5,178 research outputs found
sj-tif-2-aan-10.1177_02184923211060908 - Supplemental material for Congenital isolated absence of a single cusp of pulmonary valve
No full textSupplemental material, sj-tif-2-aan-10.1177_02184923211060908 for Congenital isolated absence
of a single cusp of pulmonary valve by Niraj Nirmal Pandey, Mumun Sinha, Arun Sharma and Ambuj Roy in Asian Cardiovascular and Thoracic Annals</p
United They Fall: Why the International Community Should Not Promote Military Integration after Civil War
No full textThe single strongest predictor of civil war is a nation having had one in the past, and preventing the recurrence of civil war has thus become the critical problem for both scholarship and policy. The conventional wisdom urges the creation of capable, legitimate, and inclusive postwar states to reduce the risk of relapse into civil war, and international peacebuilders have often encouraged the formation of a new national army including members of the war’s opposing sides. However, military integration has received little theoretical or empirical attention. Filling that gap, we argue that both the theoretical logics and the empirical record identifying military integration as a significant contributor to durable post-civil war peace are weak. Our analysis of eleven cases finds little evidence that military integration played a substantial causal role in preventing the return to civil war and little support for the likely causal mechanisms. Military integration does not usually send a costly signal of the parties’ commitment to peace, provide communal security, employ many possible spoilers, or act as a powerful symbol of a unified nation. We conclude that it is both unwise and unethical for the international community to press military integration on reluctant local forces.Based in part on a larger collective project: Roy Licklider (Ed.). (2014). New Armies from Old: Merging Competing Military Forces after Civil Wars. Washington, D.C.: Georgetown University Press; see http://press.georgetown.edu/book/georgetown/new-armies-old
Tubulin CFEOM mutations both inhibit or activate kinesin motor activity
No full textKinesin-mediated transport along microtubules is critical for axon development and health. Mutations in the kinesin Kif21a, or the microtubule subunit β-tubulin, inhibit axon growth and/or maintenance resulting in the eye-movement disorder congenital fibrosis of the extraocular muscles (CFEOM). While most examined CFEOM-causing β-tubulin mutations inhibit kinesin–microtubule interactions, Kif21a mutations activate the motor protein. These contrasting observations have led to opposed models of inhibited or hyperactive Kif21a in CFEOM. We show that, contrary to other CFEOM-causing β-tubulin mutations, R380C enhances kinesin activity. Expression of β-tubulin-R380C increases kinesin-mediated peroxisome transport in S2 cells. The binding frequency, percent motile engagements, run length and plus-end dwell time of Kif21a are also elevated on β-tubulin-R380C compared with wildtype microtubules in vitro. This conserved effect persists across tubulins from multiple species and kinesins from different families. The enhanced activity is independent of tail-mediated kinesin autoinhibition and thus utilizes a mechanism distinct from CFEOM-causing Kif21a mutations. Using molecular dynamics, we visualize how β-tubulin-R380C allosterically alters critical structural elements within the kinesin motor domain, suggesting a basis for the enhanced motility. These findings resolve the disparate models and confirm that inhibited or increased kinesin activity can both contribute to CFEOM. They also demonstrate the microtubule’s role in regulating kinesins and highlight the importance of balanced transport for cellular and organismal health.This article is published as Luchniak, Anna, Pallavi Sinha Roy, Ambuj Kumar, Ian C. Schneider, Vladimir I. Gelfand, Robert L. Jernigan, and Mohan L. Gupta Jr. "Tubulin CFEOM mutations both inhibit or activate kinesin motor activity." Molecular Biology of the Cell 35, no. 3 (2024): ar32. doi: https://doi.org/10.1091/mbc.E23-01-0020. © 2024 Luchniak et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication, it is available to the public under an Attribution–Noncommercial–Share Alike 4.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/4.0)
Ekla Chalo Re: a tribute to Ms. Mary Roy
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This is a tribute to activist Mary Roy, who passed away in 2022. The author traces the life of Mary Roy, highlighting the ways in which she challenged gendered norms and expectations. She was the applicant in a landmark case which brought equal property rights for Syrian Christian women in India. The author reminds readers that women's rights are human rights and change begins with us. 
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Yunnan (China), men with the cow caravan
No full textA cow caravan.Image is part of research conducted by Roy Chapman Andrews for the article: Traveling in China's Southland
Author(s): Roy Chapman Andrews
Source: Geographical Review, Vol. 6, No. 2 (Aug., 1918), pp. 133-146
Published by: American Geographical Society
Stable URL: http://www.jstor.org/stable/207476http://www.jstor.org/stable/207476Grayscal
Yunnan (China), cow loaded with grass and carrying a bell
No full textA cow loaded with grass and carrying a bell.Image is part of research conducted by Roy Chapman Andrews for the article: Traveling in China's Southland
Author(s): Roy Chapman Andrews
Source: Geographical Review, Vol. 6, No. 2 (Aug., 1918), pp. 133-146
Published by: American Geographical Society
Stable URL: http://www.jstor.org/stable/207476http://www.jstor.org/stable/207476Grayscal
Yunnan (China), women carrying salt from one of the large wells
No full textWomen carrying salt from one of the large wells.Image is part of research conducted by Roy Chapman Andrews for the article: Zoological Explorations in Yunnan Province, China
Author(s): Roy Chapman Andrews
Source: Geographical Review, Vol. 6, No. 1 (Jul., 1918), pp. 1-18
Published by: American Geographical Society
Stable URL: http://www.jstor.org/stable/207446http://www.jstor.org/stable/207446Grayscal
Immobile History: An Interview with Emmanuel Le Roy Ladurie
No full textThe author spoke with renowned French historian Emmanuel Le Roy Ladurie about Computers, Geography and History. Le Roy Ladurie was the "standard bearer" of the third generation of the French Annales school, a group of French intellectuals that combined different disciplines such as history, geography, anthropology, and more to delve into social history
Regional integration fifty years after the treaty of Rome. The EU, Asia, Africa and the Americas.
No full textThe European Union has been the pioneer and undisputed
leader of regional integration processes. Since its inception in
the 1950s, following the Schuman Declaration that set in motion
Jean Monnet’s innovative idea to join together European coal
and steel industries, Europe has offered a useful model for
regional integration. Strengthened by the 1957 Treaty of Rome
(exactly half a century ago), this bold entity was later transformed
into the European Union by the Maastricht Treaty.
Having successfully accomplished its primary goal (“to make
war unthinkable and materially impossible”), the EU is currently
facing challenges associated with its expansion and the deepening
of its pooled sovereignty. On the other hand, the effects
of the EU in international relations are of paramount relevance.
While the forceful transposition of national and regional structures
into other regions is a historical error, the essence of the
EU as a model to be adapted by other regions is a viable
approach to enhance stability and welfare. In this regard, this
volume examines the current challenges of the EU and the perspectives
of regional integration in Africa, Asia and Latin
America
Correspondence regarding Horace Kephart collection
No full textThis 1973 correspondence, between Congressman Roy A. Taylor, Ronald Walker, Lawrence C. Hadley, discusses the transfer of Horace Kephart collection from the library of Great Smoky Mountains National Park to Western Carolina University. Horace Kephart (1862-1931) was a noted naturalist, woodsman, journalist, and author and promoter of the Great Smoky Mountains National Park
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