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Динаміка показників легеневого ушкодження за умови експериментального HCl-індукованого гострого ураження легень = Dynamics of pulmonary damage parameters in experimental HCl-induced acute lung injury
No full textHryshchuk L. A., Besky V. O., Marushchak M. I. Динаміка показників легеневого ушкодження за умови експериментального HCl-індукованого гострого ураження легень = Dynamics of pulmonary damage parameters in experimental HCl-induced acute lung injury. Journal of Health Sciences. 2014;4(14):175-181. ISSN 1429-9623 / 2300-665X.
http://journal.rsw.edu.pl/index.php/JHS/article/view/2014%3B4%2814%29%3A175-181
https://pbn.nauka.gov.pl/works/512853
DOI: 10.5281/zenodo.13349
http://dx.doi.org/10.5281/zenodo.13349
The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1107. (17.12.2013).
© The Author (s) 2014;
This article is published with open access at Licensee Open Journal Systems of Radom University in Radom, Poland
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(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
Conflict of interest: None declared. Received: 15.11.2014. Revised 05.12.2014. Accepted: 10.12.2014.
Динаміка показників легеневого ушкодження за умови експериментального HCl-індукованого гострого ураження легень
Dynamics of pulmonary damage parameters in experimental
HCl-induced acute lung injury
Грищук Л.А., Беський В.О., Марущак М.І.
Hryshchuk L.A., Besky V.O., Marushchak M.I.
ДВНЗ «Тернопільський державний медичний університет імені
І.Я. Горбачевського МОЗ України»
SHEI Ternopil State Medical University named after I.Ya. Gorbachevsky MOH of Ukraine
Резюме. Метою даного дослідження було визначити ступінь розвитку набряку легень і рівень метаболізму сурфактанта у динаміці гострого ураження легень хлоридною кислотою. Досліди були проведені на 60 білих статевозрілих нелінійних щурах-самцях масою 200-220 г, яким моделювали гостре ураження легень шляхом інтратрахеального введення хлоридної кислоти при рН 1,2 в дозі 1,0 мл/кг на вдиху. Визначали індекс оксигенації рO2/FiO2 артеріальної крові, вміст білка у бронхоальвеолярному змиві, Wet/Dry індекси і коефіцієнт стабільності міхурців піни за R. Pattle.
Розвиток легеневого ушкодження за умови інтратрахеального введення хлоридної кислоти підтверджено як підвищенням втричі концентрації білка у БАЗ до кінця першої доби, так і розрахованими індексами розвитку легеневого набряку, які вказували на достовірне зростання набряку легеневої тканини і легеневого ексудату протягом часу спостереження. Встановлено прогресуюче зниження рівня показників поверхневої активності ССЛ протягом першої доби спостереження, що характеризується значним збільшенням рівня максимального поверхневого натягу з одночасним зниженням індексу стабільності на 45,8 % порівняно з контролем.
Отже, отримані дані чітко вказують на формування ГУЛ за рахунок розвитку набряку легеневої тканини та накопичення ексудативної рідини, і як наслідок, порушення оксигенації з розвитком гіпоксемії. Акумуляція рідини, багатої білками в альвеолах є чинником інактивації сурфактанту, що зумовлює зниженням індексу стабільності.
Ключові слова: гостре ураження легень, хлоридна кислота, набряк легень, сурфактантна система.
Summary. The aim of this study was to determine the degree of pulmonary edema and metabolic rate of surfactant in the dynamics of hydrochloric acid (HCl)-induced acute lung injury (ALI).
The development of lung damage in case of intratracheal introduction of HCl confirmed as three times higher concentration of protein in bronchoalveolar lavage after 24 hours of experiment, and rise calculated indices of pulmonary edema, which indicated a significant increase in lung tissue edema and pulmonary fluid in all groups of observation. It was found a progressive decrease in surface activity indicators of pulmonary surfactant system during the first day of observation: significant increase in the level of maximum surface tension with a simultaneous decrease in the stability index by 45.8%. Thus, the data indicate the formation of ALI by edema of the lung tissue and accumulation of exudative fluid, and as a consequence, impaired oxygenation with the development of hypoxemia. Accumulation of rich in proteins fluid in the alveoli is the factor of surfactant inactivation that leads to decreased of stability coefficient.
