4 research outputs found
Mast cell secretory granule fusion with amphisomes coordinates their homotypic fusion and release of exosomes
No full textSummary: Secretory granule (SG) fusion is an intermediate step in SG biogenesis. However, the precise mechanism of this process is not completely understood. We show that Golgi-derived mast cell (MC) SGs enlarge through a mechanism that is dependent on phosphoinositide (PI) remodeling and fusion with LC3+ late endosomes (amphisomes), which serve as hubs for the fusion of multiple individual SGs. Amphisome formation is regulated by the tyrosine phosphatase PTPN9, while the subsequent SG fusion event is additionally regulated by the tetraspanin protein CD63 and by PI4K. We also demonstrate that fusion with amphisomes imparts to SGs their capacity of regulated release of exosomes. Finally, we show that conversion of PI(3,4,5)P3 to PI(4,5)P2 and the subsequent recruitment of dynamin stimulate SG fission. Our data unveil a key role for lipid-regulated interactions with the endocytic and autophagic systems in controlling the size and number of SGs and their capacity to release exosomes
Rab5 is critical for SNAP23 regulated granule-granule fusion during compound exocytosis
No full textAbstractCompound exocytosis is considered the most massive mode of exocytosis, during which the membranes of secretory granules (SGs) fuse with each other to form a channel through which the entire contents of their granules is released. The underlying mechanisms of compound exocytosis remain largely unresolved. Here we show that the small GTPase Rab5, a known regulator of endocytosis, is pivotal for compound exocytosis in mast cells. Silencing of Rab5 shifts receptor-triggered secretion from a compound to a full exocytosis mode, in which SGs individually fuse with the plasma membrane. Moreover, we show that Rab5 is essential for FcεRI-triggered association of the SNARE protein SNAP23 with the SGs. Direct evidence is provided for SNAP23 involvement in homotypic SG fusion that occurs in the activated cells. Finally, we show that this fusion event is prevented by inhibition of the IKKβ2 kinase, however, neither a phosphorylation-deficient nor a phosphomimetic mutant of SNAP23 can mediate homotypic SG fusion in triggered cells. Taken together our findings identify Rab5 as a heretofore-unrecognized regulator of compound exocytosis that is essential for SNAP23-mediated granule-granule fusion. Our results also implicate phosphorylation cycles in controlling SNAP23 SNARE function in homotypic SG fusion.</jats:p
Rule behind the silk curtain: the Sultanahs of Aceh 1641-1699.
No full textPhDThis thesis is about the kingdom of Aceh Dar al-Salam in the latter half of the
seventeenth century when four women ruled in succession: Sultanah Tajul Alam
Safiatuddin Syah (1641-1675), Sultanah Nur Alam Naqiatuddin Syah (1675-1678),
Sultanah Inayat Zakiatuddin Syah (1678-1688) and Sultanah Iamalat Zainatuddin Syah
(1688-1699). How and why these queens came to power, and how they exercised it, are
problems that have fascinated enquirers, prompting a range of comments and
observations, especially the assertion that the queens were mere figureheads, during
whose reigns the male elite (orangkaya) captured power. The Sultanahs were held
responsible for the erosion of royal power and the kingdom's decline in the seventeenth
century. Yet no in-depth study has ever investigated these claims. The main objective of
this thesis is to evaluate the received views on these female sovereigns. The thesis also
seeks to examine the origin, nature and impact of these Sultanahs. Female rule seems a
curious phenomenon in a Muslim state. Furthermore, in a largely patriarchal kingdom
such as Aceh, queens seemed to be strangely out of place. This unique episode in Aceh's
history happened when European Companies - the Dutch VOC (Veerinigde Ooost-Indische
Compagnie) and the English East India Company - were gradually increasing their
commercial hold and flexing their military muscles in the region. Indigenous polities
suffered increasing interference and pressure from Westerners. Most Malay and Muslim
coastal polities in maritime Southeast Asia fell into European intruders' hands. By
exploring the circumstances and arguments surrounding female accession, and
examining some key episodes that show how power worked in Aceh at the time, I hope
to approach a new understanding of how and why the male elite of Aceh placed the fate
of the kingdom in the hands of women, and with what effects
0002
No full textDAILY PALO ALTO TIMES. THURSDAY. AUGUST 36. 1909
We Furnish
The Medium ...
