179 research outputs found
sj-docx-1-tag-10.1177_17562848211068659 – Supplemental material for Risk of consecutive immunogenic failure in switchers of anti-tumor necrosis factor alpha among patients with inflammatory bowel diseases
No full textSupplemental material, sj-docx-1-tag-10.1177_17562848211068659 for Risk of consecutive immunogenic failure in switchers of anti-tumor necrosis factor alpha among patients with inflammatory bowel diseases by Henit Yanai, Bella Ungar, Uri Kopylov, Tali Sharar Fischler, Irit Avni Biron, Jacob E. Ollech, Idan Goren, Manar Matar, Tsachi Tsadok Perets, Raanan Shamir, Iris Dotan, Shira Amir and Amit Assa in Therapeutic Advances in Gastroenterology</p
sj-docx-2-tag-10.1177_17562848211068659 – Supplemental material for Risk of consecutive immunogenic failure in switchers of anti-tumor necrosis factor alpha among patients with inflammatory bowel diseases
No full textSupplemental material, sj-docx-2-tag-10.1177_17562848211068659 for Risk of consecutive immunogenic failure in switchers of anti-tumor necrosis factor alpha among patients with inflammatory bowel diseases by Henit Yanai, Bella Ungar, Uri Kopylov, Tali Sharar Fischler, Irit Avni Biron, Jacob E. Ollech, Idan Goren, Manar Matar, Tsachi Tsadok Perets, Raanan Shamir, Iris Dotan, Shira Amir and Amit Assa in Therapeutic Advances in Gastroenterology</p
Waterproof Manado: Life must be safe and secure, not only today but also in the future!
No full textManado City is growing, its population is increasing. This demands the city to grow outside its borders and even into the sea by using land reclamation. Introducing new challenges or making challenges bigger, which are already present. Not only growth is present in the city, going forward and becoming better and better is an on-going fight for cities. The city came up with a vision “Manado, Model City of Eco Tourism” and a mission “Make Manado a City of Happiness” for their future. Introducing a study on this subject and to anticipate on the city’s goals, the research question is stated as; What are the options to supplement Manado’s vision and mission, making the city more safe and attractive for tourists and citizens? Within this research, two other challenges regarding Manado city will be investigated as well. In the year of 2003 a major flood occurred in the city, causing great damage to the city with many casualties. Nowadays, the risk of flooding is still present. Secondly, a challenge arises at the border of the city . The coastline of Manado suffers from erosion at specific locations, possibly caused by development of the reclaimed land in the past. Narrowing the research, an analysis will be made upon selected subjects. Analysing the coastal protection, river floods and the city’s Vision and Mission gives a clear view of the current state and what could be expected from the future. The goal is to come to a sound idea of the needs and possibilities related to coastal protection, Kota Manado and its Vision and Mission. Working towards advices, different time paths and desires are noticed. Besides recommendations, which can be adopted at any time, found solutions are divided in short, mid and long term time spans. On short term the rivers and garbage have to be handled and nuisance of either one increases day by day. At many places the river is blocked. Removing these blockages is a good start. In addition, the embankments and beds can be ‘smoothened’, to improve the river’s flow. Besides the river attention on the short term, garbage clogs up the city. Waste Management Control is already improving. Clean ups have to be supported by the government, giving a good example to its citizens. By these measures a start is made to work towards real solutions, coming to an Improved Garbage Service. As mentioned before, improving the Waste Management Control is a continuing process. Besides the short term, this solution has a mid-term basis too. By adaption of the 3R-principle, garbage will be even less. This principle represents the Reduction, Reuse and Recycle of materials. The amount of waste will reduce and the city will be cleaner, although it will take a while to adopt. Measurements need to be coordinated and monitored. Making so-called Pre-Project-Planning gives benefits to make them successful. This should not only be used in this case, but also for regular Civil Engineering projects. Erosion is another problem Manado City is facing nowadays. However, its effects evolve more slowly and are thereby less noticeable. The coastline of Manado can be divided in three sections. Section one consists of the Southern part of the coastline and the municipality is already undertaking action to stop the erosion. The adopted measures are well designed and thought through. Even on places where there’s little area to construct a protection, the chosen measure could also be used.Section two is located near the boulevard area. Large land reclamations are constructed along the shore. The reclaimed areas are well protected by big stones and do not suffer from any erosion. These large land reclamations, however, do have side effects. One of them is the change in the