17,542 research outputs found
La potencialidad de las situaciones truncas para el estudio de la política colectiva
No full textEste artículo constituye una apuesta por reivindicar el potencial analítico -y político- de las situaciones aparentemente truncas en el estudio de la política colectiva. En base a un prolongado trabajo de investigación en co-labor con la cooperativa "Reciclando Sueños" de La Matanza, el capítulo analiza el derrotero de un programa de recolección diferenciada en el distrito impulsado por la cooperativa hasta su repentina interrupción. Explicitando mis propias frustraciones frente a lo que a mis ojos se presentaba como un proyecto trunco, el artículo busca perturbar nuestra habitual preocupación por el éxito (o fracaso) de las prácticas y procesos que estudiamos. Con este objetivo, reflexiono sobre el aparente contraste entre lo que denomino narrativa de la cooperativa y el carácter contingente, fluido y móvil de esta experiencia, dado tanto por lo circunstancial de los vínculos y personas que circulaban por ese espacio como por el modo en que el programa y la cooperativa se encontraban permanente amenazados. En base a este aparente contraste, analizo el sentido que la construcción narrativa de la cooperativa tiene para la conceptualización de las prácticas colectivas, sosteniendo que a esta construcción narrativa ?en tanto acción- es parte inherente de hacer juntos(as). Sostengo en esta dirección que muchas veces la permanencia misma pasa por la circulación. Inspirada en la noción de imaginación en los términos en que la entiende David Graeber, la reflexión que propongo busca iluminar el carácter proyectual de ese hacer juntos(as). Esto exige desplazar el foco de nuestro análisis del resultado al proceso donde lo que cobra centralidad no es el logro de determinados objetivos sino ese transcurrir mismo. Este desplazamiento conlleva una advertencia metodológica que movilizo en la reconstrucción del universo etnográfico analizado: dejarnos guiar por lo que se nos presenta como discontinuo o reversible antes que partir de una lógica secuencial agregativa con un horizonte relativamente prefigurado. El capítulo señala la fertilidad de esta empresa si queremos trascender no solo las visiones miserabilistas que suelen primar al describir esta población, sino también para señalar cómo aún a partir de experiencias que pueden resultar a simple vista truncas, imaginan junto(as) y al hacerlo logran ampliar el horizonte de los posibles.Fil: Fernandez Alvarez, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Marriage record of Romero, Juan J. and Fernandez, Julia Alvarez
No full textMarriage license for Juan J. Romero and Julia Alvarez Fernandez. Joseph A. Lopez was the Notary Public
The North Sea plankton regime shift in the late 1990s: Comment on Beaugrand et al. (2014)
No full textBeaugrand et al. (2014; Mar Ecol Prog Ser 502: 85-104) reported a regime shift in the North Sea plankton community between 1996 and 2003 as a novel observation. Although they used novel methodology, a shift in the plankton community around 1998 had previously been described by Alvarez-Fernandez et al. (2012; Mar Ecol Prog Ser 462: 21-38). Both studies have similar results, but their interpretation differs: Beaugrand et al. (2014) conclude that temperature is the driving force, whereas Alvarez-Fernandez et al. (2012) attribute the regime shift to changes in nutrient dynamics
Adjustable-structure Design for Ternary Distillation Columns
No full textIn this work, the problem of jointly designing the estimator structure and the algorithm for ternary distillation columns is addressed. In particular, the choice of the estimation structure (measurements location and innovated states set) and the design of a complete or reduced algorithm with the possibility of changing the estimation structure during the column operation are considered. The proposed estimators are tested using experimental data from a 32-stage pilot column, finding that: (i) the structural decisions play a key role in the estimator performance, regardless of the kind of estimation algorithm employed, (ii) the best estimator behavior is obtained by injecting the temperature information over a few column states, and (ii) the same functioning is obtained with geometric estimation and EKF
Além da racionalidade: o estudo das emoçoes como prácticas políticas
No full textAs emoções chamaram a atenção das investigações em ação coletiva nos anos recentes. A partir duma concepção racional da ação, se desenvolveu uma visão cognitiva da emoção - baseada numa tradição occidental que opõe racional - irracional, mente - corpo, privado - público – onde as emoções seriam fatores motivacionais. Neste artigo, eu reviso parte do meu estudo etnográfico em fábricas recuperadas no Buenos Aires para analisar as emoções como práticas políticas. Com este objectivo, analiso a descrição que as e os trabalhadoras fizeram do momento da ocupação. Esta reconstrução mostra a importância das emoções para articular a experiência e definir as reivindicações. O processo de construção de demandas implicou uma objetivação desta experiência e, ao mesmo tempo, de exibição pública de certas emoções e sentimentos.Fil: Fernandez Alvarez, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Além da racionalidade: o estudo das emoçoes como prácticas políticas
No full textAs emoções chamaram a atenção das investigações em ação coletiva nos anos recentes. A partir duma concepção racional da ação, se desenvolveu uma visão cognitiva da emoção - baseada numa tradição occidental que opõe racional - irracional, mente - corpo, privado - público – onde as emoções seriam fatores motivacionais. Neste artigo, eu reviso parte do meu estudo etnográfico em fábricas recuperadas no Buenos Aires para analisar as emoções como práticas políticas. Com este objectivo, analiso a descrição que as e os trabalhadoras fizeram do momento da ocupação. Esta reconstrução mostra a importância das emoções para articular a experiência e definir as reivindicações. O processo de construção de demandas implicou uma objetivação desta experiência e, ao mesmo tempo, de exibição pública de certas emoções e sentimentos.Fil: Fernandez Alvarez, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
A simheuristic algorithm for video streaming flows optimisation with QoS threshold modelled as a stochastic single-allocation p-hub median problem