The Times dots not pester its prospective advertisers with over-much solicitation. We put that etrtcv-
alent of labor, and more, into improving the paper so
that business will come of its own accord. We reach
the people, and if you write your ads in a way that
"grabs holt" you cannot fail to produce satisfactory
and paying results.
Out of Sight, Out of Mind
It is a great mistake to imagine that the people
know you and ycu do not need to advertise. The public has a memory in such matters that is shorter than
the hair on a dog. It is too much occupied to notict.
whether you are alive or dead unless you continue to
beat your tom-tom and blow your own bazoo. The
people do not buy the bargains that were advertised
last month. They buy the ones that are going to be
put on sale TOMORROW. Every day you fail to
advertise, more people are added to the number of
those who conclude that you are dead or out of busi-
WHEBE TO EAT
-'
GAIaL
462 K
-r.-runN-G-ri n.r.t.iM.
AM> liYKlNC. WORK!
I The Greene gjj^gg^^
BOARDING gj* r'""""',' ^
Oil Waverley torort. Z
Vttomr 99BX. Z T*** Onoponj Haa the Oaly Vomt-
K.A.V. rlgh*. Mr*. R. O. Orwss-s Jl ***** ******** ******* m* !>-*->.
erty ladles ot riant-, flar* **.ty.
ntmnnttfmnmntmh*
•■- San Jose Abstract Co.
The Patterson
Mr*. J. W. Patti-v-aou.
sM lalv-T-sily Avruixe.
Rooms and Board
at ***» Wavt-rtey Hi.
Phoe* saox
I ELITE MARKET j
A. IL BteUrt, r-t^priVtor. J
I1.IBI 7. SIB iBivev-sity Av. *
laaiiBcted MsaU. Mo. 1 s-rsds
Rsnxs sad Bacon*. F1*h. 1'oal
try aad I-wllcsele*.
OB-aUel BtmtB gl*-,(>w-Q
Fald lp BIWBS9BB
mm Soar Almtrmrt Comspaaj BedidJxsg
T4 H. Pint to., BnmoAotm, OaL
University Transfer Co. {
ITl l-.lvcr.tty Aersae.
TttVHKh, as cram.
lurntturs moved la aad I
from Saa Praacla-* aad Saa J
J aaa Storag*. f
eeeeevsss.ws-aseseaas.e-e-e.ssss
| PALO ALTO CLEANING lOUS
Pt**>tfa I>ry Ivts-
vts mmA t'jrr*
• MoMiiily rowt-acis BB pat aaa.
Kt. 1-rMH-d- ssy-,
POPULAR
T A HO E
«*wt XT asd aa
Include* Steamer Ride Around
Summer Hints
Kat slowly. We koow It's dltt.-
ralt when eating Morwege's Cete-
! brated Iiuttamut Bread.
PALO ALTO HONK RARRRT.
Patents
•
$ 10 Trip from
Palo Alto
TV Beta gated oa regalsr
tralas Aagrut 37-1S. Retara
*. u goat 31st.
tJO I'P ASD CATCH *bKR*,\*
TAIN TROl-T
Ask Southern ParlRc Agent
for deUlled Information.
Scientific Jimcrican.
wUsrrT.'^aSrrrii V.rr,r.
Tto CJreat Kraptre Baltder.
