34,630 research outputs found
Reply to the letter “The first report on the effect of sacral neuromodulation on intestinal transit time and colonic motility in chronic constipation”
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Physiological parameters predicting the outcome of surgical and nonsurgical treatment of fecal incontinence
No full textFecal incontinence is a multifactorial disease. Anorectal physiology studies play an outstanding role in the evaluation of its etiology and severity, the two main factors that constitute the basis for the correct choice of treatment. However, the prognostic role of clinical factors and anorectal physiological tests in predicting the outcome to either conservative or surgical treatment is questionable. © 2007 Springer-Verlag Italia
Sacral Neuromodulation
No full textSacral nerve stimulation (SNS) is a new minimally invasive treatment available in the armamentarium for the treatment of pelvic floor dysfunctions, particularly fecal incontinence, and involves electrostimulation of the sacral nerves by means of an implantable pulse generator. Despite the fact that the exact mechanisms of action and neural pathways involved are still incompletely known, SNS has gained wide acceptance among colorectal surgeons for its ability to influence several factors responsible for continence, and as a reliable pre-implantation test, with very low surgical risk and a wide range of indications. In fact, fecal incontinence of any etiology (except complete spinal cord injury) and severity has been tested, although with variable success rates. About 15 years since its introduction in coloproctology, studies on the long-term outcome have confirmed its reliability and effectiveness, not only in symptom control but also in improving quality of life. Finally, evaluation of the cost-effectiveness ratio compared with other treatments for fecal incontinence confirms the advantages of SNS, making this technique the first option in the management algorithm of this disabling disease. © 2010 Springer-Verlag Milan
Cutting-Edge Research Trends in Colorectal Disease
No full text: The scientific effort in improving colorectal disease treatment and outcomes has allowed for a continuous shift of burdens that were previously thought to be unassailable [...]
The role of food contamination by mycotoxins in human diseases: A review
No full textDirect or indirect (by animals) contamination of food by mycotoxins produced by fungi is very common and should be considered a major problem in this era of globalization because it can severely affect human health and sometimes produce cancer. Some of the mycotoxins are well known and widely studied, but many others have not been evaluated yet for their potential toxicity. In this study we review the best-known human diseases induced by the most common mycotoxins such as aflatoxin B1, ochratoxin A, fumonisins and zearalenone and their mechanism of action. © SINPE-GASAPE
Comment: Is a Large-Scale Screening for Alzheimer's Disease Possible? Yes, in a Few Years
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