87,932 research outputs found
La bioinformatica come strumento per lo studio dell'espressione genica durante lo sviluppo embrionale
No full textRegulation of gene expression during embryogenesis and development is a crucial cluefor a normal anatomy and physiology [1]. The combined use of experimental highthroughputmethods, such as DNA microarrays, and bioinformatic methods has innovatedthe analysis of temporal patterns of gene expression in embryos. Microarray analysis, infact, provides a large amount of data -at molecular level- that once acquired, must befunctionally integrated in order to find common patterns within a defined group of biologicalsamples.Through the use of cDNA microarrays, investigators can measure mRNA [1] levels forthousands of genes simultaneously, rather than one gene at a time. In fact, DNA microarraysare constituted by small glass or filter matrix that contain arrays of DNA sequences(each highly specific to a single gene) and by means hybridization of fluorescentcDNA, they are capable of simultaneously quantifying the expression of thousands ofgenes in a single experiment. The results of these experiments are spots whose brightnessvaries from gene to gene corresponding to the transcriptional activity of the examinedgenes (Fig. 1). This analysis requires sophisticated bioinformatics tool [2]. Aninterestingly application of DNA microarrays is the analysis of mRNA expression (suchas the transcriptome) in embryos. A systematic genomic approach to analyze globalgene expression patterns and functions during embryogenesis has recently been nameddevelopmental genomics or embryogenomics [3].Functional genomics of embryo development requires the integration of informationfrom genome sequence and structure, gene and protein expression, and metabolite profileswith knowledge databases by using computational and bioinformatics tools [1,4]
Bis(cyclopentadienyl)dihydrido Mo and W complexes as Lewis’ bases. A computational study about their adducts with BX3 (X = F, Cl) and Al(CH3)3
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Conjunto Amati
No full textCrítica al concierto del Conjunto Amati, conformado desde 1965 por 11 jóvenes germanos: 6 violines, 2 violas, 2 chelos y un contrabajo. Interpretaron obras de G. F. Haendel, F. Mendelssohn, L. Van Beethoven, W. A. Mozart y J. S. BachMedellín, Biblioteca Luis Echavarría Villegas, Sala de Patrimonio Documental, Archivo Luis Miguel de Zulateg
Commento agli artt. 2623, 2624, 2625, 2626, 2627, 2628, 2629, 2632, 2633, 2634, 2635, 2637 c.c
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Mitromorpha (Mitrolumna) alyssae Amati, Smriglio & Oliverio, 2015, n. sp.
No full textMitromorpha (Mitrolumna) alyssae n. sp. (Figs 17; 18 A–E; 27 F; 28 F) Type material. Holotype, type locality, (H 7.3 mm, W 3.45 mm) (Fig. 18 A–C; 28 F) (MNHN IM- 2000-27707); paratypes: 9 sh (5 adults and 4 juv.: BA) type locality, 2 sh (MO), all from the type locality; 4 sh, Salina Is., - 46 m bioclastic sand, 2002 (CS). Type locality. Salina Is., Aeolian Islands, Italy, - 35 m. Etymology. Dedicated to Alyssa Rocchino, granddaugther of one of the authors (B. Amati). Distribution and habitat. Found so far only from the type locality area, Salina Is., in the southern Tyrrhenian Sea. Recent. Empty shells in bioclastic sands, - 35 m (cave) and - 46 m. Found sympatric with M. columbellaria and M. karpathoensis. Description. (in parentheses the data of the holotype) Shell of medium size for the genus (Figs 18 A–E; 27 F), height 7–7.95 (7.3 mm), width 3.3–3.6 (3.45 mm), solid, fusiform, biconic, slender, H/W= 2.028–2.208 (2.115). Protoconch paucispiral (Fig. 28 F) shiny, of 1.3–1.35 (1.35) convex whorl, d 0.20–0.225 (0.20 mm), Do 0.40–0.45 (0.40 mm), DM 0.55 mm, h 0.45 mm. sculptured by many densely arranged microgranules. Protoconchteleoconch boundary well marked, flexuose, opisthocline. Teleoconch of 5–5.5 (5) slightly convex whorls. Sculpture starting with 3 (3) strong spiral cordlets crossed by 12 (12) equally strong axial ribs on the first whorl. Additional spiral cordlets between the adapical ones, and between the suprasutural one and the suture. Last whorl sculptured over the entire surface by 22–25 (24) spiral cordlets, of which 7–10 (8) above the aperture. First 4 abapical spirals, rather strong, broader than the interspaces, lower 9 thinner, flat, those on the base stronger and more spaced. Axial ribs (13–16) present only on the first 3.5 whorls of all shells, producing rounded nodules at the intersection with the spirals and quadrangolar interspaces. Two columellar folds, the posterior larger and frequently bifid on the outer tip (Fig. 6 D). Growth lines visible over the entire surface. Outer lip sharp, thickened internally with 10 (10) small denticles, the second or third posterior more pronounced. Anal sinus shallow. Siphonal canal short, and wide. Coloration brown in the background, with subsutural lighter band, and periphery with small darker blotches and whitish rounded spots. Tubercles lighter than the background. Outer lip lighter, with occasional darker stripes posteriorly. Soft parts unknown. Remarks. M. alyssae n. sp. is similar to M. olivoidea in the chromatic pattern with a brown background and dark and light blotches in the peripheral area, but the blotches are larger, darker and more numerous. M. alyssae lives probably in shallower habitat (empty shells in 35–46 m v. 60 –170 m of M. olivoidea), and differs also in having less spirals on the last whorl (22–25 v. 34 –39 of M. olivoidea) and a coarser sculpture in the first whorls. M. columbellaria has a different chromatic pattern, usually monochrome, and less spirals above the aperture (4–6 v. 7–10 of M. alyssae n. sp.). M. alyssae n. sp. differs from M. karpathoensis (including all morphs), in its less brilliant and colorful chromatic pattern, in having less spirals on the last whorl (22–25 v. 30–40 in karpathoensis) and above the aperture (7– 10 v. 3–4 in karpathoensis). The morphs A and B of karpathoensis have less evident spiral and axial sculpture.Published as part of Amati, Bruno, Smriglio, Carlo & Oliverio, Marco, 2015, Revision of the Recent Mediterranean species of Mitromorpha Carpenter, 1865 (Gastropoda, Conoidea, Mitromorphidae) with the description of seven new species, pp. 151-195 in Zootaxa 3931 (2) on pages 172-174, DOI: 10.11646/zootaxa.3931.2.1, http://zenodo.org/record/23842
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