Osorge H. Cnshlag. wrlUog In the
American Magaxlne for Septsmbsr,
ha*.a good dssl to say sbout rail-
ruadlag la this ronntry during *h*
l-s.i lea years Mr. Cashing knows
wbst he te wrlilag about, aad It U
vary laterestlag lo have hla) potal
aat v-rry clearly sad succinctly Jott
whsi. ts the Isst tea years, railroad
stock B-.aalp-.UUoB. purchasing and
balldlng of leases i-osd*.' election
sad ousting of railroad president*,
bsa really meant Of th* rise of
J. J. Hill, the president of the Oreat
Northern railroad, Mr. Cashing
says: "Prom hit office lo St. Paul.
Mr. Hill explored tbe world ot possibilities a&d det-tssd the daring
plsn of picking up the cotton ot
Alabama. Mississippi. LouUtana aad
Tessa, moving ll along tit* northern
boaadary. thi-oagb the north Pacific
roast porta aad down tbe long slant
lo Japan la lh* south Pacinr-
tropics tied together by way of th*
Arctic rtrrle. aa ta speak. A confer, ace with tttayvesaBt Fish, president of the Illinois CsaU-al— th*
ealy irsBacontiDeaui north-end-
south railway of the nation- and aa
agreement bb to certain through
rale*, aa.ur.-d Mr. Hill of his supply
nf ruttoB. Tho vUlt of fiv* Utile
brown men from the Nippon Yusen
KaUha carried those ships regular*
ly to Brattle and assured Ibe open
In* of Japan lo Ihe southern roll on
Irs.le—the completion of a traffic
t-faBBnel that waa lo cause commerce
lo play ahulllecork around B rr>*-ien-
ler's -ui«.re Between Dixie and Ihe
lead of cherry blossoms. Aad white
thst plsy was la progress the northwest aslght have a chance to grow
leisurely to mat arily- -all of that
WBB traffic t**» trv
"HanUagioa blinked la his tropical office, when he heard the news.
-cowled over the sndsclty of the
iiinic. and smiled ovsr Its folly
Ihen he forgot the Incident Thai
wsb sbout the only thing he could
do, for Hill had permanently employed the Japanese, ship*, hsd cob*
tracts with shippers snd bsd naihed
a through rate wholly Inconsistent
wllh monopoly of traaa porta tloa.
"Hard upon ths heels of the cos.
trad came the Spanish-American
war. Dewey la Manila, sad ths talk
thst enm-a«rc* follow* th* Sag.
Hill. Ibe empire builder, became also
tbe gentua of traffic forsslg6t. Ia the
popalar Imagination "
» l-i iil.M AtXUC-iTAjrT.
♦ , GILLARD G. IteWR
.'ll W. tsaata Clan. Ht-. Ssa Jess
. It HITINC. AIXpIMIM:
• AMI KX PKltTIMi
l~ta* *torsge strnm-ssaatlaaa.
' Hsrsss sad vsfalclss bought aad said
it I. 8*e*ps. 171 HamlllOB see.
The Times Office will do your
JOB PRINTING
At Reasonable Rates
I'Ml-vewHy
HiudsBis all o«*ar ths count-* wl
sit op and take notice of ths dropping of about oos hundred frash*
men snd sophomores by ths author!
flea at th* t'nlverslly of Chicago. To
the midway undergraduate hosta
thl* action does aot corns Ilka a halt
from tbs bla*. Thsy havs hsd am
ale warning, not oaly la the animal
report of tbe president. Doctor Jad-
ton. bat la previous dtemlasah- sad
re lection* It taay be doabtsd,
bowtivwr, whether ihe educators sad
Btndeat rommaalty ef the country at
large have bad a *ufOclently vivid
realltlag aeDse of th* true Inward-
Bess ot the poller of the Chlca-ro
t'nl varsity.