No full textModern telecommunication networks are comprised of a countless number of nodes exchanging data among them. In particular, multimedia traffic–composed of audio, video, and images–represents a challenging scenario requiring link optimisation techniques. The hub-and-spoke topology is frequently used to design more effective telecommunication networks. This work considers a hub-and-spoke network in which a large number of nodes are exchanging real-time multimedia data, and where the quantity of data sent from one node to another is a random variable. Given a fixed number of hubs, (Formula presented.), the goal is to select the best location for these (Formula presented.) hubs in order to minimise the total expected cost of transmission. This scenario is modelled as an uncapacitated single-allocation (Formula presented.) -hub median problem under uncertainty conditions. Additionally, with the purpose of considering the effect of transmission delays on the video signal, service quality thresholds are assigned to every potential hub in the network. Since real-life networks tend to be large in size, we propose a simheuristic algorithm to cope with this stochastic and large-scale optimisation problem. A series of computational experiments illustrate these concepts and allow for testing the performance of our simheuristic approach. Finally, a statistical analysis of the obtained results is provided
Thermodynamic Diagram Based Estimation Structure Design for Ternary Distillation Column
No full textIn this work the ternary distillation column estimation problem is addressed, using an ethanol-tertbutanol-water pilot experimental column. The estimation problem is more difficult and less studied that the one of the binary case. The combination of a thermodynamic framework with results drawn in a previous structure-oriented geometric estimation study yields a procedure with criteria with physical meaning to jointly design the estimation structure and algorithm. The approach is illustrated and tested with an adjustable-structure geometric estimator implementation
Data for: Low-quality management of Marine Protected Areas in the North-East Atlantic
No full textAnnex 4 is the data base of the study formed by 48 colummns. The name of each column correpond to a item of the MPA MEAT tool. The items of the MPA MEAT tool are detailed in annex 2. The surveys used in this study were not originally designed to be used for the MPA MEAT tool, an equivalence has been established between the items in our surveys and the items defined in the MPA MEAT survey form and this equivalence is also detailed in annex 2
SEROLOGICAL IMMUNE RESPONSE AGAINST ADAM10 IN COLORECTAL CANCER PATIENTS IS A FAVORABLE SIGNATURE
No full textIn cancer the immune system is activated in response to qualitative and quantitative aberrant expression by tumor cells of certain proteins named tumor-associated antigens (TAAs). In a previous study in the laboratory, has been investigated the presence of TAAs inducing auto-antibodies (auto-Abs) in the Colorectal cancer (Crc) by exploiting the patients serological reactivity against the surface membrane proteoma. Among several candidates, a specific immunoreactivity against A Disintegrin And Metalloprotease 10 (ADAM10) protein has been identify.ADAM10 is a disintegrin metalloprotease with a potential role in tumor progression and invasion due to its sheddase activity. ADAM10 is able to promote ERK1/2 signaling activation promoting cell proliferation by the cleavage of the extracellular domain (ECD) of the HER2 tyrosine kinase receptor, which is released in serum. Moreover, ADAM10 plays a critical physiological function in the epithelial morphogenesis since its sheddase activity is crucial for the cell migration and extracellular matrix (ECM) remodelling, a phenomenon that also drives tumor metastasis. Thus, an aberrant expression of the ADAM10 in epithelial tissues might elicit a specific serological immune response. The serological screening performed on purified ADAM10, showed a significant presence of immunoreactivity against ADAM10 in the sera from patients affected by tumors of epithelial origin like Crc, Pancreatic cancer (Pc) and Breast cancer (Brc) if compared with serological reactivity of healthy subjects. On the contrary, sera from patients affected by hematological malignancies such as chronic lymphocytic leukemia (B-CLL) and Multiple Myeloma (MM), did not showed significant immunoreactivity against ADAM10. These results suggested that the presence of auto-Abs against ADAM10 in patients sera might be a candidate biomarker for carcinomas of epithelial origin. Since it is known that ADAM10 is overexpressed in advanced stages of the Crc disease, when the lymph nodes are infiltrated by the tumor, we evaluated the disease course of this patients after surgical resection in order to define whether the presence of auto-Abs anti-ADAM10 is a favourable or detrimental signature, correlating the immunoreactivity with the patients follow-up. The results showed that the presence of auto-Abs anti-ADAM10 prolonged significantly the disease-free condition if compared with Crc patients without serological immunoreactivity against ADAM10. Thus, in order to investigate the effects of these auto-Abs, in vitro experiments of both HER2 ECD release and cell migration were performed using the Colon carcinoma cell line LoVo. Results showed that commercial anti-ADAM10 antibodies resulted to be effective in inhibiting cell migration and HER2 ECD release in LoVo cell line while IgG fraction purified from representative Crc patients did not. This lack of inhibition might be the consequence of the fact that LoVo cell line did not express the specific epitope that elicited the serological reactivity in Crc patients. In fact, Crc patients showed different expression of ADAM10 in tumoral tissues. Patients with a positive immunoreactivity against ADAM10 (Ser-ADAM10 +) showed an overexpression of the inactive form of ADAM10 and, accordingly, an high expression of the inactive HER2 (p195) isoform and a decreased expression of phosphorilated-ERK1/2. These results suggest a reduced activity of ADAM10 on the HER2 ECD cleaveage which is supported by the observation that Ser-ADAM10 + patients showed lower HER2 ECD concentrations in serum compared to Ser-ADAM10 - patients.
In conclusion, the presence of auto-antibodies anti-ADAM10 may be considered a biomarker of favourable prognosis for Crc patients at advanced stages of the disease that reflects an overexpression of inactive ADAM10 during the cell transformation and accordingly the lower protein maturation leads to a decrease of its sheddase activity which in turnt declines the proliferative and invasive capacity of tumor cells
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