current, leading to a flow towards the ’Bunaken’ coral reef area. This flow transports a lot of sediment, dust and garbage and killing a lot of fish and coral. So, for future land reclamations, an investigation into these effects must be done if the city really cares about its environment and wants to prevent it from destroying. Section three is situated in the North of Manado. The protection of the northern coastline consists of vegetation and Mangroves. Due to certain changes in the past, among others construction of reclaimed areas, part of the northern shoreline started to erode. The continuing process of erosion can be resolved on a mid-term base. With solutions like, for instance Mangroves, it can stop the erosion and improve the environmental value of the coastline as well, leading to an eco-friendly solution. A sustainable future for the city of Manado is obtained by their vision “Manado Model City for Ecotourism” and mission “To Make Manado City a city of Happiness”. The government cannot do this on its own. Involving and, most important, convincing the local community of the vision and mission will speed up the progression. This combines the short and long term philosophy. On short notice the local community has to be convinced and at the same time, the long term vision and mission can be fulfilled too. Manado City has a great amount of opportunities to fulfil their mission and are they are well available. Even small improvements can make a change. A good example to use the opportunities and to anticipate on the mission and vision of the city is to construct several parks or a beach in the centre of town. A park or a beach can be created to attract not only tourists but also local citizens. For tourists, including divers, it will be a welcoming relaxing spot to comfort their stay in Manado. So in this way it will give the mission and vision of Manado a tremendous boost.Hydraulic EngineeringCivil Engineering and Geoscience
Exclusive enteral nutrition for inducing remission in inflammatory bowel disease in paediatric patients
No full textFinancial engineering in pricing agricultural derivatives based on demand and volatility
No full text© 2016, © Emerald Group Publishing Limited.Purpose – The purpose of this paper is twofold. First, the author proposes a financial engineering framework to model commodity prices based on market demand processes and demand functions. This framework explains the relation between demand, volatility and the leverage effect of commodities. It is also shown how the proposed framework can be used to price derivatives on commodity prices. Second, the author estimates the model parameters for agricultural commodities and discuss the implications of the results on derivative prices. In particular, the author see how leverage effect (or inverse leverage effect) is related to market demand. Design/methodology/approach – This paper uses a power demand function along with the Cox, Ingersoll and Ross mean-reverting process to find the price process of commodities. Then by using the Ito theorem the constant elastic volatility (CEV) model is derived for the market prices. The partial differential equation that the dynamics of derivative prices satisfy is found and, by the Feynman-Kac theorem, the market derivative prices are provided within a Monte-Carlo simulation framework. Finally, by using a maximum likelihood estimator, the parameters of the CEV model for the agricultural commodity prices are found. Findings – The results of this paper show that derivative prices on commodities are heavily affected by the elasticity of volatility and, consequently, by market demand elasticity. The empirical results show that different groups of agricultural commodities have different values of demand and volatility elasticity. Practical implications – The results of this paper can be used by practitioners to price derivatives on commodity prices and by insurance companies to better price insurance contracts. As in many countries agricultural insurances are subsidised by the government, the results of this paper are useful for setting more efficient policies. Originality/value – Approaches that use the methodology of financial engineering to model agricultural prices and compute the derivative prices are rather new within the literature and still need to be developed for further applications
Anti-TNFα treatment after surgical resection for Crohn's disease is effective despite previous pharmacodynamic failure
No full textBackground: The outcome of patients with Crohn's disease who failed anti-tumor necrosis factor alpha (anti-TNF alpha) therapy despite adequate serum drug levels (pharmacodynamic failure) is unclear. We aimed to assess such pediatric patients who underwent intestinal resection and were re-treated with the same anti-TNF alpha agent postoperatively.
Methods: Pediatric patients with Crohn's disease who underwent intestinal resection and were treated with anti-TNF alpha agents postoperatively were assessed retrospectively. Patients were stratified to those with preoperative anti-TNF alpha pharmacodynamic failure and those with no preoperative antiTNF alpha treatment.