The aathorltlss of tli* university
mean bualsees. The main tent Is
aot ready to be swallowed np by the
sideshows, .and the ring matter* al
the former have the means of at-
t reeling attention snd attendance
The freshmea who an* no', yet con
vlBCed Of (hs bsneflta of Intellectual
com pell tloa. or who srs aot ears
that a college education Involved
something besides enlhuslsstle devotion to sthletlca aad drnmatl-a
am! fraternity life, will feel that
ther* U sortie force Ib Ihe argument
lor more work, more attention lo
booke and scholarship, thst lake*
the form of summsry eviction.
The t'nlverslty of Chicago Is big,
tbs late Doclo* Hani* r one* or twice
declared thai, bigness wss no crime
and Inst Sx great university eoald
grow v. Mill.... lo.. ring Its standards
and making Ihlng* easy for Idler*
and shirkers, President Jadson
proposes lo let quantity Uke care of
Itself and give .-aallty a Beoded fillip
Tads, aa be wrote In bU Ust report.
ro-M be done without waiting for
tbe aolo tloo of Ihe difficult problem
Of reconciling.coltnTe with tOAonty.
ot eoauterjictln- In Ihe lalereet of
| the hsmsaltlea aad of liberal leara-
Ing. the preaejns demands of modern life for tbe practical aad useful
l-srta of the curricnlom.
If the other iBsfllnllona . whose
malnlrntB are deserted or neglected
la favor ot sideshow* wUI follow th*
.-•.ample of ths Halverslty of Chicago li will aot ba ps-sasary for
their rlngmaatere io talk pstb-tle-
ally of resigning their Job* and seeking cheer and sympathy elsewhere
thaa among Ibe loo goodaatnred
pareata of apotled and Irrepressible
j eollege tnutha Chicago Record'
F ll-rald
I
H. He-i-imSfl -annot be called
oa* of tbe idle rich." He works
harder than hi* own locomotor**.—
Washington Krenlng S'ar.
Hew Attract..-. Aets.
Ailrs.-triMi act. very c-arioosly. Tha*
tf tbere were a men In lb* inooo snd
If be were like tbe uh*u on Ibe eenh
he woald Is* ahte in lenp nrers tbre*
si-r.e-d IXCSJ-e Willi ae ■Ullt-b ".-.t-e SS
I.i.in—r *ifii<i*a ...er a
... -...
. ,-■■>
tn *-. of a irs.ildii btiug uio-cb lea*
*1 lis* *•*->>.-- -urface ilssa st tbe
•*rt i. * An ek, **<-,( tl *-c, i,.i.l bs
bb ■_.. : I--ml a> la* d--r b-c-r- A
boy iLrt.alng alitas* SUlgBI i-aaily laud
tbem In an ndjulnlixg rxtsoiy. Un ilse
otbrr band. Itw m-erae of ail ihi-
aoui.i a-appea lu Japller or tislum.
Tbey being so murb greeier Ibsn tb*
esnh ii.vir -iiirstllfiu woeM so li»-
scsrrely In* slilr in i-rswl. and lni_v
animal* would lie crushed by- ibelr
own vrtrlghl.
la llta Land sf Wi ltd mil Is.
Tbe Iluli-ii wben Ibey ln.lt.- yotl.
aad loey are oot a gtiest aeeklag rscv.
ar* extremely Enatpilable aud make
yea at .*o> -v Wvat-vtur. Soiortiu>e-i.
howevar. wbeu ll i-iiumw lo dluoec.
Ibelr Brtt-e t*.»|.|lsilly deu-aods SB eo-
erretlc re*^-gult*oo. The table I* laid
Wltb pile* Ot* plate, before rfh cbalr.
Oa yoar Bret t lalt tbe s|.-tni* aad fork,
are hasty silver. Ibe kolree at th*
0-rr.t *lc*t aod Ivory. lou never,
boweter. eel wlib tbt-m again. Wbea
yoa hare tun. shown tbat a family
poet, sirs tliiui tbst ends It. Yoa est
thereafter from everyday ware
"Wbat woald tbe silver ts- like for
oar dr-awitdBi.t- If we used It often y
aa old ls.li n.Levl me. "What would
we bsve if oar spi-ralors bad bt-rii
carelesar-IiiB xl.dd.u la Us-per's
A Cwr.sa.ly In a.undariat.