Key words: acute lung injury, hydrochloric acid, pulmonary edema, surfactant system.Hryshchuk L. A., Besky V. O., Marushchak M. I. Динаміка показників легеневого ушкодження за умови експериментального HCl-індукованого гострого ураження легень = Dynamics of pulmonary damage parameters in experimental HCl-induced acute lung injury. Journal of Health Sciences. 2014;4(14):175-181. ISSN 1429-9623 / 2300-665X.
http://journal.rsw.edu.pl/index.php/JHS/article/view/2014%3B4%2814%29%3A175-181
https://pbn.nauka.gov.pl/works/512853
DOI: 10.5281/zenodo.13349
http://dx.doi.org/10.5281/zenodo.1334
La Palsa Filosofia, o el ateismo, deismo, materialismo, y demas nuevas sectas, convencidas de crimen de estado contra los Soberanos y sus regalias, contra los Magistrados y Potestades legitimas.
No full textBook One. Where the vain hypotesis and seditious Principles of Atheists, Deists, Patalists, Naturalists, and other so-called Philosophers are fought. Volume Two. Its author Fr. Fernando de Zevallos, Monge Geronymo of the Monastery of San Isidro del Campo. Second impression. Et nunc Reges intelligire: Erudimini qui judicatis terram. Psalm. 2. v. 10. With privilege and the necessary licenses in Madrid In the Press of Antonio Fernandez. Year of 1775. 1775Book One. Where the vain hypotesis and seditious Principles of Atheists, Deists, Patalists, Naturalists, and other so-called Philosophers are fought. Volume Two. Its author Fr. Fernando de Zevallos, Monge Geronymo of the Monastery of San Isidro del Campo. Second impression. Et nunc Reges intelligire: Erudimini qui judicatis terram. Psalm. 2. v. 10. With privilege and the necessary licenses in Madrid In the Press of Antonio Fernandez. Year of 1775. 177
Hedging with Stochastic and Local Volatility
No full textWe derive the local volatility hedge ratios that are consistent with a stochastic instantaneous volatility and show that this ‘stochastic local volatility’ model is equivalent to the market model for implied volatilities. We also show that a common feature of all Markovian single factor stochastic volatility models, (log)normal mixture option pricing models and ‘sticky delta’ models is that they predict incorrect dynamics for implied volatility. As a result they over-hedge the Black-Scholes model in the presence of a market skew and this explains the poor delta hedging performance of these models reported in the literature. Whilst the traditional ‘sticky tree’ local volatility models do not possess this unfortunate property, they cannot be used for pricing without exogenous and ad hoc smoothing of results. However the stochastic local volatility framework allows one to extend a good pricing model into a good hedging model. The theoretical results are supported by an empirical analysis of the hedging performance of seven models, each with different volatility characteristics, on the SP500 index skew.Local volatility, stochastic volatility, implied volatility, hedging, dynamic delta hedging, volatility dymamics
Improved guidance is needed to optimise diagnostics and treatment of patients with thyroid cancer in Europe
No full textAlthough thyroid cancer (TC) is generally associated with a favourable prognosis, there are certain high-risk groups with a clear unmet therapeutic need. Unravelling the genomic landscape of TC has recently led to the development of novel effective targeted treatments. To date, these treatments have mostly been evaluated in non-randomised single-arm phase II clinical trials and are consequently non-reimbursed in several countries. Furthermore, most of these agents must be tailored to individual patient molecular characteristics, a context known as personalised cancer medicine, necessitating a requirement for predictive molecular biomarker testing. Existing guidelines, both in Europe and internationally, entail mostly therapeutic rather than molecular testing recommendations. This may reflect ambiguity among experts due to lack of evidence and also practical barriers in availability of the preferred molecular somatic screening and/or targeted treatments. This article reviews existing European recommendations regarding advanced/metastatic TC management with a special focus on molecular testing, and compares findings with real-world practice based on a recent survey involving TC experts from 18 European countries. Significant disparities are highlighted between theory and practice related to variable access to infrastructure, therapies and expertise, together with the insufficient availability of multidisciplinary tumour boards. In particular, practitioners’ choice of what, how and when to test is shown to be influenced by the expertise of the available laboratory, the financing source and the existence of potential facilitators, such as clinical trial access. Overall, the need of a collaborative initiative among European stakeholders to develop standardised, accessible molecular genotyping approaches in TC is underscored.</p
International Arbitration in Latin America: Energy and Natural Resources Disputes.
