87,758 research outputs found
Cerebrovascular assessment for the risk prediction of Alzheimer’s disease.
No full textCerebrovascular Assessment for the Risk Prediction of Alzheimer's Disease.
Silvestrini M, Viticchi G, Altamura C, Luzzi S, Balucani C, Vernieri F.
Neurological Clinic, Marche Polytechnic University, Ancona, Italy.
Increasing evidence is emerging that vascular disease and its risk factors play a
role in the development of Alzheimer's disease (AD) and affect the probability of
an adverse outcome. The aims of this review are to explore the relationship
between vascular risk factors and AD and to discuss the potential use of vascular
markers in the clinical approach to cognitive impairment. Moreover, we present
evidence about the potential use of ultrasonographic and neuroradiologic markers
of cognitive impairment in order to establish possible treatment strategies in
subjects with a clinical profile at risk of developing AD
Malvinas: el triángulo dominante. Análisis geográfico militar de un archipiélago argentino
No full textArtículo de Correa Roselló, D. G.; Ponte, G. E.; y Altamura, O. F.; perteneciente a la revista Defensa Nacional Nº 4.Fil: Ponte, Gustavo E.Correa Roselló, D. G.; Ponte, G. E.; Altamura, O. F. (2020). Malvinas: el triángulo dominante. Análisis geográfico militar de un archipiélago argentino, pp. 235-260. Recuperado de http://www.cefadigital.edu.ar/handle/1847939/151
L’uomo di Altamura, vent’anni dopo: nuove ricerche sullo scheletro della grotta di Lamalunga (Altamura, Bari)
No full textThe “aLtaMura Man”, twentY Years Later. new researches on the skeLeton FroM the LaMaLunGa caVe (aLtaMura, itaLY) - the human skeleton from Lamalunga (altamura, bari) represents a keystone fossil specimen for our comprehension of human evolution in europe during the Pleistocene. the exceptional conditions of preservation (representing a unique case-study of its kind) offer the rare opportunity to add precious information on the morphology and genetics of the neanderthal lineage, as well as on the paleo-ecological and evolutionary dynamics occurred among human populations in the italian peninsula. it is also of great interest that the skeleton from altamura shows a peculiar combination of both derived (neanderthal) and more archaic features. although neanderthal traits predominate, in fact, other characters appear more plesiomorphic, particularly in the cranium. the recovery in 2009 of the articular portion of the right scapula in conditions of absolute sterility preventing any exogenous contamination, together with other se- lected samples of calcite, allowed to reach the following results: a) the first absolute dating of the skeleton; b) the first quantitative analysis of a single anatomic district; c) an equally unprecedented paleogenetic characterization of the Lamalunga skeleton. overall, these results concurred in indicating that the Lamalunga skeleton belongs to the hypodigm of Homo neanderthalensis, with some significant phenetic peculiarities. this conclusion appear consistent with a chronology that suggest a time window close to the end of the Middle Pleistocen
Should the term antipsychotic be changed to 'multidimensional stabiliser' in bipolar disorder? Towards a new denomination for atypical antipsychotics
No full textIl “morto di paglia”. Il sacrificio dell'autore tra cristologia e “mito dell’eterno ritorno” nel teatro di Pasolini
No full textNella sua opera teatrale, ma non solo, Pasolini espone il proprio corpo nella pubblica piazza dei mass media – accettando stoicamente l’alone di ambiguità che simile gesto fatalmente assume nella nascente società dello spettacolo. L’interventismo pasoliniano spazia senza posa tra "il qui e l’altrove, l’impegno e la pura opposizione anarchica", tradendo una larvata tensione per la performance. Come dice Siti, "il ‘teatro’ di Pasolini è grande come l’intera società e perché la sua strategia riesca bisogna che la società sia informata sul corpo e sulla vita dell’autore – questo comporta un gioco pericoloso con i media". Il corpo acquisisce una dimensione pubblica e simbolica perché incarna volontariamente la colpa di una intera società
Colorimetric characterization of ochres in a Palaeolithic flint pebble from Maschio dell’Artemisio, Latium, Italy
No full textThe flint pebble from Maschio dell’Artemisio, a peak of the Artemisio mountain range (South-East of Rome), represents one of the first complex artefacts from the Upper Palaeolithic of the Alban Hills possibly displaying a symbolic/artistic value (Altamura & Mussi, 2014). It has been used as a hammer stone and retoucher, to create or modify lithic implements. It shows a diffuse and intense ochraceous colour on almost half of its surface. In the present work we discuss the results of an innovative colorimetric approach to define the use of pigments in the Palaeolithic community of the area and eventually compare the raw materials with local supplies. Second-derivative diffuse reflectance spectroscopy (DRS) is a data treatment on colorimetric data used from the ‘80s in the characterization of soil (Scheinost et al., 1998). More recently, it has been applied on iron oxide and hydroxide minerals, to investigate their colour and crystal properties (Torrent & Barrón, 2003). Here it was used directly on an archaeological artefact, to determine the presence of yellow and red ochres, but also to quantify the amount of each pigment present in mixture on the surface. Data were acquired using either a colorimeter and fibre optic reflectance spectroscopy (FORS) and then compared to test the efficiency of both techniques.