Ab.Mii itsj yaixls fr..m ibe sutloa at
Urr-M-aux. at Ibe rro**-rt-i-da Irom
Ottdtuaidt lu Itosbsli. os tie way
troot Toaraal lu M.^ias-toti. tstrre Is*
dlrv-ctlag t*-*t sblch from a tuta-grai*b-
ac-al point of view Ib b .-urioalty. ThU
post mark* the -a-rwrstt.w'1-Hwees tbe
two cx-satrles. Fraoc* aad Hrlgtam;
three pnrton* or dctiartnu-ot*. Le
Nurd. vreate-Ti Plamlers and H.luault;
three li!.i...|.ni■*. Caralirsl, Darg-* sad
Tournsl. Itirit* rapes dwell arvutKl II.
a|-raklng Ibree lauguagee. Kreiirb.
lie.iii.i. aud Willi,.ii it I* also In
three rvminanee, Wsiirelos. Bersesas
SBd Katslini.liiB -l^.iiili*o Olobe.
Ths Only Wst ts Knew.
C*ll*erltie b.«i B.k.il so many iiuea-
tloo*, aad fataer waa growing lm-*-
Oent. Plnsily be **ld. --tjb. t^iberUrv.
I caa't satwer belf yoar .-aMStl-aas.**
-*l kaow yoa • *n t. fa I ber. bat tbea
I do sot
aaswer."
Nt4tlier P*lrts Nse Wlss.
Mrs. Trtlin-lt *-.-.-| polite to tare
yosr back oa p--optc
Teilltt-lt l-ni si*, ritlier. aalees
■Wa are ea-e that yoar .' .-. 1* but-
ion.il in tb* limit Think lUai over*—
Chlcsgo News
SaolUry In.traction la more Important Ibsn ssniury lcrt*latlf.n -Deet.y
MANZANITA
HALL
*lt*alot-d sad Wilson Aveswss.
A srhool designrd to
give l*t-y* a titorx-dagfa prap-
ontmtm tot college or baal-
Indlvldaal sUeextloa bj eg-
p. Henced men tesvehers
make for rapid sdvanci--
it-d-r'. Omde work for
y*-*sger t-oya U ta rliargt-
■ ■f B
Ht-vewi*-swih ytmr f-*tr-txs Aagw-4
80. IBrt). fat-Joar*e -eat on
W. A. SHEDD
III \H MAHTKIt
WATERLESS BAIrllNG.
A Os*d Hub and a* Air Beth s Suh-
st.tMt. Par ihs Tub.
The CviMjUl.rfit BBd cvioxeiilioas of
oar clvQb*iilito drnxasil fr-*qa*ui bsib-
tBg It Is l-l.sl.rly suii—a-.| tbat IBS*
freijueoi lasihlug |e ext*>*-iiiUi lo MsltB-
-Tbts te .julie aoirvte mj* ibe Medical Journal *Vtr tsie -#ea B** aat!
vt-v-*n--is ...eo aimiag ia*- nahiiiuts ef '
Csnsds *Bo bsd eever uuu a fail
bstb IB ibelr Uvea Were the tratb
known, many tbrtaeaacte of oar feilow
riilteos probably know, ootblag of las
altt-w-d t-eneuts of ibe lab. ibougb
maiuialnlDf ai-elleBl average health.