No full textIncludes bibliographic references.States as International Actors in Energy and Natural Resources Disputes : The Latin-American Experience / Mélida N. Hodgson & Pablo Garrido Cardozo -- Complex Procedural Issues Arising from Energy and Natural Resources Disputes / Eduardo Zuleta-Jaramillo & Rafael Rincón-Ordóñez & Juan Ignacio Guerra-Toro -- Complex Substantive Issues Arising from Energy and Natural Resources Disputes / Eduardo Damião Gonçalves, Flávio Spaccaquerche Barbosa & Caio Gabra & Ana Clara Nascimento -- Petroleum Contracts, Applicable Laws and Lex Petrolea in Latin America / Enrique A. Jaramillo & Marlon M. Meza-Salas -- Gas and Liquefied Natural Gas Disputes in Latin America, Issues of Force Majeure, Hardship, and Price Reopeners / Emmanuel E. Kaufman & Sofia Svinkovskaya -- International Investment Arbitration in the Latin-American Electricity Sector / Alvaro Galindo & Catalina Echeverri -- Renewable Energy Arbitration in Latin America / John Adam -- Corruption in Energy and Natural Resources Investment Disputes in Latin America / Mélanie Riofrio Piché & Patricia Saiz -- Damages in Energy and Natural Resources Arbitrations in Latin America / Noiana Marigo & Michael Seelhof -- Recognition and Enforcement of National and International Arbitration Awards in Latin America: Energy and Natural Resources Disputes / Adrián Magallanes & Montserrat Manzano & Claus Von Wobeser -- Arbitration in Brazilian-Related Energy and Natural Resources Disputes / Felipe V. Sperandio -- Disputes in the Brazilian Electricity Market Renato Stephan Grion -- Take-or-Pay Contracts in Project Finance: Focus on Gas-Supply Contracts in Brazil / Peter Christian Sester -- Three Notable Issues from the Venezuela Experience / Hugh Carlson & Anton Chaevitch & Liz Snodgrass -- Intimate Enemies : Are Stabilization Clauses and Human Rights Compatible under International Law? / Fabio Núñez del Prado & Eugenia Simo García & José Ignacio García Cueto -- Measuring Public Participation in International Investment Treaty Law : A Study of the Latin American Extractive Industries Gloria M. Alvarez & Ilias Kazeem -- Enabling Frameworks for Energy Investment in Latin America: A Global Perspective / Ernesto Bonafé -- Achieving Latin America's Energy Transition : Looking into the Roles of International Arbitration and Dispute Avoidance / Eric Franco & Alejandra Verdera -- Climate Change and International Arbitration in Latin America / Daniela Páez-Salgado & Emily Westphalen -- Mediation in the Energy and Natural Resources Sector : The Latin-American Experience / Fernando Navarro & Joe Tirado -- Concluding Thoughts on the Energy Arbitration in Latin America / Mélanie Riofrio Piché & Celia Cañete & Gloria M Alvarez.1 online resource (502 p.
Proyecto producción campesina. Abastecimiento y distribución de alimentos
No full textIP 1203-07-012-84Este proyecto es la excepción, porque todos los informes de avance, son incluidos como informe final según la coordinadora María Clara Espinosa.v.1. Produccion y comercializacion de la cebolla larga enla Region de Aquitania (Boyaca) / Pierre Raymond v.2. Cultivo, cultura y economia : productores y comerciantesdefrijol enlos municipios de Villanueva, Barichara y San Gil / Azucena Samudio, Ricardo Davila -- v.3.La agroindustria panelera en la Hoya del Rio Suarez / Guillermo Rudas -- v. 4. De la plaza España a Corabastos : estudio del mercado mayorista de alimentos en Bogotá / Elcy Esperanza Corrales, Jaime Forero Alvarez, Guiilermo Ruda
Proyecto producción campesina. Abastecimiento y distribución de alimentos
No full textIP 1203-07-012-84Este proyecto es la excepción, porque todos los informes de avance, son incluidos como informe final según la coordinadora María Clara Espinosa.v.1. Produccion y comercializacion de la cebolla larga enla Region de Aquitania (Boyaca) / Pierre Raymond v.2. Cultivo, cultura y economia : productores y comerciantesdefrijol enlos municipios de Villanueva, Barichara y San Gil / Azucena Samudio, Ricardo Davila -- v.3.La agroindustria panelera en la Hoya del Rio Suarez / Guillermo Rudas -- v. 4. De la plaza España a Corabastos : estudio del mercado mayorista de alimentos en Bogotá / Elcy Esperanza Corrales, Jaime Forero Alvarez, Guiilermo Ruda
Directorio Moral, que Comprehende, en breve, y claro estilo todas las materias de la Theologia Moral, y novissimos Decretos de los Sumos Pontifices, que han condenado diversas Proposiciones.