Altamura F., Mussi M., Arte mobiliare paleolitica dalla Catena del Tuscolano-Artemisio, Lazio e Sabina 10 (2014), Atti del Convegno Decimo Incontro di Studi sul Lazio e la Sabina, Roma, 4-6 Giugno 2013, pp. 119-125
Scheinost A. C., Chavernas A., Barrón V., Torrent J., Use and limitations of second-derivative diffuse reflectance spectroscopy in the visible to near-infrared range to identify and quantify Fe oxide minerals in soils, Clays and Clay Minerals, 46(1998), 528-536
Torrent J., Barrón V., The visible diffuse reflectance spectrum in relation to the color and crystal properties of hematite,Clays and Clay Minerals, 51(2003), 309-31
fMRI-vs-MEG evaluation of post-stroke interhemispheric asymmetries in primary sensorimotor hand areas
No full textGrowing evidence emphasizes a positive role of brain ipsilesional (IL) reorganization in stroke patients with partial recovery. Ten patients affected by a monohemispheric stroke in the middle cerebral artery territory underwent functional magnetic resonance (fMRI) and magnetoencephalography (MEG) evaluation of the primary sensory (S1) activation via the same paradigm (median nerve galvanic stimulation). Four patients did not present S1 fMRI activation [Rossini, P.M., Altamura, C., Ferretti, A., Vernieri, F., Zappasodi, F., Caulo, M., Pizzella, V., Del Gratta, C., Romani, G.L., Tecchio, F., 2004. Does cerebrovascular disease affect the coupling between neuronal activity and local haemodynamics? Brain 127, 99-110], although inclusion criteria required bilateral identifiable MEG responses. Mean Euclidean distance between fMRI and MEG S1 activation Talairach coordinates was 10.1 ± 2.9 mm, with a 3D intra-class correlation (ICC) coefficient of 0.986. Interhemispheric asymmetries, evaluated by an MEG procedure independent of Talairach transformation, were outside or at the boundaries of reference ranges in 6 patients. In 3 of them, the IL activation presented medial or lateral shift with respect to the omega-shaped post-rolandic area while in the other 3, IL areas were outside the peri-rolandic region. In conclusion, despite dissociated intensity, the MEG and fMRI activations displayed good spatial consistency in stroke patients, thus confirming excessive interhemispheric asymmetries as a suitable indicator of unusual recruitments in the ipsilesional hemisphere, within or outside the peri-rolandic region. © 2006 Elsevier Inc. All rights reserved
Giant vesicles as compartmentalized bio-reactors: A 3D modelling approach
No full textGiant lipid vesicles have been extensively used in recent years as in vitro artificial models for protocells, i.e. primitive cell models or synthetic cell-like systems of minimal complexity. Due to their dimensions in the micrometer range, giant vesicles can be designed as micro-sized enzymatic chemical reactors fed by a flux of substrates from the outside and monitored by confocal light microscopy in order to follow the production of fluorescence compounds. In this paper we present a 3D modelling approach to the simulation of giant vesicle where enzymatic reactions take place, and we apply this approach to a case study of a three-enzymes metabolic pathway
Measurement and Numerical Modeling of Cell-Free Protein Synthesis: Combinatorial Block-Variants of the PURE System
No full textProtein synthesis is at the core of bottom-up construction of artificial cellular mimics. Intriguingly, several reports have revealed that when a transcription-translation (TX-TL) kit is encapsulated inside lipid vesicles (or water-in-oil droplets), high between-vesicles diversity is observed in terms of protein synthesis rate and yield. Stochastic solute partition can be a major determinant of these observations. In order to verify that the variation of TX-TL components concentration brings about a variation of produced protein rate and yield, here we directly measure the performances of the PURE system' TX-TL kit variants. We report and share the kinetic traces of the enhanced Green Fluorescent Protein (eGFP) synthesis in bulk aqueous phase, for 27 combinatorial block-variants. The eGFP production is a sensitive function of TX-TL components concentration in the explored concentration range. Providing direct evidence that protein synthesis yield and rate actually mirror the TX-TL composition, this study supports the above-mentioned hypothesis on stochastic solute partition, without excluding, however, the contribution of other factors (e.g., inactivation of components)
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