"Bocb people do not preset* i tbs
fresh sud piesBlng appesraore of lh*
flreiiiMai tMiber, bowerer long llrsd
tbey may Its. Is aot. however, roach
of the i-'iiri-i atlrlbui-d lo lh* water
ta reality das to tbe coropieie exposure
of the afeln to lbs airT
-The respiratory fuoctloa of the
•hla te of blgb imporiar-ce. and. ai-
tdMagb watsr oxay be dl->p*ae-d wits,
rhilag the pores ta sir woald r-soit
lo apeedy aapl-yxUlloo Tae bhtforlc
laaUBce of the boy wbo Imtwrtrocaied
John lbs lUptut U a a-*-dlae*sl t-ro-
ciaalca aad wboae hsdy waa covered
with gold tear with rapidly fatal re-
salts U proof.
-The tee rotd la-lb te a aupertUtion:
it te a paHlt-xe for the abnormally
vlgo-uus. not deslrsbl* for tbe average
civilised tii.ii. a l-aib i."i loo f-3*W la
really so sgrrvsble atlmoisnt as well
as being* luxury. Tb* feeling of well
being after s bath rea hardly be ob-
lalnc-j lo mi) olber way. Bad tbs
rapid mall (plication of tubs la ttotrla
sad private rraidearv-a. aoon lo ap-
proacb one to toe ladlvUaal. shows
bow tbey srs apf-*---*ai*d.
-Uahsppy ptnooa. however, *bc*e
travela In Ibe pruvloi-t-x or lato ihe
deeert msy temporarily deprive tbeta
of aafflcteoi water for bstblag may
and a sobetltsie Ihst wfll st Mat gf-
ford a psrt of thrtr seeaai**-n-r-d eo-
J*yta*ai. Tb* body may be riier-.-i-
kslly rebt-rd wltb s bra*b or t-osrse
TarkUfa towel and sfirrward exposed
to lb* sir for Ofleen inluoi-s or so
Tbe ai. u.ii.me.1 feeling of rlf-or will
follow aud Ibe protwss will be fonod
by Ibe anlnliuied lo be ssionlstiiagiy
cleansing " ^^^^^^^^^
A STRANGE TRIBE.
Th* Tbuscsqs. Is When- Tlmbulrte
Owee It* Origin.
A recent eiplore*. Joureeylag from
Tripoll serous ih* .great dee-rt of Ba-
I bars, gives sm-asi of mecb o*a-*al-
Ooo to bis i*-*grtes oBered by tb* vs-
rtoos wsiideting tttbn. Mach of ths
-start sertca* troob-r was .-Based by
Ibe Toutn-gs a strauge band ot r-et-ple,
SB|atos*d bj tomt to hare dew-roded
from the cr-**ad*rs. ~~a*st- dtrrilera of
the desert are dl*tii>gul*t*-*d try tbe
wearing of Telia, a rast-t-B wbtro bss
csused much dlscussioo. Mays Pell*
DoImIs Ib -Tlmbuatu tbe Mysterloa*-.-
As yotl travel an aliWMpbere of at-
rrery borer* over ta* country, sad yoa
remember ibal tbeee mysterious Tons*
•fega are stJII nwmeotsrtly tu opprea*-
or* sad anatara.
These pe-rpis keep tbetr eye* from
the eireeslTe glow of Ibe desert by
two veils, oa* rolled roaad tbe temples
• atjaaafalllng do-en lo front, the otber
X ' reaching from the nostrils to the edge
♦ of tbe rlotblag. rov-rlsg the lower
X * parr of the face Savant* seek all
e , a-aaax-r of farteti bed origlas lo eg-
| pteln ibis cwaioni Hygls-ae te oarrteos-
| ly tbe only -satire. This hi protstJ try
' tbelr.owo stairinei.is asd hy the ss-
bricjort. -isoaths for Bies."* wblrb tbey
give lo all wbo do oot wear tbe veils.
