1,721,200 research outputs found
Eighty years of CIRM. A journey of commitment and dedication in providing maritime medical assistance
Full text linkBACKGROUND:
A review of activities of Centro Internazionale Radio Medico (International Radio Medical Centre, CIRM) from its foundation in 1935 until its 80th anniversary in 2015 was accomplished. CIRM was founded in 1935 to provide medical assistance via radio to ships with no doctor on board and other distant patients who cannot be reached by a doctor. In 1950 CIRM was established as a non-profit-making foundation and has benefited since 1957 from an annual contribution from the Italian government.
METHODS:
Review of CIRM case histories and other published material from 1935 to 2015 and presenting them in a scientific yet simplified manner through the use of basic mathematical analysis. All the data was collected from CIRM's official archives in Rome.
RESULTS AND CONCLUSIONS:
The results achieved by the Centre over 80 years include medical assistance to 81,016 patients on board ships (as well as on small islands and aircraft), with more than 500,000 medical messages received and transmitted. CIRM from its inception was organised into a medical service, a telecommunications service and a studies section. In 2002 the Centre was recognised as the Italian Telemedical Maritime Assistance Service (TMAS). In the 2010 the Centre was reorganised as a structure articulated in 4 departments, namely maritime telemedicine, telecommunication, research and occupational medicine. This was achieved to cover the different activities related to comprehensive health protection of seafarers. The 24-h continuous medical service is provided by doctors at the CIRM headquarters. The doctor on duty gives instructions for managing the case and continues to follow the patient with subsequent appointments until recovery or landing. In case of emergencies CIRM co-ordinates the transfer of patients assisted on board ships to a hospital ashore. CIRM has developed innovative approaches for the treatment of diseases and accidents on board of seagoing vessels by introducing standard telemedicine equipment on board ships, allowing the transmission of biomedical data from ships to the Centre. These new solutions are aimed at bringing a significant improvement of medical care for seafarers
Changes of [3H]spiroperidol binding in the renal artery of aged rabbits
No full textUsing mature (12 months), old (70 months) rabbits and 3H-labeled spiroperidol, the characteristics of renal artery dopamine receptors were studied. In old age the dissociation constant of [3H]spiroperidol was unchanged, while maximum specific binding was reduced more than 45%. The present data seem to indicate an impairment of peripheral dopaminergic function in ageing
The autonomic innervation of rat jugular vein
No full textThe autonomic innervation of rat jugular vein was studied using glyoxylic acid fluorescence and acetylcholinesterase histochemical methods. The rat jugular vein is provided with both adrenergic and cholinergic nerve fibers organized in plexuses located at the adventitial-medial border. The existence of these nerve plexuses does not seem to support biochemical findings that suggests a lack of innervation in the rat jugular vein and which propose this blood vessel as a model for the analysis of drug-smooth muscle cell interaction without the interference of neuronal uptake mechanisms
Indoleaminergic innervation of rat choroid plexus: a fluorescence histochemical study
No full textUsing a fluorescence histochemical technique we found that the precursor of serotonin, 5-hydroxytryptophan (5-HTP), is taken up by a population of nerve fiber-like structures, indoleaminergic in nature since selectively destroyed by the neurotoxin 6-hydroxytryptamine, within rat choroid plexus. Nerve fiber-like structures are localized within the wall of choroid blood vessels. More infrequently nerve fibers end in the stroma or in close relation to epithelial cells of the plexus. The electrolytic lesioning of raphe nuclei causes the disappearance of 5-HTP fluorescence, suggesting that these nerve fibers originate from raphe nuclei. These results suggest a direct influence of indoleaminergic pathways originating from the brainstem on the blood flow through choroid plexus as well as on the production of cerebrospinal fluid
Vasoactive intestinal polypeptide-sensitive cyclic adenosine monophosphate generating system in the rat portal vein
No full textThe effect of vasoactive intestinal polypeptide (VIP) on the 3'-5'-cyclic adenosine monophosphate (cAMP) generating system in membrane particles of rat portal vein was studied. In the presence of 10 microM GTP, VIP increased the concentration of cAMP in a dose-dependent manner. The removal of endothelium had no effect on cAMP production elicited by VIP. alpha- and beta-adrenergic as well as muscarinic receptor blocking agents did not inhibit VIP-dependent cAMP increase. Also various peptides, structurally analogous to VIP or active on portal vein smooth muscle, had no effect on cAMP production elicited by VIP. The present data, combined with those reported in the literature of an active relaxation of portal vein smooth muscle by VIP, suggest the existence of functionally active VIP receptors coupled to the adenylate cyclase system in the rat portal vein
Stimulatory effect of beta-estradiol treatment on GABA-degradative enzymes within rat cerebellar cortex
No full textThe influence of neonatal beta-estradiol treatment on the development of GABA-degradative enzymes (GABA transaminase and succinic semialdehyde dehydrogenase) within rat cerebellar cortex has been studied using a semiquantitative histochemical technique. Both enzymatic activities were stimulated following beta-estradiol treatment. In particular, the granule and Purkinje cells were the most influenced cerebellar components. The findings seem to suggest that granule and Purkinje cells may represent the principal target of the cerebellar cortex for sex hormones
5-hydroxytryptophan uptake in indoleaminergic nerve fibers within rat cerebrovascular tree
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Influence of treatment with Ca2+ antagonists on cerebral vasculature of spontaneously hypertensive rats
No full textEffect of Different Dihydropyridine-type Ca2+ Antagonists on Left Ventricle Hypertrophy and Coronary Changes in Spontaneously Hypertensive Rats
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