240 research outputs found
I disegni di opere d'arte decorativa di Giacomo Amato per i monasteri di Palermo
No full textSi esaminano i disegni di Giacomo Amato conservati nel Gabinetto dei Disegni e delle Stampe della Galleria Regionale della Sicilia di Palazzo Abatellis e si analizzano quelli legati alle opere d'arte decorativa, in particolar modo quelli destinati al rinnovamento degli altari e dei relativi arredi mettendo in luce la ricchezza delle suppellettili liturgiche del tardo Barocco palermitano. Si ricostruisce inoltre l'attività di poco note figure di argentieri attivi a Palermo
Amato di Fucarino
No full textSi delinea la personalità artistica del miniatore Amato di Fucarino e si ricostruisce il catalogo delle sue oper
Concetta Zuccarello cooking in the family kitchen on Bloomfield Avenue.
No full textConcetta Zuccarello, an immigrant from Sicily, in the familiy kitchen 218 Bloomfield Ave., Cold Water Flat. Concetta is grandmother of Josephine Zuccarello, wife of photographer. Both 1910 and 1911 listed as a date for photograph
Serpotta e le arti decorative
No full textSi analizza la produzione artistica del patrimonio d'arte decorativa strettamente legato alla cultura di Serpotta, Amato e Grano nella Palermo capitale del primo Settecento evidenziando l'unità dell'arte attraverso il confronto dei diversi settori artistic
G-Qadruplexes from Human Telomeric DNA: How Many Conformations in PEG Containing Solutions?
No full textG-quadruplex structures are an attractive target for the development of anticancer drugs as their formation in human telomere induces a DNA damage response followed by apoptosis in cancer cells. However, the development of new anticancer drugs by means of structural-based drug design, is hampered by a lack of an accurate information on the exact G-quadruplex conformation adopted by the human telomeric DNA under physiological condition. Several groups reported that in a molecular crowded, cell-like environment, simulated by polyethylene glycol (PEG), the human telomeric DNA adopts the parallel G-quadruplex conformation. These studies have suggested that 40% (w/v) PEG concentration induces complete structural conversion from the other known human telomeric G-quadruplex conformations to the parallel G-quadruplex, thus simplifying the high structural polymorphism existing in absence of PEG. In this study, we demonstrate that the structural conversion to the parallel G-quadruplex is not a complete reaction at physiological temperature. We report a complete kinetic and thermodynamic characterization of the conformational transitions involving the (TTAGGG)4TT and (TTAGGG)8TT human telomeric DNA sequences in K+ solution containing PEG. Our data show that the hybrid-type and parallel conformations coexist at equilibrium in presence of PEG at the physiological temperature and the degree of the quadruplex interconversion depends on the PEG molecular weight. Further, we find that telomeric DNA folds in the parallel quadruplex in seconds time scale, a much larger time scale than the one reported for the hybrid quadruplex folding (~ms). The whole of our data allow us to predict the relative amount of each G-quadruplex conformation as function of temperature and time. The effect of other crowding agent like Ficoll 400 and glycerol on the quadruplex interconversion has been also explored
“L’Animo ciascuna sua passion sotto el contrario manto ricopre”. Guichardin et les passions “italiennes” dans le livre I des Essais
No full textThe article analyzes the relationship between history and the passions thorough the borrowings from the Storia d’Italia. Guicciardini by Francesco Guicciardini. Guicciardini's influence on the author of the Essais seems to extend to both the content and the form of the borrowed texts (their style, description techniques, and so on), and indeed to the treatment of the passions described. The analysis of the examples borrowed from Guicciardini in Book I fo the Essais leads to some initial conclusions ; although, there is further research yet to be done.L’étude analyse le rapport entre l’Histoire et les passions à travers les emprunts à la Storia d’Italia de Guichardin. L’influence de Guichardin sur l’auteur des Essais semble toucher tant le contenu des textes empruntés que la forme (style, modalités de la description, etc.), ainsi que le traitement des passions décrites. L’analyse des exemples empruntés à Guichardin dans le livre I des Essais permet de tirer les premières conclusions ; cependant, la recherche aurait besoin d’être poursuivie
"J'ay un dictionnaire tout à part moy": la pratique du 'dictionnaire' chez Montaigne écrivain italien
No full textThe article focuses on the writing of the italian part of Montaigne's "Journal the voyage". The author has maybe read or used grammar books, dictionaries or linguistic works to learn how to write correctly. The article gives a general overview of such linguistic production in the period of Montaigne's travel to Italy (1580-81)
La formazione filosofica di Orazio nella lettura degli esegeti antichi
No full textIn una delle Vite di Orazio riportate dai manoscritti che conservano gli scolii antichi alla sua opera si legge che il poeta, in seguito alla formazione culturale romana, si sarebbe recato ad Atene per il tradizionale ‘viaggio d’istruzione’ al fine di apprendere la filosofia; tale insegnamento sarebbe stato innanzitutto epicureo. L’elemento costituisce una novità rispetto a quanto riportato da Svetonio, con cui le vite dei manoscritti presentano in generale evidenti affinità. L’autore della Vita riferisce inoltre che Orazio avrebbe ammesso di essere epicureo 'in principio carminis' ritenendo d’altronde felice chi agisce secondo il proprio istinto, chi considera la 'voluptas' il sommo bene. Nella lettura di un commentatore tardoantico ne derivava pertanto che Orazio fosse epicureo in questa prospettiva vengono così lette le Satire e anche - ma in maniera differente, come l’analisi mette in luce - le Epistole.One of the Lives of Horace in the manuscripts preserving the ancient scholia to his work records that the poet, following the Roman cultural education, would have gone to Athens for the traditional ‘educational journey’ in order to learn philosophy; this teaching would have been mostly epicurean. This constitutes a novelty with respect to what is reported by Suetonius, with which the lives of manuscripts generally have evident affinities. The author of the Life also says that Horace would have admitted to being an epicurean in principio carminis, considering happy who acts according to his own instinct and looks at voluptas as the highest good. Thus, in the reading of the late commentator, Horace was epicurean and the Satires and also - but in a different way, as clarified in the analysis - the Epistles are evaluated in this perspective
G-Quadruplex on Oligo Affinity Support (G4-OAS): An Easy Affinity Chromatography-Based Assay for the Screening of G-Quadruplex Ligands
No full textA simple, cheap, and highly reproducible affinity chromatography-based method has been developed for the screening of G-quadruplex binders. The tested compounds were flowed through a polystyrene resin functionalized with an oligonucleotide able to form, in proper conditions, a G-quadruplex structure. Upon cation-induced control of the folding/unfolding processes of the immobilized G-quadruplex-forming sequence, small molecules specifically interacting with the oligonucleotide structure were first captured and then released depending on the used working solution. This protocol, first optimized for different kinds of known G-quadruplex ligands and then applied to a set of putative ligands, has allowed one to fully reuse the same functionalized resin batch, recycled for several tens of experiments without loss in efficiency and reproducibility
- …