Results: A total of 53 children were included, 18 with pharmacodynamic failure and 35 controls. Median age at intestinal resection was 14.8 years with 23 (43%) girls. The median time from intestinal resection to anti-TNF alpha initiation was 8 months (interquartile range 4-14 months). At the time of postoperative anti-TNF alpha initiation there were no differences in clinical, laboratory, and anthropometric measures between groups. Similar proportions of patients from both groups were in clinical remission on anti-TNF alpha treatment after 12 months and at the end of follow-up (1.8 years, interquartile range, 1-2.9 years): 89% versus 88.5% and 83% versus 80% for pharmacodynamic failure patients and controls, respectively; P = 0.9. No significant differences were observed at 14 weeks and 12 months of postoperative anti-TNF alpha treatment including endoscopic remission rate and fecal calprotectin. Both groups significantly improved all measures during postoperative anti-TNF alpha treatment.
Conclusions: Pediatric patients with Crohn's disease who failed anti-TNF alpha therapy despite adequate drug levels and underwent intestinal resection can be re-treated with the same agent for postoperative recurrence with high success rate similar to that of anti-TNF alpha naive patients
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No full textCompiles addresses delivered by the author especially as president of the social science organizations, the ASSA and the ABA, among others. Cf. Page 4
Should Cost Reviews and Supply Chain Integration: A Case Study at ASSA ABLOY Entrance Systems
No full textAbstract Title: Should Cost Reviews and Supply Chain Integration: A Case Study at ASSA ABLOY Entrance Systems Author: Andrew Cardinali Supervisors: Henrik Wallström - Ph. D., Candidate Packaging Logistics, Department of Design Sciences Faculty of Engineering LTH, Lund University Mats Johnsson - Ph.D., Associate Professor Packaging Logistics, Department of Design Sciences Faculty of Engineering LTH, Lund University Klas Hagelin - VA/VE Manager ASSA ABLOY Entrance Systems Problem Discussion: Competition in the global economy has lead companies to seek different ways to remain competitive and profitable. Growth though mergers and acquisitions and global sourcing are alternatives available to organizations to promote growth and reduce costs. The case study organization has chosen both methods as part of their business strategy. In addition the firm has recently implemented a strategic cost management program known as should-cost. This cost reduction method has received little attention in academic studies in general, and specifically, in regards to its relationship with the current concepts of supply chain integration. Furthermore it is considered whether this cost reduction program, in addition to its primary purpose as a cost savings tool, could promote integration and if so can the insights gained from the study be used to improve the should-cost program to further develop the integration process? Purpose: An exploration of the relationship between the strategic cost management program, known as should-cost, and supply chain integration is one aim of this study. Achieving this goal helps fill a gap in the relevant academic literature. An additional goal is to demonstrate how should-cost can promote integration within a firm. The final aspiration of this study is to use the results of the study to further develop should-cost not only as a strategic cost reduction method but also as an aid to integration. Method and Limits: This is an exploratory study and common with this type of research the case study method was chosen. Given the deductive nature of the paper a review of the relevant literature was the starting point of the project. From there data was gathered from multiple sources at the subject firm. The primary sources of data were interviews, documents and archival artifacts, and participant observation. This data was then analyzed in order to explore the issues raised in the problem discussion. The main limitation of this study is that interviews were primarily conducted with management personnel and not the purchasing staff. Conclusion: Should-cost was found to aid internal integration. In particular, by developing the knowledge and skills of the purchasing personal it was found to increase functional coordination and improve communication between functional groups. Additionally, by raising the knowledge and skills of the purchasing staff, should-cost promotes integration by raising the strategic value of the purchasing function. Although not a stated purpose of this study, should-cost, by revealing potential suppliers for improved relations via supplier development, aids external integratio
PHYTOCHEMICAL AND ANTIOXIDANT ACTIVITY OF CINNAMOMUM TAMALA LEAF EXTRACT
No full textCinnamon tamala, is a tree that is also known as bay leaf or tejpatta, it is native to India and included in the family Lauraceae. It has been proved that this plant has various pharmacological activities such as anti-tumor, anti-inflammatory, anti-oxidant, etc. In this present study, the phytochemical profile of the leaf is investigated both qualitatively and quantitatively. After the phytochemical investigation of the leaf, antioxidant potency for free radical scavenging (ABTS and DPPH) was examined. The presence of various alkaloids, steroids, and flavones was revealed by qualitative assessment. Cinnamon oil exhibited highest antioxidant activity having IC50 value of 40.85± 4.96 and 18.57 ± 0.10μg/ml in DPPH and ABTS assa
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