TI*--* veils ar* never rei-Mit-ed. even
at nwslllmea, Tbey ar* so much a
part of tbetr wearers Ibal soy one deprived of such entering is unrecog
nixed W hla friend* nml relatives. If
S nvmber of the tribe stmuitl be hilled
Id i* it-i«* in* one c.tiiii Identify tbem
If I hey bsd oof oa their veils
Theft te Ihe Tf-asreg-s natural form
of Indhstry. "Thai word." says a na
tl-* prvwerb. **te like wsler fallen apoa
•aad. after to' be found again " Tb*
BadsBewa term tbem aa "ibletr*.
hyena* shd ststbdoaed of Ood - TM.
to this at-sag* tribe 'nmbokta owes
ttt origU _______________
The Feree et HsMt*
Oa*' of ibe camper, bad doae aoaxe-
tblag prr-alteriy tdiotk. aad law deaa
said* "I'lck reminds me of 1 bon-af
eoH." _
-What Bt-ooi Tboinaa' coltr asfM
Dtek ebeerfolly.
"Why." ibe dean >-**pooded readily,
■wbetp I lived In Maine wben I wss a
boy sn old man i>*iir*vl Thorns* rat*t_
horse*, lie oar* pat oat to pasture s
roll whlcb bsd lieeu fed from lu birth
la B box stsll sod wsiered st Ibe
troagb lo the yard.
--Tbe |*.tore Uy ai-rosvi . a aoMll
:
a tw
fi«
POR im:si
Severs! Bit* ranches Also S*V-
eral ran' h'* for sal* Bear PbIs Alto.
A1*o raaches la sdjolalag coflnUt*.' nver. sod in ibe middle of tb* day the
both for fsrailag aad stochraislag r roil swam ibe atr-atn to go op lo li
PROr-CSSIONAlV
S. W. CHaMOES
FRmERICK SCHNEIDE R
ATTORl*xTYS-AT-LAV
Simkin tinikling Palo Alta, Cal.
1-OIK.KHS, tDOTH *un>
X diiaai'at|s at latw
* Noury pahlle la aaat
t Pbaae tliK. MsdlsoD-Th*iaa
* block. Palo Alio, Cal.
NMMAN E. MALCOLa,
ATTORXBT AT LAW
ROTART m-RUC
llrst National aakak VAnU
Pal* Alt*. Offlca phoae IMS;
DBS hiIK.
JOB. L iraBtTUssW
Attoe-aey al Law
Telephone I04K. La.
ibaildlnfc, Unlvsralty avt
\ Pslo Alto, otr.es ko%*-s U ta 9
DENTISTS.
*_•
Gto. Bldkciky Lmk
DIWTBT
Palo Ah*. Csl.
Harry C Reynold*
DENTIST
Nevada Rurrd,raj Palo Aho
Hoars 9 lo is sad I :-***»
IHL THOU P. HAMMOND
lac eea* nr la Dr. Mefa*-rr*
Hoam I lo II l a. sad 1
it I p. a. Ledysrs, 1
Mtsia
Mrs. Valeria fanta
grsdnste ot the Vienna
tory of Mnttc, and for as*
pupil ot Profsasor Wadai
wlshsa to or-*nl*# a rotmS
Rstee, |l per moBth, oaa twssoa a-ar
weak; til per month taa f
psr weak. Ppr farther |
Inquire at tha *todlo, III WM
tt***L Phone 4I4K.
dfivlf-s Gertrude N. Brt~*im
Vfaeta CTLtUM
it.Pnok Kdjrtart TsSBa
Owartaw atta* New
Tsar* Varsl I s*f HSW.
*.■! Ds.n* S.j-s.11-.. I 2TU.
4iaC-sa*amM.,ssMljBivw*iv A*e.
-tDtTCAl-lORAL.
CASTILLRJA SCHOOL *-<rR
GIRLS open* Augtitt 30, l*vaw.
