iron-related gliosis and extend our understanding of its impact on cognition by showing that this relationship also explains individual differences in memory performance
Differential Effects of Physiological Arousal Following Acute Stress on Police Officer Performance in a Simulated Critical Incident
No full textBackground: Police officer response in a critical incident is often a life-or-death scenario for the officer, the suspect, and the public. Efficient and accurate decisions are necessary to ensure the safety of all involved. Under these conditions, it is important to understand the effects of physiological arousal in response to acute stress on police officer performance in critical and dangerous incidents. Prior research suggests that physiological arousal following a stressor differentially affects police performance – communication may be impaired, whereas well-rehearsed, tactical behaviors may be resilient.Objectives: In this study, we examine the differential effects of physiological arousal across three police skill domains: verbal communication, nonverbal communication, and tactical skill.Methods: A sample of Swedish police cadets (N = 17) participated in a critical incident simulation, which was a reenactment of a real-life incident that had resulted in a police officer death; the simulation included multiple calls, dynamic environments, and surprise threats. An expert rater evaluated the cadets across multiple domains of skill, and physiological arousal was monitored by continuous heart rate monitoring and measures of circulating cortisol and antithrombin taken before and after the incident simulation.Results: The simulation increased police officer arousal, as reflected in elevated heart rate, but this alone did not predict differences in performance. Greater increase in antithrombin was associated with better general performance, but a specific deficit in verbal communication as compared to tactical performance and nonverbal communication. Change in cortisol was unrelated to the skill assessments.Conclusions: Police officer performance during a critical incident simulation is affected by physiological arousal. The findings are discussed with implications for police officer decision-making and real-world performance
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