No full textVery useful work, and necessary for a straight examination of Confessors, and parish, with impertantissimas warnings for the practice [sic] of the Confessionario. It contains eight parts, The I. The Human Acts. II. The sacraments. III. The Precepts of the Decalogue. IV. Of Justice, & Jure. V. The Ecclesiastical Precepts. SAW. The Censures. VII. The address of the Parrocos. VIII. The Convicted Proposals, Denunciations to the Holy Tribunal, and definitions of the moral matters. At the end a copious Cast of remarkable things is placed. Sixth Impression. Corrected, Majorada, and Added by its Author. Dedicate to Maria Santissima in her Purssima Concepcion. For the M.R.P. Fr. Francisco Echarri Preacher Guardian current of Logrono, and Former Diffuser of the Province of Burgos, of the Order of S. Francisco. With License: Vich: By Pedro Morera Impressor. And Gerona: By Narcisco Oliva Impressor. Sell ??in these printers and their coasts year 1755. 1755Very useful work, and necessary for a straight examination of Confessors, and parish, with impertantissimas warnings for the practice [sic] of the Confessionario. It contains eight parts, The I. The Human Acts. II. The sacraments. III. The Precepts of the Decalogue. IV. Of Justice, & Jure. V. The Ecclesiastical Precepts. SAW. The Censures. VII. The address of the Parrocos. VIII. The Convicted Proposals, Denunciations to the Holy Tribunal, and definitions of the moral matters. At the end a copious Cast of remarkable things is placed. Sixth Impression. Corrected, Majorada, and Added by its Author. Dedicate to Maria Santissima in her Purssima Concepcion. For the M.R.P. Fr. Francisco Echarri Preacher Guardian current of Logrono, and Former Diffuser of the Province of Burgos, of the Order of S. Francisco. With License: Vich: By Pedro Morera Impressor. And Gerona: By Narcisco Oliva Impressor. Sell ??in these printers and their coasts year 1755. 175
Ecología de comunidades de murciélagos en zonas áridas y semiáridas colombianas
No full textIP 1101-13-011-93Contrato No. 072-95 Incluye anexos. Incluye resúmenes de tesis y de ponencias sobre el temav.1. Informe final -- v.2. Anexosde una comunidad de murcielagos polinivoros del cañon delrioChicamocha,departamento de Santander, Colombia;/ Jimmy Alvarez ... [et al.] -- En: Congreso de biologia de laconservacion. (1 : 1997 jul. 9-12 : Cali) --;[s.l. :s.n.]. -- p. 43 ; 28 cm.;cactacea columnar al suroccidente de Colombia / Jimmy Alvarez... [et al.]'-- en: Congreso de biologia de La;conservacion. (1 : 1997 jul. 9-12 : Cali) -- [s.l. :s.n.].--p.32 ; 28 cm. -- Contribucion al conocimiento;PONENCIA(S) EN CONGRESO: Ecologia de una comunidad de murcielagos y sus interrelaciones con las cactaceas en;una zona arida colombiana / J. Alvarez ... [et al.] -- En:congreso iberoamericano de biodiversidad y;zoologia de vertebrados. (8 : 1997 abr. 22-25 : Concepcion, Chile) -- Concepcion, Chile : Universidad de;Concepcion, 1997. -- p. 119 ; 28 cm. -- Reporte de visitasdeReithrodontomys mexicanus a flores de un
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