(Jradusle* are admitted to rJla-tftara*.
ths I'nlversltr of Calllorals. WaDaa-
I*y ami Hn.llh. Oesldss the rtsjhlBwl'
piano aad vocal work, .a new cawtm
la Music which will msct rr'fii Rj
r-rqalr*m*nia ks* been added t* thsr *
high achool rar-leataai. ■ A *«■■
Sdeoce dsiatrt-ssat has aha*
beea addsd. eMhodytag a fo»r jom*
coarse la cooking aad sevriag, aatat
leading to t'olverslty credit. ■**>-
rial one-jeer coareaa for sdsRs asaf
pupils outside tbs school are t-aaag-
forrot-d, and * roa-BS la rJ*asa*sT
Csh rookery will be given. Tto
iwer School (grammar. Inl*traa
dial* asd primary departments) Is*
open to boyt aad girls. Appt-rta**.-
m-BU with Mtaa l*ock
llryant street msy be mads by ttajV
Phoas &*tX.
i ■ >i- -Mi
Several i*l-e rol'sges. from foai
lo lea rooma. in Palo Alto-
good bsrgslDs right bow.
I - .i: RKHT.
t*r*n»r*d for s Brisk of wsiee."
k*r 1*« Mlaa Rge**a
•a a das* far Saa>
' ta advaao* nttnto
Is-iiih as B**A*n In tt****.
1 ma.t confess la -wseing tbsl sfier
I lifetime a-a-ni o-too' LnglUb I bad
I nearly a* marb dllBf-eliy wltb Ihat lao*
r n to Hi room hoaaea, far* guaa*- -a* sbe te spoke" a poo ibe'*
nlehnd or unlurnlthed.
A f-w nlra ptocss of screags IB
the Joaquin country for r-ssidenee
property la Palo Alto.
POR i xi ii \m.i:,
Any one Booking the shove properties will do well to call sod uih
with
HKHrTH A 1WAP.
lOOxllO-foot lot. with S Ms-room
hoes*, with s aatsll boas* always
reatad. ThU te a corner lot sat. csa
bs boaght for 11,11*. Por lofos-
mstloa. S*o
t, n. Min,
Wr-rec. Palo Alto.
BtreetB of Lot-dmi by the common peo-
plh a* I **xd with P-eacb and I'erman
tn I'srl. sad li-rilu Tbr roost popo- .
lar -en***ti.-tisl Joxinial of London at I
the Dally Hall. Tbey esll It (be Oily
Mile. Usny otber w<--ilse-eec|tially aa-1
i-v-ognlralile l_.iitd.in Letter lo ttr-tisg. ,
tteld iMsss.i R-tmMleatt.
A Never PsiliHg *upy»y
Tbt food be«U.od ws- -u*Hng Me '<
wife »ff wltb Ibe rblwr- for tbetr \
v*e*llon la the *-**Bir- Aa age get j
toxo the li-aln be aald. *Hni. sty dear. '
weoi yoa take ->n-e b> itt-n io resdT*
-Ob. ivor sbe r*-dt*i-aded «we-*tly. *-|
shall d*-petid ape* year l-tiee. fraag i
■te.*riw---l*c*r-t**i ISiler
Aboat September
Ingraham win opes ■
bcglaaers slightly Is
klBdergartea age. Sh* haa haa* a>
auccs-asfal ex-*..eB-e ab a tesv-*s«r as*
Utile chlld-rs. aad ton InrtmU tto
best of ref*r*a-a* Hoar* ft t»
1*;3«: terma II per school ataaah.
Interviews srrsagad by **>*txh«as
IT1R1.
" jm. KiHtttauiAttrmt.
< U\m ALH3B JAtJ-UtON
wlll reopen -her klodargartaa t-JJssav
August t*. !-•• At Raaas fraaa
3 to 5 p. r*. at 1031 Bryaat •***-*-**,
Appolnts-eal by Ulephoa*. BwB*.
MRS. BTOWRt
♦***♦*> *-***
tcuom*
Ht-ewt. '
her 1st. PTt-aary aad Orasa-
axsr grades ladl-htaaJ ha
